Article
Infectious Diseases
Meiry Leandra de Lacerda, Daise Aparecida Rossi, Eduarda Cristina Alves Lourenzatto, Micaela Guidotti Takeuchi, Wesley Almeida Souza, Raphael Tristao Cruvinel Silva, Luma Goncalves Julio, Wendell Guerra, Roberta Torres de Melo
Summary: This work synthesized and characterized two metal complexes and investigated their antibacterial activity against Campylobacter jejuni in combination with antibiotics. The results showed that complex I exhibited a promising alternative for controlling resistant strains of C. jejuni.
Article
Engineering, Biomedical
Kun Shang, Lingpu Zhang, Yingjie Yu, Haihua Xiao, Yajuan Gao, Liu Yang, Jia Huang, Haiqin Song, Hongbin Han
Summary: The study designed composite nanoparticles that encapsulate USP1 inhibitor and platinum (IV) prodrug using a glutathione-sensitive amphiphilic polymer. These nanoparticles can target USP1 to inhibit DNA damage repair, increase the sensitivity of tumor cells to cisplatin, and enhance the anti-cancer efficacy of cisplatin.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Priya Mondal, Syed Musthapa Meeran
Summary: Platinum-based drugs are widely used for cancer therapy, but long-term use can lead to chemoresistance and side effects. Recent research has shown that targeting non-coding RNAs (ncRNAs) could be an effective approach for overcoming chemoresistance in lung cancer. This review article discusses the role of ncRNA in chemoresistance and its molecular mechanisms in human lung cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maria Grazia Ferraro, Marialuisa Piccolo, Gabriella Misso, Rita Santamaria, Carlo Irace
Summary: The search for effective and safe cancer drugs is a multidisciplinary effort. Metal-based complexes have great potential as yet unexplored anticancer drugs. Transition metals other than platinum, such as ruthenium, palladium, rhodium, and iridium, have been proposed as alternative chemotherapeutic options and have unique chemical and biological features. This review focuses on the applications and progress in metal-based chemotherapy, particularly on the development of anticancer agents based on these transition metals.
Article
Chemistry, Multidisciplinary
Tushar Ranjan Panda, M. Manikandan, Shreyas P. Vaidya, Sushanta Chhatar, Suman Sinha, Megha Mehrotra, Sourav Chakraborty, Shubhankar Gadre, Prakash Duari, Pritha Ray, Malay Patra
Summary: Even in the era of precision medicine and immunotherapy, chemotherapy with platinum drugs is still widely used against various cancers. However, the efficacy of these drugs is limited by resistance and toxicity. In this study, we designed kinetically inert organometallic platinum anticancer agents with a novel mechanism of action. Our best candidate showed promising antitumor efficacy and could mitigate nephrotoxicity associated with cisplatin. This study demonstrates the importance of kinetic inertness in improving the therapeutic benefits of platinum-based anticancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Pharmacology & Pharmacy
Andreia Valente, Ana Podolski-Renic, Isabella Poetsch, Nenad Filipovic, Oscar Lopez, Iztok Turel, Petra Heffeter
Summary: Drug resistance remains a major cause of cancer treatment failure, especially in the late stage of the disease. Metal and metalloid compounds offer the possibility to design fine-tuned drugs to overcome drug-resistant cancer cells. This review highlights the importance of platinum drugs in clinics and discusses strategies to reverse resistance to platinum drugs and multidrug resistance based on ABC efflux pumps.
DRUG RESISTANCE UPDATES
(2021)
Review
Engineering, Biomedical
Tianyuan Zhong, Jie Yu, Yong Pan, Ning Zhang, Yanxin Qi, Yubin Huang
Summary: Platinum drugs are widely used in cancer treatment, but their toxicity and drug resistance pose challenges. Combination therapy with platinum drugs can effectively inhibit tumor growth and metastasis, reducing toxicity and overcoming resistance. This review summarizes the current progress and challenges in platinum-based combination therapy, including gene editing, ROS-based therapy, thermal therapy, immunotherapy, and imaging modality. It hopes to inspire researchers for the development of more effective platinum-based anti-cancer complexes in the future.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Environmental Sciences
L. Alicia Garcia-Costa, I. A. Teresa Gouveia, M. Fernando R. Pereira, Adrian M. T. Silva, Arminda Alves, M. Luis Madeira, S. F. Monica Santos
Summary: This study successfully removed five cytostatics of concern from Portuguese WWTP effluents using non-catalytic ozonation. CAP and MPA were quickly eliminated while BICA, CYC, and IFO required breakdown via hydroxyl radicals generation for degradation. Increasing ozone dosage improved removal efficiency, with CAP, MPA, and IFO completely eliminated after 180 minutes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Inorganic & Nuclear
Miguel A. Soto, Raksha Kandel, Mark J. MacLachlan
Summary: Platinum(II) complexes exhibit versatile chromic behavior due to their square planar geometry, which allows for intra- and intermolecular Pt...Pt interactions. These interactions, along with various functional groups and environmental factors, can modulate the electronic properties and transitions of the complexes, making them attractive candidates for chromic devices in memory, encryption, sensors, and optoelectronics.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Guihua Fang, Aiwen Zhang, Lu Zhu, Qiuxiang Wang, Feilong Sun, Bo Tang
Summary: This review presents recent advancements in nanocarriers containing platinum compounds for combination cancer chemotherapy. These nanocarriers have the potential to address side effects and resistance associated with platinum-based drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shuang Ren, Fei Pan, Wen Zhang, Guo-Wu Rao
Summary: Cyclobutyl has become increasingly influential in drug design, serving as both a useful intermediate for synthesizing biomedical candidate materials and an indispensable framework for drug design and application. Platinum-based anticancer drugs containing cyclobutyl fragments have achieved remarkable success, bringing hope for the development of more cyclobutyl drugs.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Panpan Lv, Shuli Man, Lu Xie, Long Ma, Wenyuan Gao
Summary: Platinum resistance is a challenge in lung cancer treatment, and understanding its molecular mechanisms, identifying predictive markers, and developing more effective and less toxic agents are crucial. Addressing this issue could lead to the development of improved treatment for refractory lung cancer in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Plant Sciences
Alberto Gonzalez, Daniel Laporte, Alejandra Moenne
Summary: The study found that cadmium induced oxidative stress in Ulva compressa, which was mitigated by activating antioxidant enzymes and synthesizing glutathione and ascorbate. Calcium-dependent protein kinases, calmodulin-dependent protein kinases, calcineurin B-like protein kinases, and MAPKs are involved in cadmium accumulation and GSH and phytochelatin synthesis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Fantao Meng, Benzhi Ju, Zhenzhi Wang, Ronghui Han, Yuang Zhang, Shufen Zhang, Ping Wu, Bingtao Tang
Summary: We present a new synthetic strategy that combines N-carboxyanhydride (NCA) chemistry and photonic crystals for the fabrication of polypeptide structural color films. Through surface-initiated ring-opening polymerization, a di-NCA derivative of L-cystine (Cys) is utilized to replicate functionalized colloidal crystal templates and create freestanding P(Cys) films with adjustable structural color. The feasibility of producing patterned polypeptide photonic films is demonstrated through template microfabrication. The introduction of L-glutamate (Glu) components enables the P(Cys-co-Glu) copolypeptide films to exhibit visual color responsiveness to pH changes. Additionally, the polypeptide photonic films possess on-demand degradability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Environmental Sciences
Joanna M. Goncalves, Clara Beckmann, Maria Joao Bebianno
Summary: The effects of 5-Fluorouracil and a mixture of emerging contaminants on mussels were studied. The results showed that both treatments caused genotoxicity in mussels, and antagonism was observed between contaminants in the mixture. In addition, the mixture had a synergistic effect on oxidative stress and damage in mussels.
Article
Chemistry, Multidisciplinary
Min Xu, Chuchu Ren, Yue Zhou, Zbynek Heger, Xiaoyang Liang, Vojtech Adam, Nan Li
Summary: Inhibition of foam cell formation is a promising treatment method for atherosclerosis. The authors designed Pd@HA/ALO nanozymes that can scavenge ROS and downregulate COX-2 expression to induce macrophage polarization, thus inhibiting foam cell formation. The nanozymes actively accumulate in atherosclerotic plaques and exhibit antioxidative and anti-inflammatory effects. The combined therapy also promotes macrophage polarization.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yunsheng Dou, Ping Liu, Ziqiao Ding, Yue Zhou, Huaqing Jing, Yingzi Ren, Zbynek Heger, Vojtech Adam, Nan Li
Summary: Intestinal milieu disorders are closely associated with the development of inflammatory bowel diseases (IBDs), which involve mucosa destruction, epithelium disruption, and loss of tight junction (TJ) proteins. An excess of H2S in the intestinal milieu produced by sulfate-reducing bacteria metabolism leads to breakdown of the epithelial barrier in IBDs. Conventional interventions for IBDs, such as surgery and anti-inflammatory medications, are not completely effective due to frequent recurrence and complications. In this study, a novel oral delivery system called HUR was developed, which consists of a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based polymer-coated UiO-66 metal-organic framework with a Cu-x-rhodamine B (CR) probe. HUR has the ability to reduce H2S levels and restore the intestinal lumen milieu, exhibiting therapeutic efficacy in terms of mucosa recovery, epithelium integrity restoration, and upregulation of TJ proteins.
ADVANCED MATERIALS
(2023)
Article
Agriculture, Multidisciplinary
Katerina Stuskova, Jakub Pecenka, Dorota Anna Tekielska, Milan Spetik, Zuzana Bytesnikova, Pavel Svec, Frantisek Ondreas, Andrea Ridoskova, Lukas Richtera, Vojtech Adam, Ales Eichmeier
Summary: The study tested various nanoparticles and chemicals for their inhibitory effects on grapevine trunk pathogens, and found that silver nitrate and AgSe nanoparticles showed significant inhibition of fungal growth.
ANNALS OF APPLIED BIOLOGY
(2023)
Article
Marine & Freshwater Biology
Marketa Dobesova, Martina Kolackova, Ondrej Pencik, Petr Capal, Pavel Chaloupsky, Pavel Svec, Andrea Ridoskova, Martin Motola, Veronika Cicmancova, Hanna Sopha, Jan. M. Macak, Lukas Richtera, Vojtech Adam, Dalibor Huska
Summary: Recently, more accessible transcriptomic approaches have improved our understanding of environmental toxicity. This study focused on the transcriptomic profiles of green microalgae Chlamydomonas reinhardtii exposed to TiO2 nanotubes (NTs), a commonly used one-dimensional nanomaterial. The results showed that the NTs had a dose-dependent negative effect on the algae, causing metabolic disruption, damage to cellular structures, solute loss, and cell wall damage. Additionally, apoptosis-related transcripts and reactivation of transposons were observed, while genes involved in signaling and transcription pathways were downregulated.
AQUATIC TOXICOLOGY
(2023)
Review
Environmental Sciences
Martina Kolackova, Anna Janova, Marketa Dobesova, Monika Zvalova, Pavel Chaloupsky, Olga Krystofova, Vojtech Adam, Dalibor Huska
Summary: Proficient photosynthetic microalgae/cyanobacteria produce a remarkable amount of various biomolecules. Secondary metabolites (SM) represent high value products for global biotrend application. Production improvement can be achieved by nutritional, environmental, and physiological stress as a first line tools for their stimulation. However, deep understanding and connection of specific stress elucidator are missing. Hence, the present review summarizes recent evidence with an emphasis on the carotenoids, phenolic, and lessdiscussed compounds (glycerol, proline, mycosporins-like amino acids), highlighting the need to expand knowledge in this area using genome-editing tools and omics approaches.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Soumajit Mukherjee, Zuzana Bytesnikova, Sophie Martin, Pavel Svec, Andrea Ridoskova, Jana Pekarkova, Cendrine Seguin, Jean-Luc Weickert, Nadia Messaddeq, Yves Mely, Lukas Richtera, Halina Anton, Vojtech Adam
Summary: Graphene-based 2D nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), exhibit antimicrobial effects on bacteria and viruses. This study focuses on the antiviral properties of reduced GO-based nanocomposites decorated with Ag nanoparticles (rGO-Ag) against human immunodeficiency virus-1 pseudovirus. The results show that rGO-Ag induces peroxidation of the pseudoviral lipid membrane, leading to a reduction in cell entry, and is efficiently internalized in the host cell, resulting in an elevated expression of pro-inflammatory cytokines.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Engineering, Biomedical
Hana Stepankova, Hana Michalkova, Zbynek Splichal, Lukas Richtera, Pavel Svec, Tomas Vaculovic, Jan Pribyl, Martin Kormunda, Simona Rex, Vojtech Adam, Zbynek Heger
Summary: Although the general concept of nanotechnology relies on exploiting the size-dependent properties of nanoscaled materials, the relationship between the size/morphology of nanoparticles and their biological activity is still not well understood. In this study, we investigated the biological activity of Se nanoparticles with different morphologies (nanorods vs. spherical particles) and aspect ratios (AR) in human cells and mice. Our findings suggest that the aspect ratio is a critical factor for the cytotoxicity and biocompatibility of nanorod-shaped Se nanomaterials.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Katerina Mitrevska, Miguel Angel Merlos Rodrigo, Natalia Cernei, Hana Michalkova, Zbynek Splichal, David Hynek, Ondrej Zitka, Zbynek Heger, Pavel Kopel, Vojtech Adam, Vedran Milosavljevic
Summary: The combination of in ovo and ex ovo chorioallantoic membrane (CAM) assay has been used to study the anticancer activity of platinum nanoparticles (PtNPs) and the fluctuations of amino acids in the liver and brain. PtNPs showed higher efficiency in inhibiting tumor growth and metastasis compared to cisplatin (CDDP). PtNPs had a depleting effect on amino acid content, while CDDP treatment had more side effects on amino acid metabolism. Different sets of enzymes in the tricarboxylic acid (TCA) cycle were targeted by PtNPs and CDDP, indicating different mechanisms of action. CAM assay demonstrated the capability of PtNPs to repress angiogenesis, decrease amino acid content, and disrupt the TCA cycle.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Environmental
Yue Zhou, Siyu Wang, Xiaoyang Liang, Zbynek Heger, Qiang Lu, Wen Li, Vojtech Adam, Nan Li
Summary: This study demonstrates that combination immune checkpoint blockade of ADAR1 and PD-1 can improve the tumor immune microenvironment and enhance immune response. By delivering shADAR1 using a nanosystem and combined treatment with an anti-PD-1 antibody, immune evasion is reduced and antitumor immunity is activated. Mechanistic and transcriptomic analysis confirm that this combination therapy regulates the abundance of immune cells.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Atripan Mukherjee, Amir M. Ashrafi, Zuzana Bytesnikova, Pavel Svec, Lukas Richtera, Vojtech Adam
Summary: CeO2 nanoparticles with enzyme-like activity can serve as alternatives to natural enzymes in electrochemical sensing, exhibiting favorable mediator and catalytic roles in H2O2 reduction reactions.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Yihao Li, Haoyu Gao, Eugenie Nepovimova, Qinghua Wu, Vojtech Adam, Kamil Kuca
Summary: Recombinant ferritins play a crucial role in maintaining iron homeostasis in living organisms. They have found wide application in multimodal nanomedicine, particularly in anticancer treatment and vaccination. The fusion of viral proteins and ferritin subunits in recombinant particles has been shown to enhance the immune response and antibody production. Targeted ferritin nanoparticles can specifically deliver drugs to tumor tissue, while ferritin linked with contrast agents or fluorescent dyes has potential use in cancer theranostics. This review provides a comprehensive summary of the utilization of recombinant ferritins in multimodal nanomedicine, with emphasis on their role as nanovaccines, nanozymes, and targeted therapy carriers for bioimaging.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Siyu Wang, Long Binh Vong, Zbynek Heger, Yue Zhou, Xiaoyang Liang, Vojtech Adam, Nan Li
Summary: Researchers designed a PEGylated PtNi trilobal-shaped nanostructure for pyroptosis-triggered tumor immunotherapy through a nanozyme catalytic and magnetocaloric oscillation dual strategy. By applying an alternating magnetic field, the nanostructure generated hyperthermia and mechanical oscillation to activate the caspase-1-NLRP3-GSDMD pathway, leading to cell rupture and cytokine release, resulting in significant reduction of breast tumors.
Article
Chemistry, Analytical
Navid Assi, Tomas Rypar, Mirek Macka, Vojtech Adam, Marketa Vaculovicova
Summary: Microfluidic paper-based analytical devices modified with molecularly imprinted polymers (mu PADs@MIPs) were developed for fluorescent detection of targeted thiols via in situ UV-induced formation of quantum dots (mu PADs@MIPs@QDs). The selectivity enhancement by the MIP layer formed on the filter paper surface was demonstrated for the isolation of L-homocysteine from wine. The proposed method has a good relationship between the fluorescence intensity of ZnCdCu/S QDs and L-homocysteine in a linear range from 0.74 to 7.40 mu M with a limit of detection (LOD) and quantification (LOQ) of 0.51 and 1.71 mu M respectively. This method was applied for the determination of L-homocysteine in white wine with RSD under 6.37%.
Article
Environmental Sciences
Ondrej Pencik, Katarina Molnarova, Michaela Durdakova, Martina Kolackova, Daniel Klofac, Attilla Kucsera, Petr Capal, Pavel Svec, Zuzana Bytesnikova, Lukas Richtera, Martin Brtnicky, Vojtech Adam, Dalibor Huska
Summary: This research focuses on the impact of PET-MPs on green microalgae and cyanobacteria. The study found that C. reinhardtii is the most sensitive to PET-MPs, while the cyanobacteria have the highest adsorption of PET-MPs. Additionally, all tested organisms showed cell damage after exposure to PET-MPs, with the cyanobacteria being the least affected. Further long-term experiments on environmentally relevant organisms are needed to study the effects of PET-MPs.
ENVIRONMENTAL POLLUTION
(2023)
Review
Engineering, Environmental
Ondrej Pencik, Michaela Durdakova, Katarina Molnarova, Attila Kucsera, Daniel Klofac, Martina Kolackova, Vojtech Adam, Dalibor Huska
Summary: Plastic pollution poses a serious risk to the environment, as it enters rivers and eventually reaches the oceans where it forms microplastics and nanoplastics. These particles become more toxic as they interact with environmental pollutants. In vitro studies on microplastics and nanoplastics often fail to consider environmentally relevant microorganisms and other factors that can affect their effects on living systems. This article summarizes the latest findings on microplastics and nanoplastics in the environment and proposes recommendations for future in vitro experiments.
JOURNAL OF HAZARDOUS MATERIALS
(2023)