期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 12, 页码 7527-7529出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01208-16
关键词
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资金
- Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT
Recent findings have identified Escherichia coli strains that are pan-beta-lactam susceptible (PBL-S) but piperacillin-tazobactam resistant (TZP-R) in vitro. We assessed the in vivo significance of this resistance profile in a neutropenic murine pneumonia model using humanized exposures of TZP with 18 clinical E. coli isolates, 8 TZP-S/PBL-S and 10 genotypically confirmed TZPR/PBL-S. Despite phenotypically and genotypically defined resistance, TZP displayed efficacy against these isolates. Additional studies are required to define the clinical implications of these TZP-R/PBL-S strains.
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