Article
Biochemistry & Molecular Biology
Valeria Sutti Nunes, Edite Vieira Silva de Campos, Jamal Baracat, Victor Franca, Erica Ivana Lazaro Gomes, Raissa Peres Coelho, Edna Regina Nakandakare, Vanessa Helena Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintao
Summary: This study investigated the relationships between plasma cholesterol synthesis and absorption markers and cardiovascular disease risk factors, cIMT, and carotid plaques in asymptomatic subjects. The findings suggested that campesterol may be associated with atherosclerotic plaques, while the ratios of lathosterol/campesterol or lathosterol/sitosterol may indicate an inverse association. This highlights the inverse relationship between cholesterol synthesis and absorption, with the absorption marker campesterol reflecting changes in body cholesterol homeostasis and atherosclerotic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Johan Nilsson Sommar, Margareta Norberg, Christer Gronlund, David Segersson, Ulf Naslund, Bertil Forsberg
Summary: This study estimated the association between long-term exposure to particulate air pollution and sub-clinical atherosclerosis, finding that particle concentrations were related to plaque presence but not associated with plaque progression or carotid intima-media thickness.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyuan Miao, Guo Zhou, Anran Bao, Yaming Sun, Huaping Du, Liyan Song, Yongjun Cao, Shoujiang You, Chongke Zhong
Summary: This study found an association between TyG index and carotid atherosclerosis in patients with ischemic stroke, suggesting that TyG could be a promising marker for atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Karri Parkkila, Antti Kiviniemi, Mikko Tulppo, Juha Perkiomaki, Y. Antero Kesaniemi, Olavi Ukkola
Summary: In a prospective study with over 20 years of follow-up, the length of plaques in abdominal-pelvic main arteries (SUM) was found to be a superior indicator for evaluating overall cardiovascular risk compared to carotid intima-media thickness (IMT). SUM significantly predicted CV events and improved the discrimination and reclassification of patients when added to the established model, while IMT only predicted cardiovascular events in univariate analysis and did not improve discrimination or reclassification.
Article
Cardiac & Cardiovascular Systems
Marc J. T. Blaauw, Marvin A. H. Berrevoets, Wilhelm A. J. W. Vos, Albert L. Groenendijk, Louise E. van Eekeren, Nadira Vadaq, Gert Weijers, Andre J. A. M. van der Ven, Joost H. W. Rutten, Niels P. Riksen
Summary: This study found that traditional cardiovascular risk factors were significantly associated with higher carotid intima-media thickness (cIMT), but not with carotid plaques. HIV-specific factors were not associated with either ultrasound measurements. It is recommended to improve guideline adherence on lipid-lowering treatment in high- and very high-risk patients for cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Huaping Du, Tingting Guo, Huan Ye, Yingshi Bao, Zhuoyin Qiu, Yaming Sun, Shoujiang You, Yuan Liu, Yuan Xu, Chunqing Zhang, Chunfang Qiu
Summary: An elevated concentration of serum phosphorus is associated with carotid atherosclerosis in ischemic stroke patients, as measured by cIMT.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Jose Luis Perez-Lasierra, Jose A. Casajus, Alejandro Gonzalez-Aguero, Jose Miguel Arbones-Mainar, Jose A. Casasnovas, Martin Laclaustra, Belen Moreno-Franco
Summary: This study analyzed the association between the APOE e4 genetic variant and carotid atherosclerosis, as well as the association between cardiorespiratory fitness (CRF) and atherosclerosis in individuals with the APOE e4 genetic variant. The findings showed that the APOE e4e4 genotype was associated with increased carotid atherosclerosis, while CRF was a modifiable factor that could be targeted to decrease the atherosclerotic risk in individuals with the APOE e4e4 genetic variant.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Anna Kopczak, Andreas Schindler, Dominik Sepp, Anna Bayer-Karpinska, Rainer Malik, Mia L. Koch, Julia Zeller, Christoph Strecker, Daniel Janowitz, Frank A. Wollenweber, Johann-Martin Hempel, Tobias Boeckh-Behrens, Clemens C. Cyran, Andreas Helck, Andreas Harloff, Ulf Ziemann, Sven Poli, Holger Poppert, Tobias Saam, Martin Dichgans
Summary: Complicated nonstenosing carotid artery plaques (CAPs) are an underestimated cause of stroke. This study aimed to determine the association between complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) and recurrent ischemic stroke or transient ischemic attack (TIA). The study found that patients with icCAP had a higher frequency of recurrent events, and a ruptured fibrous cap and intraplaque hemorrhage were significantly associated with an increased risk of recurrence.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Transplantation
Miriam Goepfert, Till Ittermann, Marcus Doerr, Nele Friedrich, Henry Voelzke, Thomas Dabers, Stephan B. Felix, Ulf Schminke, Sylvia Stracke, Sabrina von Rheinbaben
Summary: This study aimed to investigate the association between carotid atherosclerotic parameters and renal function decline. The results showed that carotid intima-media thickness (cIMT) and carotid plaques were associated with a decrease in estimated glomerular filtration rate (eGFR) and an increased risk of chronic kidney disease (CKD). However, there was no association between atherosclerotic parameters and the risk of developing albuminuria.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Mingjun Xu, Suqin Jin, Fan Li, Guoyong Jia, Cheng Zhang, Mei Zhang, Yun Zhang
Summary: This study found that measuring carotid intima thickness and other areas' intima thickness can help differentiate patients with large-artery atherosclerosis stroke from normal control subjects. The relevant intima thickness is associated with traditional atherosclerotic risk factors and can provide additional diagnostic value.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Multidisciplinary Sciences
Hye Jeong Kim, Seong Soon Kwon, Sang Joon Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Duk Won Bang, Hyeong Kyu Park
Summary: This study suggests that the TyG index and thyroid function status are important predictors of carotid plaque risk in healthy individuals. Early evaluation of carotid plaques may be necessary for patients with high insulin resistance and subclinical hypothyroidism.
Review
Health Care Sciences & Services
Anna Maria Rychter, Dariusz Naskret, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Atherosclerosis is strongly associated with obesity, with carotid intima-media thickness (cIMT) serving as a predictor of cardiovascular events and subclinical atherosclerosis. Behavioral interventions can directly impact cIMT values, influencing cardiovascular disease risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Peripheral Vascular Disease
Ruimei Feng, Yiquan Dai, Shanshan Du, Wenbin Liang, Hongyu Chen, Cheng Chen, Tianmin He, Tao Tao, Zhijian Hu, Pingfan Guo, Weimin Ye
Summary: The associations between several blood inflammatory indicators and the risk of vascular plaques, especially in femoral arteries, were found in this study.
Article
Cardiac & Cardiovascular Systems
Sophia J. Kiechl, Anna Staudt, Katharina Stock, Nina Gande, Benoit Bernar, Christoph Hochmayr, Bernhard Winder, Ralf Geiger, Andrea Griesmacher, Markus Anliker, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Raimund Pechlaner
Summary: The study revealed that systolic blood pressure, arterial hypertension, low-density and non-high-density lipoprotein cholesterol, and alanine transaminase predicted cIMT progression in adolescents, even when risk factor levels were within established reference ranges. These findings underline the importance of initiating prevention early in life and question the current focus on high-risk youngsters in guideline recommendations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Evangelos Oikonomou, George Lazaros, Vasiliki Chara Mystakidi, Nikolaos Papaioannou, Panagiotis Theofilis, Georgia Vogiatzi, Christos Chasikidis, Petros Fountoulakis, Maria-Argentina Papakostantinou, Margarita Niki Assimakopoulos, Nikolaos Barmparesos, Panagiotis Tasios, Juan C. Kaski, Dimitris Tousoulis
Summary: The study demonstrates that residents in areas with high concentrations of gaseous air pollutants have increased carotid atherosclerotic burden and inflammation compared to residents in other regions. High levels of CO, NO2, and SO2 were observed in Region 4, where individuals also showed higher levels of C reactive protein and greater carotid plaque burden. Additionally, the propensity score analysis indicated higher differences in mean cIMT among individuals with coronary artery disease in high pollution areas compared to low pollution areas.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Justyna Rosinska, Joanna Maciejewska, Robert Narozny, Krystyna Osztynowicz, Beata Raczak, Slawomir Michalak, Cezary Watala, Wojciech Kozubski, Maria Lukasik
Review
Clinical Neurology
Marta Kowalska, Katarzyna Wize, Michal Prendecki, Margarita Lianeri, Wojciech Kozubski, Jolanta Dorszewska
CURRENT ALZHEIMER RESEARCH
(2020)
Review
Clinical Neurology
Pitchaya Wanleenuwat, Piotr Iwanowski, Wojciech Kozubski
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Review
Clinical Neurology
Michal Prendecki, Marta Kowalska, Ewa Toton, Wojciech Kozubski
CURRENT ALZHEIMER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Marta Kowalska, Michal Prendecki, Magdalena Kapelusiak-Pielok, Teresa Grzelak, Urszula Lagan-Jedrzejczyk, Malgorzata Wiszniewska, Wojciech Kozubskr, Jolanta Dorszewska
Article
Biochemistry & Molecular Biology
Marta Kowalska, Thomas Piekut, Michal Prendecki, Agnieszka Sodel, Wojciech Kozubski, Jolanta Dorszewska
DNA AND CELL BIOLOGY
(2020)
Editorial Material
Neurosciences
Jolanta Dorszewska, Wojciech Kozubski, Wioletta Waleszczyk, Matthew Zabel, Kevin Ong
Article
Clinical Neurology
Izabela Domitrz, Aurelia Lipa, Jacek Rozniecki, Adam Stepien, Wojciech Kozubski
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2020)
Article
Medicine, Research & Experimental
Anna Pietrzak, Alicja Kalinowska-Lyszczarz, Krystyna Osztynowicz, Alima Khamidulla, Wojciech Kozubski, Slawomir Michalak
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Wojciech Ambrosius, Slawomir Michalak, Wojciech Kozubski, Alicja Kalinowska
Summary: MOG-associated disease (MOGAD) is a rare inflammatory disorder of the central nervous system with various phenotypes, most commonly presenting as optic neuritis and ADEM. Diagnosis relies on detecting serum antibodies and MRI imaging, while treatment includes acute immunotherapy and immunosuppressive therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marta Kowalska, Michal Prendecki, Thomas Piekut, Wojciech Kozubski, Jolanta Dorszewska
Summary: Migraine is a common neurological disease divided into two main types: with aura and without aura. Research shows that the activation of the trigeminovascular system and release of neuropeptides play crucial roles in headache pathogenesis. Cortical spreading depression, responsible for aura, stems from aberrant interactions between neurons and glia, particularly studied in FHM models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Adam Stepien, Wojciech Kozubski, Jacek J. Rozniecki, Izabela Domitrz
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2021)
Review
Neurosciences
Wojciech Kozubski, Kevin Ong, Wioletta Waleszczyk, Matthew Zabel, Jolanta Dorszewska
Summary: This article discusses the importance of neural plasticity in neurodegenerative diseases, explores the main causes and symptoms of dementia, highlights the challenges in diagnosis and treatment of neurodegenerative diseases, and looks forward to potential breakthroughs in the future.
Article
Oncology
Mikolaj Piotr Zaborowski, Patrycja Stefens-Stawna, Krystyna Osztynowicz, Tomasz Piorunek, Halina Batura-Gabryel, Agnieszka Dyzmann-Sroka, Wojciech Kozubski, Ewa Nowak-Markwitz, Slawomir Michalak
Summary: The cytotoxic response measured in peripheral blood by GrB in PBMC is impaired both in the course of malignancy and PNS. Levels of GrB in PBMC were higher if onconeural antibodies were detected. Tracking reactive immune responses, such as GrB in PBMC may have diagnostic and monitoring value in malignancy and PNS.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Cell Biology
Jolanta Dorszewska, Marta Kowalska, Michal Prendecki, Thomas Piekut, Joanna Kozlowska, Wojciech Kozubski
Summary: Parkinson's disease (PD) is the second most common cause of neurodegeneration, with oxidative stress leading to dopaminergic neuron degeneration. Mutations in genes such as SNCA, PRKN, PINK1, DJ1, and LRRK2 are associated with disrupted oxidoreductive homeostasis in PD. Treatment options for PD include optimizing dopaminergic therapy and introducing advanced therapies such as deep brain stimulation, with genetic factors playing a role in response to treatment.
NEURAL REGENERATION RESEARCH
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
