期刊
REPRODUCTIVE TOXICOLOGY
卷 87, 期 -, 页码 100-107出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2019.05.064
关键词
Marijuana; Cannabinoids; THC; CBD; Endometrial stromal cells; Decidua; Decidualization; Trophoblast-endometrium cross -talk models; Embryo; Fertility; Reproduction; Medicine
资金
- National Institute on Drug Abuse [DA032507]
- University of Washington National Institute on Drug Abuse
Marijuana (cannabis) use by pregnant women in the United States is increasing and there is a dire need to understand the beneficial or harmful effects of cannabis during pregnancy. Uterine endometrial stromal cells are fibroblast-like cells that differentiate into secretory cells, a process called decidualization, to create a micro environment conducive for placenta formation and early embryonic growth. In this study, using model human cell lines, we for the first time demonstrate that Delta(9)-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) inhibit endometrial stromal cell decidualization and have adverse effects on trophoblast-endometrium cross-talk.
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