期刊
ORGANIC LETTERS
卷 21, 期 10, 页码 3741-3745出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01184
关键词
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资金
- National Natural Science Foundation of China [21772044]
- National Young Top-Notch Talent Support Program
- Program of Shanghai Science and Technology Committee [18JC1411303]
- Fundamental Research Funds for the Central Universities
- Program of Shanghai Academic/Technology Research Leader [18XD1401500]
The synthetic approach to the core framework of the calyciphylline A-type Daphniphyllum alkaloids and total synthesis of himalensine A were described herein. Nitrone-induced 1,3-dipolar [3 + 2] cycloaddition was applied for the construction of A/C rings along with the all-carbon quaternary center. Pd-catalyzed enolate alkenylation and ring closing metathesis (RCM) were adopted to install the B/D rings to accomplish the [6,6,5,7] core framework. Nazarov reaction was utilized to install the F ring to complete the total synthesis of himalensine A.
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