期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 4, 页码 1955-1966出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02183-15
关键词
-
资金
- National Centre for Research and Development, Poland [Lider/27/55/L-2/10/2011]
- Ministry of Science and Higher Education, Poland [IP 2010 033870, IP 2011 044371]
- National Science Center, Poland [UMO-2012/07/E/NZ6/01712]
- Foundation for Polish Science - EU European Regional Development Fund [VENTURES/2013-11/1]
- European Union structural funds [POIG.02.01.00-12-064/08, POIG.02.01.00-12-167/08]
- Ministry of Science and Higher Education of the Republic of Poland
- [PSP K/DSC/001476]
Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized, and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NSPAHs were found to be nontoxic and very soluble in water, in contrast to gel-forming and thus generally poorly soluble carrageenans. In vitro and ex vivo studies using susceptible cells (Madin-Darby canine kidney epithelial cells and fully differentiated human airway epithelial cultures) demonstrated the antiviral effectiveness of NSPAHs. The activity of NSPAHs was proportional to the molecular mass of the chain and the degree of substitution of amino groups with sulfonate groups. Mechanistic studies showed that the NSPAHs and carrageenans inhibit influenza A and B virus assembly in the cell.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据