4.6 Review Book Chapter

The Lymphatic System in Disease Processes and Cancer Progression

期刊

出版社

ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-112315-031200

关键词

lymphatic vessels; lymphedema; lymph node metastasis; lymphatic pumping; lymph transport; lymphangiogenesis

资金

  1. NATIONAL CANCER INSTITUTE [R00CA137167, R01CA149285, P01CA080124] Funding Source: NIH RePORTER
  2. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL128168, R01HL106584] Funding Source: NIH RePORTER
  3. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI097745] Funding Source: NIH RePORTER
  4. OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD008780] Funding Source: NIH RePORTER
  5. NCI NIH HHS [R01 CA149285, R00 CA137167, P01 CA080124] Funding Source: Medline
  6. NHLBI NIH HHS [R01 HL128168, R01 HL106584] Funding Source: Medline
  7. NIAID NIH HHS [R21 AI097745] Funding Source: Medline
  8. NIH HHS [DP2 OD008780] Funding Source: Medline

向作者/读者索取更多资源

Advances in our understanding of the structure and function of the lymphatic system have made it possible to identify its role in a variety of disease processes. Because it is involved not only in fluid homeostasis but also in immune cell trafficking, the lymphatic system can mediate and ultimately alter immune responses. Our rapidly increasing knowledge of the molecular control of the lymphatic system will inevitably lead to new and effective therapies for patients with lymphatic dysfunction. In this review, we discuss the molecular and physiological control of lymphatic vessel function and explore how the lymphatic system contributes to many disease processes, including cancer and lymphedema.

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