Article
Biochemistry & Molecular Biology
Debojyoti Pal, Archita Rai, Rahul Checker, R. S. Patwardhan, Babita Singh, Deepak Sharma, Santosh K. Sandur
Summary: Mammalian cell survival and proliferation rely heavily on their response and adaptation to changes in the redox environment, with cancer cells often living in altered redox environments. Glutathione plays a crucial role in maintaining redox homeostasis by S-glutathionylation, protecting cysteine residues from oxidation and functioning as a sensor for redox status.Understanding the role of redox adaptations during carcinogenesis, including S-glutathionylation of specific redox-sensitive proteins, is important for developing new treatment strategies, such as redox targeting drugs, for refractory/resistant cancers.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Heidi Budde, Roua Hassoun, Melina Tangos, Saltanat Zhazykbayeva, Melissa Herwig, Marharyta Varatnitskaya, Marcel Sieme, Simin Delalat, Innas Sultana, Detmar Kolijn, Kamilla Goemoeri, Muhammad Jarkas, Maria Lodi, Kornelia Jaquet, Arpad Kovacs, Hans Georg Mannherz, Vasco Sequeira, Andreas Muegge, Lars Leichert, Samuel Sossalla, Nazha Hamdani
Summary: The oxidative modifications of myofilament proteins in end-stage human failing hearts contribute to altered cardiomyocyte function, which can be corrected by treatment with reduced glutathione enzyme. Increased oxidative stress parameters and altered mechanical properties in failing hearts are partially due to phosphorylation and S-glutathionylation effects.
Article
Endocrinology & Metabolism
Chia-Chi Liu, YunJia Zhang, Angela Makris, Helge H. Rasmussen, Annemarie Hennessy
Summary: The study compared the glutathionylation of the beta(1) subunit of the Na+-K+ pump in placentas from healthy pregnancies and preeclampsia. The results showed a significant increase in GSS-beta(1) levels in preeclamptic placentas, providing new insights into the mechanism of Na+-K+ pump dysfunction in preeclampsia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Paolo Tucci, Roberta Lattanzi, Cinzia Severini, Luciano Saso
Summary: In this review, we present the scientific literature supporting the role of nuclear transcription factor-2 (Nrf2) in Huntington's disease (HD) and the potential prophylactic and therapeutic role of this compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Howard T. Jacobs, J. William O. Ballard
Summary: The physiological role of alternative oxidase (AOX) in animals is still poorly understood. Accumulated evidence suggests that AOX may help animals resist various stresses, but further research is needed to address why AOX has been lost in certain animal groups.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Review
Pharmacology & Pharmacy
Xia Li, Yan Ma, Junzhou Wu, Maowei Ni, Aiping Chen, Yun Zhou, Wumin Dai, Zhongjian Chen, Ruibin Jiang, Yutian Ling, Qinghua Yao, Wei Chen
Summary: 5-Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy. However, the development of 5-Fu resistance limits its effectiveness and leads to poor prognosis. Transglutaminase 2 (TGM2) is associated with chemoresistance in CRC and is regulated by thiol oxidative stress. Upregulation of thiol oxidative stress reverses 5-Fu resistance through downregulation of TGM2 and enhances apoptosis. TGM2 may serve as a potential therapeutic target for treating 5-Fu-resistant CRC.
DRUG RESISTANCE UPDATES
(2023)
Article
Clinical Neurology
Eduardo Benarroch
Summary: Mitochondria have multiple essential functions in cells, and their shape and dynamics play a critical role in mitochondrial function. Abnormalities in mitochondrial shape and dynamics are associated with various diseases.
Review
Food Science & Technology
Xinxin Chang, Yudan Wang, Bing Zheng, Yi Chen, Jianhua Xie, Yiming Song, Xiaomeng Ding, Xiaoyi Hu, Xiaobo Hu, Qiang Yu
Summary: Neurodegenerative diseases involve the loss of specific neurons, which is often caused by environmental pollutants like acrolein. Acrolein is highly active and contributes to oxidative stress, polyamine metabolism, and neuronal damage, thereby impacting the progression of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Jonathan Hirschenson, Ryan J. Mailloux
Summary: The study demonstrates that glutathionylation can enhance ROS production by mitochondria, with different effects depending on the oxidizing sources and inhibitors used.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Aslam M. A. Mazari, Leilei Zhang, Zhi-Wei Ye, Jie Zhang, Kenneth D. Tew, Danyelle M. Townsend
Summary: The cytosolic glutathione S-transferase (GST) family in humans, consisting of 16 genes in seven classes, shares structural similarity and overlapping functionalities. Apart from their primary role in Phase II metabolism, GSTs also regulate stress-induced signaling pathways and contribute to drug resistance in tumors. Recent studies found that GST genetic polymorphisms are associated with increased risk and severity of COVID-19. These functional properties make GSTs potential targets for therapeutics, and GST inhibitors have progressed in clinical trials to treat cancer and other diseases.
Article
Biochemistry & Molecular Biology
Jian Yang, Van Anthony M. Villar, Pedro A. Jose, Chunyu Zeng
Summary: The kidney plays a crucial role in blood pressure control, with dopamine regulating oxidative stress. Understanding the antioxidative effects of renal dopamine receptors is important in hypertension pathogenesis.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Marcin Wroblewski, Joanna Wroblewska, Jaroslaw Nuszkiewicz, Marta Pawlowska, Roland Wesolowski, Alina Wozniak
Summary: Impaired levels of trace elements such as selenium, zinc, copper, iron, manganese, and iodine can negatively impact the thyroid endocrine system by affecting oxidative stress and antioxidant defense. There is a limited number of studies that directly correlate trace element supplementation with the prevention or slowing down of thyroid diseases and the improvement of the antioxidant profile. However, some studies have shown that supplementation with zinc and selenium can reduce lipid peroxidation levels and improve antioxidant activity in thyroid diseases like hypothyroidism and autoimmune thyroiditis. This systematic review provides an overview of the current knowledge on the relationship between trace elements and thyroid diseases in terms of oxidoreductive homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vincenza Valerio, Gizem Keceli, Donato Moschetta, Benedetta Porro, Michele Ciccarelli, Ilaria Massaiu, Paola Songia, Angela S. Maione, Valentina Alfieri, Veronika A. Myasoedova, Marco Zanobini, Nazareno Paolocci, Paolo Poggio
Summary: This study investigates the role of oxidative stress and endothelial dysfunction in the progression of calcific aortic valve stenosis (CAVS). The results indicate that oxidation-induced protein S-glutathionylation (P-SSG) contributes to the phenotypic switch in human aortic valvular tissue, leading to calcium deposition. The use of antioxidants can prevent these alterations.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
William J. Chen, George P. Kung, Jaya P. Gnana-Prakasam
Summary: Iron accumulation with age can lead to cellular aging and systemic disorders. Research has identified its involvement in various diseases and conditions. Therapeutic approaches to reduce iron levels, such as phlebotomy and iron chelation, have become standard care. Iron chelators may play an increasingly important role in promoting health and preventing age-related diseases.
Review
Physiology
Alessia Remigante, Sara Spinelli, Michael Pusch, Antonio Sarikas, Rossana Morabito, Angela Marino, Silvia Dossena
Summary: Bicarbonate, a major anion in mammalian tissues and fluids, plays a critical role in cell and systemic pH homeostasis and is involved in transporting ions and substrates across cell membranes. Chloride/bicarbonate exchangers, abundant in erythrocytes and epithelial cells, are particularly susceptible to oxidative stress. This review focuses on the physiological functions and pathophysiological changes of Cl-/HCO3- exchangers belonging to the SLC4 and SLC26 superfamilies in relation to oxidative stress.
Review
Cell Biology
Grazia Tamma, Giovanna Valenti, Elena Grossini, Sandra Donnini, Angela Marino, Raul A. Marinelli, Giuseppe Calamita
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Multidisciplinary Sciences
Annarita Di Mise, Grazia Tamma, Marianna Ranieri, Mariangela Centrone, Lambertus van den Heuvel, Djalila Mekahli, Elena N. Levtchenko, Giovanna Valenti
SCIENTIFIC REPORTS
(2018)
Article
Physiology
Nandu Goswami, Johannes Reichmuth, Annarita Di Mise, Bianca Brix, Andreas Roessler, Mariangela Centrone, Marianna Ranieri, Annamaria Russo, Natale Gaspare De Santo, Grazia Tamma, Ferdinando Carlo Sasso, Giovanna Valenti
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Marianna Ranieri, Annarita Di Mise, Graziana Difonzo, Mariangela Centrone, Maria Venneri, Tommaso Pellegrino, Annamaria Russo, Maria Mastrodonato, Francesco Caponio, Giovanna Valenti, Grazia Tamma
Article
Cell Biology
Marianna Ranieri, Maria Venneri, Tommaso Pellegrino, Mariangela Centrone, Annarita Di Mise, Susanna Cotecchia, Grazia Tamma, Giovanna Valenti
Article
Biochemistry & Molecular Biology
Mariangela Centrone, Patrizia Gena, Marianna Ranieri, Annarita Di Mise, Mariagrazia D'Agostino, Maria Mastrodonato, Maria Venneri, Davide De Angelis, Stefano Pavan, Antonella Pasqualone, Carmine Summo, Valentina Fanelli, Giovanna Valenti, Giuseppe Calamita, Grazia Tamma
Article
Food Science & Technology
Mariangela Centrone, Mariagrazia D'Agostino, Graziana Difonzo, Alessandra De Bruno, Annarita Di Mise, Marianna Ranieri, Cinzia Montemurro, Giovanna Valenti, Marco Poiana, Francesco Caponio, Grazia Tamma
Summary: The production of olive oil leads to the generation of a significant amount of waste and by-products. Research shows that extracts from olive wastewater exhibit higher antioxidant ability compared to those from olive pomace and olive leaf, likely due to differences in phenolic composition. These findings suggest that phenols in the by-product extracts may have health benefits through interfering with signaling molecules in cells.
Article
Food Science & Technology
Michela Costantini, Carmine Summo, Mariangela Centrone, Iga Rybicka, Mariagrazia D'Agostino, Paolo Annicchiarico, Francesco Caponio, Stefano Pavan, Grazia Tamma, Antonella Pasqualone
Summary: Epidemiological studies have shown a negative correlation between legume consumption and age-related diseases, likely due to the presence of antioxidant compounds such as phenolic and flavonoid compounds. Different pea and chickpea accessions exhibited varying antioxidant activity, with chickpeas having higher DPPH scavenging activity and peas showing higher antioxidant activity as evaluated using the ABTS assay. Chemical composition was found to influence antioxidant activity, with pea accessions having higher content of total phenolic compounds, Zn, and Cu, while black and brown chickpeas had higher levels of anthocyanins, Mn, Mg, and Ca.
POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bianca Maria Rotoli, Rossana Visigalli, Francesca Ferrari, Marianna Ranieri, Grazia Tamma, Valeria Dall'Asta, Amelia Barilli
Summary: This study evaluated the effects of desmopressin on human pulmonary microvascular endothelial cells and found that it had no cytotoxic effect on the endothelium, but significantly stimulated the production of nitric oxide.
Review
Green & Sustainable Science & Technology
Giusy Rita Caponio, Fabio Minervini, Grazia Tamma, Giuseppe Gambacorta, Maria De Angelis
Summary: Grapes, especially Vitis vinifera L., are widely cultivated and winemaking produces a large amount of waste. These residues are causing environmental and economic sustainability issues. To combat this, researchers are exploring ways to create high-value products from these waste materials. Grape pomace, a byproduct of winemaking, contains compounds like polyphenols, phenolic acids, resveratrol, and fiber that have antioxidant properties. Traditional uses of grape pomace include producing distillates and extracting tartaric acid and coloring substances, but newer applications include extracting antioxidants, using it as fermentation substrates and biomass for energy production, and extracting fiber for high-value bioactive product development. This article discusses the involvement of bioactive molecules from grape pomace in human biological functions and their applications in the agri-food sector.
Article
Cell Biology
Stine Julie Tingskov, Mariagrazia D'Agostino, Frederic H. Login, Grazia Tamma, Lene N. Nejsum, Rikke Norregaard
Summary: In this study, the effect of tamoxifen (TAM) on the expression and localization of aquaporin 3 (AQP3) in collecting ducts was investigated. TAM attenuated the downregulation of AQP3 in a unilateral ureteral obstruction (UUO) model and a lithium-induced nephrogenic diabetes insipidus (NDI) model, and affected the intracellular localization in the collecting ducts. TAM also influenced the expression profile of other basolateral proteins.
Article
Biochemistry & Molecular Biology
Aurelia Lamanuzzi, Ilaria Saltarella, Antonia Reale, Assunta Melaccio, Antonio Giovanni Solimando, Concetta Altamura, Grazia Tamma, Clelia Tiziana Storlazzi, Doron Tolomeo, Vanessa Desantis, Maria Addolorata Mariggio, Jean-Francois Desaphy, Andrew Spencer, Angelo Vacca, Benedetta Apollonio, Maria Antonia Frassanito
Summary: Extracellular vesicles (EVs) derived from fibroblasts play an important role in promoting angiogenesis in the bone marrow of multiple myeloma patients. The cargo of these EVs contains angiogenic cytokines that mediate this process. The uptake-independent and uptake-dependent mechanisms of FBEVs contribute to different stages of angiogenesis.
Article
Cell Biology
Caterina Allegretta, Graziana Difonzo, Francesco Caponio, Grazia Tamma, Onofrio Laselva
Summary: The deletion of phenylalanine at position 508 (F508del) causes misfolded CFTR protein, leading to its retention in the ER and degradation. This dysfunction of CFTR channel activity is associated with chronic infection and inflammation, primary causes of lung function decline in CF patients. Additionally, LPS-dependent oxidative stress further reduces CFTR function in airway epithelial cells. Olive leaf extract (OLE) has been found to decrease ROS levels and attenuate inflammatory response in CFBE and HNE cells, mimicking the infection and inflammatory status of CF patients. OLE also restores the decrease in F508del-CFTR function caused by LPS, suggesting its potential for preventing chronic lung damage in CF patients.
Review
Biochemistry & Molecular Biology
Angela Tesse, Elena Grossini, Grazia Tamma, Catherine Brenner, Piero Portincasa, Raul A. Marinelli, Giuseppe Calamita
FRONTIERS IN MOLECULAR BIOSCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Annarita Di Mise, Marianna Ranieri, Mariangela Centrone, Maria Venneri, Grazia Tamma, Daniela Valenti, Giovanna Valenti
FRONTIERS IN MOLECULAR BIOSCIENCES
(2018)