期刊
BIOMARKERS
卷 20, 期 4, 页码 232-239出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1068853
关键词
Angiogenesis; IL-17; non-small cell lung cancer; prognosis; VEGF
资金
- National Natural Science Foundation of China [81101758, 81201828]
- Special Chinese National Postdoctoral Science Foundation [2013T60389]
- Chinese National Postdoctoral Science Foundation [2012M11514]
- Young People Foundation of Heilongjiang Provincial of China [QC2012C013]
- Harbin city science and Technology Bureau [2014RFXGJ039]
- Wu Jieping project [320.6750.12311, 320.6750.12204]
Objective: The aim of this study was to explore the clinical role of serum interleukin-17 in patients with non-small-cell lung cancer (NSCLC). Materials and method: IL-17 expression and microvessel density (MVD) were measured via immunohistochemistry in 58 NSCLC tissues. Serum IL-17 and VEGF levels in NSCLC patients (n = 43) and healthy controls (n = 37) were analyzed via enzyme-linked immunosorbent assay. Results: Serum IL-17 was elevated and the levels positively correlated with VEGF concentration in NSCLC patients. Multivariate analyses revealed that serum IL-17 levels were an independent prognostic factor in NSCLC. Conclusion: IL-17 may play a role in NSCLC progression by promoting angiogenesis.
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