Review
Medicine, General & Internal
Lie Zheng, Sheng-Lei Duan, Yan-Cheng Dai, Shi-Cheng Wu
Summary: This review explores the relationship between adherent invasive E. coli (AIEC) and inflammatory bowel disease (IBD), including the relationship between AIEC and the intestinal immune system, the prevalence and relevance of AIEC in patients with Crohn's disease and ulcerative colitis, and the relationship between AIEC and disease site, activity, and postoperative recurrence. Furthermore, potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa are highlighted.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Medicine, General & Internal
Razie Kamali Dolatabadi, Awat Feizi, Mehrdad Halaji, Hossein Fazeli, Peyman Adibi
Summary: This study revealed that colonization by AIEC is more frequent in IBD and is associated with IBD (CD and UC). The most frequent AIEC phylogroup in the IBD, CD, and control groups was B-2.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Waleska Saitz, David A. Montero, Mirka Pardo, Daniela Araya, Marjorie De la Fuente, Marcela A. Hermoso, Mauricio J. Farfan, Daniel Ginard, Ramon Rossello-Mora, Dave A. Rasko, Felipe Del Canto, Roberto M. Vidal
Summary: The study aimed to identify molecular markers for screening AIEC strains. By analyzing outer membrane proteins and genes in AIEC strains, the study found that chuA, eefC, and fitA genes are significantly correlated with AIEC strains and can serve as markers for AIEC strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yancong Zhang, Amrisha Bhosle, Sena Bae, Lauren J. McIver, Gleb Pishchany, Emma K. Accorsi, Kelsey N. Thompson, Cesar Arze, Ya Wang, Ayshwarya Subramanian, Sean M. Kearney, April Pawluk, Damian R. Plichta, Ali Rahnavard, Afrah Shafquat, Ramnik J. Xavier, Hera Vlamakis, Wendy S. Garrett, Andy Krueger, Curtis Huttenhower, Eric A. Franzosa
Summary: This article investigates the role of microbial communities and their associated bioactive compounds in inflammatory bowel diseases (IBD). It systematically identifies potentially bioactive protein families involved in gut inflammation during IBD and validates their bioactivity using a combination of metagenomics, metatranscriptomics, and metaproteomics. The results provide candidate microbial proteins that interact with the host immune system in IBD, expanding our understanding of potentially bioactive gene products in chronic diseases.
Review
Microbiology
Li Zhang, Fang Liu, Jessica Xue, Seul A. Lee, Lu Liu, Stephen M. Riordan
Summary: This article reviews bacterial species associated with human IBD and their pathogenic mechanisms and proposes a three-stage pathogenesis model. Furthermore, microbe-targeted therapeutic strategies based on this model are recommended.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Romana R. Gerner, Suzana Hossain, Artur Sargun, Kareem Siada, Grant J. Norton, Tengfei Zheng, Wilma Neumann, Sean-Paul Nuccio, Elizabeth M. Nolan, Manuela Raffatellu
Summary: Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the gastrointestinal tract and alterations to the gut microbiome. This study found that immunization targeting siderophores reduced the colonization and association of adherent-invasive Escherichia coli (AIEC) with the gut mucosa, leading to a reduction in colitis severity. The study also laid the foundation for developing monoclonal antibodies against siderophores as a potential therapeutic strategy.
Article
Gastroenterology & Hepatology
Allison Agus, Damien Richard, Tiphanie Fais, Emilie Vazeille, Melissa Chervy, Virginie Bonnin, Guillaume Dalmasso, Jeremy Denizot, Elisabeth Billard, Richard Bonnet, Anthony Buisson, Nicolas Barnich, Julien Delmas
Summary: Crohn's disease is a chronic inflammatory disorder influenced by gut microbiota, genetics, and environment. Dysbiosis, including an increase in pathogenic bacteria like AIEC and a decrease in anti-inflammatory SCFAs, is common in CD patients. Targeting SCFAs with a GPR43 agonist shows potential for controlling gut inflammation in CD.
Review
Biochemistry & Molecular Biology
Patricia Teixeira Santana, Siane Lopes Bittencourt Rosas, Beatriz Elias Ribeiro, Ygor Marinho, Heitor S. P. de Souza
Summary: Microbe-host communication is crucial for maintaining vital functions of a healthy host. Disruption of this communication is associated with various diseases, including Crohn's disease and ulcerative colitis. Identifying microorganisms that affect disease susceptibility and phenotypes in humans is still challenging. Recent insights into the role of diet and environmental factors on the gut microbiome have direct implications for the immune response and the development of IBD. The complexity of IBD pathogenesis suggests the need for an integrative approach to identify specific therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Vadim Dubinsky, Leah Reshef, Keren Rabinowitz, Nir Wasserberg, Iris Dotan, Uri Gophna
Summary: This study reveals that Escherichia coli is a commensal species adapted to the overactive mucosal immune milieu in inflammatory bowel disease (IBD) rather than causing it. Mutations that may lead to attenuated antigenicity in some E. coli strains are also identified.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
Mireia Lopez-Siles, Carla Camprubi-Font, Eva M. Gomez del Pulgar, Miriam Sabat Mir, David Busquets, Yolanda Sanz, Margarita Martinez-Medina
Summary: The study found that adherent-invasive Escherichia coli (AIEC) may be associated with both Crohn's disease (CD) and ulcerative colitis (UC), but not with colorectal cancer (CRC). Additionally, further research on E. coli strains in celiac disease (CeD) would be of interest.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xu Zhilu, Dong Xiangqian, Yang Keli, Chevarin Caroline, Zhang Jingwan, Lin Yu, Zuo Tao, Chu Lok Cheung, Sun Yang, Zhang Fengrui, Chan Francis Kl, Sung Joseph Jy, Yu Jun, Buisson Anthony, Barnich Nicolas, Colombel Jean-Frederic, Wong Sunny Hei, Miao Yinglei, Ng C. Siew
Summary: The study found a high prevalence of AIEC in CD patients in Hong Kong, which was associated with severe microbiota dysbiosis and impeded restoration of normal gut microbiota. AIEC may serve as a keystone bacterium in CD and impact the efficacy of FMT.
Article
Clinical Neurology
Donghui Wang, Xiaoshuang Zhang, Hongwu Du
Summary: Alzheimer's disease is a central nervous system disease associated with intestinal microbes and inflammatory bowel disease. Patients with inflammatory bowel disease are at a higher risk of developing Alzheimer's disease.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Immunology
Alaullah Sheikh, James M. Fleckenstein
Summary: Pathogenic Escherichia coli can be classified into specific variants (pathovars) based on their behavior and the expression of specific virulence factors. These pathogens interact with CEACAMs through both core elements common to all E. coli and pathovar-specific virulence traits that target the IgV regions of CEACAMs. Recent data suggests that these interactions may not only benefit the pathogen but also provide a mechanism for pathogen elimination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Olivia Dwijayanti Wiguna, Diana Elizabeth Waturangi, Yogiara
Summary: This study found that DW-EC bacteriophage isolated from Indonesian traditional food has inhibitory and destructive effects on the biofilms of pathogenic E. coli, and its activity is significantly higher than that against B. cereus. This indicates that DW-EC bacteriophage has the potential to be used as an anti-biofilm candidate for polystyrene and stainless steel equipment in the food industry.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Lacey R. Lopez, Ju-Hyun Ahn, Tomaz Alves, Janelle C. Arthur
Summary: Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and severe comorbidities. Disease-associated alterations to the intestinal microbiota and microbial metabolites play a crucial role in IBD development. Understanding the microbial function in the context of IBD and characterizing disease-associated microbial metabolites are necessary for targeted treatment strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jun-young Kim, Joel Cramer, Kyujoon Lee, Dong-Soo Han, Dongwook Go, Pavel Salev, Pavel N. Lapa, Nicolas M. Vargas, Ivan K. Schuller, Yuriy Mokrousov, Gerhard Jakob, Mathias Klaeui
Summary: This study investigates current-induced spin-orbit torques in VO2/NiFe heterostructures and reveals that the change in spin absorption across the VO2 phase transition leads to a twofold increase in the Gilbert damping parameter alpha with temperature. Furthermore, a significant modulation and sign change of the current-induced spin-orbit torque across the VO2 phase transition suggest the existence of two competing spin-orbit torque generating mechanisms.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Gastroenterology & Hepatology
Yong Eun Park, Yoo Jin Lee, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seong-Eun Kim, Seung-Jae Myung
Summary: The optimal management of patients with inflammatory bowel disease during the COVID-19 pandemic has been a challenge. The Korean Association for the Study of Intestinal Diseases developed a consensus statement to provide recommendations for the risk and treatment of COVID-19 in IBD patients. The statement emphasizes that IBD is not a risk factor for COVID-19 and advises on maintaining medications to avoid exacerbating the disease.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Miyoung Choi, Seung-Jae Myung
Summary: This article introduces an expert consensus statement on COVID-19 vaccination issues for Korean IBD patients developed by the Korean Association for the Study of Intestinal Diseases. It emphasizes the importance of COVID-19 vaccination for IBD patients and states that it is safe for IBD patients receiving immunomodulatory therapy.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Seung Wook Hong, Byong Duk Ye, Jae Hee Cheon, Ji Hyun Lee, Ja Seol Koo, Byung Ik Jang, Kang-Moon Lee, You Sun Kim, Tae Oh Kim, Jong Pil Im, Geun Am Song, Sung-Ae Jung, Hyun Soo Kim, Dong Il Park, Hyun-Soo Kim, Kyu Chan Huh, Young-Ho Kim, Jae Myung Cha, Geom Seog Seo, Chang Hwan Choi, Hyun Joo Song, Gwang Ho Baik, Ji Won Kim, Sung Jae Shin, Young Sook Park, Chang Kyun Lee, Jun Lee, Sung Hee Jung, Yunho Jung, Sung Chul Park, Young-Eun Joo, Yoon Tae Jeen, Dong Soo Han, Suk-Kyun Yang, Hyo Jong Kim, Won Ho Kim, Joo Sung Kim
Article
Biochemistry & Molecular Biology
Jae Gon Lee, Jiyoung Lee, A-reum Lee, Su Vin Jo, Chan Hyuk Park, Dong Soo Han, Chang Soo Eun
Summary: Supplementation of SCFAs did not lead to a significant reduction in colon inflammation, but it did increase the expression of regulatory T cells and IL-17-producing T cells, as well as promote both protective and aggressive gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Health Care Sciences & Services
Eun Jeong Gong, Chan Hyuk Park, Da Hyun Jung, Sun Hyung Kang, Ju Yup Lee, Hyun Lim, Do Hoon Kim
Summary: This study comprehensively evaluated the efficacy of various endoscopic and surgical treatments for gastroesophageal reflux disease (GERD). The results showed that endoscopic plication, reinforcement of the lower esophageal sphincter (LES), and surgical fundoplication were effective in reducing the requirement of proton pump inhibitor (PPI) continuation compared to PPI therapy. Radiofrequency energy delivery also tended to reduce the requirement of PPI continuation. All endoscopic and surgical treatments were superior to PPI therapy in terms of GERD-health-related quality of life questionnaire score (GERD-HRQL).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Chan Hyuk Park, Jung Ho Park, Yoon Suk Jung
Summary: Immunosuppressive therapy (IST) negatively affects the performance of interferon gamma release assays (IGRAs) in patients with inflammatory bowel disease (IBD), supporting the need for IGRA screening before initiating IST. Using both an IGRA and tuberculin skin test (TST) in IBD patients on IST may improve the diagnosis rate of latent tuberculosis infection (LTBI).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Seung In Seo, Tae Jun Kim, Chan Hyuk Park, Chang Seok Bang, Kyung Joo Lee, Jinseob Kim, Hyon Hee Kim, Woon Geon Shin
Summary: This study found that the use of metformin in patients with diabetes may reduce the risk of colorectal cancer incidence and improve overall survival, based on an analysis of the Korean National Health Insurance Service database.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Yoo Jin Lee, Seong-Eun Kim, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Jae Gon Lee, Hee Chan Yang, Seung-Jae Myung
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Sang Pyo Lee, Hyun Joo Jang, Sea Hyub Kae, Jae Gon Lee
Summary: This study compared the outcomes of two ESD methods for gastric body tumors and found that both the pocket-creation method and conventional method had similar treatment success rates and complication rates. There were no significant differences in hospitalization period, resection margin status, incidence of surgical operation, procedure time, or inflammatory response after ESD between the two groups.
Article
Nutrition & Dietetics
Sang Young Kim, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: This study found a significant association between high glycemic index and glycemic load and an increased risk of gastric cancer, especially among males, older individuals, smokers, drinkers, and people with Helicobacter pylori infection.
NUTRITION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim
Summary: This study provides evidence that infliximab is effective and well-tolerated in patients with moderate-to-severe active intestinal Behcet's disease.
Article
Nutrition & Dietetics
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: This study evaluated the association of individual or a combination of protective foods on the incidence of gastric cancer in H. pylori-positive subjects. Results showed that a higher intake of soy products and fruits was associated with a lower risk of gastric cancer. Additionally, the combination of soy products or fruits with dairy products also reduced the risk of gastric cancer.
NUTRITION RESEARCH AND PRACTICE
(2023)
Article
Health Care Sciences & Services
Chan Hyuk Park, Myung Jin Song, Byung Wook Jung, Jung Ho Park, Yoon Suk Jung
Summary: In the treatment of Helicobacter pylori infection, a 10-day tegoprazan-based concomitant therapy showed higher eradication rate and lower adverse event rate compared to a 14-day tegoprazan-based triple therapy. The adherence rates were similar between the two therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Jae Gon Lee, Yong Eun Park, Ji Young Chang, Hyun Joo Song, Duk Hwan Kim, Young Joo Yang, Byung Chang Kim, Shin Hee Lee, Myung-Won You, Seong-Eun Kim
Summary: This systematic review and meta-analysis investigated the outcomes of medical treatment in immunocompromised and immunocompetent patients with diverticulitis. The results showed that immunocompromised patients had higher risks of emergency surgery, postoperative mortality, and overall mortality compared to immunocompetent patients, while there was no significant difference in postoperative mortality after elective surgery between the two groups.
INTESTINAL RESEARCH
(2023)