Article
Chemistry, Applied
Xiuling Ji, Suping Wang, Yiyong Luo, Xiaotian Yuan, Yunlin Wei, Qi Zhang, Kunhao Qin, Yujiao Tu
Summary: Fluorescent carbon dots (CDs) derived from Weissella sp. Kl-3, known as CDs-Ws, exhibit strong fluorescence, excellent biocompatibility, and low cytotoxicity. CDs-Ws can selectively label and differentiate cells, as well as function as a fluorescence nanosensor for detecting Cr(VI) and VB12 with high sensitivity and detection limits. The CDs-Ws show great potential in bioimaging and detection of specific substances.
Article
Chemistry, Analytical
Bin Wang, Xiao-Qin Zhou, Jun-Ming Lin, Shu-Yu Liu, Cong-Hua Lu, Li-Juan Liu, Yu Chen, Li-Ping Yu
Summary: The study synthesized HPEI-CDs with concentration-modulated dual-excitation fluorescence property and successfully detected Fe3+ using them as a ratiometric sensor, demonstrating a wide linear response concentration range and low detection limit. The sensor showed good selectivity and anti-interference capacity due to the high concentration of HPEI-CDs.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Jorge Espina-Casado, Tania Fontanil, Alfonso Fernandez-Gonzalez, Santiago Cal, Alvaro J. Obaya, Marta Elena Diaz-Garcia, Rosana Badia-Laino
Summary: Carbon dots were synthesized from glutathione and surface-modified with beta-Cyclodextrin and FP, showing potential applications as drug carriers. The fluorescence changes allowed distinction of cancer cells with no alterations in cell morphology, enabling bioimaging and cancer diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Zahra Golsanamlou, Jafar Soleymani, Soheil Abbaspour, Mohammadreza Siahi-Shadbad, Elaheh Rahimpour, Abolghasem Jouyban
Summary: A novel amine-functionalized silica quantum dots fluorescent nanoprobe was developed for sensing lead concentration and tracing; the probe showed high sensitivity and specificity; it exhibited excellent cell membrane permeability and biocompatibility for intracellular applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Jia An, Guoyi Liu, Meizhu Chen, Yongqin Hu, Rubing Chen, Ying Lyu, Chao Zhang, Yufei Liu
Summary: A simple and universal method was developed to synthesize CDs-silica (SiO2) spheres composites with high fluorescence enhancement and easy purification. The fabricated composites showed superior photoluminescence (PL) stability and intensity even in tough environments, potentially expanding the applications of CDs in clinical analysis, optical sensing, bioimaging, and light-emitting diodes (LEDs).
Review
Chemistry, Physical
Fengming Lin, Chenyang Jia, Fu-Gen Wu
Summary: This article reviews the recent progress in the use of carbon dots (CDs) for intracellular detection, including fluorescence imaging, fluorescence detection, and monitoring of cellular parameters. The synthesis, functionalization, and performance of CDs as fluorescent nanoprobes are also discussed, along with their working mechanisms and future research directions.
Article
Chemistry, Physical
Hongwei Zhao, Rui Li, Yinxiu Wang, Zhonghua Zhao, Shaomin Shuang
Summary: In this study, red-emitting nitrogen-doped carbon dots (N-CDs) were synthesized using p-phenylenediamine and poly-ethylene glycol 20,000 as precursors. The N-CDs exhibited uniform spherical shape with an average particle size of 2.36 nm. These N-CDs displayed excitation-independent fluorescence with optimal excitation and maximum emission wavelengths at 487 and 628 nm, respectively. The prepared N-CDs demonstrated rapid and highly selective recognition of Cu2+ with a detection limit of 45.87 μM, and the addition of Cu2+ caused a visible color change of the N-CDs solution. Furthermore, a smartphone-based platform was developed for real-time detection of Cu2+ in the linear range of 20-140 μM, with a detection limit of 35.83 μM.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Analytical
Le Minh Tu Phan, Thi Xoan Hoang, Sungbo Cho
Summary: Iron dyshomeostasis at a cellular level may lead to oxidative stress and neuronal damage. A study has developed nitrogen-doped carbon dots (NCDs) as a fluorescence probe for accurate detection and visualization of intracellular iron ions. The NCDs exhibit high biocompatibility, strong fluorescence properties, selectivity, and rapid response.
Article
Chemistry, Physical
Songrui Li, Xuerong Song, Zhiru Hu, Guodong Feng
Summary: A new fluorescent and pH-dependent carbon dots-based ratiometric probe was developed using one-pot hydrothermal method, showing promising application in living systems for tracking pH changes.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Physical
Alan Meng, Yue Zhang, Xianghu Wang, Qinhai Xu, Zhenjiang Li, Liying Sheng, Lijun Yan
Summary: In this study, boron-doped carbon quantum dots were synthesized and demonstrated excellent selectivity and sensitivity for mercury ions. They also showed potential as a bioimaging agent.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
YingTe Wang, RongRong Wu, YuanYuan Zhang, SiRong Cheng, Yong Zhang
Summary: N-doped carbon dots (N-CDs) with green fluorescence were synthesized by hydrothermal reaction using o-aminophenol and ethylenediamine as carbon and nitrogen sources, and they exhibited a quantum yield of 38.4%. The N-CDs were characterized by FT-IR, XPS, UV-vis, and fluorescence spectroscopy, confirming their excellent fluorescence properties and stability. Furthermore, the N-CDs were utilized as a sensor for Ag+ detection through static quenching effect, with a linear range of 30-210 μmol/L and a detection limit of 4.7 μmol/L. The N-CDs also showed potential applications in bioimaging for Ag+ sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Juan Yue, Ling Yu, Li Li, Pai Liu, Qian Mei, Wen-Fei Dong, Ru Yang
Summary: Chloride ion is essential for maintaining normal cell functions, and a green fluorescent carbon quantum dot was developed for accurate detection through an off-on mechanism, with a low detection limit. Cell and zebrafish experiments confirmed the biosafety and biocompatibility of the carbon dots.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Meng Yang, Hui Jin, Rijun Gui
Summary: In this study, a metal-doping strategy was proposed to construct metal-doped borophene and boron quantum dots (BQDs). Ag+ was identified as the optimal metal ion for preparing Ag+-doped borophene derived BQDs (Ag-BQDs) based on theoretical calculations. The doping of Ag+ enhanced the stability and fluorescence properties of borophene. Experimental results demonstrated the excellent performance of Ag-BQDs in various applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Juan Yue, Qian Mei, Panyong Wang, Peng Miao, Wen-Fei Dong, Li Li
Summary: The yellow fluorescent carbon dots (CDs) for detecting GSSG through a fluorescence off-on process show linear correlation with GSSG concentration and a detection limit of 0.18mu M. Additionally, the CDs can also be used for fluorescence imaging in living cells and zebrafish.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Lijuan Liu, Shengting Zhang, Xiaodan Zheng, Hongmei Li, Qi Chen, Kunhao Qin, Yafang Ding, Yunlin Wei
Summary: Intracellular Fe3+ plays a critical role in human health, and the development of efficient probes for its detection is crucial for early disease diagnosis. Carbon dots synthesized from Fusobacterium nucleatum demonstrate strong fluorescence, stability, and biocompatibility, with promising applications for intracellular Fe3+ detection in vivo.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Physical
Gurvinder Singh, Hesamodin Jami, Pooria Lesani, Shubhayan Bhattacharya, Yogambha Ramaswamy, Prem B. Bisht, Hala Zreiqat
Summary: Understanding surface processes is crucial in producing reproducibly stellated or branched gold nanoparticles with precise control. By tuning reaction variables, such as reduction rate and molecules/ions density, various shapes of thermodynamically stabilized and kinetic gold nanoparticles can be obtained. High temperature stability and self-assembly abilities of these nanoparticles have been studied, showing potential for advanced applications.
Review
Materials Science, Multidisciplinary
Zaheri Mahmud, Mahbub Hassan, Anwarul Hasan, Vincent G. Gomes
Summary: The fabrication of 3D printed nanocomposites can meet the functional requirements of complex vascular structures, serving as an effective intervention against cardiovascular diseases.
Article
Biophysics
Van Chinh Hoang, Atefeh Shafaat, Skaidre Jankovskaja, Vincent G. Gomes, Tautgirdas Ruzgas
Summary: By evaluating biosensors in Franz cell setup, opportunities and obstacles can be better understood to avoid issues during testing in animals and humans.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Cell Biology
Fareed Sairi, Vincent G. Gomes, Fariba Dehghani, Peter Valtchev
Summary: This study investigates the impact of cell culture conditions on the synthesis of hemocyanin by Rhongocyte cells. The results show that the addition of lipoprotein supplement to the culture media leads to a burst secretion of hemocyanin. The study also demonstrates that the culture time and composition of the media affect the cell growth and hemocyanin synthesis.
CELL AND TISSUE RESEARCH
(2022)
Article
Engineering, Biomedical
Aklima Nasrin, Mahbub Hassan, Maria Montero Mirabet, Norbert Windhab, Vincent G. Gomes
Summary: Multifunctional 3D-printed nanocomposites based on PLGA were developed for bone tissue engineering, with CQDs enhancing cell biocompatibility, promoting cellular nesting, and improving osteogenesis.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Chemistry, Physical
Vijay Kumar Sagar, Soumyodeep Dey, Shubhayan Bhattacharya, Pooria Lesani, Yogambha Ramaswamy, Gurvinder Singh, Hala Zreiqat, Prem Ballabh Bisht
Summary: In this study, long wavelength emitting nitrogen and sulfur co-doped graphene quantum dots were synthesized via hydrothermal route, exhibiting high quantum yield and excitation-wavelength independent photoluminescence. The interaction of these quantum dots with a dye rhodamine B showed evidence of Förster resonance energy transfer (FRET), along with the capability of two-photon absorption at near infrared wavelength for deep-tissue imaging up to 175 µm.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Polymer Science
Zaheri Mahmud, Aklima Nasrin, Mahbub Hassan, Vincent G. Gomes
Summary: Nanocomposites fabricated through 3D printing technology for small diameter vascular stents exhibit improved properties when carbon quantum dots are added, enhancing hydrophilicity, tensile strength, compressive strength, and cell proliferation. The combination of bioresorbable polymer and carbon quantum dots shows promise for cardiovascular applications with noninvasive imaging for monitoring composite condition and cell growth.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Engineering, Environmental
Pooria Lesani, Gurvinder Singh, Zufu Lu, Mohammad Mirkhalaf, Elizabeth J. New, Hala Zreiqat
Summary: We report the design and development of a two-photon ratiometric carbon dot-based nanoprobe for real-time monitoring of intracellular pH. The nanoprobe exhibits sensitivity across a wide pH range, remarkable thermal and photo stability, as well as two-photon near-infrared excitation capability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
G. Singh, T. Agrawal, P. Lesani, P. B. Bisht, H. Zreiqat
Summary: This study introduces a simplified seed-mediated method to control the surface structure and stability of concave cubic gold nanoparticles by manipulating different halides and their concentrations, achieving precise control over the size, morphology, and plasmonic properties of the nanoparticles.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
ZuFu Lu, Gurvinder Singh, Pooria Lesani, Hala Zreiqat
Summary: This article discusses the impact of cellular senescence on tissue regeneration capacity and explores the potential of nanotechnology in restoring and enhancing tissue regeneration ability in the aging population.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Engineering, Environmental
Khyati Dave, Zaheri Mahmud, Vincent G. Gomes
Summary: This study explores the enhancement of cellular adhesion, growth, proliferation, differentiation, and migration on polymer-based scaffolds by fabricating biocompatible scaffolds with quantum nanoparticle additives and surface functionalization. The results show that plasma treatment increases cellular proliferation, and carbon dots introduce nanoscale roughness on the scaffolds. The plasma-treated PLA-CD composite has the potential to produce high-performance scaffolds for tissue engineering.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Geriatrics & Gerontology
ZuFu Lu, Liting Jiang, Pooria Lesani, WenJie Zhang, Ning Li, Danyang Luo, Yusi Li, Yulin Ye, Ji Bian, Guocheng Wang, Colin R. Dunstan, XinQuan Jiang, Hala Zreiqat
Summary: This study shows that nicotinamide mononucleotide (NMN) could partially reverse the negative effects of tumor necrosis factor-alpha (TNF-α) on osteoblasts, including inducing senescence, reducing differentiation ability, and affecting mitochondrial function. In addition, NMN can protect cells from aging damage by increasing mitophagy activity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Khyati Dave, Vincent G. Gomes
Summary: The study focused on optimized 3D printing of bioresorbable scaffolds with fluorescent carbon quantum dots (CDs) to enhance cell proliferation, bone mineralization, and osteogenic differentiation. The CD-based scaffolds showed better outcomes compared to toxic dyes used clinically, with increased cellular proliferation, bone mineralization, and osteogenic differentiation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Review
Materials Science, Multidisciplinary
Pooria Lesani, Aina Hazeera Mohamad Hadi, Zufu Lu, Stefano Palomba, Elizabeth J. New, Hala Zreiqat
Summary: Carbon dots are promising for various biological applications due to their unique physicochemical properties. Red-emissive two-photon carbon dots have gained increasing attention recently, showing superior properties and broad applications in bioimaging, biosensing, and phototherapeutic fields.
COMMUNICATIONS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Pooria Lesani, Zufu Lu, Gurvinder Singh, Maya Mursi, Mohammad Mirkhalaf, Elizabeth J. New, Hala Zreiqat
Summary: Carbon dots (CDs) are widely studied for biological imaging applications, and one-step hydrothermal synthesis is considered a promising method due to its simplicity and low cost. Optimizing synthetic parameters can improve optical properties and cellular uptake efficiency, opening new pathways for designing CDs tailored for specific biomedical applications.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)