Review
Oncology
Jiali Yao, Yingrui Chen, Zhijie Lin
Summary: The tumor microenvironment (TME) plays a critical role in the development and progression of colorectal cancer (CRC), with signaling molecules promoting tumor angiogenesis and immune escape. Exosomes, as messengers between tumor and host cells, are considered key mediators in the tumor-promoting TME. However, the exosome-mediated communication networks in the CRC microenvironment are still unclear.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Cell Biology
Lavanya Goodla, Xiang Xue
Summary: This brief review discusses the involvement of three representative cytokines (TNF-alpha, IL-6 and IL-1 beta), a lipid molecule PGE2 and two chemokines (CXCL1 and CXCL2) in the process of CRC liver metastases.
Article
Oncology
Chieko Kitamura, Hirofumi Sonoda, Hiroyuki Anzai, Yuzo Nagai, Shinya Abe, Yuichiro Yokoyama, Hiroaki Ishii, Junko Kishikawa, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara
Summary: Immunolabeling showed that DDHD1 and GPR55 expression in colorectal cancer tissues is correlated with tumor invasion depth, with GPR55 being highly expressed regardless of invasion depth. However, the expression levels of DDHD1 and GPR55 were not associated with disease-free survival.
ANTICANCER RESEARCH
(2021)
Review
Oncology
Gwangbeom Heo, Yunna Lee, Eunok Im
Summary: Inflammatory mediators play a crucial role in the development of colorectal cancer, influencing carcinogenesis, progression, and metastasis. The gut microbiota, particularly in the colon, are closely associated with CRC through inflammatory mediators and can be targeted for therapeutic interventions such as fecal microbiota transplantation and probiotics.
Article
Oncology
Navkiran K. Shokar, Jennifer Salinas, Alok Dwivedi
Summary: This study utilized structural equation modeling to identify factors influencing participation in colorectal cancer screening among uninsured Hispanic individuals. The findings indicate that self-efficacy, perceived benefits, and fatalism significantly affect the effectiveness of screening interventions.
Article
Biochemical Research Methods
Jelmer J. Dijkstra, Hannah K. Neikes, Somayeh Rezaeifard, Xuhui Ma, Emile E. Voest, Daniele V. F. Tauriello, Michiel Vermeulen
Summary: Loss of SMAD4 in colorectal cancer leads to changes in biological processes, including decreased differentiation and activation of pro-migratory and cell proliferation processes, disruption of key oncogenic pathways, and increased secretion of proteins involved in pro-metastatic processes. SMAD4-mutant organoids specifically secrete DKK3, which reduces the antitumor effects of natural killer cells.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nicholas J. Lyons, Rabina Giri, Jakob Begun, David Clark, David Proud, Yaowu He, John D. Hooper, Thomas Kryza
Summary: This article discusses the role of reactive oxygen species (ROS) in normal and malignant colonic cell biology and explores how existing and emerging therapies can utilize ROS for therapeutic benefit. Recent research has shed light on the contribution of ROS to the cytotoxicity of conventional chemotherapy, as well as the generation of ROS in response to excitatory stimuli in emerging therapies such as photodynamic therapy, sonodynamic therapy, and radiodynamic therapy. However, the poor prognosis and resistance associated with metastatic colorectal cancer necessitate the development of new and more effective treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Bashar Emon, You Jin Song, M. Saddam H. Joy, Mounisha V. Kovour, Kannanganattu V. Prasanth, M. Taher A. Saif
Summary: Most solid tumors become stiff with progression of cancer, which is mediated by Cancer Associated Fibroblasts (CAFs). However, how CAFs in stiffer tumor microenvironment (TME) promote metastatic progression is not clear. In this study, we controlled the mechanical stiffness of substrates and collected gene expression data with human colorectal CAFs to understand the role of TME stiffness in CAF-cancer cell crosstalk.
Article
Engineering, Environmental
Xu Hong, Gengfu Wang, Xingcun Liu, Ming Wu, Xindong Zhang, Xiaohui Hua, Pengpeng Jiang, Sheng Wang, Song Tang, Xiaoming Shi, Yichao Huang, Tong Shen
Summary: This study found a higher level of bisphenol A (BPA) in the urine of colorectal cancer (CRC) patients compared to controls, and a positive correlation between BPA and CRC biomarkers. Lipidomic screening revealed significant perturbation in the glycerophospholipid metabolism pathway, which contributed to the association between BPA exposure and CRC. These findings contribute to a better understanding of the etiology of CRC induced by environmental stressors.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Microbiology
Narjess Bostanghadiri, Shabnam Razavi, Aref Shariati, Malihe Talebi, Shiva Mirkalantari, Amirnader Emami Razavi, Davood Darban-Sarokhalil
Summary: The study highlights the importance of Fusobacterium nucleatum and changes in gene expression in colorectal cancer (CRC). Studying the microbial profile and gene expression changes in CRC patients may be a promising approach to improve screening methods and provide therapeutic strategies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Satoshi Ishikawa, Naohiro Nishida, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Taroh Satoh, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial phenotypic change during cancer metastasis, and the identification of 90 candidate EMT mediators that are predictive of survival in clinical samples suggests new therapeutic avenues for colorectal cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Emer O'Connell, Ian S. Reynolds, Andreas U. Lindner, Manuela Salvucci, Tony O'Grady, Orna Bacon, Sanghee Cho, Elizabeth McDonough, Daniel Longley, Fiona Ginty, Deborah A. McNamara, John P. Burke, Jochen H. M. Prehn
Summary: Apoptotic and necroptotic mediators are differentially expressed in mucinous and non-mucinous colorectal cancers, suggesting potential targets for investigating cell death mechanisms in the mucinous subtype.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Ismaiel, Brenda Murphy, Sarah Aldhafiri, Hugh E. Giffney, Kevin Thornton, Anindya Mukhopadhya, Ciara E. Keogh, Sarinj Fattah, Helen M. Mohan, Eoin P. Cummins, Evelyn P. Murphy, Des C. Winter, Daniel Crean
Summary: Inflammation plays a crucial role in CRC initiation and progression, and modulation of inflammatory pathways, such as with NR4A agonist Cytosporone B (CsnB), can potentially improve disease outcome. The study demonstrated that CsnB did not adversely affect colon tissue and could attenuate the pro-inflammatory state of human CRC tissue ex vivo, especially in tumors from males who had not undergone chemoradiotherapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Edoardo Botteri, Giulia Peveri, Paula Berstad, Vincenzo Bagnardi, Sairah L. F. Chen, Torkjel M. Sandanger, Geir Hoff, Christina C. Dahm, Christian S. Antoniussen, Anne Tjonneland, Anne Kirstine Eriksen, Guri Skeie, Aurora Perez-Cornago, Jose Maria Huerta, Paula Jakszyn, Sophia Harlid, Bjoern Sundstroem, Aurelio Barricarte, Evelyn M. Monninkhof, Jeroen W. G. Derksen, Matthias B. Schulze, Bas Bueno-de-Mesquita, Maria-Jose Sanchez, Amanda J. Cross, Konstantinos K. Tsilidis, Maria Santucci De Magistris, Rudolf Kaaks, Verena Katzke, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Pilar Amiano, Paolo Contiero, Carlotta Sacerdote, Marcel Goldberg, Mathilde Touvier, Heinz Freisling, Vivian Viallon, Elisabete Weiderpass, Elio Riboli, Marc J. Gunter, Mazda Jenab, Pietro Ferrari
Summary: This study investigated the impact of changes in lifestyle habits on the risk of colorectal cancer. The results showed that adhering to a healthy lifestyle was associated with a lower risk of colorectal cancer, while not adhering to a healthy lifestyle was associated with an increased risk of colorectal cancer.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
C. Galindo-Pumarino, M. Collado, M. E. Castillo, J. Barquin, E. Romio, M. J. Larriba, G. J. Munoz de Mier, A. Carrato, C. de la Pinta, C. Pena
Summary: Resistance to antitumor treatments is a major challenge in managing colorectal cancer patients. Cancer-Associated Fibroblasts (CAFs) play a role in drug resistance mechanisms, and the expression of SNAI1 in fibroblasts may serve as a predictive biomarker for response to oxaliplatin and cetuximab treatments in colorectal cancer patients.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
