Article
Multidisciplinary Sciences
Jeong-Rang Jo, Seungwon An, Swati Ghosh, Balachandar Nedumaran, Yong Deuk Kim
Summary: This study investigated the link between GH and the BTG2-YY1 signaling pathway in glucose metabolism, showing that GH treatment elevated Btg2 and Yy1 expression in the liver, leading to increased glucose production. The findings suggest that BTG2 and YY1 are novel regulators of GH-dependent regulation of hepatic gluconeogenic genes and glucose production.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Yilang Li, Jiaxuan Cai, Yinan Liu, Conglin Li, Xiaoqing Chen, Wing-Leung Wong, Wenyue Jiang, Yuan Qin, Guiping Zhang, Ning Hou, Wenchang Yuan
Summary: CcpA-knockout S. aureus strains may affect the glucose and lipid metabolism phenotypes of the host in a high-glucose environment, leading to metabolic disorders.
Article
Cell Biology
Zhendong Liu, Zhehao Fan, Rui Wang, Xiaolei Li, Hui Chen, Jingcheng Wang
Summary: This study investigated the effect of IFN-alpha-2b on preventing postoperative arthrofibrosis in rats and its antiproliferation effect on fibroblasts in vitro, as well as its molecular mechanism. The results showed that IFN-alpha-2b significantly reduced arthrofibrosis by inhibiting fibroblast proliferation and migration, possibly through the regulation of STAT1/p21 signaling pathway.
MEDIATORS OF INFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ewa Kilanczyk, Jesus M. Banales, Ewelina Jurewicz, Piotr Milkiewicz, Malgorzata Milkiewicz
Summary: The study revealed an interaction between PDC-E2 and phosphorylated STAT3 under cholestatic conditions, which may play a role in the development of primary biliary cholangitis.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Zhen Li, Lina Yang, Shuai Zhang, Jiaqi Song, Huanran Sun, Changliang Shan, Dan Wang, Shuangping Liu
Summary: Energy metabolism programming, specifically the Warburg effect, plays a crucial role in cancer progression. This study demonstrates that Valproic acid (VPA) can attenuate the Warburg effect in breast cancer cells by decreasing PKM2 expression, leading to inhibited cell proliferation and colony formation. The mechanism behind this involves the inactivation of ERK1/2 phosphorylation through reduced HDAC1 expression, ultimately suppressing breast cancer growth.
CELL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Ni Fan, Xiuying Zhang, Wei Zhao, Jia Zhao, Dan Luo, Yilu Sun, Ding Li, Chenliang Zhao, Yu Wang, Hongjie Zhang, Jianhui Rong
Summary: This study demonstrated that celastrol can reprogram metabolic and inflammatory pathways in M1 macrophages by binding to pyruvate kinase M2 (PKM2). Celastrol inhibits the expression of glycolytic enzymes and related signaling proteins, shifts aerobic glycolysis to mitochondrial oxidative phosphorylation, and skews macrophage polarization from inflammatory M1 type to anti-inflammatory M2 type. Animal experiments showed that celastrol can reduce weight loss, serum cholesterol level, lipid accumulation, and hepatic fibrosis in the mouse model of NAFLD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Infectious Diseases
Zhao-Ming Chen, Xiao-Yun Yang, Zheng-Tu Li, Wei-Jie Guan, Ye Qiu, Shao-Qiang Li, Yang-Qing Zhan, Zi-Ying Lei, Jing Liu, Jian-Quan Zhang, Zhong-Fang Wang, Feng Ye
Summary: The presence of anti-IFN-gamma autoantibodies inhibits immune responses of CD4(+) Th1 and CD8(+) T cells, and increases the release of IL-10.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, Research & Experimental
Jiameng Lu, Xiaoqing Ji, Lixia Wang, Fei Sun, Chuanjun Huang, Haiying Peng, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Yanbo Ji, Degan Lu
Summary: This study found that prophylactic administration of IL-27 can improve asthma by restoring the STAT1 and STAT3 pathways, alleviating the Th2 inflammatory environment in the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mohd Adnan, Anas Shamsi, Abdelbaset Mohamed Elasbali, Arif Jamal Siddiqui, Mitesh Patel, Nawaf Alshammari, Salem Hussain Alharethi, Hassan H. Alhassan, Fevzi Bardakci, Md Imtaiyaz Hassan
Summary: This study identified Tuberosin as a potential activator of PKM2 through screening a virtual library of phytochemicals. The compound showed appreciable binding affinity towards PKM2 and exhibited good stability and drug-like properties. Modulating PKM2 with natural compounds such as Tuberosin is suggested as an attractive approach in treating cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: Persistent activation of signal transducer and activator of transcription 3 (STAT3) via interleukin-6 (IL-6) trans-signaling is involved in fibrosis of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Immunology
Huanhuan Zhu, Shaopeng Tong, Congrong Yan, Acheng Zhou, Minying Wang, Chunwei Li
Summary: In this study, it was found that TP attenuated the activation of macrophages and induced M1-to-M2 repolarization by repressing the mTOR/STAT3 signaling pathway. This suggests that TP could be an effective agent for the treatment of inflammatory bowel disease (IBD).
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Jiangnan Ye, Huang Chen, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi, Yihua Chen
Summary: This study describes the design, synthesis, and structure-activity relationship studies of triaromatic heterocyclic derivatives as potent dual phosphorylation STAT3 inhibitors. The best compound 3h (HP590) was discovered with high inhibitory activity against p-Tyr(705) and p-Ser(727), resulting in the growth inhibition of gastric cancer both in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Yuhan Su, Tianyu Tao, Xiuxing Liu, Wenru Su
Summary: This review summarizes the diverse roles of the JAK-STAT signaling pathway in ocular homeostasis and non-infectious uveitis (NIU) pathology, and discusses the safety and efficacy of JAK inhibitors for treating NIU and potential approaches for treatment optimization.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Ranzhiqiang Yang, Yinghui Song, Kashif Shakoor, Weimin Yi, Chuang Peng, Sulai Liu
Summary: Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumor with a poor prognosis, characterized by neoplastic transformation of intrahepatic biliary epithelial cells. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that may serve as a target for ICC treatment. Further research is needed to improve understanding of STAT3 and its role in ICC development.
MOLECULAR MEDICINE REPORTS
(2022)