Article
Materials Science, Multidisciplinary
Min-Yu Li, Juan Liu, Ran Gao, Duo-Yu Lin, Fei Wang, Jian Zhang
Summary: Zeolitic tetrazolate-imidazolate frameworks (ZTIFs) are a new type of materials that enhance host-guest interactions and balance functionality and stability. Their diverse topological structures and promising applications in various fields make them a subject of growing interest.
MATERIALS TODAY ADVANCES
(2021)
Article
Nanoscience & Nanotechnology
Jacob Deneff, Kimberly S. Butler, Paul G. Kotula, Braden E. Rue, Dorina F. Sava Gallis
Summary: Zeolitic imidazolate framework (ZIF) nanoparticles have emerged as attractive platforms for various biologically relevant applications due to their facile synthesis, tailorable porosity, diverse compositions, and low toxicity. This study demonstrates the rapid synthesis and size tunability of ZIF-20 particles, their stability in biologically relevant media, biocompatibility with A549 human epithelial cells, and ability to encapsulate and release methylene blue. ZIF-20 NPs display unique behavior based on their specific structural and chemical features, highlighting the importance of expanding the design space within the broader ZIFs family for a wider range of relevant properties in biological applications and beyond.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Chemical
David Peralta, Anna -Caroline Lavergne-Bril, Emmanuel Billy, Jean-Francois Colin, Didier Bloch, Sebastien Patoux
Summary: The demand for cobalt is expected to sharply increase due to the intensive development of Li-ion batteries for transportation applications, while more than half of cobalt production is concentrated in the Democratic Republic of the Congo, making recycling and reusing cobalt from used batteries crucial to limit imports.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Omar M. Yaghi
Summary: Understanding the mechanism of MOF crystal growth is crucial for their design. In this study, Deng and colleagues employ an optical method to visualize and track the crystal interface during MOF growth. They also derive a reaction kinetic equation for individual crystals of MOFs, which offers valuable guidance for MOF synthesis.
Article
Nanoscience & Nanotechnology
Shao-Fei Wu, Bing-Zhi Yuan, Li-Wei Wang
Summary: Sorption working pairs have the potential to convert low-grade heat into cold energy or store thermal energy, making them future carbon-neutral materials. This Comment focuses on the advantages of metal-organic framework (MOF)-ammonia working pairs for adaptable thermal management in extreme climates and discusses strategies for designing MOFs with high stability and ammonia sorption capacity.
NATURE REVIEWS MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Syed Shoaib Ahmad Shah, Tayyaba Najam, Muhammad Sufyan Javed, Mohammed M. Rahman, Panagiotis Tsiakaras
Summary: A multi-step heating strategy was applied to produce mesoporous N-doped carbon nanostructures with dual-metallic active sites from mixed-metal zeolitic imidazolate frameworks. The unique structure of the catalyst not only offers high electrochemical performance for the ORR in acidic media, but also enhances operational durability. Additionally, the catalyst displays good performance for the ORR in alkaline solution.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Chun-Rong Ye, Wen-Jian Wang, Wei Chen, Yonghong Xiao, Hai-Feng Zhang, Bing-Ling Dai, Si-Han Chen, Xu-Dong Wu, Mian Li, Xiao-Chun Huang
Summary: The research involves an adaptive material with a metal-organic framework that can accommodate benzene molecules in crystalline porous solids, enabling the liquid-phase production of ultrahigh-purity cyclohexane and surpassing the performance of other porous and nonporous crystals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Nikita Gupta, Z. V. P. Murthy
Summary: The study showed that ZIF-67 can enhance the pure water flux of polysulfone membranes, but a high concentration of ZIF-67 in the membrane may lead to a decrease in salt rejection and permeate collection.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nikita Kulachenkov, Quentin Haar, Sergei Shipilovskikh, Andrei Yankin, Jean-Francois Pierson, Alexandre Nomine, Valentin A. Milichko
Summary: The digital industry faces dangers of raw material shortages and needs to consider resource sustainability; Metal-organic frameworks are gaining attention as a sustainable solution with potential for various storage devices; MOFs are seen as a new generation of sustainable materials that can bring many benefits to microelectronic devices.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Linna Liang, Ye Zhong, Jiamin Chen, Jianguo Zhang, Tonglai Zhang, Zhimin Li
Summary: A novel bimetallic MOF material was synthesized and found to have good thermal stability and high energy density. Additionally, the bimetallic MOF acted as a hypergolic promoter, reducing the ignition delay time of the hypergolic propellant and exhibiting better catalytic effect in the ionic liquid hypergolic ignition.
INORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Li-Hao Xu, Shen-Hui Li, Heng Mao, Yan Li, Ao-Shuai Zhang, Sen Wang, Wei-Min Liu, Jing Lv, Tao Wang, Wei-Wei Cai, Le Sang, Wen-Wen Xie, Chan Pei, Zheng-Zheng Li, Ying-Nan Feng, Zhi-Ping Zhao
Summary: This study presents a strategy to create highly flexible metal-organic framework nanosheet membranes for alcohol-water separation. The membranes exhibited ultrafast transport channels and achieved high flux and separation performance.
Article
Chemistry, Analytical
Chan Yang, Shuo Tian, Weiyu Qiu, Liuting Mo, Weiying Lin
Summary: Developing a nanotheranostic with high sensing performance and efficient therapy is significant for cancer diagnosis and treatment. In this study, a nanotheranostic was constructed using Au nanoparticles and hairpin-loaded photosensitive metal-organic framework (PMOF@AuNP/hairpin). The nanotheranostic not only facilitated efficient PDT through the conversion of O-2 into ROS, but also showed catalase-like activity to generate O-2 from H2O2, enhancing the antitumor effect of PDT. Additionally, it demonstrated high loading efficiency of hairpins and sensitive detection of miR-21 in living cells and in vivo, as well as dynamic monitoring of miR-21 level.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Deborah Turetsky, Diego M. Alzate-Sanchez, Megan C. Wasson, Anna Yang, Hyunho Noh, Ahmet Atilgan, Timur Islamoglu, Omar K. Farha, William R. Dichtel
Summary: This study synthesizes UiO-66-NH2 on cotton fabrics via a hot pressing method and improves the quality of MOFs by preactivating the fabric and modifying the synthesis method. The resulting composites demonstrate high MOF loadings and homogeneous coverage, showing efficient decontamination of nerve agents.
ACS MATERIALS LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Young-Moo Jo, Yong Kun Jo, Jong-Heun Lee, Ho Won Jang, In-Sung Hwang, Do Joon Yoo
Summary: In order to improve the performance of gas sensors and enhance the quality of life, the use of metal-organic frameworks (MOFs) as sensing materials has been explored. MOFs are known for their high surface area, porosity, and unique surface chemistry, making them promising for gas-sensor innovations. Various types of MOFs have been developed by studying their compositional and morphological dependences, and incorporating catalysts and light activation. Additionally, MOFs have multiple applications as molecular sieves, absorptive filtering layers, and heterogeneous catalysts due to their separation properties and catalytic activity.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Nikita Hanikel, Daria Kurandina, Saumil Chheda, Zhiling Zheng, Zichao Rong, S. Ephraim Neumann, Joachim Sauer, J. Ilja Siepmann, Laura Gagliardi, Omar M. Yaghi
Summary: A linker extension strategy is proposed to generate metal-organic frameworks (MOFs) with enhanced moisture-capturing properties. The design approach results in MOF-LA2-1 {[Al(OH)(PZVDC)], featuring a 50% increase in water capacity compared to MOF-303, the state-of-the-art water-harvesting material. The strategy not only increases the pore volume of the MOF, but also retains its ability to capture and release water in arid environments, while reducing regeneration heat and temperature.
ACS CENTRAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Michael A. Luzuriaga, Fabian C. Herbert, Olivia R. Brohlin, Jashkaran Gadhvi, Thomas Howlett, Arezoo Shahrivarkevishahi, Yalini H. Wijesundara, Sundharamani Venkitapathi, Kavya Veera, Ryanne Ehrman, Candace E. Benjamin, Sarah Popal, Michael D. Burton, Molly A. Ingersoll, Nicole J. De Nisco, Jeremiah J. Gassensmith
Summary: The increasing resistance of bacterial infections to antibiotics calls for next generation approaches to prevent potential pandemics. The development of vaccines against pathogenic bacteria has been challenging due to genetic diversity, but enhancing immunogenicity through slow releasing depots can significantly improve immune responses and survival rates.
Article
Chemistry, Multidisciplinary
Arezoo Shahrivarkevishahi, Michael A. Luzuriaga, Fabian C. Herbert, Alisia C. Tumac, Olivia R. Brohlin, Yalini H. Wijesundara, Abhinay Adlooru, Candace Benjamin, Hamilton Lee, Perouza Parsamian, Jashkaran Gadhvi, Nicole J. De Nisco, Jeremiah J. Gassensmith
Summary: A new generation immunophotothermal agent is developed by utilizing a chemically modified VLP called bacteriophage Q beta to adjuvant photothermal ablation. This system, named PhotothermalPhage, combines the benefits of near-infrared absorbing croconium dyes with the structure of VLPs to generate more heat and act as an immunoadjuvant, leading to effective tumor suppression and increased survival time.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Nanoscience & Nanotechnology
Michael A. Luzuriaga, Arezoo Shahrivarkevishahi, Fabian C. Herbert, Yalini H. Wijesundara, Jeremiah J. Gassensmith
Summary: Vaccines are a significant medical advancement that has prevented millions of deaths, but challenges like thermal sensitivity and required booster shots have been highlighted; integrating vaccine technology with biomaterials shows promise, offering sustained-release properties and thermal stabilization; advancements in sustained release biomaterial hold potential for infectious disease vaccines and thermally stable single-shot formulations in nanomedicine research.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shashini D. Diwakara, Whitney S. Y. Ong, Yalini H. Wijesundara, Robert L. Gearhart, Fabian C. Herbert, Sarah G. Fisher, Gregory T. McCandless, Sampath B. Alahakoon, Jeremiah J. Gassensmith, Sheel C. Dodani, Ronald A. Smaldone
Summary: This study successfully synthesized a novel COF called PyCOFamide, which has a pore size greater than 6 nm in diameter and shows permanent porosity and high crystallinity. The pore size of this COF is large enough to accommodate fluorescent proteins.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Olivia R. Brohlin, Ryanne N. Ehrman, Fabian C. Herbert, Yalini H. Wijesundara, Arun Raja, Arezoo Shahrivarkevishahi, Shashini D. Diwakara, Ronald A. Smaldone, Jeremiah J. Gassensmith
Summary: Metal-organic frameworks (MOFs) can stabilize proteins and oligonucleotides, protecting them from degradation and increasing their immunogenicity and adjuvanticity. By encapsulating the CpG oligonucleotide in a zinc-based MOF, the DNA is protected and shows improved cellular uptake, leading to enhanced B-cell activation.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
A. Shahrivarkevishahi, L. M. Hagge, O. R. Brohlin, S. Kumari, R. Ehrman, C. Benjamin, J. J. Gassensmith
Summary: Nanoparticle-based therapeutics, specifically virus-like particles-engineered and non-infectious self-assembling systems, offer a customizable tool for designing and engineering multicomponent therapeutic agents for cancer treatments. These systems overcome key barriers in small molecule therapeutics and provide biocompatibility, degradability, and the ability for chemical modifications.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Microbiology
Sundharamani Venkitapathi, Yalini H. Wijesundara, Samuel A. Cornelius, Fabian C. Herbert, Jeremiah J. Gassensmith, Philippe E. Zimmern, Nicole J. De Nisco
Summary: This study investigates the role of type 1 and type 3 fimbriae, important colonization factors encoded by all Klebsiella species, in bladder epithelial cell attachment of Klebsiella quasipneumoniae in vitro. The absence of the C-terminal phosphodiesterase (PDE) domain in the FimK protein of K. quasipneumoniae leads to a loss of cross-regulation of type 3 fimbriae expression. This finding contributes to the understanding of the virulence factors of K. quasipneumoniae and its role in urinary tract infections.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Virology
Mohamad Ammar Ayass, Trivendra Tripathi, Natalya Griko, Victor Pashkov, Jun Dai, Jin Zhang, Fabian C. Herbert, Ramya Ramankutty Nair, Tutku Okyay, Kevin Zhu, Jeremiah J. Gassensmith, Lina Abi-Mosleh
Summary: In this study, the researchers demonstrated the efficacy and safety of a novel single-stranded DNA aptamer, AYA2012004_L, in targeting and neutralizing the uptake of SARS-CoV-2 variants. The aptamer showed promising results in in vivo and in vitro experiments, making it a potential therapeutic agent for COVID-19 management.
Article
Multidisciplinary Sciences
Sneha Kumari, Yalini H. Wijesundara, Thomas S. Howlett, Mohammad Waliullah, Fabian C. Herbert, Arun Raja, Ikeda Trashi, Rodrigo A. Bernal, Jeremiah J. Gassensmith
Summary: This research explores the possibility of using biolistic delivery as an alternative to needle-and-syringe-based vaccine administration. By encapsulating liposomes in a nano-sized shell made of Zeolitic Imidazolate Framework-8 (ZIF-8), the liposomes are protected from stress and can effectively penetrate the skin. This work demonstrates the mechanical protection provided by ZIF-8 to liposomes and provides a preliminary investigation for using biolistic delivery as an alternative vaccine delivery method.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Sneha Kumari, Thomas S. Howlett, Ryanne N. Ehrman, Shailendra Koirala, Orikeda Trashi, Ikeda Trashi, Yalini H. Wijesundara, Jeremiah J. Gassensmith
Summary: ZIF-8 shows potential in antigen protection and slow-release platform, but its biosafety in mammalian intranasal administration is not well studied. We observed slower release of ZIF-8-coated liposomes in the nasal cavity due to degradation by mucosal fluid. We found no noticeable differences in diagnostic proteins, lung diffusing capacity, and tissue morphology after administering varying doses of ZIF-8.
Article
Chemistry, Multidisciplinary
Yalini H. Wijesundara, Fabian C. Herbert, Orikeda Trashi, Ikeda Trashi, Olivia R. Brohlin, Sneha Kumari, Thomas Howlett, Candace E. Benjamin, Arezoo Shahrivarkevishahi, Shashini D. Diwakara, Sachini D. Perera, Samuel A. Cornelius, Juan P. Vizuet, Kenneth J. Jr Jr Balkus, Ronald A. Smaldone, Nicole J. De Nisco, Jeremiah J. Gassensmith
Summary: This study introduces a method to achieve controlled delivery of protein, DNA, and RNA drugs by encapsulating them in ZIF-8, allowing for burst or slow release. The release profiles of these biomolecules can be modulated through judicious selection of carrier gases in the MOF-Jet.
Article
Biochemistry & Molecular Biology
Anjala W. Bulathge, Rhiza Lyne E. Villones, Fabian C. Herbert, Jeremiah J. Gassensmith, Gabriele Meloni
Summary: This study investigated the preferential reactivity of cisplatin towards human Zn7MT-2, MTF-1 zinc fingers, and the entire MTF-1 zinc finger domain through in vitro competition reactions. The results demonstrated that cisplatin preferentially reacts with Zn7MT-2, releasing zinc and triggering MTF-1 activation and binding to specific DNA sequences.
