Review
Biochemistry & Molecular Biology
Yao Chen, Jue Hou, Zhangang Xiao, Yueshui Zhao, Fukuan Du, Xu Wu, Mingxing Li, Yu Chen, Lin Zhang, Chi Hin Cho, Qinglian Wen, Wei Hu, Jing Shen
Summary: Vitamin D supplementation is associated with reduced cancer risk and a good prognosis, especially in gastrointestinal cancer. It plays a key role in the development of gastrointestinal cancer and has immunomodulatory, anti-inflammatory, and anti-infection effects. Research supports the beneficial effects of vitamin D in cancer and inflammatory diseases, but more clinical trials are needed for reliable conclusions.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Sheng-Kang Chiu, Kuo-Wang Tsai, Chia-Chao Wu, Cai-Mei Zheng, Chung-Hsiang Yang, Wan-Chung Hu, Yi-Chou Hou, Kuo-Cheng Lu, You-Chen Chao
Summary: COVID-19 is characterized by significant immune dysfunction, requiring the development of effective treatments; various types of COVID-19 vaccines are under development and optimization, increasing public immunity may enhance vaccine effectiveness; Vitamin D supplementation may help mitigate the progression of COVID-19, but its role in vaccine efficacy remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juhi Arora, Jinpeng Wang, Veronika Weaver, Yongwei Zhang, Margherita T. Cantorna
Summary: This study found that immune cells express vitamin D receptor (VDR) and the expression of VDR can be assessed by measuring Vdr protein. It was also discovered that some immune cells may never express VDR, while others such as neutrophils and monocytes express high levels of VDR.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Immunology
Lori A. Plum, William Blaser, Logan Peter, Jean Prahl, Jeremy Seeman, Hector F. DeLuca
Summary: The study found that vitamin D is not necessary for producing antibodies, as neither vitamin D deficiency, absence of the vitamin D receptor, nor hypocalcemia affected the ability of mice to mount an antibody response to an antigen challenge.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
L. P. Blakely, T. L. Wells, M. F. Kweh, S. Buoniconti, M. Reese, P. Celi, C. Cortinhas, C. D. Nelson
Summary: This study aimed to test the effects of dietary vitamin D3 compared with 25-hydroxyvitamin D3 on vitamin D status and response to an endotoxin challenge. The results showed that supplementing 25-hydroxyvitamin D3 was more effective at increasing serum 25-hydroxyvitamin D, calcium, and phosphorus concentrations compared with dietary vitamin D3.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Nutrition & Dietetics
Qiuzhen Wang, Aiguo Ma, Evert G. Schouten, Frans J. Kok
Summary: Tuberculosis and diabetes coexistence in China poses a significant challenge, with diabetes potentially exacerbating the tuberculosis epidemic, and vitamin D deficiency being a global health issue. Recommendations include bidirectional screening for both diseases and focusing on the impact of vitamin D deficiency in public health interventions.
CLINICAL NUTRITION
(2021)
Review
Immunology
Amirhossein Ghaseminejad-Raeini, Ali Ghaderi, Amirmohammad Sharafi, Behrad Nematollahi-Sani, Maryam Moossavi, Afshin Derakhshani, Gholamreza Anani Sarab
Summary: For many years, vitamin D has been known for its role in maintaining calcium and phosphate balance, but recent research has focused on its immunomodulatory role, which has generated conflicting results. The presence of vitamin D receptors in various immune cell types has allowed for the investigation of its precise role in diseases, specifically autoimmune disorders. Physiologically activated vitamin D not only modulates innate and acquired immune cell responses, but also promotes a tolerogenic immune state. Recent studies suggest that this important micronutrient plays a complex role in immune system pathways and associated disorders. Understanding this field is still relatively new, and some studies indicate that patients with severe autoimmune illnesses often have vitamin D deficiencies. This review aims to provide a clear understanding of the latest research on the immune system-related roles of vitamin D, including the pathophysiology of major disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Review
Endocrinology & Metabolism
F. M. Panfili, M. Roversi, P. D'Argenio, P. Rossi, M. Cappa, D. Fintini
Summary: The COVID-19 pandemic requires urgent therapeutic interventions, especially for vulnerable populations such as elderly males. Vitamin D has shown promising immunomodulatory effects and may play a role in the prevention and treatment of SARS-CoV-2 infection in both adults and children.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Niklas S. Jensen, Markus Wehland, Petra M. Wise, Daniela Grimm
Summary: Hypertension is a major global health burden, with an increasing prevalence due to aging populations and sedentary lifestyles. While there is evidence of the role of vitamin D in regulating blood pressure, its direct antihypertensive effect remains unclear. However, supplementing vitamin D in combination with other antihypertensive agents may have promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alice Albergamo, Giulia Apprato, Francesca Silvagno
Summary: The genomic activity of vitamin D has significant effects on metabolism and physiological functions, particularly in relation to viral infections such as COVID-19. This review examines the correlation between vitamin D deficiency and increased risks of severe COVID-19 and respiratory distress syndrome. Clinical trials have tested vitamin D supplementation with promising results. Additionally, a biochemical analysis explores the antioxidant and anti-inflammatory functions of vitamin D and its influence on different biochemical pathways in the body's defense against viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tudor Lucian Pop, Claudia Sirbe, Gabriel Benta, Alexandra Mititelu, Alina Grama
Summary: Vitamin D plays a crucial role in phospho-calcium metabolism, maintaining calcium levels, and bone health development. Deficiency in vitamin D has been linked to fibrosis progression in chronic liver disease. Vitamin D binding protein, synthesized by the liver, is involved in vitamin D transportation and inflammatory response. A better understanding of the involvement of vitamin D, vitamin D receptors, and vitamin D binding protein in liver inflammation and fibrogenesis could lead to new strategies for diagnosis, prognosis, and treatment of liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
John D. Sluyter, Yoshihiko Raita, Kohei Hasegawa, Ian R. Reid, Robert Scragg, Carlos A. Camargo
Summary: Using machine learning models to predict vitamin D deficiency showed higher accuracy in predicting 25(OH)D <25 nmol/L compared to traditional models, suggesting a potential role for machine learning models in participant selection for vitamin D supplement trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Nuzhat Ahsan, Mohammad Imran, Yousuf Mohammed, Fatme Al Anouti, Mohammad Idreesh Khan, Tanushree Banerjee, Mohd Adnan, Fauzia Ashfaq, Marek Kieliszek, Syed Amir Ashraf, Afrozul Haq
Summary: The pathophysiology of COVID-19 involves inflammation, weakened immunity, immune cell infiltration, necrosis, lung hyperplasia, severe pneumonia, and potential mortality due to septic shock and organ failure. Vitamin D, zinc, and magnesium have been reported to improve the immune system against respiratory illnesses. This comprehensive review focuses on the mechanistic details of these micronutrients as immunomodulators and their potential role in preventing and treating respiratory illnesses.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Nutrition & Dietetics
Fritzlaine C. Roche, Tamia A. Harris-Tryon
Summary: Vitamin A is crucial for skin immunity, deficiencies can lead to impaired immune response and increased susceptibility to skin infections. Recent evidence shows that vitamin A and its derivatives play a role in innate immune regulation by promoting skin immunity and sustaining the skin microbiome.
Article
Nutrition & Dietetics
Kristina S. Petersen, Kristin M. Davis, Connie J. Rogers, David N. Proctor, Sheila G. West, Penny M. Kris-Etherton
Summary: Incorporating a relatively high culinary dosage of mixed herbs and spices into a suboptimal US-style diet tended to improve 24-hour blood pressure in adults at elevated risk of cardiometabolic diseases.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Microbiology
Zhaoyong Ba, Yujin Lee, Huicui Meng, Penny M. Kris-Etherton, Connie J. Rogers, Zachery T. Lewis, David A. Mills, Emily J. Furumoto, M. Laura Rolon, Jennifer A. Fleming, Robert F. Roberts
Summary: This study compared the effects of delivering Bifidobacterium animas subsp. lactis BB-12 through a yogurt smoothie or a capsule on healthy adults. The results showed that daily consumption of BB-12 did not significantly alter the composition of the gut microbiota, gut transit times, or fecal SCFA concentration in the study cohort.
Article
Nutrition & Dietetics
Ester S. Oh, Kristina S. Petersen, Penny M. Kris-Etherton, Connie J. Rogers
Summary: The study found that consuming a medium-dose spice blend for four weeks reduced fasting plasma IL-6 and postprandial plasma IL-1 beta, IL-8, and TNF-alpha levels, as well as altering monocyte function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Janhavi J. Damani, Mary Jane De Souza, Hannah L. VanEvery, Nicole C. A. Strock, Connie J. Rogers
Summary: This article reviews the potential role of prunes in improving bone health, highlighting evidence that prunes can protect bone by modulating oxidative and inflammatory pathways. Osteoporosis is a common condition in postmenopausal women, and prunes are being studied as a nonpharmaceutical intervention.
ADVANCES IN NUTRITION
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Emily Van Syoc, Connie J. Rogers, Erika Ganda
Meeting Abstract
Biochemistry & Molecular Biology
Janhavi J. Damani, Nicole C. A. Strock, Mary Jane De Souza, Connie J. Rogers
Article
Multidisciplinary Sciences
Callum R. K. Arnold, Sreenidhi Srinivasan, Sophie Rodriguez, Natalie Rydzak, Catherine M. Herzog, Abhinay Gontu, Nita Bharti, Meg Small, Connie J. Rogers, Margeaux M. Schade, Suresh Kuchipudi, Vivek Kapur, Andrew F. Read, Matthew J. Ferrari
Summary: This study found that university students had a higher seroprevalence rate compared to community residents, indicating a potential source of transmission. Contact with known positive individuals and attendance at small gatherings were significant predictors of antibody detection among students.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Mary Jane De Souza, Nicole C. A. Strock, Nancy Williams, Hang Lee, Kristen J. Koltun, Connie Rogers, Mario G. Ferruzzi, Cindy H. Nakatsu, Connie Weaver
Summary: This study evaluated the effects of prune consumption on bone mineral density in postmenopausal women and found that a daily dose of 50 grams of prunes can prevent a decrease in hip bone mineral density. This effect persisted for 12 months with high compliance and retention rates.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Connie J. Rogers, Kristina Petersen, Penny M. Kris-Etherton
MEDICAL CLINICS OF NORTH AMERICA
(2022)
Article
Physiology
Emily Van Syoc, Evelyn Weaver, Connie J. Rogers, Justin D. Silverman, Ramesh Ramachandran, Erika Ganda
Summary: Studies suggest that dietary supplementation of metformin affects the gut microbiome of broiler breeder hens in a dose-dependent manner, with results consistent with the effects of metformin treatment in type 2 diabetes and polycystic ovary syndrome in humans. Metformin supplementation shows promise in improving gut health and reproductive efficiency in broiler breeder hens.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Janhavi J. Damani, Mary Jane De Souza, Nicole C. A. Strock, Kristen J. Koltun, Nancy Williams, Connie Weaver, Connie J. Rogers
Summary: This study aimed to investigate the association between circulating inflammatory markers and bone outcomes in postmenopausal women. The findings showed a negative correlation between inflammatory markers and bone density, geometry, and strength, suggesting that inflammatory markers may play an important role in postmenopausal bone loss.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Sport Sciences
Dan Lin, Cheryl L. Thompson, Djibril M. Ba, Joshua E. Muscat, Shouhao Zhou, Connie J. Rogers, Kathleen M. Sturgeon
Summary: The study revealed an inverse association between leisure-time physical activity level and white blood cell count, as well as neutrophil-to-lymphocyte ratio, suggesting that higher levels of physical activity may lead to lower levels of inflammation, which could be important for future chronic disease outcomes.
SPORTS MEDICINE-OPEN
(2023)
Article
Biochemistry & Molecular Biology
Abigayle M. R. Simpson, Mary Jane De Souza, Janhavi Damani, Connie Rogers, Nancy I. Williams, Connie Weaver, Mario G. Ferruzzi, Sydney Chadwick-Corbin, Cindy H. Nakatsu
Summary: This study aims to characterize the effect of prune supplementation on the gut microbiome of postmenopausal women. The results show that prune consumption leads to a decrease in gut microbiome diversity, and different doses of prunes have different effects on the gut microbiome. In addition, prune consumption may enrich beneficial bacterial taxa and correlate with urinary phenolic metabolites and inflammatory markers. These findings suggest that prunes may exert health effects by modulating the gut microbiome.
Meeting Abstract
Geriatrics & Gerontology
M. J. De Souza, N. C. Strock, N. I. Williams, H. Lee, K. J. Koltun, C. Rogers, M. G. Ferruzzi, C. H. Nakatsu, C. Weaver
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Mary Jane De Souza, Nicole C. A. Strock, Connie J. Rogers, Nancy I. Williams, Mario G. Ferruzzi, Cindy H. Nakatsu, Abigayle M. R. Simpson, Connie Weaver
Summary: This study is a randomized controlled trial aiming to investigate the effects of daily prune consumption on bone density, immune function, inflammation, and cardiovascular health in postmenopausal women. It also includes detailed phenolic and gut microbiota analyses. The findings will provide insights into the clinical implications and underlying mechanisms of prune as a functional food therapy.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
