期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 8, 页码 5047-5050出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00168-16
关键词
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资金
- HHS | National Institutes of Health (NIH) [1R56AI102503-0A1]
- regular federal budget of the Ministry of Health of Argentina
Klebsiella pneumoniae strains producing K. pneumoniae carbapenemase (KPC) cause serious infections in debilitated and immunocompromised patients and are associated with prolonged hospital stays and increased mortality rates. Daptomycin is a lipopeptide used against Staphylococcus aureus infection and considered inactive against Gram-negative bacteria. We investigated the effectiveness of a daptomycin-meropenem combination by synergy kill curve and a pharmacokinetic/pharmacodynamic model. The combination may represent a novel therapeutic strategy against infections caused by KPC-producing K. pneumoniae strains.
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