期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 5, 页码 3187-3192出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02638-15
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资金
- HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [K08AI114883, R21AI111037]
Aminoglycoside treatment of carbapenem-resistant (CR) Klebsiella pneumoniae bacteremia was associated with a 70% rate (23/33) of 30-day survival. Successful treatment was associated with sources of bacteremia amenable to reliable aminoglycoside pharmacokinetics (P = 0.037), acute physiology and chronic health evaluation II (APACHE II) scores of <20 (P = 0.16), and nonfatal underlying diseases (P = 0.015). Success rates were 78% and 100% if >= 2 and all 3 factors were present, respectively. Clinicians may consider the use of aminoglycosides against CR K. pneumoniae bacteremia if strains are susceptible and the sources of infection are amenable to reliable pharmacokinetics.
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