Review
Endocrinology & Metabolism
Kanikkai Raja Aseer, Josephine M. Egan
Summary: Endocannabinoids (ECs) are produced in the periphery where they regulate various physiological processes, including energy storage, glucose and lipid metabolism, insulin secretion and synthesis, and hepatocyte function. Within the islet of Langerhans, there is an autonomous EC system (ECS) that influences beta-cell responses to stressors primarily through the CB1 receptor. Further research is needed to understand the therapeutic potential of targeting EC/CB1R and CB2R in treating diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Daniel D. Lam, Rhiannan H. Williams, Ernesto Lujan, Koji Tanabe, Georg Huber, Nay Lui Saw, Juliane Merl-Pham, Aaro Salminen, David Lohse, Sally Spendiff, Melanie J. Plastini, Michael Zech, Hanns Lochmueller, Arie Geerlof, Stefanie M. Hauck, Mehrdad Shamloo, Marius Wemig, Juliane Winkelmann
Summary: Collagen VI plays a crucial role in muscle basement membranes and genetic variants can cause muscular dystrophies. Recent studies have shown that collagen VI is also involved in central nervous system function and dystonia. In this study, mice with a truncation of the collagen alpha 3 (VI) C-terminal domain were generated and showed a dystonia-like phenotype. It was found that collagen VI interacts with the cannabinoid receptor 1 complex in a C-terminal domain-dependent manner. The mice exhibited impaired excitatory input in the basal pontine nuclei, which improved with CB1R agonist treatment, suggesting a therapeutic addressable synaptic mechanism for motor control.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
P. H. Gobira, S. R. Joca, F. A. Moreira
Summary: Addiction to psychostimulant drugs is a significant public health issue and cannabinoid receptors CB1R and CB2R play a crucial role in modulating the rewarding effects of these drugs. This review summarizes studies on pharmacological intervention targeting CB1R and CB2R and their interaction in psychostimulant responses.
ACTA NEUROPSYCHIATRICA
(2022)
Article
Cell Biology
Mariantonia Braile, Leonardo Cristinziano, Simone Marcella, Gilda Varricchi, Giancarlo Marone, Luca Modestino, Anne Lise Ferrara, Agnese De Ciuceis, Sara Scala, Maria Rosaria Galdiero, Stefania Loffredo
Summary: Neutrophils play a central role in inflammation and tumor angiogenesis by releasing angiogenic factors. This study found that CB agonists can modulate the release of VEGF-A from LPS-activated PMNs, indicating a potential novel therapeutic strategy for patients with sepsis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kelsey Andreis, Jenna Billingsley, Kian Naimi Shirazi, Jim Wager-Miller, Clare Johnson, Heather Bradshaw, Alex Straiker
Summary: Saliva has multiple important functions in the body, including aiding in food preparation and defense against oral pathogens. Dry mouth is a common symptom in Sjogren's syndrome and a side effect of drug treatments. The basis for dry mouth in cannabis users is still unknown. The study found that cannabinoid CB1 receptors are expressed in cholinergic neurons innervating the submandibular gland. THC and cannabinoid-related ligands reduced salivation, while CBD reversed the effect of THC. The enzyme FAAH, which metabolizes endocannabinoids, also regulates salivation.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Stephen Schultz, Georgianna G. Gould, Nicola Antonucci, Anna Lisa Brigida, Dario Siniscalco
Summary: Persistent deficits in social communication and interaction, as well as restricted, repetitive patterns of behavior, interests, or activities, are core features of autism spectrum disorder (ASD). Strong inflammation has been associated with ASD, and the endocannabinoid system (ECS) may play a role in ASD pathophysiology. Acetaminophen use has been linked to an increased risk of ASD.
Article
Psychology, Clinical
Luke J. Ney, Allison Matthews, Chia-Ming Ken Hsu, Daniel Zuj, Emma Nicholson, Trevor Steward, David Nichols, Bronwyn Graham, Ben Harrison, Raimondo Bruno, Kim Felmingham
Summary: The study found that the endocannabinoid receptor 1 and arachidonoyl ethanolamide play important roles in human fear extinction learning. The effect of FAAH gene polymorphism on fear extinction is moderated by plasma AEA level. These findings suggest that FAAH inhibitors may be effective for targeting anxiety in PTSD, but further research in clinical populations is needed.
DEPRESSION AND ANXIETY
(2021)
Article
Immunology
Sofia R. Gardeta, Eva M. Garcia-Cuesta, Gianluca D'Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, Jose Miguel Rodriguez-Frade, Mario Mellado
Summary: The local lipid environment plays an important role in regulating CXCR4 organization and function, and modulating chemokine-triggered directed cell migration. Treatment of T cells with bacterial sphingomyelinase alters the lipid composition of the cell membrane, affecting membrane fluidity and CXCR4 nanoclustering and dynamics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Camilla Di Meo, Daniel Tortolani, Sara Standoli, Clotilde Beatrice Angelucci, Federico Fanti, Alessandro Leuti, Manuel Sergi, Salam Kadhim, Eric Hsu, Cinzia Rapino, Mauro Maccarrone
Summary: The decriminalization and legalization of cannabis have opened up opportunities for investigating the potential use of pCBs as natural therapeutics for human diseases. This study focuses on the effects of rare pCBs on the expression of ECS elements and endocannabinoid-like compounds in human keratinocytes. The findings suggest that these rare pCBs have unique modulatory effects on the ECS and may hold therapeutic potential for skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shijie Song, Xiaoyuan Kong, Cesar Borlongan, Vasyl Sava, Juan Sanchez-Ramos
Summary: The study found that the subacute effects of G-CSF in promoting brain repair after TBI do not depend on the activation of CB1 or CB2 receptors. CB receptor antagonists were also ineffective in preventing the effects of G-CSF on these receptors, which should be accepted with caution.
CANNABIS AND CANNABINOID RESEARCH
(2021)
Review
Psychiatry
Ardavan Mohammad Aghaei, Alexandra Saali, Maria Alejandra Canas, Jeremy Weleff, Deepak Cyril D'Souza, Gustavo A. Angarita, Anahita Bassir Nia
Summary: This paper reviews the clinical and preclinical literature on the dysregulation of the endocannabinoid system (ECS) after exposure to opioids. The results show that opioids disrupt various ECS components in specific brain regions. However, the literature results are heterogeneous and contradictory, suggesting the need for further research to determine the effects of opioids on ECS components in different brain regions.
PSYCHIATRY RESEARCH
(2023)
Review
Endocrinology & Metabolism
Myriam Dao, Helene Francois
Summary: By examining the expression and mechanism of action of CB1R in normal kidneys, as well as its effects on metabolic and non-metabolic CKD and renal fibrosis, it is found that the inhibition of CB1R can help prevent and treat kidney diseases, especially in patients with metabolic syndrome, obesity, and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Claudia Caroline Bosio Meneses, Lais N. Pizzatto, Carla R. Sipert, Anibal Diogenes
Summary: The study found that stem cells of the apical papilla (SCAP) express the genes of the main components of the endocannabinoid system (ECS) and transient receptor potential vanilloid 1 (TRPV1). Endogenous cannabinoids (eCBs) may affect SCAP viability, mineralization, and gene expression.
JOURNAL OF ENDODONTICS
(2021)
Article
Immunology
Maycon Eduardo Matias, Thiago Rodrigues da Silva, Ana Maria Raymundi, Cristina Aparecida Jark Stern, Aleksander Roberto Zampronio
Summary: This study examined whether rats that survived sepsis develop the generalization of fear memory as a model of PTSD, and evaluated the effectiveness of interventions targeting the ET-1/cannabinoid system and glial activation in the early stages of sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Tibor M. Brunt, Matthijs G. Bossong
Summary: The endocannabinoid system is a complex neuronal system involved in various biological functions, and its understanding has been driven by the potential therapeutic benefits of cannabinoid ligands. This review provides an overview of the neuropharmacology of cannabinoid receptor ligands, including endocannabinoids, herbal cannabis, and synthetic cannabinoids, focusing on their modulatory actions through other neurotransmitter systems. The effects of cannabinoid ligands on neurotransmitter systems such as dopamine, serotonin, glutamate, noradrenaline, opioid, and GABA are discussed, as well as their therapeutic potential and adverse effects.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)