Article
Cell Biology
Zhen-hua Feng, Lin Zheng, Teng Yao, Si-yue Tao, Xiao-an Wei, Ze-yu Zheng, Bing-jie Zheng, Xu-yang Zhang, Bao Huang, Jun-hui Liu, Yi-lei Chen, Zhi Shan, Pu-tao Yuan, Cheng-gui Wang, Jian Chen, Shu-ying Shen, Feng-dong Zhao
Summary: The circRNA circPRKAR1B is found to be widely expressed in osteosarcoma cells and plays a key role in promoting cell proliferation and migration by sponging miR-361-3p to modulate FZD4 expression. Additionally, circPRKAR1B is involved in regulating chemoresistance in osteosarcoma.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chuanlin Zhang, Yuhuai Wu, Qiaoning Yue, Xiguang Zhang, Yinglu Hao, Jianping Liu
Summary: This study investigates the role of miR-28-5p in the development of osteosarcoma. The results show that miR-28-5p suppresses URGCP expression, leading to accelerated proliferation and migration of osteosarcoma cells and inhibiting apoptosis. This suggests that miR-28-5p could be a potential target for treating osteosarcoma.
BIOCHEMICAL GENETICS
(2023)
Article
Cell Biology
Meng Zhou, Xiaoqiu Liu, E. Qiukai, Yanxing Shang, Xiaoqian Zhang, Shuting Liu, Xuesen Zhang
Summary: The study reveals that Xist in perinatal mouse ovaries controls oocyte death by promoting autophagy, thereby influencing the reproductive capacity of female mammals.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Liang Liu, Wenze Huang
Summary: This study investigates the role of circ_0020378, miR-339-3p, and COL1A1 in osteosarcoma progression. The upregulation of circ_0020378 and COL1A1, along with the downregulation of miR-339-3p, is observed in osteosarcoma cells and tissues. Silencing circ_0020378 inhibits the proliferation, colony formation, and migration of osteosarcoma cells. Circ_0020378 acts as a sponge for miR-339-3p, which targets COL1A1. Therefore, circ_0020378 promotes osteosarcoma progression by downregulating miR-339-3p/COL1A1 expression.
CANCER BIOLOGY & THERAPY
(2023)
Article
Cell Biology
Qixuan Cai, Xin Zhao, Yanbing Wang, Shuai Li, Jincheng Wang, Zhuoyuan Xin, Fan Li
Summary: The study identified that LINC01614 is significantly upregulated in osteosarcoma tissues and promotes the proliferation and invasion activities of osteosarcoma cells through the miR-520a-3p/SNX3 axis.
CELLULAR SIGNALLING
(2021)
Article
Medicine, General & Internal
Jingyong Zhang, Shubao Wang, Yang Bai, Aasi Mohammad Ali, Jiewen Deng, Yushi Chen, Yonghui Fu, Ming He
Summary: First-line treatment for osteosarcoma includes chemotherapy and surgery, but the survival rate of refractory osteosarcoma remains unsatisfactory. Osteosarcoma cancer stem cells, which possess stemness and chemoresistance, play a critical role in poor response to chemotherapy. This study discovered that miR-197-3p confers osteosarcoma stemness and chemotherapy resistance by targeting SPOPL gene, providing promising therapeutic candidates for refractory osteosarcoma treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Reproductive Biology
Qinyao Wei, Juan Li, Haorong He, Yuchen Cao, Dongmei Li, Felix Kwame Amevor, Yao Zhang, Jianping Wang, Chunlin Yu, Chaowu Yang, Huarui Du, Xiaosong Jiang, Qing Zhu, Huadong Yin
Summary: miR-23b-3p plays a role in regulating the proliferation and steroid hormone synthesis of chicken granulosa cells by inhibiting the expression of GDF9. Elevated expression of miR-23b-3p significantly inhibits granulosa cell proliferation and steroid hormone synthesis without affecting apoptosis. It was found that GDF9 is a target gene of miR-23b-3p and miR-23b-3p can down-regulate its expression.
Article
Pharmacology & Pharmacy
Jie Zou, Xiaoyun Zhu, Dejuan Xiang, Yanqiu Zhang, Jie Li, Zhigui Su, Lingyi Kong, Hao Zhang
Summary: Limb and CNS expressed 1 like (LIX1L) is over-expressed in various tumors, especially hepatocellular carcinoma (HCC). Overexpression of LIX1L enhances proliferation, migration, and invasion of HCC cells, while reducing glucose consumption and lactate production. Through upregulation of miR-21-3p and suppression of FBP1, LIX1L promotes HCC growth and metastasis. Inhibition of miR-21-3p could suppress tumor growth in an orthotopic tumor model.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biotechnology & Applied Microbiology
Liang Fan, Xing Cao, Yanrong Lei
Summary: Studies have shown that upregulation of miR-23b-3p in osteosarcoma promotes cell proliferation, migration, and viability. VEPH1, a target of miR-23b-3p, attenuates the malignancy effects of miRNA on osteosarcoma cells by inhibiting the PI3K/AKT signaling pathway.
Article
Biotechnology & Applied Microbiology
Peng Wang, Changchao Wang, Leyin Zhu, Ping Li, Xiaobo Tang, Jian Wang, Fangyong Hu, Gaoshan Qiao, Cheng Xie, Chengdong Zhu
Summary: miR-151-3p plays a crucial role in osteosarcoma progression by promoting EMT, migration, and invasion of MG63 cells through EVs-mediated transfer. By modulating the CHL1/integrin 1 beta axis, CAF-EVs derived miR-151-3p activates the TGF-beta pathway, leading to increased proliferation and tumor growth in OS cells.
CANCER GENE THERAPY
(2021)
Article
Anatomy & Morphology
Daguo Zhou, Guangrong Ji, Guojun Wei, Zongguang Li, Naichun Yu, Yanling Wang, Binhui Lin, Linlin Zhang, Yue Yin
Summary: MiR-361-3p is upregulated in osteosarcoma and is associated with prognosis. It promotes cell proliferation, migration, and invasion by targeting ARID3A. These findings suggest that miR-361-3p is an important biomarker and targeting the miR-361-3p/ARID3A axis may be a promising strategy for osteosarcoma therapy.
Article
Biochemical Research Methods
Zun Zhang, Jin Wang, Xiaoyan Zhang, Bo Ran, Jie Wen, Hong Zhang
Summary: This study revealed that Neuropilin and tolloid-like 2 (NETO2) promotes osteosarcoma (OS) progression, but its upstream mechanism in OS cells is still unclear. It was found that NETO2 is negatively regulated by microRNA-101-3p (miR-101-3p), which binds to long noncoding RNA (lncRNA) TYMS opposite strand RNA (TYMSOS). Additionally, TYMSOS was found to promote the malignancy of OS by increasing NETO2 expression as a miR-101-3p sponge.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Oncology
Masamichi Hayashi, Suguru Yamada, Keisuke Kurimoto, Hiroshi Tanabe, Sho Hirabayashi, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera
Summary: miR-23b-3p is found to function as an oncogenic microRNA in HCC cell lines. Overexpression of miR-23b-3p in resected HCC tissues is a significant prognostic factor of overall survival. Both MICU3 and AUH may be candidate gene targets of miR-23b-3p.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Longshuai Lin, Hongjie Wang, Weihong Guo, Enjun He, Kai Huang, Qinghua Zhao
Summary: The research confirmed that osteosarcoma cell-derived exosomes promote osteoclastogenesis and aggravate bone loss through miR-501-3p, potentially regulated via the PTEN/PI3K/Akt signaling pathway.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Michele Manganelli, Ilaria Grossi, Manuela Ferracin, Paola Guerriero, Massimo Negrini, Michele Ghidini, Chiara Senti, Margherita Ratti, Claudio Pizzo, Rodolfo Passalacqua, Sarah Molfino, Gianluca Baiocchi, Nazario Portolani, Eleonora Marchina, Giuseppina De Petro, Alessandro Salvi
Summary: The study investigated the longitudinal levels of cell-free long ncRNA GAS5 and microRNAs miR-126-3p and miR-23b-3p in patients with hepatocellular carcinoma (HCC) undergoing sorafenib treatment. The results highlighted the significant downregulation of miR-23b-3p in untreated HCC patients and its diagnostic relevance.