期刊
ACS CATALYSIS
卷 9, 期 5, 页码 4296-4301出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b00992
关键词
boron; catalysis; copper; ketones; oxidation
资金
- University of Sheffield
- EPSRC
- Royal Society [RSG\R1\180065]
The oxidation of benzylic boronic esters directly to the ketone is reported. This mild Cu-catalyzed method uses an ambient atmosphere of air as the terminal oxidant and is notably chemoselective. Oxidation of the C-B bond occurs selectively, even in the presence of unprotected alcohols. Initial investigation suggests the reaction proceeds through an alkylboron to Cu transmetalation, peroxide formation, and rearrangement to give the carbonyl.
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