期刊
PSYCHOTHERAPY AND PSYCHOSOMATICS
卷 88, 期 3, 页码 171-176出版社
KARGER
DOI: 10.1159/000498854
关键词
Bipolar disorder; Lithium therapy; Grey matter increase; Neurite density
资金
- French Agence Nationale pour la Recherche [ANR-11-IDEX-0004 Labex BioPsy, ANR-10-COHO-10-01 psyCOH, ANR-DFG ANR-14-CE35-0035 FUNDO]
- Fondation pour la Recherche Medicale (Bioinformatique pour la biologie 2014)
- Fondation de l'Avenir (Recherche Medicale Appliquee 2014)
- life-insurance company AG2R La Mondiale
- APHP
- LabEx Bio-Psy
- French program Investissement d'Avenir by the Agence Nationale pour la Recherche
- grant Infrastructure d'avenir en Biologie Sante [ANR-11-INBS-0006]
Background: MRI studies in patients with bipolar disorder have suggested that lithium is associated with grey matter increases that may underlie its therapeutic effects. However, the relationship between grey matter volume and cellular microstructural changes is not straightforward, as modifications of different cellular compartments of grey matter may be involved. Objectives: Our aim was to test the hypothesis that dendritic density is higher in patients undergoing lithium therapy than in patients without lithium, using advanced modelling of water diffusion investigated with MRI. Method: We included 41 patients and 40 controls matched for age and gender from two sites. All subjects underwent 3T MRI with 3 shells of diffusion. We used neurite orientation dispersion and density imaging to compare the grey matter neurite density between patients undergoing lithium therapy or not and control subjects. Results: We found a significant group effect in the left prefrontal region (p = 0.001, Bonferroni corrected): patients without lithium had a lower frontal neurite density than controls (p = 0.009), while those on lithium had a higher mean neurite density than those without (p < 0.001). Patients on lithium were not different from controls (p = 0.08). Conclusions: This is the first study to report in vivo evidence of preserved neurite density of the prefrontal cortex in humans associated with lithium intake. Changes of intracellular volume fraction are thought to reflect changes of grey matter microstructural organization. This reinforces the hypothesis of lithium having a positive effect on the neuronal compartment in humans.
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