Article
Immunology
Qi Tian, Yina Li, Shi Feng, Chengli Liu, Yujia Guo, Guijun Wang, Heng Wei, Zhibiao Chen, Lijuan Gu, Mingchang Li
Summary: Inhibition of CCR1 attenuates neuroinflammation after subarachnoid hemorrhage (SAH) via the JAK2/STAT3 signaling pathway, which may provide a new target for the treatment of SAH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael D. Kruppa, Brian M. Peters
Summary: This study characterizes the glycogen metabolism pathways in Candida albicans and shows that glycogen metabolism is important for the long-term survival and virulence of the fungus.
Article
Biochemistry & Molecular Biology
Olav Larsen, Sara Schuermans, Anna Walser, Stavroula Louka, Ida Aaberg Lillethorup, Jon Vabeno, Katrine Qvortrup, Paul Proost, Mette M. Rosenkilde
Summary: This study investigates the signaling capacity of peptides related to inflammatory chemokines. The peptides showed weak potency but retained their signaling on CCR1, while none of the peptides generated a signal on CCR5. However, a tetrapeptide derived from CCL3 acted as a positive modulator on CCR5.
Article
Biochemistry & Molecular Biology
Xufei Du, Fei Li, Chao Zhang, Na Li, Huaqiong Huang, Zhehua Shao, Min Zhang, Xueqin Zhan, Yicheng He, Zhenyu Ju, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen
Summary: This study identifies the involvement of the CCL6-CCR1 axis in the crosstalk between eosinophils and HSCs during the development of allergic airway inflammation, suggesting a potential therapeutic strategy targeting GPCRs for future clinical treatment of asthma.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Infectious Diseases
Vasiliki Soulountsi, Theodoros Schizodimos, Serafeim Chrysovalantis Kotoulas
Summary: In recent decades, invasive candidiasis (IC) has become a significant cause of morbidity, mortality, and economic burden in the intensive care unit (ICU). The epidemiology of IC remains a difficult and unsolved puzzle for the literature. IC burden estimation is challenging due to various definitions and limitations in case-finding methodologies. Candidemia and intra-abdominal candidiasis (IAC) are the predominant types of IC in the ICU, with an increasing incidence of candidemia, particularly in elderly or immunosuppressed patients, and a shift towards non-albicans species worldwide.
Article
Microbiology
Junko Yano, David J. White, Anthony P. Sampson, Floyd L. Wormley, Paul L. Fidel
Summary: Despite some clinical evidence suggestive of off-target efficacy of leukotriene receptor antagonists (LTRAs) in recurrent vulvovaginal candidiasis (RVVC), leukotrienes and associated signaling pathways appear to be dispensable in the immunopathogenesis of vulvovaginal candidiasis (VVC) as shown in a mouse model study.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Annette Gilchrist, Stephanie L. Echeverria
Summary: Multiple myeloma is a difficult-to-cure malignancy with a lower survival rate compared to other hematologic cancers. Treatment options are limited, and there is a need for new approaches. Antagonists targeting chemokine-receptor 1 (CCR1) may provide a new treatment option for multiple myeloma. Existing studies have shown the potential therapeutic effects of CCR1 antagonists, but clinical trials are yet to be conducted.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Eunae Cho, YounJung Park, Ki-Yeol Kim, Dawool Han, Hyun Sil Kim, Jeong-Seung Kwon, Hyung-Joon Ahn
Summary: The study investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis, revealing significant differences in clinical factors among different hyphae groups. It suggested that low-grade hyphae infection might represent a subclinical state of OC, and identified a new subtype named MNSC.
Article
Microbiology
Vinicius Tatsuyuji Sakima, Yuliana Vega-Chacon, Paulo Sergio Cerri, Bhumika Shokeen, Renate Lux, Ewerton Garcia de Oliveira Mima
Summary: This study evaluated the induction of denture stomatitis (DS) using acrylic devices and Candida spp. in rats. The results showed that both Candida spp. and acrylic devices did not cause significant inflammation in immunocompetent rats, but the shift in microbiota may precede the manifestation of inflammation.
Article
Microbiology
Jessica S. Price, Melissa Fallon, Raquel Posso, Matthijs Backx, P. Lewis White
Summary: This study evaluated the performance of the commercially available OLM CandID real-time PCR in serum testing for invasive candidiasis (IC). The study found that CandID had excellent sensitivity and specificity, and when combined with (1-3)-beta-D-Glucan testing, it could accurately confirm or exclude IC.
Review
Pharmacology & Pharmacy
Gina P. Rodriguez-Castano, Frank Rosenau, Ludger Staendker, Carolina Firacative
Summary: Expanding the antifungal drug arsenal is crucial for treating Candida infections, which are increasing in prevalence and often resistant to existing treatments. This review provides a comprehensive summary of antimicrobial peptides (AMPs) with anti-Candida activity that have undergone successful preclinical or clinical trials. The source, mode of action, and animal model of infection or clinical trial for these AMPs are presented. The advantages of combination therapy using AMPs and other drugs to fight Candida infections are also discussed.
Review
Dentistry, Oral Surgery & Medicine
Romeo Patini, Gioele Gioco, Cosimo Rupe, Maria Contaldo, Rosario Serpico, Michele Giuliani, Carlo Lajolo
Summary: This study assessed the prevalence of oral colonization by Candida spp. in patients with psoriasis and the prevalence of oral lesions associated with Candida spp. It also identified the risk factors for oral lesions. The results showed that psoriatic patients had a higher risk of oral Candida colonization, especially those who received immunosuppressive therapies.
Article
Microbiology
Xiaoqian Wang, Lihong Chen, Hongjie Ruan, Zhengai Xiong, Wenying Wang, Jin Qiu, Weihua Song, Chunlian Zhang, Fengxia Xue, Tianhua Qin, Bei Zhang, Ruifang An, Xiping Luo, Wei Wang, Songling Zhang, Yunlang Cai, Jiali Kang, Henan Deng, Shangrong Fan, Manhua Cui, Shijin Wang, Xiaowan Luo, Zhiying Su, Jing Shu, Quanren Wang, Fang Wang, Jianling Bai, Qinping Liao, Damian J. Krysan
Summary: Fluconazole remains the dominant treatment option for severe vulvovaginal candidiasis (VVC), but this study found that Oteseconazole demonstrated significant and clinically meaningful superiority in treating severe VVC with good tolerability.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Ari Soares de Oliveira Neto, Israel Lucas Antunes Souza, Maria Eliza Samuel Amorim, Thalita de Freitas Souza, Vinicius Novaes Rocha, Rene Oliveira do Couto, Rodrigo Luiz Fabri, Marcelo Gonzaga de Freitas Araujo
Summary: This study demonstrated the antifungal activity of atorvastatin and its potential as a therapeutic agent for treating Candida albicans infections. Atorvastatin-containing oral and vaginal emulgels showed effective treatment outcomes for oral and vulvovaginal candidiasis in animal models, suggesting its promising application for drug repositioning in the treatment of opportunistic mycoses.
Article
Biotechnology & Applied Microbiology
Mohsen Rashidi, Ali Bazi, Alireza Ahmadzadeh, Orazio Romeo, Ali Rezaei-Matehkolaei, Mahdi Abastabar, Iman Haghani, Sepideh Mirzaei
Summary: The present study investigated the growth inhibitory and apoptotic effects of umbelliprenin against Candida albicans in a BALB/c mice model of disseminated candidiasis. Umbelliprenin was able to eradicate fungal infection in BALB/c mice and promote antifungal effects, partly via inducing apoptosis and inhibiting the expression of enzymes and genes involved in antifungal resistance and adhesins encoding genes.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Review
Immunology
Vasileios Oikonomou, Timothy J. Break, Sarah L. Gaffen, Niki M. Moutsopoulos, Michail S. Lionakis
Summary: APECED is caused by mutations in the AIRE gene leading to autoimmune attacks on multiple tissues and increased susceptibility to specific infections such as CMC and COVID-19.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Immunology
Shubham Goel, Hye Sun Kuehn, Javier Chinen, Julie Niemela, Jennifer Stoddard, Daisuke Yamanaka, Mary Garofalo, Sophia Samir, Melanie Migaud, Vasileios Oikonomou, Thomas Fleisher, Anne Puel, Michail S. Lionakis, Sergio D. Rosenzweig
Summary: This study reveals that mutations in the CARD9 gene can lead to increased susceptibility to fungal infections and affect specific functions of T and B cells. Different CARD9 mutations and gene dosage can impact the functions of lymphocytes and monocytes, potentially contributing to the phenotype of CARD9 deficiency.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Daniel Chauss, Tilo Freiwald, Reuben McGregor, Bingyu Yan, Luopin Wang, Estefania Nova-Lamperti, Dhaneshwar Kumar, Zonghao Zhang, Heather Teague, Erin E. West, Kevin M. Vannella, Marcos J. Ramos-Benitez, Jack Bibby, Audrey Kelly, Amna Malik, Alexandra F. Freeman, Daniella M. Schwartz, Didier Portilla, Daniel S. Chertow, Susan John, Paul Lavender, Claudia Kemper, Giovanna Lombardi, Nehal N. Mehta, Nichola Cooper, Michail S. Lionakis, Arian Laurence, Majid Kazemian, Behdad Afzali
Summary: Research suggests that Vitamin D plays a crucial role in regulating the transcriptional response of T cells, leading to the transition from pro-inflammatory to suppressive cells. In patients with severe COVID-19, disruptions in Vitamin D signaling may be responsible for dysregulation of the immune system, resulting in increased inflammation.
Meeting Abstract
Genetics & Heredity
Bryce Seifert, Morgan Similuk, Michael Setzer, Jia Yan, Michael Kamen, Colleen Jodarski, Leila Jamal, Kathleen Jevtich, Yunting Yu, Rylee Duncan, Devin Hunt, Madison Mixer, Breanna Beers, Vasu Kuram, Justin Lack, Eric Karlins, Andrew Oler, Rajarshi Ghosh, Jenna Bergerson, Alexandra Freeman, Ivan Fuss, Michail Lionakis, Warren Strober, Gulbu Uzel, Christa Zerbe, Steven Holland, Weimin Bi, Luis Franco, Magdalena Walkiewicz-Yvon
GENETICS IN MEDICINE
(2022)
Review
Immunology
Sally H. H. Mohamed, Tinashe K. K. Nyazika, Kenneth Ssebambulidde, Michail S. S. Lionakis, David B. B. Meya, Rebecca A. A. Drummond
Summary: Cryptococcal meningitis is the leading cause of central nervous system fungal infections in humans, especially in Africa due to high HIV burden and limited access to antifungal treatments. The immune response to Cryptococcus neoformans is not fully understood, but CD4(+) T-cells producing IFN-gamma play a crucial role in fungal clearance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jiaxin Tang, Jiamin Li, Jinqing Pan, Xiaoyuan Shen, Xiangsheng Ye, Jiamin Zhou, Ni Wang, Liang Xie, Beth Burgwyn Fuchs, Michail S. Lionakis, Eleftherios Mylonakis, Xiaojiang Tan
Summary: Recent studies have shown that the coexistence of fungi and bacteria in the airway can increase the risk of infection, contribute to the development of pneumonia, and worsen the severity of the disease. Interleukin 17A (IL-17A) plays a crucial role in host defense against bacterial and fungal infections. This study aimed to investigate the effects of IL-17A on rats infected with Acinetobacter baumannii after previous Candida albicans airway inoculation. The results showed that IL-17A had a protective effect on A. baumannii pneumonia associated with C. albicans in the airway.
INFECTION AND IMMUNITY
(2023)
Article
Cell Biology
Anastasiia Gainullina, Denis A. Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, Jigar V. Desai, Barbara Maier, Sebastien This, Peter Wang, Stephanie Vargas Aguilar, Lucie Poupel, Sebastien Dussaud, Tyng-An Zhou, Veronique Angeli, J. Magarian Blander, Kyunghee Choi, Marc Dalod, Ivan Dzhagalov, Emmanuel L. Gautier, Claudia Jakubzick, Kory Lavine, Michail S. Lionakis, Helena Paidassi, Michael H. Sieweke, Florent Ginhoux, Martin Guilliams, Christophe Benoist, Miriam Merad, Gwendalyn J. Randolph, Alexey Sergushichev, Maxim N. Artyomov
Summary: This study focuses on the diversity and metabolic variability of mononuclear phagocyte (MNP) subpopulations. Through metabolic network analysis of large-scale transcriptional datasets, it was found that cholesterol synthesis is particularly active in migratory dendritic cells, while glutathione synthesis is essential for cysteinyl leukotriene production by peritoneal and lung macrophages.
Article
Biochemistry & Molecular Biology
Jigar Desai, Dhaneshwar Kumar, Tilo Freiwald, Daniel Chauss, Melissa D. Johnson, Michael S. Abers, Julie M. Steinbrink, John R. Perfect, Barbara Alexander, Vasiliki Matzaraki, Brendan D. Snarr, Marissa A. Zarakas, Vasileios Oikonomou, Lakmali M. Silva, Raju Shivarathri, Emily Beltran, Luciana Negro Demontel, Luopin Wang, Jean K. Lim, Dylan Launder, Heather R. Conti, Muthulekha Swamydas, Micah T. McClain, Niki M. Moutsopoulos, Majid Kazemian, Mihai G. Netea, Vinod Kumar, Jorg Kohl, Claudia Kemper, Behdad Afzali, Michail S. Lionakis
Summary: Systemic candidiasis, a common and high-mortality nosocomial fungal infection, can be a complication of anti-complement C5-targeted monoclonal antibody treatment, which highlights the important role of C5 in antifungal immunity. Transcription of complement system genes was found to be the top biological pathway induced in candidemic patients and predictive of candidemia. Mechanistically, C5a-C5aR1 promotes fungal clearance and host survival in a mouse model of systemic candidiasis by enhancing phagocyte effector function and ensuring survival in infected tissues. Local production of C5 by phagocytes provides a crucial substrate for antifungal protection.
Review
Microbiology
Diana M. Proctor, Rebecca A. Drummond, Michail S. Lionakis, Julia A. Segre
Summary: Candida auris and Candida albicans can colonize human skin and gastrointestinal tracts without symptoms but can also cause invasive fungal diseases. This article reviews the factors influencing the microbiome and explores the molecular mechanisms of C. albicans to switch between commensal and pathogenic lifestyles. The association between host physiology, immunity, antibiotic use, and progression from colonization to infection with C. auris is also discussed, along with hypotheses explaining the increased risk of invasive candidiasis with antibiotic treatment. The integration of genomics and immunology is highlighted as a future direction for advancing understanding of invasive candidiasis and human fungal disease.
CELL HOST & MICROBE
(2023)
Article
Immunology
Thomas Clarke, Pan Du, Satyendra Kumar, Shinji L. Okitsu, Mark Schuette, Qi An, Jinyang Zhang, Evgeni Tzvetkov, Mark A. Jensen, Timothy B. Niewold, Elise M. N. Ferre, Julie Nardone, Michail S. Lionakis, Jaromir Vlach, Julie DeMartino, Andrew T. Bender
Summary: Autoimmune diseases can vary in the pattern and range of autoantibodies produced, and these differences may be caused by various breaks in tolerance. By comparing three different autoimmune diseases, APECED, SLE, and SjS, researchers gained insights into the triggers of autoimmunity. APECED was found to have a focused set of shared anti-cytokine antibodies, while SLE had broader autoantibody repertoires targeting mostly intracellular antigens. SjS patients showed few specific autoantibodies, with the highest reactivity against Ro-52 and La. These findings suggest different mechanisms driving autoimmunity in monogenic and polygenic disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Bergithe E. Oftedal, Kristian Assing, Safa Baris, Stephanie L. Safgren, Isik S. Johansen, Marianne Antonius Jakobsen, Dusica Babovic-Vuksanovic, Katherine Agre, Eric W. Klee, Emina Majcic, Elise M. N. Ferre, Monica M. Schmitt, Tom DiMaggio, Lindsey B. Rosen, Muhammad Obaidur Rahman, Dionisio Chrysis, Aristeidi Giannakopoulos, Maria Tallon Garcia, Luis Ignacio Gonzalez-Granado, Katherine Stanley, Jessica Galant-Swafford, Pim Suwannarat, Isabelle Meyts, Michail S. Lionakis, Eystein S. Husebye
Summary: APS-1 is an autosomal recessive disease caused by mutations in the AIRE gene, characterized by severe and childhood onset organ-specific autoimmunity. Dominant-negative mutations in PHD1, PHD2, and SAND domains have also been associated with a milder phenotype. This study identified additional families with a range of phenotypes and emphasized the need for functional studies and close follow-up of individuals and families.
Article
Immunology
Yuanyuan Gao, Yan Wang, Daniel Chauss, Alejandro V. Villarino, Verena M. Link, Hiroyuki Nagashima, Camille A. Spinner, Vishal N. Koparde, Nicolas Bouladoux, Michael S. Abers, Timothy J. Break, Laura B. Chopp, Jung-Hyun Park, Jinfang Zhu, David L. Wiest, Warren J. Leonard, Michail S. Lionakis, John J. O'Shea, Behdad Afzali, Yasmine Belkaid, Vanja Lazarevic
Summary: Lazarevic and colleagues demonstrate that the transcription factor EGR2 controls a pathogenic T(H)17 cell-specific transcriptional program in the CNS. EGR2 is elevated in myelin-reactive CD4(+) T cells from patients with multiple sclerosis and mice with autoimmune neuroinflammation. Mechanistically, EGR2 enhances T(H)17 cell differentiation and myeloid cell recruitment to the CNS by upregulating pathogenesis-associated genes and myelomonocytic chemokines.
Article
Endocrinology & Metabolism
Caleigh Mandel-Brehm, Sara E. Vazquez, Christopher Liverman, Mickie Cheng, Zoe Quandt, Andrew F. Kung, Audrey Parent, Brenda Miao, Emmanuel Disse, Christine Cugnet-Anceau, Stephane Dalle, Elizaveta Orlova, Elena Frolova, Diana Alba, Aaron Michels, Bergithe E. Oftedal, Michail S. Lionakis, Eystein S. Husebye, Anil K. Agarwal, Xilong Li, Chengsong Zhu, Quan Li, Elif Oral, Rebecca Brown, Mark S. Anderson, Abhinmanyu Garg, Joseph L. DeRisi
Summary: This study identified autoantibodies to PLIN1 in a murine model of APS1 and in patients with acquired lipodystrophy, indicating that PLIN1 autoantibodies may be markers of acquired autoimmune lipodystrophies.
Meeting Abstract
Biochemistry & Molecular Biology
Daniel Chauss, Tilo Freiwald, Reuben McGregor, Luopin Wang, Bingyu Yan, Dhaneshwar Kumar, Estefania Nova Lamperti, Zonghao Zhang, Heather Teague, Erin E. West, Jack Bibby, Audrey Kelly, Amna Malik, Alexandra F. Freeman, Daniella Schwartz, Didier Portilla, Susan John, Paul Lavender, Michail S. Lionakis, Nehal N. Mehta, Claudia Kemper, Giovanna Lombardi, Majid Kazemian, Arian Laurence, Behdad Afzali
MOLECULAR IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Rachael Laura Philips, Chen Yao, Joshua D. Milner, Michail S. Lionakis, John J. O'Shea
JOURNAL OF IMMUNOLOGY
(2021)
