Article
Multidisciplinary Sciences
Caner Caglar, Jeffrey Friedman
Summary: Activation of PPP1R17 neurons in Leptin-deficient mice does not increase food intake as hypothesized, but instead decreases it, suggesting these neurons play a role in limiting overconsumption. The neurons in the DMH expressing PPP1R17 are indirectly affected by Leptin and serve to constrain binge eating behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Marcelo Farina, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: Studies have shown that methylmercury enhances leptin effects in male mice, leading to anorexigenic behavior, with different impacts on the leptin signaling pathway in males and females. Understanding the molecular alterations induced by methylmercury in the hypothalamus advances knowledge of its neurotoxicity and potential for novel therapies.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Alan C. Rupp, Abigail J. Tomlinson, Alison H. Affinati, Warren T. Yacawych, Allison M. Duensing, Cadence True, Sarah R. Lindsley, Melissa A. Kirigiti, Alexander MacKenzie, Joseph Polex-Wolf, Chien Li, Lotte Bjerre Knudsen, Randy J. Seeley, David P. Olson, Paul Kievit, Martin G. Myers Jr
Summary: The study found that the adipose-derived hormone leptin controls food intake and body weight by acting on a specific group of GABAergic hypothalamic neurons through its receptor LepRb. This group of neurons shows conservation across species.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Alexandre Caron, Natalie Jane Michael
Summary: Histamine, a neuromodulator in the brain, contributes to the regulation of various physiological processes, including energy balance, through histaminergic signaling in the hypothalamus. Two histamine receptors, H1R and H3R, play important roles in key hypothalamic nuclei involved in energy homeostasis. Activation of H1R suppresses food intake, while activation of H3R stimulates appetite. The central histaminergic system is implicated in weight gain induced by atypical antipsychotics and has potential as a therapeutic target for obesity treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Emanuela Pannia, Rola Hammoud, Ruslan Kubant, Jong Yup Sa, Rebecca Simonian, Brandi Wasek, Paula Ashcraft, Teodoro Bottiglieri, Zdenka Pausova, G. Harvey Anderson
Summary: The study found that high levels of MTHF compared to FA can promote weight gain in offspring and induce changes in central and peripheral mechanisms. However, when fed folate diets at the requirement level, there were no differences found in offspring.
Article
Neurosciences
Ana M. P. Campos, Frederick Wasinski, Marianne O. Klein, Jackson C. Bittencourt, Martin Metzger, Jose Donato Jr
Summary: The study found species-specific differences in the effects of fasting on animals, with a reduction in PVHTRH neurons in rats but not mice, as well as differences in the action of leptin in rats and mice.
NEUROSCIENCE LETTERS
(2021)
Article
Food Science & Technology
Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Aaron B. Bowman, Michael Aschner
Summary: MeHg disrupts the physiological functions of ghrelin differently in males and females, enhancing ghrelin-induced body weight gain in males by activating the AMPK/UCP2 signaling pathway and mitigating ghrelin-induced weight gain in females by inhibiting mTOR signaling and decreasing Npy mRNA expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luciana da Costa Oliveira, Gustavo Paroschi Morais, Franciane Pereira de Oliveira, Milene Montavoni Mata, Allice Santos Cruz Veras, Alisson Luiz da Rocha, Lucila Leico Kagohara Elias, Giovana Rampazzo Teixeira, Camila de Moraes, Dennys E. Cintra, Eduardo R. Ropelle, Leandro P. de Moura, Jose R. Pauli, Ellen C. de Freitas, Rodrigo Rorato, Adelino Sanchez R. da Silva
Summary: Consuming a high-fat diet leads to hypothalamic inflammation and disrupts the leptin pathway, resulting in dysregulated hypothalamic neuronal activities and increased risk of obesity. Intermittent fasting and exercise training have been shown to effectively modulate hypothalamic inflammation and neuronal activity. However, it is unknown whether combining these interventions can better restore hypothalamic homeostasis in the presence of a high-fat diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Ying Liu, Yu-Chen Xu, Yu-Gui Cui, Shi-Wen Jiang, Fei-Yang Diao, Jia-Yin Liu, Xiang Ma
Summary: Excess androgen increases food intake in rats and promotes obesity by downregulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the cerebrospinal fluid.
NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Rizaldy C. Zapata, Dinghong Zhang, Dongmin Yoon, Chanond A. Nasamran, Daisy R. Chilin-Fuentes, Avraham Libster, Besma S. Chaudry, Mariela Lopez-Valencia, Devasena Ponnalagu, Harpreet Singh, Michael Petrascheck, Olivia Osborn
Summary: Clic1 inhibition reduces food intake and body weight in mouse models, suggesting it as a potential therapeutic target for obesity treatment.
MOLECULAR METABOLISM
(2023)
Article
Medicine, Research & Experimental
Gabriel O. de Souza, Frederick Wasinski, Jose Donato
Summary: This study aimed to compare the responses of male and female C57BL/6 mice to various metabolic challenges. The results showed that male mice had stronger responses to food restriction and refeeding, while female mice had higher protection against diet-induced obesity. Additionally, male mice had different feeding responses to ghrelin and leptin compared to females. However, these sex differences were not explained by differences in central responsiveness or neuron fiber density.
Article
Endocrinology & Metabolism
Anna Aulinas, Maged Muhammed, Kendra R. Becker, Elisa Asanza, Kristine Hauser, Casey Stern, Julia Gydus, Tara Holmes, Helen Burton Murray, Lauren Breithaupt, Nadia Micali, Madhusmita Misra, Kamryn T. Eddy, Jennifer J. Thomas, Elizabeth A. Lawson
Summary: This study examined the response of anorexigenic oxytocin to food intake in adolescents and young adults with avoidant/restrictive food intake disorder (ARFID). It was found that individuals with ARFID had higher levels of oxytocin compared to healthy controls at all time points.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shota Yamamoto, Hiroki Noguchi, Asuka Takeda, Ryosuke Arakaki, Maimi Uchishiba, Junki Imaizumi, Saki Minato, Shuhei Kamada, Tomohiro Kagawa, Atsuko Yoshida, Takako Kawakita, Yuri Yamamoto, Kanako Yoshida, Masafumi Kon, Nobuo Shinohara, Takeshi Iwasa
Summary: PCOS is a common condition in reproductive-age females, often exacerbated by obesity. Recent studies have found that oxytocin can reduce weight gain and food intake, making it a potential treatment for obese PCOS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Danielle Renzi, Takara Stanley, Jessica Waxler, Hang Lee, Barbara Pober, Marianne Nordstrom
Summary: This study investigated the relationship between predicted dietary intake and body weight differences in adults with Williams syndrome. The study found that deviations in dietary intake and behaviors related to food were associated with increased body mass index (BMI) and weight gain.
FOOD & NUTRITION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Liya Kerem, Elizabeth A. Lawson
Summary: This review comprehensively describes both the central and peripheral effects of oxytocin on eating behavior and metabolism, as well as discussing the association between endogenous oxytocin levels and weight status, metabolic syndrome, and bone health. The review also highlights the potential of intranasal oxytocin as a therapeutic option for obesity treatment and the challenges of translating oxytocin research into clinical care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Maria J. Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begona Porteiro, Marcos F. Fondevila, Uxia Fernandez, Marta Varela-Rey, Ana Senra, Cristina Iglesias, Adriana Escudero, Miguel Fidalgo, Diana Guallar, Roman Perez-Fernandez, Vincent Prevot, Markus Schwaninger, Miguel Lopez, Carlos Dieguez, Roberto Coppari, Gema Fruhbeck, Ruben Nogueiras
Summary: The transcription factor p63 plays a key role in glucose metabolism by regulating SIRT1 and affecting blood glucose levels, thus influencing glucose homeostasis.
Editorial Material
Gastroenterology & Hepatology
Marc Claret, Ruben Nogueiras
Editorial Material
Gastroenterology & Hepatology
Ruben Nogueiras, Patricia Aspichueta
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Edward Milbank, Nathalia Dragano, Xavi Vidal-Gomez, Veronica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, Maria P. Pata, Jose Luis Labandeira-Garcia, Carlos Dieguez, Ruben Nogueiras, M. Carmen Martinez, Ramaroson Andriantsitohaina, Miguel Lopez
Summary: The study found that using a specific type of extracellular vesicles loaded with a defective AMPK alpha 1 gene can alleviate symptoms such as obesity and metabolic disorders in mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Editorial Material
Endocrinology & Metabolism
Vincent Prevot, Ruben Nogueiras
Summary: Food odour recognition is involved in food anticipatory response. A study in Nature Metabolism explains how the olfactory system regulates metabolic adaptations based on energy availability. These effects are controlled by a brain circuit involving the melanocortin system, which regulates systemic lipid utilization through the sympathetic nervous system.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Edward Milbank, Ramon Diaz-Trelles, Nathalia Dragano, Jessica Latorre, Rajesh Mukthavaram, Jordi Mayneris-Perxachs, Francisco Ortega, Massimo Federici, Remy Burcelin, Priya P. Karmali, Kiyoshi Tachikawa, Pad Chivukula, Miguel Lopez, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: Decreasing liver LBP levels can exacerbate oxidative stress and inflammation in the liver, further aggravating the progression of non-alcoholic steatohepatitis (NASH).
PHARMACOLOGICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Matthias Tschoep, Ruben Nogueiras, Bo Ahren
Summary: GLP-1 receptor agonists are established pharmaceutical therapies for type 2 diabetes and obesity. They reduce glucose levels by simulating GLP-1 action and induce satiety through central actions, leading to weight reduction.
Review
Biochemistry & Molecular Biology
Sayani Mukherjee, Carlos Dieguez, Johan Ferno, Miguel Lopez
Summary: Currently, there are various pharmacological therapies available for treating obesity, impacting both the central nervous system and peripheral tissues. Small extracellular vesicles (sEVs) have gained attention for their role in pathophysiological conditions due to their unique nano-sized structure and contents. In addition to transferring molecules between cells, sEVs can also modify the characteristics of recipient cells. This review explores the potential of utilizing sEVs as a CNS-targeted strategy for treating obesity and discusses the translation of current findings, such as sEV-mediated targeting of hypothalamic AMP-activated protein kinase (AMPK), into clinical application.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sebastian Zagmutt, Paula Mera, Ismael Gonzalez-Garcia, Kevin Ibeas, Maria del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M. Carmen Soler-Vazquez, Marianela Bastias-Perez, Laia Canes, Elisabeth Auge, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi Garcia, Jose Martinez-Gonzalez, Nuria Casals, Miguel Lopez, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra
Summary: Fatty acid metabolism and CPT1A in AgRP neurons play a key role in the maintenance of whole-body fluid and energy balance. This study reveals marked sex differences in fatty acid metabolism and CPT1A expression in AgRP neurons.
BIOLOGY OF SEX DIFFERENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Olga Barca-Mayo, Miguel Lopez
Summary: Ovarian estradiol and leptin play important roles in regulating whole-body energy balance in the hypothalamus. In a recent paper in Cell Metabolism, Gonzalez-Garcia et al. demonstrate that CITED1 acts as a key hypothalamic cofactor that enhances the anorectic effects of leptin, mediating the antiobesity effects of estradiol.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Pharmacology & Pharmacy
Ismael Gonzalez-Garcia, Miguel Lopez
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Maria J. Gonzalez-Rellan, Tamara Parracho, Violeta Heras, Amaia Rodriguez, Marcos F. Fondevila, Eva Novoa, Natalia Lima, Marta Varela-Rey, Ana Senra, Maria D. P. Chantada-Vazquez, Cristina Ameneiro, Ganeko Bernardo, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Jon Bilbao, Diana Guallar, Miguel Fidalgo, Susana Bravo, Carlos Dieguez, Maria L. Martinez-Chantar, Oscar Millet, Jose M. Mato, Markus Schwaninger, Vincent Prevot, Javier Crespo, Gema Fruhbeck, Paul Iruzubieta, Ruben Nogueiras
Summary: O-GlcNAcylation is a post-translational modification that affects protein function and localization, and its deregulation is associated with various human diseases. This study reveals the role of O-GlcNAcylation in the progression of NAFLD, providing new avenues for therapeutic intervention.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Vitor Ferreira, Cintia Folgueira, Maria Garcia-Altares, Maria Guillen, Monica Ruiz-Rosario, Giada DiNunzio, Irma Garcia-Martinez, Rosa Alen, Christoph Bookmeyer, John G. Jones, Juan C. Cigudosa, Pilar Lopez-Larrubia, Xavier Correig-Blanchar, Roger J. Davis, Guadalupe Sabio, Patricia Rada, Angela M. Valverde
Summary: Olanzapine (OLA), a widely used antipsychotic drug, causes weight gain and metabolic alterations when administered orally, but results in weight loss when administered via intraperitoneal (i.p.) in male mice. The protective effect of i.p. OLA is due to increased energy expenditure through AMPK activation in the hypothalamus. However, chronic OLA treatment can lead to hepatic steatosis, and in this study, the interaction between the hypothalamus and liver was investigated. The inhibition of protein tyrosine phosphatase 1B (PTP1B) showed protective effects against metabolic comorbidities induced by OLA treatment.
Review
Endocrinology & Metabolism
Sayani Mukherjee, Silje Skrede, Martha Haugstoyl, Miguel Lopez, Johan Ferno
Summary: Obesity is associated with chronic inflammation, caused by excessive nutrient intake leading to adipose tissue expansion and cellular stress. In addition to adipose tissue macrophages, other organs such as the liver, muscle, and pancreas also show pro-inflammatory activation. Pro-inflammatory signaling in the central nervous system is involved in appetite dysregulation and metabolic disturbances.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eva Rial-Pensado, Laurence Canaple, Romain Guyot, Christoffer Clemmensen, Joelle Wiersema, Shijia Wu, Sabine Richard, Anita Boelen, Timo D. Mueller, Miguel Lopez, Frederic Flamant, Karine Gauthier
Summary: Thyroid hormone signaling in neurons plays an important role in stimulating energy expenditure and limiting weight gain in response to high-fat diet. Mice with dysfunctional thyroid hormone receptors in neurons exhibit impaired thermogenic potential and increased susceptibility to diet-induced obesity. However, their ability to respond to cold exposure remains unaffected. This study provides genetic evidence for the significance of thyroid hormone signaling in neurons for energy regulation.