期刊
ORGANIC LETTERS
卷 21, 期 9, 页码 3123-3126出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00775
关键词
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资金
- National Natural Science Foundation of China [21502242, 81402794]
- State Key Laboratory of Natural and Biomimetic Drugs [K20150215]
A regio- and stereoselective synthesis of fluorinated 1,4-enynes bearing an all-carbon quaternary center at the propargylic position is developed. The synthesis starts from readily available allenoates and gem-difluoroalkenes and proceeds via a key alkynylenolate intermediate following a nucleophilic addition/beta-F elimination. This reaction occurs under mild reaction conditions with good tolerance to a variety of functional groups. Synthetic utility is demonstrated by further transformations of the products. Furthermore, the reaction can also be applied for the synthesis of alpha-alkenyl allenoates by using 3,3-disubstituted allenoates.
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