Review
Biochemistry & Molecular Biology
Sawan Ali, Graziamaria Corbi, Michael Maes, Giovanni Scapagnini, Sergio Davinelli
Summary: The latest evidence suggests that dietary flavonoids have a significant effect on improving symptoms of depression, with higher intake of flavonoids potentially beneficial for alleviating depressive symptoms. Further research is needed to clarify the causal and mechanistic links, as well as confirm the functional brain changes associated with flavonoid consumption.
Review
Biochemistry & Molecular Biology
Zhen Zeng, Christoph Centner, Albert Gollhofer, Daniel Koenig
Summary: Whole dietary strategies rich in antioxidants have gained attention for their potential to alleviate exercise-induced oxidative stress, with most studies showing favorable effects. However, research on the effects of such strategies on oxidative stress is still limited, and further systematically designed studies are needed to strengthen the evidence.
Review
Biochemistry & Molecular Biology
Antonio Schiattarella, Mauro Lombardo, Maddalena Morlando, Gianluca Rizzo
Summary: Gestational diabetes mellitus (GDM) is a challenging pregnancy complication associated with various obstetric issues and fetal problems, potentially driven by inflammatory markers. Adopting a plant-based diet rich in vegetables, fibers, and fruits may help reduce the risk of GDM.
Review
Biochemistry & Molecular Biology
Samar El Sherbiny, Giulia Squillacioti, Nicoletta Colombi, Federica Ghelli, Elena Lenta, Cloe Dalla Costa, Roberto Bono
Summary: During pregnancy, physiological increases in reactive oxygen species (ROS) may lead to oxidative stress (OS), which can contribute to complications in pregnancy and newborns. Diet is a cost-effective prevention strategy for reducing OS, but there is a lack of nutritional education during pregnancy. This review aims to summarize the association between OS and diet during pregnancy.
Article
Biochemistry & Molecular Biology
Angela Hernandez-Ruiz, Belen Garcia-Villanova, Eduardo J. Guerra-Hernandez, Cayetano Javier Carrion-Garcia, Pilar Amiano, Maria-Jose Sanchez, Esther Molina-Montes
Summary: Oxidative Balance Scores (OBS) are tools that assess individuals' antioxidant state based on dietary and lifestyle factors. New versions of OBS were developed, showing correlations with antioxidant-rich dietary patterns and biomarkers of antioxidant nutrient intake and inflammation.
Review
Clinical Neurology
Sara Jimenez-Fernandez, Manuel Gurpegui, Daniel Garrote-Rojas, Luis Gutierrez-Rojas, Maria D. Carretero, Christoph U. Correll
Summary: This study aimed to investigate the differences in oxidative stress markers and antioxidants between patients with bipolar depression and unipolar depression. The results showed that both bipolar depression and unipolar depression may be associated with an impaired oxidative stress balance, with significantly higher uric acid levels observed in unipolar depression compared to bipolar depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Ilinca Nicolae, Clara Matei, Corina Daniela Ene, Gabriela Loredana Popa, Mircea Tampa
Summary: Lichen planus is a chronic, immune-mediated inflammatory skin condition that affects the skin and oral mucosa. The key players in its pathogenesis are the inflammatory infiltrate and oxidative stress. Studies have shown the involvement of oxidative stress in LP development, particularly in oral LP, but data are scarce for cutaneous LP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Isabel Medina-Vera, Lizzette Gomez-de-Regil, Ana Ligia Gutierrez-Solis, Roberto Lugo, Martha Guevara-Cruz, Jose Pedraza-Chaverri, Azalia Avila-Nava
Summary: This study compiled scientific literature on dietary strategies using foods with antioxidant effect to improve antioxidant status in individuals with dyslipidemias, finding that various foods show significant differences in blood lipids, antioxidant activity, antioxidant enzymes, and oxidative and inflammatory markers.
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Delia Acevedo-Leon, Segundo Angel Gomez-Abril, Lidia Monzo-Beltran, Nuria Estan-Capell, Rafael Arroyo-Montanes, Celia Banuls, Jordi Salas-Salvado, Guillermo Saez
Summary: This study found that adherence to the Mediterranean diet can protect against colorectal cancer and reduce metabolic and oxidative DNA damage while improving antioxidant systems in patients.
Article
Biochemistry & Molecular Biology
Eleonora Cremonini, Elena Daveri, Dario E. Iglesias, Jiye Kang, Ziwei Wang, Russell Gray, Angela Mastaloudis, Colin D. Kay, Shelly N. Hester, Steven M. Wood, Cesar G. Fraga, Patricia Oteiza
Summary: This study investigated the effects of a cyanidin-and delphinidin-rich extract on the postprandial dysmetabolism, inflammation, and insulin signaling triggered by a high fat meal. The results showed that the extract reduced the negative effects associated with postprandial dysmetabolism and regulated glycemia and lipidemia.
Review
Biochemistry & Molecular Biology
Kim S. Stote, Gracie Burns, Kim Mears, Marva Sweeney, Cynthia Blanton
Summary: Bioactive compounds in berries protect DNA, proteins, and lipids from oxidative damage by scavenging reactive oxygen and nitrogen species. This study reviewed randomized controlled trials (RCTs) to examine the effects of non-acute berry consumption on biomarkers of oxidative stress. Out of the 28 RCTs evaluated, 32% of the biomarkers showed statistically significant beneficial results, while 68% showed no significant differences. Further well-designed and longer-term trials are needed to assess biomarkers of oxidative stress.
Article
Nutrition & Dietetics
Justin D. Roberts, Joseph Lillis, Jorge Marques Pinto, Ashley G. B. Willmott, Lata Gautam, Christopher Davies, Alvaro Lopez-Samanes, Juan Del Coso, Havovi Chichger
Summary: The role of natural polyphenols, particularly hydroxytyrosol, in reducing oxidative stress and supporting antioxidant mechanisms during exercise was investigated in this study using OliPhenolia (R). The results showed that OliPhenolia (R) significantly increased the bioavailability of hydroxytyrosol and demonstrated modest antioxidant effects, which may contribute to post-exercise recovery.
Review
Biochemistry & Molecular Biology
Michalina Anna Drejza, Katarzyna Rylewicz, Ewa Majcherek, Katarzyna Gross-Tyrkin, Malgorzata Mizgier, Katarzyna Plagens-Rotman, Malgorzata Wojcik, Katarzyna Panecka-Mysza, Magdalena Pisarska-Krawczyk, Witold Kedzia, Grazyna Jarzabek-Bielecka
Summary: This review highlights the importance of oxidative stress in reproductive and pregnancy-related disorders, and discusses the lack of consensus in standardized markers of oxidative stress in the field, posing a challenge.
Review
Chemistry, Multidisciplinary
Annu Phogat, Jagjeet Singh, Vijay Kumar, Vinay Malik
Summary: Acetamiprid, a widely used alternative to organophosphates and carbamates, has adverse effects on non-targeted organisms and is detected in various environmental sources. Metabolism of acetamiprid generates toxic metabolites that affect neurological, hepatorenal, immunological, genotoxic, and reproductive systems. Therapeutic use of plant extracts and antioxidants can alleviate acetamiprid-induced oxidative stress.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Public, Environmental & Occupational Health
Lorena Garcia-Blanco, Victor de la O. Pascual, Arantxa Berasaluce, Laura Moreno-Galarraga, Miguel Angel Martinez-Gonzalez, Nerea Martin-Calvo
Summary: This study identifies individual and family factors predicting ultra-processed food consumption in Spanish children. Large family size and longer exposure to screens were associated with higher consumption, while better knowledge of children's dietary recommendations, healthy dietary attitudes, and longer breastfeeding were associated with lower consumption. These factors accounted for approximately 16% of the variability in childhood ultra-processed food consumption.
PUBLIC HEALTH NUTRITION
(2023)
Article
Nutrition & Dietetics
Carolina Donat-Vargas, Esther Lopez-Garcia, Jose R. Banegas, Miguel A. Martinez-Gonzalez, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon
Summary: The study found that moderate daily consumption of virgin olive oil is associated with a lower risk of all-cause and cardiovascular mortality, while common olive oil does not show the same effect.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medical Laboratory Technology
Cristina Razquin, Miguel Ruiz-Canela, Andreas Wernitz, Estefania Toledo, Dolores Corella, Angel Alonso-Gomez, Montse Fito, Enrique Gomez-Gracia, Ramon Estruch, Miquel Fiol, Jose Lapetra, Lluis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvado, Matthias B. Schulze, Miguel A. Martinez-Gonzalez
Summary: In the PREDIMED trial, a nutritional intervention with Mediterranean diets was found to affect the distribution of plasma phospholipid fatty acids (FAs), and 1-year changes in FAs were associated with subsequent cardiovascular risk.
CLINICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Silvia Garcia, Cristina Bouzas, David Mateos, Rosario Pastor, Laura Alvarez, Maria Rubin, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majem, Blanca Riquelme-Gallego, Xavier Pinto, Jose J. Gaforio, Pilar Matia, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emilio Ros, Maira Bes-Rastrollo, Patricia Guillem-Saiz, Stephanie Nishi, Robert Cabanes, Itziar Abete, Leire Goicolea-Guemez, Enrique Gomez-Gracia, Antonio Jose Signes-Pastor, Antoni Colom, Antonio Garcia-Rios, Sara Castro-Barquero, Jose C. Fernandez-Garcia, Jose Manuel Santos-Lozano, Zenaida Vazquez, Jose Sorli, Maria Pascual, Olga Castaner, Maria Angeles Zulet, Jessica Vaquero-Luna, F. Javier Basterra-Gortari, Nancy Babio, Ramon Ciurana, Vicente Martin-Sanchez, Josep A. Tur
Summary: This study examined the association between adherence to an energy-restricted Mediterranean diet and the amount of CO2 emissions in an older adult population. The findings suggest that the Mediterranean diet can contribute to lower total dietary CO2 emissions, indicating its potential environmental benefits.
ENVIRONMENTAL HEALTH
(2023)
Correction
Nutrition & Dietetics
Carolina Donat-Vargas, Esther Lopez-Garcia, Jose R. Banegas, Miguel A. Martinez-Gonzalez, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Maria Barberia-Latasa, Miguel A. Martinez-Gonzalez, Carmen de la Fuente-Arrillaga, Maira Bes-Rastrollo, Silvia Carlos, Alfredo Gea
Summary: Several studies have analyzed the association between all-cause mortality and various risk factors, particularly modifiable ones like smoking, diet, and exercise, for the purpose of developing public health preventive strategies. However, specific analysis of predictors for premature and late mortality is necessary to provide more accurate recommendations. This study followed a cohort of 20,272 university graduates with a wide age range for a median of 12 years. The results showed that physical activity was the strongest independent predictor of mortality at any age, associated with reduced risk of total, premature, and late mortality.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Razquin, Miguel Ruiz-Canela, Estefania Toledo, Clary B. Clish, Marta Guasch-Ferre, Jesus F. Garcia-Gavilan, Clemens Wittenbecher, Angel Alonso-Gomez, Montse Fito, Liming Liang, Dolores Corella, Enrique Gomez-Gracia, Ramon Estruch, Miquel Fiol, Jose M. Santos-Lozano, Luis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvado, Frank B. Hu, Miguel A. Martinez-Gonzalez
Summary: The study examines the associations between baseline levels of plasma amino acids and subsequent risk of peripheral artery disease (PAD). It also investigates the potential modifying effect of a nutritional intervention with the Mediterranean diet. The findings suggest that certain amino acids and their pathways may serve as biomarkers for PAD risk, and the Mediterranean diet supplemented with olive oil offers a protective effect against PAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Indira Paz-Graniel, Montserrat Fito, Emilio Ros, Pilar Buil-Cosiales, Dolores Corella, Nancy Babio, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin-Sanchez, Xavier Pinto, Jose Juan Gaforio, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Jesus F. Garcia-Gavilan, Estefania Toledo, Stephanie K. Nishi, Jose Sorli, Olga Castaner, Antonio Garcia-Rios, Manoli Garcia de la Hera, Francisco Javier Baron-Lopez, Miguel Ruiz-Canela, Marga Morey, Rosa Casas, Eva Maria Garrido-Garrido, Lucas Tojal-Sierra, Jose C. Fernandez-Garcia, Zenaida Vazquez-Ruiz, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Helmut Schroder, Miguel A. Martinez-Gonzalez, Jordi Salas-Salvado
Summary: The COVID-19 pandemic has affected the ongoing PREDIMED-Plus study on weight-loss and cardiovascular disease prevention. Mitigating strategies were implemented to maintain the trial's integrity and minimize the effects on adiposity.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Pilar Sanchis, Rafael Maria Prieto, Jadwiga Konieczna, Felix Grases, Itziar Abete, Jordi Salas-Salvado, Vicente Martin, Miguel Ruiz-Canela, Nancy Babio, Jesus Francisco Garcia-Gavilan, Albert Goday, Antonia Costa-Bauza, Jose Alfredo Martinez, Dora Romaguera
Summary: The main objective of this study was to examine the relationship between dietary phytate intake and bone mineral density (BMD) in a Mediterranean population of postmenopausal women. The results showed that phytate intake was positively associated with BMD in Mediterranean postmenopausal women, indicating a potential protective effect on bone. However, further large-scale, long-term, and randomized prospective clinical studies are needed to assess the potential benefits of phytate consumption on BMD in postmenopausal women.
Article
Nutrition & Dietetics
Asier Oliver Olid, Laura Moreno-Galarraga, Jose Manuel Moreno-Villares, Maria del Mar Bibiloni, Miguel Angel Martinez-Gonzalez, Victor de la O, Alejandro Fernandez-Montero, Nerea Martin-Calvo
Summary: Breastfeeding for 6 months or longer is associated with a higher adherence to the Mediterranean diet during the preschool years. Children who were breastfed for at least 6 months had a one-point increase in their mean KIDMED score compared to children who were never breastfed. The odds ratio of high adherence to the MedDiet was also higher in children who were breastfed for at least 6 months.
Article
Food Science & Technology
L. Gayoso, L. Goni, V. de la O, J. Domper, C. Razquin, M. Ruiz-Canela, U. Etxeberria
Summary: This study aimed to analyze the effect of a culinary intervention on health parameters and dietary habits among patients with Type 2 Diabetes (T2D). The results showed that the patients who received the culinary intervention had significant improvements in blood glucose, cholesterol levels, and weight compared to those in the control group. These findings suggest that a culinary intervention based on the Mediterranean Diet is a promising approach for promoting healthy dietary habits in T2D patients.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2023)
Review
Nutrition & Dietetics
Jara Domper, Lucia Gayoso, Leticia Goni, Victor de la O, Usune Etxeberria, Miguel Ruiz-Canela
Summary: The study reviews the effectiveness of culinary medicine (CM) programs in promoting healthy aging. The results show that CM programs are successful in improving dietary intake and health-related outcomes, with longer duration and multi-group designs being important factors for achieving significant results.
NUTRITION RESEARCH REVIEWS
(2023)
Review
Nutrition & Dietetics
Cristina Diez-Arroyo, Monica Garcia-Garcia, Maria Jose Soto-Mendez, Esther Molina-Montes, Mercedes Gil-Campos, Angel Gil, Miriam Gutierrez-Jimeno, Angela Hernandez-Ruiz
Summary: Epilepsy is a common neurological disorder in childhood, and despite antiepileptic drugs being the preferred treatment, a significant number of children continue to experience seizures. This review examines the use of a ketogenic diet (KD) as an alternative treatment for refractory epilepsy in children.
Article
Cardiac & Cardiovascular Systems
Maria Teresa Barrio-Lopez, Miguel Ruiz-Canela, Leticia Goni, Almudena Martinez Valiente, Silvia Romero Garcia, Victor de la O, Belen Diaz Anton, Leticia Fernandez-Friera, Eduardo Castellanos, Miguel Angel Martinez-Gonzalez, Jesus Almendral
Summary: There is an association between adherence to the Mediterranean diet (MedDiet) and epicardial adipose tissue (EAT) in patients with atrial fibrillation (AF). EAT measurements and MedDiet adherence at baseline are also associated with AF recurrence after ablation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
M. S. Hershey, M. Sotos-Prieto, S. Andrieu, A. Hofman, P. Magiatis, M. A. Martinez-Gonzalez, M. Yannakoulia, S. Kales, N. Scarmeas
Summary: The A.G. Leventis Foundation International Conference focused on the role of diet and lifestyle in preventing and treating Alzheimer's Disease and cognitive decline. The conference highlighted the benefits of the Mediterranean diet and the potential therapeutic use of olive oil rich in polyphenols. It also discussed the challenges in designing rigorous clinical trials and summarized existing evidence for nutritional interventions in preventing cognitive decline.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)