Article
Medicine, Research & Experimental
Maisa Siddiq Abduh, Reem S. Alruhaimi, Haifa A. Alqhtani, Omnia E. Hussein, Mohammad H. Abukhalil, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study investigated the protective effect of the antioxidant polyphenol rosmarinic acid (RA) against chlorpyrifos (CPF)-induced kidney injury, focusing on oxidative injury, inflammation, SIRT1, and Nrf2/HO-1 signaling. The results showed that RA could alleviate the renal toxicity caused by CPF, suppress oxidative stress and inflammation, and promote cell survival.
Article
Medicine, Research & Experimental
Kaan Kaltalioglu
Summary: This study found that sinapic acid, a phytochemical, has the potential to promote wound healing in individuals with diabetes. By using sinapic acid-loaded gels, the researchers observed improved re-epithelialization and angiogenesis, increased collagen content, and decreased oxidative damage in diabetic wounds. These findings suggest that topical application of sinapic acid can be an effective approach for promoting diabetic wound healing, especially at low doses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mushtaq Ahmad Ansari, Mudassar Shahid, Sheikh F. Ahmad, Ajaz Ahmad, Abdulrazaq Alanazi, Abdul Malik, Yousef A. Bin Jardan, Sabry M. Attia, Saleh A. Bakheet, Mohammad Raish
Summary: This study investigated the protective effects of sinapic acid (SA) against 5-fluorouracil (5-FU)-induced nephrotoxicity in a rat model. The results showed that SA can alleviate kidney damage caused by 5-FU by suppressing renal inflammation and oxidative stress, promoting antioxidant defense, and restoring cytoprotective mechanisms.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Nevin Ilhan, Ibrahim Bektas, Solmaz Susam, Ibrahim H. Ozercan
Summary: The study suggests that RA may be beneficial in preventing AOM-induced colon carcinogenesis formation, reducing adenocarcinoma rates and affecting circulatory oxidant-antioxidant status.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Andrology
Velid Unsal, Engin Kolukcu, Fikret Gevrek, Fatih Firat
Summary: The study demonstrates that sinapic acid has a significant protective effect on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. By reducing testicular damage, oxidative stress, inflammation, and cell death, sinapic acid restored decreased antioxidant enzyme activities.
Article
Medicine, Research & Experimental
Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mudassar Shahid, Khalid M. Alkharfy, Abdul Ahad, Mushtaq Ahmad Ansari, Ibrahim Abdelsalam Abdelrahman, Fahad Al-Jenoobi
Summary: Sinapic acid has been found to improve cardiac damage in diabetic rats by alleviating hyperglycemia and hyperlipidemia-induced cardiac dysfunction, reducing inflammation and oxidative stress, and enhancing antioxidant defenses. Therefore, it may possess therapeutic potential for the prevention of diabetic cardiac dysfunction and cardiomyopathy via the NRF2/HO-1 and NF-kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed A. J. Jabbar, Zaenah Zuhair Alamri, Mahmood Ameen Abdulla, Ahmed S. AlRashdi, Soran Kayfi Najmaldin, Mustafa AbdulMonam Zainel
Summary: Sinapic acid (SA) has protective effects against thioacetamide (TAA) induced fibrosis in rats by reducing hepatocyte injuries, inhibiting fibrosis, promoting heat shock protein (HSP) up-regulation, down-regulating alpha-smooth muscle actin (a-SMA) expression, and improving liver index and antioxidant enzymes levels.
Article
Environmental Sciences
Sibel Cigdem Tuncer, Serkan Ali Akarsu, Sefa Kucukler, Cihan Gur, Fatih Mehmet Kandemir
Summary: This study aimed to determine the effects of lead acetate (PbAc) and sinapic acid (SNP) on oxidative stress, apoptosis, inflammation, sperm quality, and histopathology in rat testicular tissue. PbAc administration increased oxidative stress and inflammation parameters, while SNP treatment inhibited these changes and improved sperm quality. Overall, PbAc caused histopathological damage and impaired spermatogenesis, whereas SNP treatment showed protective effects.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Ajaz Ahmad, Khalid M. Alkharfy, Yousef A. Bin Jardan, Mudassar Shahid, Mushtaq Ahmad Ansari, Saeed Alqahtani, Basit L. Jan, Fahad I. Al-Jenoobi, Mohammad Raish
Summary: This research investigated the protective effects of sinapic acid (SA) against methotrexate (MTX) induced liver damage by modulating the Nrf2/HO-1 and NF-kappa B pathways. SA pretreatment significantly restored liver function indices, antioxidant defense mechanisms, oxidative/nitrostative stress, and inflammatory cytokines affected by MTX. The study concluded that SA prevented hepatic damage by inhibiting apoptosis and stimulating Nrf2/HO-1-mediated antioxidant enzymes through NF-kappa B inhibition.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
W. A. Saka, R. E. Akhigbe, A. O. Abidoye, O. S. Dare, A. O. Adekunle
Summary: The study showed that Dichlorvos induced hepatic and renal damage, accompanied by redox dyshomeostasis. L-arginine was found to reverse the damage and improve organ structure, suggesting a potential therapeutic role against Dichlorvos-induced toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Junyi Chu, Ran Yan, Sai Wang, Guoyang Li, Xiaohui Kang, Yan Hu, Musen Lin, Wen Shan, Yan Zhao, Zhecheng Wang, Ruimin Sun, Jihong Yao, Ning Zhang
Summary: This study demonstrates that sinapic acid (SA) reduces alcoholic liver disease (ALD) through regulating BRD4, showing significant antioxidant, anti-inflammatory, and liver protective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Lenise de Lima Silva, Carine de Freitas Souza, Thaylise Vey Parodi, Amanda Leitao Gindri, Patricia da Silva Pacheco, Adriane Erbice Bianchini, Bernardo Baldisserotto
Summary: The study evaluated the anesthetic potential of an ethanolic extract of Hyptis mutabilis on silver catfish (Rhamdia quelen) and found promising sedative effects at 100 mg L-1. Long-term exposure showed good safety and stress prevention abilities, making it suitable for use in the transport of aquatic animals.
Article
Multidisciplinary Sciences
Atul Srivastava, Vinita Pandey, Vandana Yadav, Sangita Singh, Ragini Srivastava
Summary: This study aims to investigate the protective effect of Ocimum sanctum leaf extract (OLE) in a cigarette smoke-induced model of Chronic Obstructive Pulmonary Disease (COPD). The results showed that OLE can reduce inflammation, decrease oxidant concentration, and increase antioxidant concentration. Molecular docking studies also demonstrated strong binding interaction between the major phytocompounds of OLE and antioxidant enzymes. Therefore, OLE extract may be a therapeutic option for COPD prevention and treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Mudassar Shahid, Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mushtaq Ahmad Ansari, Abdul Ahad, Khalid M. Alkharfy, Ahmed L. Alaofi, Fahad Al-Jenoobi
Summary: The study demonstrates that sinapic acid has significant therapeutic effects on AA-induced UC in rats, exerting its effects through the inhibition of inflammation, oxidative stress, and apoptosis.
Article
Food Science & Technology
Fikret Altindag, Murat Cetin Ragbetli, Ugur Ozdek, Necat Koyun, Jamal Khalid Ismael Alhalboosi, Sadi Elasan
Summary: Our study demonstrates that individual and combined treatments of sinapic acid and ellagic acid can restore changes in glucose and insulin levels, increase insulin expression of beta-cells, and improve oxidative stress parameters in streptozotocin-induced diabetic rats.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Szalabska-Rapala, Weronika Borymska, Ilona Kaczmarczyk-Sedlak
Summary: Research indicates that magnolol, a polyphenolic compound found in magnolia bark, shows promising effects in diabetes treatment by improving parameters related to blood glucose, lipid metabolism, and oxidative stress, thus potentially becoming a novel approach to managing diabetes and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Lech Sedlak, Marta Swierczynska, Weronika Borymska, Maria Zych, Dorota Wygledowska-Promienska
Summary: The use of benzalkonium chloride-preserved carbonic anhydrase inhibitors increases oxidative stress in the tear film, leading to alterations in certain oxidative stress biomarkers.
Article
Pharmacology & Pharmacy
Piotr Bramora, Weronika Borymska, Maria Zych, Ilona Kaczmarczyk-Sedlak
Summary: The study investigated the effect of naringenin on oxidative stress parameters in the heart tissue of rats with type 1 diabetes. It was found that naringenin alleviated oxidative damage and reduced oxidative stress index in the heart tissue, suggesting its potential utility in antidiabetic therapy.
ACTA POLONIAE PHARMACEUTICA
(2021)
Article
Nutrition & Dietetics
Weronika Borymska, Maria Zych, Slawomir Dudek, Ilona Kaczmarczyk-Sedlak
Summary: This study evaluated the effect of silymarin on oxidative stress markers in the lenses of type 1 diabetic rats. The results showed that silymarin had a faint positive effect on improving the overall state of diabetic animals.
Article
Biotechnology & Applied Microbiology
Maria Zych, Jan Burczyk, Weronika Borymska, Ilona Kaczmarczyk-Sedlak
Summary: Based on the research findings, the presence or absence of algaenan in the cell walls of green microalgae affects their ability to accumulate proteins in the growth medium. It was observed that strains without algaenan accumulated significantly more proteins in the medium compared to those with algaenan. These findings are valuable for strain selection in specific applications.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Review
Food Science & Technology
Daniel Jamrozik, Weronika Borymska, Ilona Kaczmarczyk-Zebrowska
Summary: This article discusses the therapeutic effects of roselle in diabetes and its comorbidities. With various active compounds, roselle exhibits hypoglycemic, antioxidant, hypotensive, and anti-lipidemic activities, as well as other indirect effects. It can be used as a standalone or adjunctive treatment to prevent or treat diabetes and its accompanying diseases.
Article
Pharmacology & Pharmacy
Piotr Bramora, Maria Zych, Weronika Borymska, Ilona Kaczmarczyk-zebrowska
Summary: Chronic hyperglycemia leads to the formation of oxygen-free radicals, causing damage to various organs. The development of diabetic cardiomyopathy is associated with damage to proteins and lipids in the heart. Supplementation of silymarin can alleviate oxidative stress and improve oxidative damage in heart tissues.
ACTA POLONIAE PHARMACEUTICA
(2022)
Article
Pharmacology & Pharmacy
Maria Zych, Weronika Borymska, Katarzyna Urbisz, Marek Kostrzewski, Ilona Kaczmarczyk-Zebrowska
Summary: This study evaluated the effect of rosmarinic acid (RA) and sinapic acid (SA) on oxidative stress markers in the lenses of type 2 diabetic female rats. The results showed that neither RA nor SA could counteract the reduced levels of glutathione caused by diabetes, indicating that they may not be promising agents for diabetic cataract prevention.