Article
Clinical Neurology
Roxanne Lofredi, Ute Scheller, Aurika Mindermann, Lucia K. Feldmann, Joachim K. Krauss, Assel Saryyeva, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: This study observed that movement speed gradually increased after cessation of pallidal stimulation in dystonia patients. The association between movement slowness and beta oscillations indicates symptom-specific oscillatory patterns in the motor circuit, which has implications for improving deep brain stimulation therapy.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Roxanne Lofredi, Ute Scheller, Aurika Mindermann, Lucia K. Feldmann, Joachim K. Krauss, Assel Saryyeva, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: Pallidal deep brain stimulation (DBS) can alleviate symptoms in dystonia patients, but it may also cause movement slowness. This study found that after the cessation of pallidal stimulation, the movement speed of dystonia patients increased over time. The beta oscillations in the pallidum were found to be associated with the variance in movement speed.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Adilijiang Aihemaitiniyazi, Huawei Zhang, Yue Hu, Tiemin Li, Changqing Liu
Summary: This study is the first meta-analysis demonstrating significant improvements in health-related quality of life in patients with acquired dystonia following deep brain stimulation (DBS). Both physical and mental aspects of life quality showed significant improvements after DBS.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Clarice Listik, Rubens Gisbert Cury, Sara Carvalho Barbosa Casagrande, Eduardo Listik, Debora Arnaut, Natally Santiago, Valquiria Aparecida Da Silva, Ricardo Galhardoni, Julia de Lima Arantes Machado, Jessica Campelo de Almeida, Egberto Reis Barbosa, Manoel Jacobsen Teixeira, Daniel Ciampi De Andrade
Summary: The study demonstrates that DBS surgery has significant improvement on non-motor symptoms in patients with refractory generalized inherited/idiopathic dystonia, especially in alleviating chronic pain.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Vanessa M. Holanda, Robert Stephen Eisinger, Leonardo Almeida, Takashi Tsuboi, Huimin Wang, Michael S. Okun, Wissam Deeb, Addie Patterson, Aparna Wagle Shukla, Janine Lobo Lopes, Kelly Douglas Foote
Summary: This study aimed to evaluate the evolution of GPi DBS targeting in patients with dystonia or PD. During 15 years of follow-up, lead locations in the PD group migrated laterally, posteriorly, and dorsally, whereas leads in the dystonia group showed a trend in the dorsal direction. The evolving target may result from improvements in targeting techniques and clinical feedback intraoperatively and post-operatively.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Carolina Candeias da Silva, Wilson Fung, Mojgan Hodaie, Alfonso Fasano
Summary: Cervical dystonia is a common adult-onset focal dystonia that can affect sleep quality. Deep brain stimulation (DBS) is an effective treatment for cervical dystonia, although its impact on sleep is not well understood. We present a case of an unusual form of insomnia in a patient with cervical dystonia following DBS surgery, which resolved after surgical revision of the extension wire.
Article
Multidisciplinary Sciences
Andreas Horn, Martin M. Reich, Siobhan Ewert, Ningfei Li, Bassam Al-Fatly, Florian Lange, Jonas Roothans, Simon Oxenford, Isabel Horn, Steffen Paschen, Joachim Runge, Fritz Wodarg, Karsten Witt, Robert C. Nickl, Matthias Wittstock, Gerd-Helge Schneider, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Joachim K. Krauss, Gunther Deuschl, Jens Volkmann, Andrea A. Kuhn
Summary: This study retrospectively investigated the clinical results of deep brain stimulation (DBS) for cervical and generalized dystonia in 80 patients. The researchers modeled the optimal stimulation sites based on imaging and found that the optimal treatment for cervical dystonia involved modulation of the striatopallidofugal axis, while pallidothalamic bundles were responsible for optimal treatment of generalized dystonia. Additionally, the study showed a common network substrate in the form of connectivity to the cerebellum and somatomotor cortex for both types of dystonia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Stefanie Perl, Anika Luettig, Rudiger Koehling, Angelika Richter
Summary: This review provides an overview of DBS research in animal models of dystonia, discussing the research aims, opportunities and limitations of different animal models, and technical challenges.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Vittorio Rispoli, Matias Eduardo Diaz Crescitelli, Francesco Cavallieri, Francesca Antonelli, Stefano Meletti, Luca Ghirotto, Franco Valzania
Summary: During the COVID-19 pandemic, patients with dystonia faced challenges such as social isolation, increased symptoms, and disrupted healthcare services. Their needs were not adequately met, leading to significant impact on their health.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Vinith Johnson, Robert Wilt, Roee Gilron, Juan Anso, Randy Perrone, Martijn Beudel, Dan Pina-Fuentes, Jeremy Saal, Jill L. Ostrem, Ian Bledsoe, Philip Starr, Simon Little
Summary: The study utilized a novel, sensing-enabled deep brain stimulator device implanted in a patient with cervical dystonia to record neural data and conduct a proof-of-principle trial. It found that low-frequency oscillations are related to dystonia and demonstrated the potential for a novel adaptive stimulation strategy.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Shiro Horisawa, Kotaro Kohara, Taku Nonaka, Atsushi Fukui, Tatsuki Mochizuki, Mutsumi Iijima, Takakazu Kawamata, Takaomi Taira
Summary: This study retrospectively analyzed the efficacy and adverse events of unilateral pallidothalamic tractotomy in 35 patients with cervical dystonia. The results showed significant improvement in symptoms after a follow-up period of 13.9 months, but there were also some adverse events.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Caroline Trompette, Caroline Giordana, Aurelie Leplus, David Grabli, Cecile Hubsch, Claire Marse, Denys Fontaine
Summary: The study suggests that combined stimulation of the ventral intermediate thalamic nucleus (VIM) and the globus pallidus interna (GPi) in deep brain stimulation (DBS) treatment shows better results for treating dystonic tremor (DT) symptoms compared to single stimulation of either VIM or GPi. Furthermore, by modulating the networks involved in DT pathophysiology, combined stimulation may provide comprehensive improvements in motor, functional, and activities of daily living.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Clinical Neurology
Audrey K. S. Soo, Arianna Ferrini, Manju A. Kurian
Summary: Targeted precision medicine is becoming increasingly important in treating genetic childhood movement disorders, with personalized approaches including repurposing existing treatments and developing new therapies. Close collaboration between clinicians, researchers, affected families, and stakeholders in the wider community is crucial for successfully delivering these precision therapies to children with movement disorders.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Food Science & Technology
Carolina Gorodetsky, Paula Azevedo, Carolina Candeias da Silva, Alfonso Fasano
Summary: In a retrospective study of dystonia patients, approximately half underwent deep brain stimulation (DBS) surgery, with reasons for declining DBS including patient refusal, functional dystonia, and successful use of AbobotulinumtoxinA after failed treatment with other botulinum neurotoxins. The study emphasizes the importance of structured patient education to increase DBS acceptance, careful evaluation for functional dystonia, and the potential benefit of changing botulinum toxin formulations.
Article
Psychology, Clinical
Adrianna M. Ratajska, Francesca Lopez, Lauren Kenney, Charles Jacobson, Kelly D. Foote, Michael S. Okun, Dawn Bowers
Summary: The study identified three cognitive subtypes of ET patients undergoing DBS, with 27.4% meeting criteria for MCI. The majority of MCI cases were in the Low Executive or Low Memory Multi-Domain groups, with the latter having a higher percentage of members classified as MCI. Future work should focus on examining these subgroups for progression to dementia.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Otorhinolaryngology
Sayaka Yokoi, Naoki Nishio, Takashi Maruo, Mariko Hiramatsu, Nobuaki Mukoyama, Hidenori Tsuzuki, Akihisa Wada, Naoki Atsuta, Daisuke Ito, Takashi Tsuboi, Gen Sobue, Masahisa Katsuno, Yasushi Fujimoto, Michihiko Sone
Summary: This study retrospectively analyzed the clinical and surgical data of 26 patients with ALS who underwent laryngeal closure surgery. The results showed that laryngeal closure surgery can safely maintain swallowing function and reduce the risk of chronic aspiration in patients with ALS.
Letter
Dermatology
Yuta Yamashita, Takuya Takeichi, Yoji Ishizu, Nobuaki Suzuki, Takashi Tsuboi, Kentaro Matsuura, Haruka Koizumi, Yoshinao Muro, Masashi Akiyama
JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Veerle Visser-Vandewalle, Pablo Andrade, Philip E. Mosley, Benjamin D. Greenberg, Rick Schuurman, Nicole C. McLaughlin, Valerie Voon, Paul Krack, Kelly D. Foote, Helen S. Mayberg, Martijn Figee, Brian H. Kopell, Mircea Polosan, Eileen M. Joyce, Stephan Chabardes, Keith Matthews, Juan C. Baldermann, Himanshu Tyagi, Paul E. Holtzheimer, Chris Bervoets, Clement Hamani, Carine Karachi, Damiaan Denys, Ludvic Zrinzo, Patric Blomstedt, Matilda Naesstrom, Aviva Abosch, Steven Rasmussen, Volker A. Coenen, Thomas E. Schlaepfer, Darin D. Dougherty, Philippe Domenech, Peter Silburn, James Giordano, Andres M. Lozano, Sameer A. Sheth, Terry Coyne, Jens Kuhn, Luc Mallet, Bart Nuttin, Marwan Hariz, Michael S. Okun
Summary: Deep brain stimulation is an effective but underutilized treatment for obsessive-compulsive disorder. Psychologists, psychiatrists, and insurers should take action to make this therapy accessible to patients with otherwise intractable cases, in order to improve their mental health.
Article
Neurosciences
Takashi Tsuboi, Yuki Satake, Keita Hiraga, Katsunori Yokoi, Makoto Hattori, Masashi Suzuki, Kazuhiro Hara, Adolfo Ramirez-Zamora, Michael S. Okun, Masahisa Katsuno
Summary: Selegiline, rasagiline, and safinamide, three MAO-BIs drugs, have different effects on the quality of life and non-motor symptoms of patients with Parkinson's disease. However, the understanding of these effects is still unclear and further high-quality studies are needed to verify them.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Satoshi Maesawa, Jun Torii, Daisuke Nakatsubo, Hiroshi Noda, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takashi Tsuboi, Masashi Suzuki, Takafumi Tanei, Masahisa Katsuno, Ryuta Saito
Summary: This study reports a case of intractable Holmes tremor treated with dual-lead deep brain stimulation (DBS) targeting multiple locations in the posterior subthalamic area (PSA) and thalamus. The patient achieved good tremor control without any side effects, suggesting that the dual-lead DBS technique may be safe and effective for treating Holmes tremor.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Aparna Wagle Shukla, Caroline Lunny, Ibrahim Hisham, Jackson Cagle, Joyce Malea, Alfonso Santos, Ashutosh M. Shukla
Summary: This study describes four patients who developed tremors after kidney transplant surgery and receiving treatment with tacrolimus immunosuppressant. The tremors mainly affected the hands, and limb cooling was found to temporarily reduce the tremor severity. Limb cooling may be considered as a therapeutic option for tacrolimus-induced tremor.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2023)
Article
Clinical Neurology
Frederick L. Hitti, Alik S. Widge, Patricio Riva-Posse, Donald A. Malone Jr, Michael S. Okun, Maryam M. Shanechi, Kelly D. Foote, Sarah H. Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F. Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S. Kubu, Winston Chiong, Jennifer A. Chandler, Rafael Carbunaru, Binith Cheeran, Robert S. Raike, Rachel A. Davis, Casey H. Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K. Bick, Cameron C. McIntyre, R. Mark Richardson, Darin D. Dougherty, Brian H. Kopell, Jennifer A. Sweet, Wayne K. Goodman, Sameer A. Sheth, Nader Pouratian
Summary: Despite advances in treatment, neuromodulation, such as deep brain stimulation, has not gained widespread adoption as a potential therapy for psychiatric diseases. In 2016, the American Society for Stereotactic and Functional Neurosurgery organized a meeting to discuss the future path forward. A follow-up meeting in 2022 aimed to review the current state of the field and identify barriers and milestones for progress.
Article
Clinical Neurology
Katsunori Yokoi, Yurie Iribe, Norihide Kitaoka, Takashi Tsuboi, Keita Hiraga, Yuki Satake, Makoto Hattori, Yasuhiro Tanaka, Maki Sato, Akihiro Hori, Masahisa Katsuno
Summary: This study compared the language of patients with Parkinson's disease and healthy controls using automated morphological analysis tools. The results showed that patients with Parkinson's disease used fewer morphemes in a sentence. Furthermore, they had a higher rate of verbs, case particles (dispersion), and verb utterances, and a lower rate of common noun utterances, proper noun utterances, and filler utterances. These conversational changes can be used for the diagnosis of Parkinson's disease.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Makoto Hattori, Keita Hiraga, Yuki Satake, Takashi Tsuboi, Daigo Tamakoshi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Akihiro Hori, Motoshi Kawashima, Hideaki Shimizu, Hiroshi Matsuda, Katsuhiko Kato, Yukihiko Washimi, Masahisa Katsuno
Summary: Individuals with prodromal symptoms of Lewy body disease (LBD), such as rapid eye movement sleep behavior disorder (RBD), often showed imaging defects similar to patients with Parkinson's disease and dementia with Lewy bodies. The simultaneous evaluation of dopamine transporter (DaT) single-photon-emission computed tomography (SPECT) and metaiodobenzylguanidine (MIBG) scintigraphy may capture a wide range of individuals with prodromal LBD.
NPJ PARKINSONS DISEASE
(2023)
Review
Pharmacology & Pharmacy
Aparna Wagle Shukla, Caroline Lunny, Omar Mahboob, Uzair Khalid, Malea Joyce, Nivedita Jha, Nandakumar Nagaraja, Ashutosh M. Shukla
Summary: This study reviewed 81 studies and found that calcineurin inhibitors, such as cyclosporine and tacrolimus, can induce tremors, while non-calcineurin inhibitors, such as sirolimus and everolimus, may also cause tremors. Tremors were more common in kidney transplant and bone marrow transplant patients, and there is limited research on risk factors, treatment strategies, and outcomes for tremors.
Article
Clinical Neurology
Jun Torii, Satoshi Maesawa, Daisuke Nakatsubo, Takahiko Tsugawa, Sachiko Kato, Tomotaka Ishizaki, Sou Takai, Masashi Shibata, Toshihiko Wakabayashi, Takashi Tsuboi, Masashi Suzuki, Ryuta Saito
Summary: This study retrospectively investigated the outcomes and associated factors of MRgFUS ablation for essential tremor in Japanese patients. The results showed that MRgFUS can effectively control essential tremor with acceptable adverse effects. The cutoff values obtained in this study may be useful for improving treatment outcomes in Asian patients with essential tremor.
JOURNAL OF NEUROSURGERY
(2023)
Review
Clinical Neurology
Aparna Wagle Shukla
Summary: Peripheral stimulation techniques, such as the Cala system, show promise in treating symptoms of essential tremor. However, the current clinical evidence on efficacy is inconsistent and more data is needed to establish peripheral nerve stimulation as a standard of care.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)
Review
Clinical Neurology
G. R. A. C. E. HEY, W. E. HU, J. O. S. H. U. A. WONG, T. A. K. A. S. H. I. TSUBOI, M. A. T. T. H. E. W. R. BURNS, A. D. O. L. F. O. RAMIREZ-ZAMORA
Summary: Holmes Tremor is an irregular, slow-frequency tremor characterized by resting, postural, and action tremors of the upper extremities. It is caused by neuronal damage and aberrant axonal sprouting and synaptic dysfunction. Treatment options include medication and surgical management.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)
Article
Clinical Neurology
Sachiko Kato, Satoshi Maesawa, Epifanio Bagarinao, Daisuke Nakatsubo, Takahiko Tsugawa, Satomi Mizuno, Kazuya Kawabata, Takashi Tsuboi, Masashi Suzuki, Masashi Shibata, Sou Takai, Tomotaka Ishizaki, Jun Torii, Manabu Mutoh, Ryuta Saito, Toshihiko Wakabayashi, Masahisa Katsuno, Norio Ozaki, Hirohisa Watanabe, Gen Sobue
Summary: This study investigated the changes of brain networks in ET patients after MRgFUS thalamotomy by analyzing resting-state networks (RSNs). The results showed that ET patients had decreased functional connectivity in the sensorimotor network, primary visual network, and visuospatial network before surgery. The decrease in functional connectivity in the sensorimotor network was correlated with the severity of tremor. After MRgFUS thalamotomy, the connectivity in the sensorimotor network decreased in a small area, but the cerebellar network showed increased connectivity. The functional connectivity in the sensorimotor network and visuospatial network significantly increased after treatment.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)