Non-genetic inheritance via the male germline in mammals

Single-cell multi-omics sequencing of human early embryos

(2018) Lin Li et al.   NATURE CELL BIOLOGY

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

Exploring the extent and scope of epigenetic inheritance

(2018) Elizabeth J. Radford   Nature Reviews Endocrinology

Effects of paternal high-fat diet and rearing environment on maternal investment and development of defensive responses in the offspring

(2018) Austin C. Korgan et al.   PSYCHONEUROENDOCRINOLOGY

Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment

(2018) Qianhua Xu et al.   TRENDS IN CELL BIOLOGY

Intergenerational Transmission of Gene Regulatory Information in Caenorhabditis elegans

(2018) Olga Minkina et al.   TRENDS IN GENETICS

Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice

(2018) Colin C. Conine et al.   DEVELOPMENTAL CELL

Associating cellular epigenetic models with human phenotypes

(2017) Tuuli Lappalainen et al.   NATURE REVIEWS GENETICS

Developmental origins of health and disease: current knowledge and potential mechanisms

(2017) Daniel J Hoffman et al.   NUTRITION REVIEWS

High-fat diet disrupts metabolism in two generations of rats in a parent-of-origin specific manner

(2016) T. J. G. Chambers et al.   Scientific Reports

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development

(2015) Shuiqiao Yuan et al.   DEVELOPMENT

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression

(2015) Minoru Terashima et al.   Epigenetics

Commentary: Far-reaching hypothesis or a step too far: the inheritance of acquired characteristics: Figure 1.

(2015) Luke Isbel et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Double-stranded RNA made inC. elegansneurons can enter the germline and cause transgenerational gene silencing

(2015) Sindhuja Devanapally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

(2015) K. Siklenka et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Nongenetic inheritance and transgenerational epigenetics

(2015) Moshe Szyf   TRENDS IN MOLECULAR MEDICINE

Response to: the nature of evidence for and against epigenetic inheritance

(2015) Piroska E. Szabó   GENOME BIOLOGY

The nature of evidence for and against epigenetic inheritance

(2015) Joseph H. Nadeau   GENOME BIOLOGY

Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

(2015) Khursheed Iqbal et al.   GENOME BIOLOGY

Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells

(2015) Miguel A. Brieño-Enríquez et al.   PLoS One

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Paternal Influences on Offspring Development: Behavioural and Epigenetic Pathways

(2014) K. Braun et al.   JOURNAL OF NEUROENDOCRINOLOGY

Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress

(2014) J Bohacek et al.   MOLECULAR PSYCHIATRY

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Epigenetic reprogramming in plant sexual reproduction

(2014) Tomokazu Kawashima et al.   NATURE REVIEWS GENETICS

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Oxidative Stress in Mouse Sperm Impairs Embryo Development, Fetal Growth and Alters Adiposity and Glucose Regulation in Female Offspring

(2014) Michelle Lane et al.   PLoS One

Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring

(2014) John J. Bromfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

Dynamic changes in DNA modification states during late gestation male germ line development in the rat

(2014) Catherine M Rose et al.   Epigenetics & Chromatin

Early life stress in fathers improves behavioural flexibility in their offspring

(2014) Katharina Gapp et al.   Nature Communications

Epigenetic reprogramming: preparing the epigenome for the next generation

(2013) Catherine M. Rose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa

(2013) Serap Erkek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

Daddy Issues: Paternal Effects on Phenotype

(2012) Oliver J. Rando   CELL

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects

(2012) Amanda J. Drake et al.   Epigenetics

Erratum: Corrigendum: Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

Epigenetic inheritance of a cocaine-resistance phenotype

(2012) Fair M Vassoler et al.   NATURE NEUROSCIENCE

Understanding transgenerational epigenetic inheritance via the gametes in mammals

(2012) Lucia Daxinger et al.   NATURE REVIEWS GENETICS

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

(2012) S. Seisenberger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations

(2012) Mohan Manikkam et al.   PLoS One

Paternal social enrichment effects on maternal behavior and offspring growth

(2012) R. Mashoodh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Unbiased Assessment of the Role of Imprinted Genes in an Intergenerational Model of Developmental Programming

(2012) Elizabeth J. Radford et al.   PLoS Genetics

Transgenerational epigenetic inheritance in plants

(2011) Marie-Theres Hauser et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR

(2011) Megan P. Hitchins et al.   CANCER CELL

Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans

(2011) Oded Rechavi et al.   CELL

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

De novo DNA methylation: a germ cell perspective

(2011) Sébastien A. Smallwood et al.   TRENDS IN GENETICS

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

(2008) J. C. Jimenez-Chillaron et al.   DIABETES

Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA in Caenorhabditis elegans

(2008) Rosa M. Alcazar et al.   GENETICS

Vinclozolin—The lack of a transgenerational effect after oral maternal exposure during organogenesis

(2008) S SCHNEIDER et al.   REPRODUCTIVE TOXICOLOGY