期刊
BIOMARKERS
卷 20, 期 6-7, 页码 453-459出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1096305
关键词
Ischemia; reperfusion; renal cortex; renal dysfunction; tubular injury
资金
- Mexican Council of Science and Technology [CONACyT 235855, 181267]
- National University of Mexico [IN223915]
We demonstrated that urinary heat shock protein of 72 KDa (Hsp72) is a sensitive biomarker for the early detection of acute kidney injury (AKI). However, whether Hsp72 induction during an AKI episode is kidney-specific is unknown, as well as, the degree of Hsp72 stability in urine samples. In rats that underwent bilateral renal ischemia and reperfusion (I/R), Hsp72 levels were evaluated in several tissues and in collected urines under different storage and temperature conditions, as well as in variable numbers of freeze-thaw cycles. The effect of room temperature and five freeze-thaw cycles on urinary Hsp72 levels was also evaluated in urine samples from AKI patients. We found that Hsp72 increased exclusively in the renal cortex of I/R group, emphasizing its performance as an AKI biomarker. Urinary-Hsp72 remained constant at room temperature (48 h), during 9 months of storage and was not affected by five freeze/thaw cycles.
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