期刊
ANTIVIRAL THERAPY
卷 21, 期 7, 页码 627-631出版社
INT MEDICAL PRESS LTD
DOI: 10.3851/IMP3049
关键词
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资金
- Gilead Sciences
- Technische Universitat Munchen
Background: Insulin resistance (IR) was one of the first reported complications in HIV-positive patients who were receiving antiretroviral therapy (ART). However, the metabolic effects of newer fixed-dose ART combinations are unclear. Methods: This Phase I prospective randomized open-label study evaluated the effects on IR in 30 healthy volunteers who were receiving newer fixed-dose combinations of tenofovir disoproxil fumarate, emtricitabine, elvitegravir and cobicistat (E/C/F/TDF, 10 patients) or the established ART regimens, such as tenofovir disoproxil fumarate/emtricitabine with lopinavir/ritonavir (F/TDF+ LPV/r, 9 patients) or darunavir/ritonavir (F/TDF+ DRV/r, 9 patients). IR was measured before and after the 14-day treatments using the hyperinsulinemic-euglycemic clamp technique, and changes in IR were evaluated using the mean glucose disposal rate that was normalized to body weight (M-BW) and lipid metabolism. Results: The groups exhibited similar pretreatment IR, although M-BW was significantly lower after the 14-day F/TDF+ LPV/r treatment compared with baseline (12.5 +/- 3.3 versus 9.2 +/- 1.8 mg glucose/minxkg; P= 0.037). No significant IR changes were observed for E/C/F/TDF (11.2 +/- 3.2 versus 11.3 +/- 2.5) or F/TDF+ DRV/r (11.6 +/- 2.5 versus 11.3 +/- 2.4). Compared with baseline, F/TDF+ LPV/r and F/TDF+ DRV/r treatments significantly increased day 14 triglyceride levels (62 [54-73] versus 119 [77-147] mg/dl, P= 0.0109; 75 [56-95] versus 96 [93-128] mg/dl, P= 0.009, respectively). Conclusions: Short-term treatment using fixed-dose combinations of E/C/F/TDF or F/TDF+ DRV/r did not affect IR, although IR significantly increased after treatment using F/TDF+ LPV/r.
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