Article
Medicine, Research & Experimental
Jun Wu, Quan Wang, Xiaoqi Dong, Min Xu, Juliang Yang, Xiaoqing Yi, Biao Chen, Xiyuan Dong, Ying Wang, Xiaoding Lou, Fan Xia, Shixuan Wang, Jun Dai
Summary: Nanoparticle drug delivery system (NDDS) offers a solution to drug resistance and side effects in traditional chemotherapy. Py-TPE/siRNA@PMP is a multifunctional polymeric nanoparticle designed to combat resistance and side effects in chemotherapy for ovarian cancer, showing promising therapeutic effects in both in vitro and in vivo experiments.
Article
Cell Biology
Chung-Pu Wu, Megumi Murakami, Yu-Shan Wu, Ya-Chen Chi, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Suresh Ambudkar
Summary: The study explored the potential of using branebrutinib to resensitize P-gp-overexpressing multidrug-resistant cancer cells to chemotherapy by inhibiting the drug transport function of P-gp. Results showed that branebrutinib could reverse P-gp-mediated MDR at sub-toxic concentrations while maintaining cytotoxicity against drug-sensitive parental cell lines and P-gp-overexpressing multidrug-resistant variants. This new pharmacological action of branebrutinib against P-gp activity warrants further investigation in future drug combination studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yanqing Wang, Gantao Chen, Fangfang Dai, Li Zhang, Mengqin Yuan, Dongyong Yang, Shiyi Liu, Yanxiang Cheng
Summary: This study investigated the impact of miR-21 on chemotherapy resistance in ovarian cancer cells, revealing that high expression of miR-21 can enhance proliferation, invasion, and migration abilities of OC cells. The interaction between CD44v6 and P-gp may play a role in mediating miR-21 involvement in chemotherapy resistance.
ONCOTARGETS AND THERAPY
(2021)
Article
Engineering, Environmental
Xiaqing Wu, Jiao Yan, Xiaoqing Han, Runxiao Zheng, Panpan Song, Yanjing Wang, Haiyuan Zhang
Summary: This study successfully reprogrammed tumor-associated macrophages (TAMs) from immunosuppressive to immunostimulatory state using Au-DP@FeCaC NPs, and achieved efficient chemotherapy of multidrug-resistant (MDR) cancer by releasing doxorubicin (Dox) under acidic conditions.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Medicinal
I-Ting Wu, Chan-Yen Kuo, Ching-Hui Su, Yu-Hsuan Lan, Chin-Chuan Hung
Summary: This study investigated the inhibitory effects of pinostrobin and tectochrysin on P-gp in MDR cancer cells and the underlying mechanisms. The results showed that these compounds were not substrates of P-gp and did not affect its expression, but they noncompetitively inhibited the efflux of rhodamine 123 and doxorubicin through P-gp, leading to the resensitization of MDR cancer cells. Therefore, pinostrobin and tectochrysin are effective P-gp inhibitors and potential candidates for resensitizing MDR cancer cells.
Review
Oncology
Yichen Tian, Yongrong Lei, Yani Wang, Jiejuan Lai, Jianhua Wang, Feng Xia
Summary: This review summarizes the mechanisms of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp), including the regulation of efflux activity, the inhibition of P-gp expression, and the knockout of the ABCB1 gene. Inhibiting P-gp through screening and designing suitable compounds and techniques can overcome P-gp-mediated MDR, providing a reference for studying the reversal of P-gp-mediated MDR.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Engineering, Biomedical
Ye Yuan, Jia Liu, Xiangnan Yu, Xingxin Liu, Yanni Cheng, Cheng Zhou, Mingyi Li, Lin Shi, Yan Deng, Huan Liu, Guobin Wang, Lin Wang, Zheng Wang
Summary: A tumor-targeting, pH/redox dual-responsive nanosystem was designed for the co-delivery of chemo-drugs and siRNA. This nanosystem efficiently delivered DOX and siGCN5 into drug-resistant cancer cells, inhibiting tumor growth significantly and downregulating P-gp epigenetically. In an MDR breast tumor model, DOX and siGCN5 loaded HPMSNs effectively inhibited tumor growth, abolished P-gp expression, and minimized DOX's systemic toxicity.
ACTA BIOMATERIALIA
(2021)
Article
Cell Biology
Yuling Chen, Xiaohong Li, Lei Shi, Pengfei Ma, Wei Wang, Nan Wu, Youlin Gan, Xu Han, Shanshan Huang, Xiaohui Kang, Shuxin Liu, Yuhong Zhen
Summary: The study demonstrated that the combination of GQ and miR-451 could reverse drug resistance in breast cancer cells by reducing the expression of MDR1 and P-gp.
Article
Chemistry, Physical
Sara Ranjbar, Faramak Faramin Lashkarian, Mehdi Khoshneviszadeh, Fatemeh Moosavi, Amirhossein Sakhteman, Farshid Zargari, Luciano Saso, Omidreza Firuzi, Najmeh Edraki
Summary: In this study, novel 5-oxo-hexahydroquinoline derivatives were synthesized and tested for their ability to reverse multidrug resistance (MDR) in cancer cells overexpressing P-glycoprotein (P-gp). Most of the compounds showed enhanced intracellular accumulation of rhodamine 123, a P-gp substrate, and some exhibited better results than the established P-gp inhibitor verapamil. Certain compounds also effectively reversed resistance to doxorubicin and showed cytotoxic effects against leukemia and colon cancer cells. Molecular simulation analysis confirmed the interaction of selected compounds with the drug-substrate binding site of P-gp.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Cell Biology
Rebar N. Mohammed, Mohsen Khosravi, Heshu Sulaiman Rahman, Ali Adili, Navid Kamali, Pavel Petrovich Soloshenkov, Lakshmi Thangavelu, Hossein Saeedi, Navid Shomali, Rozita Tamjidifar, Alireza Isazadeh, Ramin Aslaminabad, Morteza Akbari
Summary: Balanced cell death and survival pathways, including anastasis, play a critical role in cell development and homeostasis. Anastasis is a natural cell recovery pathway that promotes the survival of damaged or tumor cells, and contributes to the development of malignancy and drug resistance.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Laila A. Jaragh-Alhadad, Hesham Farouk Oraby, Mohamed A. M. Atia, Othman R. Alzahrani, Gamal A. H. Mekhemer, Mahmoud F. Moustafa, Ahmed M. Shawky, Peter A. Sidhom, Alaa H. M. Abdelrahman
Summary: The development of multidrug resistance (MDR) caused by overexpression of P-glycoprotein (P-gp/ABCB1/MDR1) is the main reason for the failure of chemotherapy in carcinoma treatment. An in silico study was conducted to discover potential P-gp inhibitors by assessing the binding energies of 512 drug candidates. Five promising drug candidates, valspodar, dactinomycin, elbasvir, temsirolimus, and sirolimus, showed strong binding energies against P-gp transporter and displayed good pharmacokinetic properties. These results indicate their potential as prospective P-gp inhibitors and require further in vitro/in vivo investigations.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Daniel R. Principe, Alexandre F. Aissa, Sandeep Kumar, Thao N. D. Pham, Patrick W. Underwood, Rakesh Nair, Rong Ke, Basabi Rana, Jose G. Trevino, Hidayatullah G. Munshi, Elizaveta Benevolenskaya, Ajay Rana
Summary: There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC). In this study, researchers identified a subset of gemcitabine-resistant tumor cells enriched for calcium/calmodulin signaling. Inhibition of calcium-dependent calmodulin activation led to the loss of drug-resistant phenotypes, and calcium chelation or depletion impaired ERK activation and restored therapeutic responses to gemcitabine. Calcium channel blockers also enhanced therapeutic responses to gemcitabine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Physical
Linna Liang, Wendi Huo, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin, Xinjian Yang
Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nutrition & Dietetics
Chul Yung Choi, Sung-Chul Lim, Tae-Bum Lee, Song Iy Han
Summary: Multidrug resistance (MDR) is a major obstacle to the success of cancer chemotherapy. Resveratrol, a polyphenol, acts as a potential MDR inhibitor in drug-resistant cancer cells by interfering with transporters and enzymes, increasing DNA damage, inhibiting cell cycle progression, inducing apoptosis and autophagy, and preventing epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs).
Review
Cell & Tissue Engineering
Hamed Rezayatmand, Mahboobeh Razmkhah, Iman Razeghian-Jahromi
Summary: Drug resistance caused by cancer stem cells (CSCs) is the main reason for the failure and relapse of cancer therapy. CSCs possess the ability to self-renew and differentiate into heterogeneous cancer cells, and play a significant role in metastatic dissemination. Although chemotherapy can destroy most tumor cells, CSCs are left mostly intact, leading to resistance to treatment. It is crucial to understand the key features of drug resistance caused by CSCs in order to develop effective treatment strategies, but there are challenges in differentiating CSCs from normal cells.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Masomeh Maleki, Nafiseh Khelghati, Forough Alemi, Simin Younesi, Zatollah Asemi, Rozita Abolhasan, Mahtab Bazdar, Hossein Samadi-Kafil, Bahman Yousefi
Summary: Melatonin interacts with regulatory RNAs such as lncRNAs and miRNAs, influencing various physiological and pathological conditions. Studying these interactions will provide insights into the emerging functions of melatonin and the non-coding transcriptome.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Review
Biochemistry & Molecular Biology
Masomeh Maleki, Asal Golchin, Samira Javadi, Nafiseh Khelghati, Pejman Morovat, Zatollah Asemi, Forough Alemi, Mostafa Vaghari-Tabari, Bahman Yousefi, Maryam Majidinia
Summary: Exosomal miRNA plays an important role in the chemo-resistance, diagnosis, and prognosis of colorectal cancer (CRC). Engineered exosomes can deliver functional miRNAs to reverse chemoresistance and serve as promising biomarkers for CRC.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Amir Valizadeh, Samira Asghari, Parinaz Mansouri, Forough Alemi, Maryam Majidinia, Ata Mahmoodpoor, Bahman Yousefi
Summary: In recent years, there has been significant progress in the understanding of cardiac regeneration mechanisms, particularly in the recognition of cardiac muscle's regenerative capacity. The study of survival, proliferation, inflammation, angiogenesis, cell-cell communication, cardiomyogenesis, and anti-aging pathways has provided new insights for the treatment of cardiovascular diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Forough Alemi, Aydin Raei Sadigh, Faezeh Malakoti, Yusuf Elhaei, Seyed Hamed Ghaffari, Masomeh Maleki, Zatollah Asemi, Bahman Yousefi, Niloufar Targhazeh, Maryam Majidinia
Summary: The cellular genome is frequently damaged by endogenous and exogenous factors, which activate PIKKs family members in DNA damage response. The DDR system protects cells from genotoxicants and repairs DNA damage, while overactivation of the PI3K/Akt pathway can stimulate DDR process leading to increased DNA repair.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Forough Alemi, Faezeh Malakoti, Mostafa Vaghari-Tabari, Jafar Soleimanpour, Nazila Shabestani, Aydin R. Sadigh, Nafiseh Khelghati, Zatollah Asemi, Yasin Ahmadi, Bahman Yousefi
Summary: Osteosarcoma is a common bone malignancy with a low survival rate, especially in advanced stages. Resistance to chemotherapy, mainly through increased DNA repair ability, is a major obstacle in the treatment of osteosarcoma. Inhibiting the DNA damage response pathway may reduce chemoresistance and improve the effectiveness of chemotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Niloufar Targhazeh, Karla J. Hutt, Amy L. Winship, Russel Reiter, Bahman Yousefi
Summary: Multi drug resistance (MDR) limits chemotherapy efficacy in cancer patients. Melatonin (MLT), with oncostatic effects, may potentially affect different microenvironmental components and regulate drug resistance. Novel strategies incorporating MLT have been used to suppress cancer resistance against therapeutics.
Review
Biochemistry & Molecular Biology
Faezeh Malakoti, Forough Alemi, Shirin Jafari Yeganeh, Foroogh Hosseini, Nazila Shabestani, Sahar Samemaleki, Masomeh Maleki, Sarvin Fathi Daneshvar, Majid Montazer, Bahman Yousefi
Summary: LncRNAs and miRNAs, two crucial non-coding RNAs, play significant roles in cancer progression or prevention. Dysregulation of lncRNAs, particularly lncRNA SNHG7, can interact with miRNAs and impact various signaling pathways, thus contributing to cancer development.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Obstetrics & Gynecology
Ramin Pourakbari, Forough Parhizkar, Mohammad Sadegh Soltani-Zangbar, Parisa Samadi, Majid Zamani, Leili Aghebati-Maleki, Roza Motavalli, Ata Mahmoodpoor, Farhad Jadidi-Niaragh, Bahman Yousefi, Hossein Samadi Kafil, Mohammad Hojjat-Farsangi, Shahla Danaii, Mehdi Yousefi
Summary: This study identifies the impact of preeclampsia (PE) exosomes on the activity of Th17 and Treg cells and their related gene expression and cytokine profiles in healthy pregnant women. PE patients exhibited decreased Treg cell number and increased Th17 cells, while intervention with PE exosomes led to significant changes in gene expression and cytokine levels. These findings suggest a possible role of PE exosomes in the pathogenesis of PE.
REPRODUCTIVE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Forough Alemi, Masomeh Maleki, Mostafa Mir, Abbas Ebrahimi-Kalan, Mojtaba Zarei, Bahman Yousefi, Nadereh Rashtchizadeh
Summary: In this study, a formulation based on graphene oxide was designed and used as an anticancer drug delivery system. The physical and chemical properties of the formulation were characterized and in vitro studies showed that it provided better drug release profile in acidic conditions and exhibited higher cytotoxicity and apoptosis rate against osteosarcoma cells.
Article
Biochemistry & Molecular Biology
Mostafa Vaghari-Tabari, Soheila Moein, Ali Alipourian, Durdi Qujeq, Faezeh Malakoti, Forough Alemi, Bahman Youse, Sepideh Khazaie
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by periods of recurrence and remission. Improper immune responses and genetic susceptibility are believed to be involved in IBD pathogenesis, along with dysbiosis and oxidative stress. Sleep disturbances have been found to be associated with IBD, and animal studies suggest that sleep deprivation can worsen inflammation. Melatonin, a sleep-related hormone, has shown promising effects in regulating the immune response, reducing inflammation, and healing intestinal ulcers in IBD animal models. Clinical studies have also suggested that melatonin supplementation may be helpful in reducing disease activity in IBD patients. This review article aims to examine the effects of sleep disturbances and melatonin supplementation on IBD, including their mechanisms of action and clinical implications.
Review
Cell Biology
Asal Golchin, Masoumeh Maleki, Forough Alemi, Faezeh Malakoti, Bahman Yousefi
Summary: Breast cancer is a common and deadly cancer among females. The study aimed to investigate the potential of free nanoparticles in inducing or inhibiting autophagy, and its impact on therapy. The analysis showed that most metallic nanoparticles induced autophagy through reactive oxygen species pathways, while a small percentage of studies mentioned the involvement of PI3K/Akt/mTOR and MAPK/ERK signaling pathways, and 31% of studies did not examine the nanoparticle-related autophagy pathway.
CELL BIOLOGY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Forough Alemi, Fatemeh Sadeghsoltani, Khashayar Fattah, Parisa Hassanpour, Faezeh Malakoti, Sina Kardeh, Melika Izadpanah, Debora Aparecida Pires de Campos Zuccari, Bahman Yousefi, Maryam Majidinia
Summary: Noncoding RNAs play important roles in key cell biological and pathological events, and their altered expression is directly and indirectly linked to cancer progression. Numerous studies have highlighted the significant role of ncRNAs in cancer prevention and therapy, making them an interesting subject for cancer treatment. However, there are limitations in the application of ncRNAs in cancer treatment, such as delivery, uptake, and short half-life. Exosomes are introduced as promising options for delivering ncRNAs to target cells. This review briefly discusses the application and barriers of ncRNAs, with a focus on exosome-based ncRNA delivery, advantages, and the latest achievements in drugging ncRNAs with exosomes.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Pharmacology & Pharmacy
Niloufar Targhazeh, Masomeh Maleki, Forough Alemi, Bahman Yousefi
Summary: This study successfully linked DOX to the surface of pH-sensitive polyhydroxy glycerol-grafted graphene oxide nanoparticles, and assessed its loading capacity, release efficiency, and cytotoxicity using various molecular tests. The results showed that the nanocarrier had no significant toxic effect on healthy tissues, indicating its high potential for drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Abdolhakim Palideh, Mostafa Vaghari-Tabari, Ali Nosrati Andevari, Durdi Qujeq, Zatollah Asemi, Forough Alemi, Hemmatollah Rouhani Otaghsara, Sona Rafieyan, Bahman Yousefi
Summary: Periodontal disease is the most common oral disease and is considered as an inflammatory disease. The immune response to bacteria in the gum line is key in its development. miRNAs, small RNA molecules, have a significant role in the immune system and are related to periodontal ligament cells. Extensive research has been conducted on the role of miRNAs in the pathogenesis of periodontal disease. They may serve as therapeutic targets for its treatment.
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
