Review
Oncology
Paula Aldaz, Imanol Arozarena
Summary: Glioblastoma (GBM) is the most common and lethal form of malignant brain tumor, and patients typically undergo surgery followed by radiotherapy and chemotherapy. Despite promising preclinical evidence, clinical trials testing the therapeutic potential of tyrosine kinase inhibitors (TKIs) targeting EGFR, PDGF receptors, and other tyrosine kinases have not led to significant breakthroughs in treating GBM over the past two decades. This article critically analyzes the reasons for the failure of TKIs in GBM treatment and proposes alternative approaches for the evaluation of TKIs in GBM patients.
Review
Biochemistry & Molecular Biology
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones
Summary: Glioblastoma multiforme (GBM) is a deadly cancer with limited response to existing therapies. Subtypes of GBM with distinct genetic signatures show aberrant activation of signal transduction pathways. Current research focuses on understanding these molecular alterations to develop more efficient targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Monika Lejman, Kinga Kusmierczuk, Kinga Bednarz, Katarzyna Ostapinska, Joanna Zawitkowska
Summary: Targeted therapy has revolutionized the treatment of poor-prognosis pediatric acute lymphoblastic leukemia (ALL) with specific genetic abnormalities, aiming to improve treatment outcomes and reduce conventional chemotherapy doses. Limited clinical research exists on the impact of targeted cell therapy on potential toxic events in children and adolescents, despite promising results in treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Faheem Hyder Pottoo, Md. Noushad Javed, Jawad Ur Rahman, Tareq Abu-Izneid, Firdos Alam Khan
Summary: Glioblastoma multiforme is a highly invasive form of glioma with limited treatment options and short survival time. Gene mutations play a crucial role in GBM formation, while miRNA has potential applications in GBM diagnosis and therapy.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Oncology
Carmelo Laface, Palma Fedele, Felicia Maria Maselli, Francesca Ambrogio, Caterina Foti, Pasquale Molinari, Michele Ammendola, Marco Lioce, Girolamo Ranieri
Summary: Hepatocellular carcinoma is the most common primary liver cancer with poor prognosis. New molecular targeted therapies have shown promising results in recent years. However, research into new treatments is still necessary.
Article
Oncology
Benjamin Lin, Julia Ziebro, Erin Smithberger, Kasey R. Skinner, Eva Zhao, Timothy F. Cloughesy, Zev A. Binder, Donald M. O'Rourke, David A. Nathanson, Frank B. Furnari, C. Ryan Miller
Summary: This article discusses the unique biology of EGFR in GBM, the challenges in treatment, and how they have influenced past and present EGFR-targeted therapeutic design and clinical trials. It also explores the adjustments needed to exploit EGFR in this disease.
Review
Chemistry, Medicinal
Julie Bolcaen, Shankari Nair, Cathryn H. S. Driver, Tebatso M. G. Boshomane, Thomas Ebenhan, Charlot Vandevoorde
Summary: Glioblastoma, a deadly brain tumor with high treatment resistance, has been explored with receptor tyrosine kinase inhibitors (RTKIs) to potentially improve prognosis and develop personalized targeted therapy. Approved RTKIs in clinics alongside radiopharmaceuticals in trials offer new avenues for theranostic applications in GB treatment.
Article
Engineering, Biomedical
Maoyuan Sun, Yan Li, Wenli Zhang, Xiang Gu, Rong Wen, Ke Zhang, Jinning Mao, Chengyao Huang, Xiong Zhang, Mao Nie, Zhiwen Zhang, Chao Qi, Kaiyong Cai, Guodong Liu
Summary: In this study, a biomimetic nanoplatform AMNP@CLP@CCM was developed for the targeted photothermal therapy and immune checkpoint blockade (ICB) treatment of glioblastoma (GBM). The nanoplatform successfully crossed the blood-brain barrier and delivered the immune checkpoint inhibitor CLP002 to GBM tissues. The photothermal therapy not only enhanced blood-brain barrier penetration but also stimulated immunogenic cell death and T lymphocyte infiltration, resulting in significant growth inhibition of orthotopic GBM.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
Anne -Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, Jared K. Woods, Shakti Ramkissoon, Lori Ramkissoon, Frank Dubois, Kathleen Schoolcraft, Jessica Tsai, Dayle Wang, Robert Jones, Jayne Vogelzang, Kristine Pelton, Sarah Becker, Fiona Watkinson, Claire Sinai, Elizabeth F. Cohen, Matthew A. Booker, Michael Y. Tolstorukov, Veerle Haemels, Liliana Goumnerova, Karen Wright, Mark Kieran, Katie Fehnel, David Reardon, Arnault Tauziede-Espariat, Rishi Lulla, Benjamin Carcamo, Stanley Chaleff, Alain Charest, Frederik De Smet, Azra H. Ligon, Adrian Dubuc, Melanie Pages, Pascale Varlet, Patrick Y. Wen, Brian M. Alexander, Susan Chi, Sanda Alexandrescu, Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon
Summary: This study comprehensively analyzed ALK expression and genomic aberrations in 371 glioblastomas and validated the abnormalities in vitro and in vivo. The findings showed that ALK aberrations were present in 12% of gliomas across a wide age range and ALK fusions were more common in congenital/infant glioblastomas. ALK fusions promoted pathways related to tumor transformation and responded well to ALK inhibitors, supporting their use in clinical trials for glioblastomas in different age groups.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Akanksha Sharma, Lauren Singer, Priya Kumthekar
Summary: Metastatic disease to the central nervous system is a serious complication with high mortality rates. Advances in targeted therapy and immunotherapy have led to successful penetration and efficacy within the CNS, improving treatment options for patients. Identifying key targets in tumorigenesis pathway and upcoming trials continue to promise significant progress in managing CNS metastases.
Review
Nanoscience & Nanotechnology
Zhongmin Li, Yilun Liu, Xuedong Fang, Zhenbo Shu
Summary: Molecular targeted therapy not only directly inhibits the proliferation and metastasis of tumor cells, but also activates the immune system through various mechanisms. However, limitations such as poor water solubility, insufficient accumulation at the tumor site, and nonspecific targeting of immune cells hinder their application. Innovative nanomaterials have been developed to overcome these obstacles and enhance the immunomodulatory effects of molecular targeted drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Marta Nyakas, Karianne Giller Fleten, Mads Haugland Haugen, Nikolai Engedal, Christina Sveen, Inger Nina Farstad, Vivi Ann Florenes, Lina Prasmickaite, Gunhild Mari Maelandsmo, Kotryna Seip
Summary: This study investigated the therapeutic potential of combining an AXL inhibitor (AXLi) and a clinically relevant BRAF inhibitor (BRAFi) for the treatment of metastatic melanoma. The results showed that AXL was expressed in the majority of melanoma lymph node metastases. In vitro experiments demonstrated that the combination of AXLi and BRAFi resulted in the largest reduction in cell viability. Moreover, pre-clinical studies using AXL(high) melanoma models showed a therapeutic benefit of adding AXLi to the BRAF-targeted therapy. Mechanistic insights revealed that AXLi potentiated BRAFi-induced apoptosis, stimulated ferroptosis, and inhibited autophagy. Overall, this study suggests that combining AXLi with standard therapy could improve the therapeutic outcome in metastatic melanoma.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Hsin-Tzu Hsieh, Hsi-Chien Huang, Chieh-Wei Chung, Cheng-Chin Chiang, Tiffaney Hsia, Hsin-Fang Wu, Rui-Lin Huang, Chi-Shiun Chiang, Jane Wang, Tsai-Te Lu, Yunching Chen
Summary: The study presents an immunotherapeutic approach using CXCR4-targeted lipid-calcium-phosphate nanoparticles for the treatment of glioblastoma multiforme (GBM). By delivering nitric oxide (NO), the approach enhances blood-brain barrier permeability and improves the delivery of siRNA against the immune checkpoint ligand PD-L1 to GBM tumors. This results in increased infiltration and activation of cytotoxic T cells, suppressing GBM progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Jiqin Zhang, Yongxian Hu, Jiaxuan Yang, Wei Li, Mingming Zhang, Qingcan Wang, Linjie Zhang, Guoqing Wei, Yue Tian, Kui Zhao, Ang Chen, Binghe Tan, Jiazhen Cui, Deqi Li, Yi Li, Yalei Qi, Dongrui Wang, Yuxuan Wu, Dali Li, Bing Du, Mingyao Liu, He Huang
Summary: A two-in-one approach to generate non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9 was successfully developed, demonstrating feasibility and efficacy in a preclinical study. An innovative type of anti-CD19 CAR-T cell with PD1 integration showed superior ability to eradicate tumor cells.
Article
Oncology
Juan Chen, Wenjuan Chen, Xiujuan Qu, Ying Chen
Summary: Hepatic sarcomatoid carcinoma (HSC) is an aggressive liver cancer with poor prognosis. This case report describes a 60-year-old patient diagnosed with HSC, who developed multiple metastases after surgery. The patient received monotherapy with sintilimab for 12 months due to high expression of PD-1, followed by a combination treatment with anlotinib and sintilimab which resulted in 11 months of effective therapeutic response.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
X. Lin, M. Lee, O. Buck, K. M. Woo, Z. Zhang, V. Hatzoglou, A. Omuro, J. Arevalo-Perez, A. A. Thomas, J. Huse, K. Peck, A. I. Holodny, R. J. Young
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)
Article
Oncology
Elena I. Pentsova, Ronak H. Shah, Jiabin Tang, Adrienne Boire, Daoqi You, Samuel Briggs, Antonio Omuro, Xuling Lin, Martin Fleisher, Christian Grommes, Katherine S. Panageas, Fanli Meng, S. Duygu Selcuklu, Shahiba Ogilvie, Natalie Distefano, Larisa Shagabayeva, Marc Rosenblum, Lisa M. DeAngelis, Agnes Viale, Ingo K. Mellinghoff, Michael F. Berger
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Article
Oncology
Xuling Lin, Martin Fleisher, Marc Rosenblum, Oscar Lin, Adrienne Boire, Samuel Briggs, Yevgeniya Bensman, Brenda Hurtado, Larisa Shagabayeva, Lisa M. DeAngelis, Katherine S. Panageas, Antonio Omuro, Elena I. Pentsova
Article
Oncology
Antonio Omuro, Kathryn Beal, Katharine McNeill, Robert J. Young, Alissa Thomas, Xuling Lin, Robert Terziev, Thomas J. Kaley, Lisa M. DeAngelis, Mariza Daras, Igor T. Gavrilovic, Ingo Mellinghoff, Eli L. Diamond, Andrew McKeown, Malbora Manne, Andrew Caterfino, Krishna Patel, Linda Bavisotto, Greg Gorman, Michael Lamson, Philip Gutin, Viviane Tabar, Debyani Chakravarty, Timothy A. Chan, Cameron W. Brennan, Elizabeth Garrett-Mayer, Rashida A. Karmali, Elena Pentsova
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Letter
Medicine, General & Internal
Yee Wei Phoon, Xuling Lin, T. Thirumoorthy, Soo Yong Tan, Hwei Yee Lee, Soon Thye Lim, Haur Yueh Lee
SINGAPORE MEDICAL JOURNAL
(2018)
Meeting Abstract
Oncology
Kathryn Sara Nevel, Natalie DiStefano, Xuling Lin, Aimee Cowan, Anna Skakodub, Shahiba Ogilvie, Elena Pentsova, Adrienne Ann Boire
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
Vaios Hatzoglou, Jung Hun Oh, Olivia Buck, Xuling Lin, Michelle Lee, Amita Shukla-Dave, Robert J. Young, Kyung K. Peck, Behroze Vachha, Andrei I. Holodny, Christian Grommes
JOURNAL OF NEURO-ONCOLOGY
(2018)
Article
Multidisciplinary Sciences
Russell J. Chander, Bonnie Y. K. Lam, Xuling Lin, Aloysius Y. T. Ng, Adrian P. L. Wong, Vincent C. T. Mok, Nagaendran Kandiah
SCIENTIFIC REPORTS
(2017)
Meeting Abstract
Oncology
Rachna Malani, Martin Fleisher, Xuling Lin, Antonio Marcilio Padula Omuro, Morris D. Groves, Nancy U. Lin, Michelle E. Melisko, Andrew B. Lassrnan, Suriya A. Jeyapalan, Samuel Briggs, Lisa Marie DeAngelis, Jeffrey J. Raizer, Elena Pentsova
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Clinical Neurology
Xuling Lin, Wai-Yung Yu, Lishya Liauw, Russell Jude Chander, Weiling E. Soon, Hwei Yee Lee, Kevin Tan
NEUROLOGY-CLINICAL PRACTICE
(2017)
Article
Clinical Neurology
Xuling Lin, Mariza Daras, Elena Pentsova, Craig P. Nolan, Igor T. Gavrilovic, Lisa M. DeAngelis, Thomas J. Kaley
NEURO-ONCOLOGY PRACTICE
(2017)
Meeting Abstract
Oncology
Xuling Lin, Thomas Joseph Kaley, Elena Pentsova, Lisa Marie DeAngelis, Mariza Daras, Igor T. Gavrilovic, Ingo K. Mellinghoff, Andrew McKeown, Malbora Manne, Jessica Hansen, Linda M. Bavisotto, Greg Gorman, Michael Lamson, Rashida A. Karmali, Antonio Marcilio Padula Omuro
JOURNAL OF CLINICAL ONCOLOGY
(2016)
Article
Neurosciences
Nagaendran Kandiah, Russell Jude Chander, Xuling Lin, Aloysius Ng, Yen Yeong Poh, Chin Yee Cheong, Alvin Rae Cenina, Pryseley Nkouibert Assam
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Neurosciences
Nagaendran Kandiah, Vivian Wang, Xuling Lin, Mei Mei Nyu, Linda Lim, Adeline Ng, Shahul Hameed, Hwee Lin Wee
JOURNAL OF ALZHEIMERS DISEASE
(2016)