期刊
ANTIVIRAL RESEARCH
卷 134, 期 -, 页码 244-249出版社
ELSEVIER
DOI: 10.1016/j.antiviral.2016.09.010
关键词
Dengue genomic RNA; Dengue RNA translation; Dengue RNA replication; Dengue RNA structure
资金
- Texas STARs Award Program of the University of Texas System
- University of Texas Medical Branch startup funds
- Agency for Science, Technology and Research, Singapore
- Ministry of Health, Singapore
Upon release of the similar to 11 kb single-stranded positive polarity dengue virus genomic RNA (gRNA) into the cytoplasm of an infected cell, it serves as the template for translation of the viral polyprotein, which is cleaved into three structural and seven non-structural proteins. The structural organization of the viral replication complex and RNA is not known but it is increasingly becoming evident that the viral gRNA and replication intermediates adopt unique structural features and localize to discrete regions in the infected cell. Both structure and location play multiple roles ranging from evasion of innate immune response to recruitment of viral and host proteins for translation and replication of the message. This review visits the various transactions that the viral gRNA undergoes between entry and RNA synthesis with the view that some of these events may be targeted by antiviral compounds. This article forms part of a symposium on flavivirus drug discovery in Antiviral Research. (C) 2016 Elsevier B.V. All rights reserved.
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