Article
Infectious Diseases
Aura Falco, Daniela Guerrero, Isabella Garcia, Adriana Correa, Sandra Rivera, Maria Beatriz Olaya, Carlos Aranaga
Summary: The study aimed to molecularly characterize 28 isolates of the E. cloacae complex resistant to cephalosporins and carbapenems from five hospitals in Cali, Colombia. It found that 43% of the isolates carried the bla(KPC-2) gene variant. High genetic diversity was observed among isolates, with the most common sequence type being ST510.
Article
Microbiology
Jacob Lazarus, Yin Wang, Matthew Waldor, David Hooper
Summary: This study found that S. marcescens has a lower propensity for developing ceftriaxone resistance compared to E. cloacae, supporting recent clinical guidance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
William Bennett, Katrin Mende, Wesley R. Campbell, Miriam Beckius, Laveta Stewart, Faraz Shaikh, Azizur Rahman, David R. Tribble, Joseph M. Yabes
Summary: This study evaluated the characteristics, antibiotic utilization, and outcomes of battlefield-related Enterobacter cloacae infections. Patients with E. cloacae infections sustained more blast trauma, required more initial blood products, and had longer durations of antibiotic therapy and hospitalizations compared to patients with non-E. cloacae infections.
Article
Microbiology
Xianggui Yang, Zhenguo Wang, Mingquan Liu, Xuejing Yu, Yuanxiu Zhong, Fuying Wang, Ying Xu
Summary: In this study, the researchers found that subinhibitory concentrations of cefazolin and imipenem can enhance the expression of AmpC and its resistance towards beta-lactams in Enterobacter cloacae. NagZ was identified as a critical determinant for this effect. The findings suggest that caution should be exercised in the use of cefazolin and imipenem as they may worsen the resistance of Enterobacter cloacae.
Article
Food Science & Technology
Alberto Pintor-Cora, Angel Alegria, Jose Ramos-Vivas, Maria-Luisa Garcia-Lopez, Jesus A. Santos, Jose M. Rodriguez-Calleja
Summary: This study investigated the presence of antimicrobial-resistant Enterobacter cloacae complex strains in fresh vegetables and their cultivation environments. The findings showed the presence of AmpC-producing ECC isolates, some of which exhibited resistance to the last resort antibiotic colistin. A colistin-resistant E. kobei strain was detected in irrigation water for the first time in Spain, highlighting the transferability of resistance genes. Monitoring and addressing antimicrobial-resistant ECC strains in fresh vegetables and their production environments is important to mitigate potential risks to public health from a One Health perspective.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Microbiology
Ryuichi Nakano, Yuki Yamada, Akiyo Nakano, Yuki Suzuki, Kai Saito, Ryuji Sakata, Miho Ogawa, Kazuya Narita, Akio Kuga, Akira Suwabe, Hisakazu Yano
Summary: Various carbapenemases have been identified in the Enterobacteriaceae, but the induction and regulation genes of carbapenemase NmcA in the Enterobacter cloacae complex (ECC) have rarely been detected. This study characterized an NmcA-positive isolate and elucidated its induction system. The isolate was highly resistant to beta-lactams and whole-genome analysis revealed a novel mobile element called EludIMEX-1 inserted into the chromosome. The study also evaluated the inducibility of beta-lactamase activity and observed upregulation of ampC and nmcA.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Gregory A. Ballash, Dimi A. Mathys, Sydnee M. Feicht, Dixie F. Mollenkopf, Amy L. Albers, Rachael J. Adams, Thomas E. Wittum
Summary: Environmental surfaces in zoological institutions can serve as reservoirs for antimicrobial-resistant bacteria, posing a potential threat to animal and public health.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Infectious Diseases
Kazushi Yamairi, Koichi Yamada, Waki Imoto, Gaku Kuwabara, Wataru Shibata, Hiroki Namikawa, Kazuhiro Oshima, Kiyotaka Nakaie, Makoto Niki, Yukihiro Kaneko, Hiroshi Kakeya
Summary: This study found that previous usage of third-generation cephalosporins was an independent predictor associated with TZP-resistant Enterobacter spp. bacteremia. Therefore, caution should be exercised when considering TZP administration in cases of suspected Enterobacter spp. bacteremia, particularly in patients who have been previously treated with third-generation cephalosporins.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
Fatma Abdel-Kader, Eman Hamza, Khaled A. Abdel-Moein, Maha A. Sabry
Summary: This study identified virulent extended-spectrum cephalosporin-resistant Salmonella in poultry shops, with some strains showing resistance to carbapenems. These resistant strains may be transmitted to humans through food consumption.
Article
Infectious Diseases
Shazad Mushtaq, Anna Vickers, Michel Doumith, Matthew J. Ellington, Neil Woodford, David M. Livermore
Summary: Taniborbactam potentiates partner beta-Lactams against various Enterobacterales with different carbapenemases, showing potential broader spectrum compared to vaborbactam.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Majed F. Alghoribi, Moayad Alqurashi, Liliane Okdah, Bassam Alalwan, Yahya S. AlHebaishi, Abdulmajeed Almalki, Maha A. Alzayer, Abdulrahman A. Alswaji, Michel Doumith, Mazin Barry
Summary: The challenging Pandrug-resistant K. pneumoniae infection can be successfully overcome and cleared rapidly through testing different drug combinations.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Philipp Kohler, Salome N. Seiffert, Simone Kessler, Gabriela Rettenmund, Eva Lemmenmeier, Laetitia Qalla Widmer, Oliver Nolte, Helena M. B. Seth-Smith, Werner C. Albrich, Baharak Babouee Flury, Celine Gardiol, Stephan Harbarth, Thomas Muenzer, Matthias Schlegel, Christiane Petignat, Adrian Egli, Delphine Hequet
Summary: This study aimed to assess the burden of ESBL-producing Enterobacterales in Swiss long-term care facilities, describe the molecular epidemiology, identify clusters of resistant pathogens, and determine factors associated with colonization. The study found a low prevalence of ESBL-E in Swiss LTCF residents, but identified clusters of residents with identical pathogens within the same institution. The use of PPIs was the only modifiable factor associated with carriage of ESBL producers.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Infectious Diseases
Julia Notter, Salome N. Seiffert, Maria Zimmermann-Kogadeeva, Anja Bosch, Robert Wenger, Carol Strahm, Manuel Frischknecht, David M. Livermore, Baharak Babouee Flury
Summary: This study reports the first in vivo resistance evolution of a C. davisae clinical isolate in a patient with a complex hand trauma, providing insights into the resistance mechanism and implications for therapeutic management.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Anna Hachfeld, Andrew Atkinson, Petra Stute, Alexandra Calmy, Philip E. Tarr, Katharine Darling, Baharak Babouee Flury, Christian Polli, Leila Sultan-Beyer, Irene A. Abela, Karoline Aebi-Popp
Summary: This study aimed to assess the prevalence and age at menopause in women living with HIV in Switzerland, identify factors associated with early menopause, and explore the provision and utilization of healthcare for these women. The results showed that the median age at menopause for women living with HIV is around 2 years lower than HIV-negative women in Switzerland.
Article
Microbiology
Michel Doumith, Sarah Alhassinah, Abdulrahman Alswaji, Maha Alzayer, Essa Alrashidi, Liliane Okdah, Sameera Aljohani, Hanan H. Balkhy, Majed F. Alghoribi
Summary: Carbapenem-resistant P. aeruginosa is a major clinical problem in Saudi Arabia. This study provides insights into the genetic characteristics and antibiotic resistance mechanisms of these clinical isolates, highlighting the global spread of specific sub-lineages. It emphasizes the importance of routine detection of rare beta-lactamases.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Onicio Leal-Neto, Thomas Egger, Matthias Schlegel, Domenica Flury, Johannes Sumer, Werner Albrich, Baharak Babouee Flury, Stefan Kuster, Pietro Vernazza, Christian Kahlert, Philipp Kohler
Summary: This study describes a web-based participatory surveillance strategy among health care workers during the COVID-19 pandemic, achieving high participation and accuracy. Loss of taste was the symptom most aligned with virus activity, showing favorable performance in individual-level predictions.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Medicine, Research & Experimental
Maha Alamri, Heba Alghamdi, Sahar Althawadi, Maysoon Mutabaggani, M. Anas Dababo, Fahad Alajlan, Maha Alzayer, Michel Doumith, Majed Alghoribi, Reem S. Almaghrabi
Summary: Neoscytalidium is a plant pathogen commonly found in plants and soil, causing skin and nail infections as well as invasive diseases in immunocompromised patients. Despite combined surgical and medical therapies, treating invasive fungal diseases caused by Neoscytalidium can be challenging and often result in fatal outcomes.
MEDICAL MYCOLOGY CASE REPORTS
(2021)
Article
Microbiology
Katie L. Hopkins, Nicholas Ellaby, Matthew J. Ellington, Michel Doumith, Nazim Mustafa, Daniele Meunier, Neil Woodford
Summary: By sequencing CPE samples from the national reference laboratory in England, we found that the epidemiology of CPE in England is diverse, indicating multiple introductions and a role for horizontal transfer of carbapenemase genes.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Immunology
Anna Hachfeld, Andrew Atkinson, Petra Stute, Alexandra Calmy, Philip E. Tarr, Katharine E. A. Darling, Baharak Babouee Flury, Christian Polli, Leila Sultan-Beyer, Irene A. Abela, Karoline Aebi-Popp
Summary: The study found that the increased rates of depression and psychiatric care during the transition through menopause do not lead to lower levels of treatment adherence or viral suppression in women living with HIV in Switzerland.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Medicine, General & Internal
Baharak Babouee Flury, Sabine Gusewell, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Moller, Philip Rieder, Markus Rutti, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Allison McGeer, Lorenz Risch, Andree Friedl, Matthias Schlegel, Stefan P. Kuster, Christian R. Kahlert, Philipp Kohler
Summary: Background knowledge about protection conferred by previous SARS-CoV-2 infection and/or vaccination against emerging viral variants allows for prediction and reduction of future COVID-19 burden. This study investigated the risk and symptoms of SARS-CoV-2 (re)infection and vaccine breakthrough infection during the Delta and Omicron waves, depending on baseline immune status and subsequent vaccinations.
Article
Infectious Diseases
Maha Alzayer, Majed F. Alghoribi, Bassam Alalwan, Abdualah Alreheli, Sameera Aljohani, Mohammad Bosaeed, Michel Doumith
Summary: This study investigated the in vitro activity of Cefiderocol against carbapenem non-susceptible Gram-negative bacteria collected in Saudi Arabia. The results showed that Cefiderocol exhibited excellent activity, especially against multidrug-resistant non-fermenting Gram-negative pathogens.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Microbiology
Anja Bosch, Magreth E. Macha, Qun Ren, Philipp Kohler, Weihong Qi, Baharak Babouee Flury
Summary: Understanding the resistance mechanisms of antibiotics in the micro-environment of the infection is crucial for evaluating their clinical applicability and preventing resistance development. This study compared the laboratory resistance evolution of Escherichia coli to delafloxacin and ciprofloxacin at different pH levels and examined the underlying resistance mechanisms. The research provides new insights into E. coli's resistance to delafloxacin and emphasizes the importance of understanding micro-environmental conditions at the infection site for the true clinical efficacy of antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Maha Alzayer, Manal M. Alkhulaifi, Ahmed Alyami, Mohammed Aldosary, Abdulaziz Alageel, Ghada Garaween, Atef Shibl, Arif M. Al-Hamad, Michel Doumith
Summary: Group B Streptococcus (GBS) has emerged as an important cause of severe infections in adults. This study investigated the epidemiology of GBS in Saudi Arabia and found that serotypes III and V were the most prevalent, and most isolates harbored pilus island 1 and 2a types. The isolates exhibited high levels of resistance to erythromycin and clindamycin, which require further surveillance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Antoine Abou Fayad, Maria El Azzi, Ahmad Sleiman, Issmat I. Kassem, Reema A. Bawazeer, Liliane Okdah, Michel Doumith, Majed F. Alghoribi, Ghassan M. Matar
Summary: The study revealed the presence of mcr and other important resistance determinants in MDR E. coli isolated from poultry farms in Lebanon, with resistance genes predominantly located on IncX4 plasmids. Some strains may pose a risk of transmission to humans.
JAC-ANTIMICROBIAL RESISTANCE
(2021)