期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 4, 页码 2509-2512出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02981-15
关键词
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资金
- FP7 project EvoTAR [HEALTH-F3-2011-2011-282004]
Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).
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