期刊
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
卷 89, 期 3, 页码 499-504出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363219030228
关键词
combretastatin-A4; cefozopram; 1,2,4-thiadiazoles; anticancer activity
A new series of amide derivatives of structurally modified combretastatin-A4 10a-10j are synthesized, and their structures are confirmed by H-1 and C-13 NMR, and mass spectral data. The products are tested for their anticancer activity towards human cancer cell lines, MCF-7 (breast), A-549 (lung), Colo-205 (colon), and A-2780 (ovarian). The compounds 10b, 10c, and 10d demonstrate the most promising activity.
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