Article
Agriculture, Multidisciplinary
Ruiqiang Zhang, Songke Qin, Caimei Yang, Yu Niu, Jie Feng
Summary: This study aimed to investigate the protective capability of Bacillus licheniformis against Clostridium perfringens-induced inflammatory responses and intestinal barrier damage in broilers. The results showed that Bacillus licheniformis improved the final body weight and alleviated the impact of necrotic enteritis on immunity and intestinal structure. Moreover, Bacillus licheniformis mitigated the inflammatory response by modulating multiple signaling pathways and increasing the abundance of beneficial intestinal flora.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Agriculture, Dairy & Animal Science
Qiao Li, Linyan Li, Yanhong Chen, Changning Yu, Paula Azevedo, Joshua Gong, Chengbo Yang
Summary: he results of the study suggest that B. licheniformis PF9 may reduce the production of inflammation-related cytokines by blocking the NF-κ B signaling pathway, and also significantly enhance the integrity of IPEC-J2 cells.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biology
Wenjuan Sun, Wenning Chen, Kun Meng, Long Cai, Guiguan Li, Xilong Li, Xianren Jiang
Summary: The study investigated the effect of BL-S6 supplementation in post-weaning piglets on growth performance and gut health. The researchers found that BL-S6 supplementation improved the piglet's immunity-oxidative capacity, composition of the cecum microbiota, and intestinal barrier function, resulting in improved growth performance and reduced diarrhea. This highlights the potential of BL-S6 as an alternative to antibiotics in pig production.
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hajar Hazime, G. Michelle Ducasa, Ana M. Santander, Nivis Brito, Eddy E. Gonzalez, Yuguang Ban, Jonathan Kaunitz, Yasutada Akiba, Irina Fernandez, Juan F. Burgueno, Maria T. Abreu
Summary: The inactivity of intestinal epithelial DUOX2 is linked to alterations in the gut microbiome and contributes to the development of Metabolic Syndrome (MetS).
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Carolina Battistini, Rafael Ballan, Marcos Edgar Herkenhoff, Susana Marta Isay Saad, Jun Sun
Summary: Inflammatory bowel disease is a chronic inflammation of the GI tract, including Crohn's disease and ulcerative colitis, associated with microbiota dysbiosis and vitamin D deficiency. Further studies are needed to explore the mechanisms and therapeutic potential related to vitamin D/VDR in gut microbiota modulation for IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Rong Cheng, Ling-Juan Guan, Mitchell N. Muskat, Cong-Cong Cao, Bin Guan
Summary: The study indicates that EPI chelates can alleviate intestinal inflammation and dysbiosis in ICR mice with iron-deficiency anemia, restoring intestinal health.
Article
Immunology
Yuyuan Li, Man Liu, He Liu, Xue Sui, Yinhui Liu, Xiaoqing Wei, Chunzheng Liu, Yiqin Cheng, Weikang Ye, Binbin Gao, Xin Wang, Qiao Lu, Hao Cheng, Lu Zhang, Jieli Yuan, Ming Li
Summary: This study demonstrated that CB RH2 can modulate ceftriaxone-induced dysbacteriosis by altering gut microbiota diversity, improving colonic architecture and intestinal integrity, reducing inflammation, and positively impacting the immune system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Xiangjun Xiao, Xiangbing Mao, Daiwen Chen, Bing Yu, Jun He, Hui Yan, Jianping Wang
Summary: This review provides a detailed overview of the role of micro-ribonucleic acids (miRNAs) in the intestinal epithelial barrier of inflammatory bowel disease (IBD), including their regulation of inflammation, immunity, and microorganisms. The findings of this review contribute to the understanding of the interaction between miRNAs and the intestinal epithelial barrier in IBD and provide a theoretical reference for future prevention and treatment of IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Qichen Shen, Zhuizui Huang, Jiachen Yao, Yuanxiang Jin
Summary: This review discusses the modulatory functions of extracellular vesicles (EVs) in the intestine, with a focus on their roles and applications in the clinical therapy of inflammatory bowel disease (IBD). By establishing EV-mediated interaction systems between host intestine and microbiota, the possible mechanisms of IBD pathogenesis and its cure are described.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Microbiology
Shruti Ahlawat, Pramod Kumar, Hari Mohan, Sandeep Goyal, Krishna Kant Sharma
Summary: The human gut microbiota plays a crucial role in host health, with alterations in composition leading to the development of gastrointestinal disorders. Modulating gut microbiota composition and utilizing advanced treatment methods are key approaches for managing gut disorders in the future.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Immunology
Samuel Adefisoye Lawal, Athalia Voisin, Hana Olof, Michael Bording-Jorgensen, Heather Armstrong
Summary: The gut microbiota plays a crucial role in the development of inflammatory bowel diseases, and there are significant differences in the microbiota communities of different intestinal sub-organs between healthy individuals and those with IBD. However, research focusing on the mycobiome and virome is limited, and the differences in microbiota composition in different segments of the intestinal tract in IBD remain largely unknown.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Lei Li, Man Wang, Jikuai Chen, Zhuoran Xu, Shaokang Wang, Xinyu Xia, Dong Liu, Sheng Wang, Chaoyu Xie, Jianghong Wu, Jinfeng Li, Jiqianzhu Zhang, Meitang Wang, Jiangbo Zhu, Changquan Ling, Shuogui Xu
Summary: Pre-administration of the probiotic Bacillus licheniformis strain (BL) for 7 days showed significant preventive effects on heat stroke (HS) in rats, attenuating hyperthermia, reducing HS-induced death, alleviating multiple-organ injury, and decreasing levels of serum inflammatory cytokines. The study also found that BL sustained intestinal barrier integrity by alleviating intestinal injury and modulating gut microbiota, increasing ratios of probiotic bacteria such as Lactobacillus and Lactococcus. Additionally, a candidate biomarker for HS diagnosis, Romboutsia, was unexpectedly detected.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Yang Cheng, Tyler R. Hall, Xiao Xu, Ivy Yung, Donald Souza, Jie Zheng, Felix Schiele, Matthias Hoffmann, M. Lamine Mbow, James P. Garnett, Jun Li
Summary: This study reveals that the coordinated upregulation of uPA and uPAR in IBD mucosa is associated with the breakdown of the intestinal epithelial barrier. Inhibiting the interaction between uPA and uPAR through genetic and pharmacological approaches can protect the epithelial barrier. Additionally, uPAR deficiency enhances EGF/EGFR signaling, promoting epithelial homeostasis and repair.
Article
Agriculture, Dairy & Animal Science
Chengling Bao, Wenxiu Zhang, Jian Wang, Yajing Liu, Heng Cao, Feiyu Li, Suozhu Liu, Zhengda Shang, Yunhe Cao, Bing Dong
Summary: This study investigated the probiotic mechanism of Bacillus amyloliquefaciens on broilers by adding different levels of the bacteria to their diets. The results showed that the addition of Bacillus amyloliquefaciens TL106 improved the growth performance, immune response ability, and intestinal health of broilers. It also regulated the development and composition of the intestinal microbiota. Therefore, Bacillus amyloliquefaciens TL106 may be a suitable alternative to antibiotics for improving the health and performance of broilers.
