Article
Radiology, Nuclear Medicine & Medical Imaging
Qi-Chen Yang, Fan Yao, Qiu-Yu Li, Min-Jie Chen, Li-Juan Zhang, Hui-Ye Shu, Rong-Bin Liang, Yi-Cong Pan, Qian-Min Ge, Yi Shao
Summary: This study evaluated microvascular changes in the eyes of Sjogren syndrome patients using OCTA, revealing decreased microvascular density in the retinal layers and increased density in the conjunctiva. Furthermore, a negative correlation was found between conjunctival microvascular density and both superficial and deep retinal microvascular densities in Sjogren syndrome patients.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Biology
Hung-yin Lai, Alexander Chen, Po-chiung Fang, Hun-ju Yu, Ming-tse Kuo
Summary: This study compared tear film viscosity in Sjogren and non-Sjogren dry eye diseases. They found that Sjogren patients had lower tear film viscosity indices and higher symptom severity. The researchers concluded that tear film viscosity indices can be useful in early detection of Sjogren dry eye disease.
Article
Rheumatology
David A. Ripsman, Arthur A. M. Bookman
Summary: The severity of oral and ocular dryness symptoms is correlated to objective measures to some extent, with oral symptoms showing a stronger correlation to objective findings than ocular symptoms. Profound ocular dryness and damage may exist in patients with few or insignificant eye symptoms, while some patients with few or no symptoms of oral dryness may have objective salivary hypofunction.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Cell Biology
Laura A. Krueger, Ann C. Morris
Summary: This article provides an overview of the development of the vertebrate visual system and congenital disorders affecting the eye, focusing on CHARGE syndrome. The role of the CHD7 gene in ocular and retinal development is discussed, along with potential avenues for further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Shin, Seul-Gi Yoon, Miso Kim, Eun Jeong Cheon, Youngseo Jeon, Hyun Jung Lee, So-Hyang Chung
Summary: This study aimed to investigate the effects of mesenchymal stem cells (hMSCs) on dry eyes (DE) in a Sjogren's syndrome (SS) mouse model. The results showed that treatment with hMSCs via subconjunctival or lacrimal gland injections alleviated DE symptoms by reducing clinical markers such as tear secretion and corneal staining, goblet cell counts, and inflammatory foci infiltration. In addition, the expression of proinflammatory cytokines and autophagy markers in the lacrimal glands and cornea decreased in the hMSCs-treated mice. These findings suggest the therapeutic potentials of hMSCs in SS-related DE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Xuan Luo, Yu Peng, Ying-Ying Chen, An-Qi Wang, Chui-Wen Deng, Lin-Yi Peng, Qing-Jun Wu, Yan Zhao, Yun-Yun Fei, Wen Zhang
Summary: The study identified 2819 differentially methylated positions in monocytes from pSS patients compared to healthy controls, affecting 1313 unique genes, with IFN-signaling pathway related genes being hypomethylated. Functional analysis revealed involvement in various pathways and metabolic diseases, with enrichment in signaling pathways correlated with serum IgG levels.
CHINESE MEDICAL JOURNAL
(2021)
Review
Immunology
Jozelio Freire de Carvalho, Aaron Lerner
Summary: The study described a rare association between Sjogren syndrome and Plummer-Vinson syndrome, highlighting the need for vigilance in patients presenting with iron-deficiency anemia, dysphagia, and weight loss. The cases varied in disease duration and treatment, but all had a good outcome.
IMMUNOLOGIC RESEARCH
(2022)
Article
Rheumatology
Andreina Manfredi, Caterina Vacchi, Giovanni DellaCasa, Stefania Cerri, Giulia Cassone, Giovanna Di Cecco, Fabrizio Luppi, Carlo Salvarani, Marco Sebastiani
Summary: This study investigated the prevalence of fibrosing patterns in pSS patients with ILD and found that over half of the patients had a fibrotic pattern, which tended to occur in younger patients with shorter pSS duration compared to those with nonfibrotic patterns.
Article
Medicine, General & Internal
Seitaro Komai, Norihiko Yokoi, Hiroaki Kato, Aoi Komuro, Yukiko Sonomura, Shigeru Kinoshita, Chie Sotozono
Summary: This study investigated the clinical features differences of dry-eye disease patients with and without patchy pattern corneal staining (PPCS). It was found that patients with PPCS showed significant differences in conjunctival epithelial damage, Schirmer's 1 test results, and the prevalence of Sjogren's syndrome compared to those without PPCS. Patients with PPCS may not only indicate Sjogren's syndrome itself, but also exhibit ophthalmological characteristics compatible with SS.
Review
Clinical Neurology
Andreas Liampas, Konstantinos Parperis, Maria Faidra Erotocritou, Antonios Nteveros, Marianna Papadopoulou, Christos Moschovos, Mohammed Akil, Stefano Coaccioli, Georgios M. Hadjigeorgiou, Marios Hadjivassiliou, Panagiotis Zis
Summary: This systematic review and meta-analysis provides a comprehensive analysis of the evidence on primary Sjogren syndrome (pSS)-related peripheral neuropathy (PN). The study found that PN is very common in pSS patients, with distal axonal polyneuropathy being the most common type. Increasing age and presence of vasculitis are risk factors for developing PN. Glucocorticoids are the most commonly used treatment option for managing pSS-related PN.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Hui Gao, Ye Sun, Xiao-Ying Zhang, Linfeng Xie, Xue-Wu Zhang, Yu-Chao Zhong, Jing Zhang, Yu-Ke Hou, Zhan-Guo Li
Summary: The study aimed to determine characteristics and prognosis of pSS-ILD patients, and to identify risk factors for mortality. Among the pSS-ILD patients, majority were women, with NSIP being the most common HRCT pattern. Impairment in diffusion capacity was the most common pulmonary function test abnormality. Age, smoking, and severity of lung involvement were identified as risk factors for mortality.
Article
Nutrition & Dietetics
Anna Luczak, Rafal Malecki, Michal Kulus, Marta Madej, Ewa Szahidewicz-Krupska, Adrian Doroszko
Summary: Endothelial dysfunction is impaired in patients with pSS and is associated with disease activity, indicating the crucial role of inflammation in the development and maintenance of cardiovascular diseases.
Article
Ophthalmology
Jay Won Rhim, Youngsub Eom, Eun Gyu Yoon, Seo Yeon Park, Young Choi, Jong Suk Song, Hyo Myung Kim
Summary: This study evaluated the efficacy of topical cyclosporin A (CsA) in patients with obstructive meibomian gland dysfunction (MGD). The results showed that treatment with 0.05% CsA nanoemulsion in combination with warm compress twice daily alleviated dry eye symptoms in patients with obstructive MGD, but glandular loss could not be restored.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Immunology
Simone Appenzeller, Samuel de Oliveira Andrade, Mariana Freschi Bombini, Samara Rosa Sepresse, Fabiano Reis, Marcondes C. Franca Jr
Summary: This article reviews the epidemiology, clinical and immunological characterization, diagnosis, and treatment of neurologic events in primary Sjogren's Syndrome (pSS). It highlights the lack of diagnostic criteria and clinical trials to support treatment, and emphasizes the need for well-designed clinical trials to improve therapeutic options.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Rheumatology
Pierre-Andre Jarrot, Robin Arcani, Olivier Darmon, Jean Roudier, Raphael Cauchois, Karin Mazodier, Rodolphe Jean, Nathalie Balandraud, Gilles Kaplanski
Summary: A study on patients with primary Sjogren syndrome (pSS) found that 20% of them presented with axial articular manifestations (AAMs), with most of these patients also experiencing peripheral arthralgia and arthritis. Among those with associated spondyloarthritis (SpA), the majority required biologic therapies, showing positive clinical outcomes.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Seong Woo Lee, Ha Eun Sim, Jae Yong Park, Jae Suk Kim, In Beom Chang, Young Soon Park, Je Hyung Hwang
Article
Ophthalmology
Jae Yong Park, Min-Ji Kang, Bum Gi Kim, Kyu Ho Chung, Ha Eun Sim, Seong Woo Lee, Jae Suk Kim, Hyeon Seok Lee, Je Hyung Hwang
Summary: The study found that during the development of CNV, there is a significant increase in choroidal thickness in the corresponding subfield. Additionally, three months before the development of CNV, the choroidal thickness in the central subfield also significantly increases. Regular measurement of choroidal thickness may help in predicting CNV development.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Jae Yong Park, Je Hyung Hwang, Min Ji Kang, Ha Eun Sim, Jae Suk Kim, Kyung Soo Ko
Summary: The study found that an increase in HbA1c standard deviation was associated with a higher risk of DR progression and that both mean HbA1c and HbA1c standard deviation were associated with a lower risk of progression. Achievable and consistent glycemic control may delay the progression of DR.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Min-Ji Kang, Jehyung Hwang, So-Hyang Chung
Summary: A comparison study between pulsed and continuous accelerated crosslinking for keratoconus patients found that pulsed accelerated crosslinking may provide better post-crosslinking effects than continuous accelerated crosslinking.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2021)
Article
Ophthalmology
Ha Eun Sim, Min Ji Kang, Jee Hye Lee, Seung Hwa Baik, Sun Young Kim, Seong Woo Lee, Je Hyung Hwang
Summary: This report describes a case of successful repositioning of a misaligned thick free flap after LASIK surgery using Scheimpflug topography. By detecting the rotation angle of the flap through topography, a significant improvement in vision and refractive power was achieved.
CASE REPORTS IN OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Jin-Sung Yuk, Je Hyung Hwang
Summary: This study found that menopause and patient factors do not have a significant impact on the development of age-related macular degeneration in Korean women. Age and diabetes mellitus are the main risk factors for developing age-related macular degeneration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ha-Eun Sim, Kyeong-Do Jeong, Je-Hyung Hwang
Summary: This study evaluated the impact of the COVID-19 pandemic on the Ophthalmology Department. The results showed a decrease in the number of ophthalmic outpatients during the early stage of the pandemic, but the number gradually recovered to the pre-pandemic level during the late stage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Jee-Hye Lee, Min-Ji Kang, Ha-Eun Sim, Je-Hyung Hwang
Summary: This study evaluates the incidence of microbial contaminations in single-use vials of preservative-free artificial tears, and finds a significantly higher risk of contamination when fingertips touch the vial mouth.
Article
Ophthalmology
Ha Eun Sim, Jae Suk Kim, Je Hyung Hwang
Summary: This report describes a case of choroidal effusion after intravitreal brolucizumab injection for wet AMD, highlighting the importance of close monitoring for potential complications associated with brolucizumab injections.
CASE REPORTS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Je Hyung Hwang
Summary: This report describes a case of acute uveitis following COVID-19 vaccination. The patient showed improvement after treatment.
CASE REPORTS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ha Eun Sim, Je Hyung Hwang
Summary: This study presents 11 cases of new-onset acute uveitis following COVID-19 vaccination. The uveitis responded well to steroid therapy, with no visual impairment observed.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ha Eun Sim, Seung Hwa Baik, Je-Hyung Hwang
Summary: This study reports the risk factors and treatment outcomes of visually disturbing vitreous opacities after Nd:YAG laser posterior capsulotomy. Vitrectomy was found to be an effective treatment for these opacities.
CASE REPORTS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jin-Sung Yuk, Jae Yong Park, Ha Eun Sim, Je Hyung Hwang
Summary: This study aimed to evaluate the effects of menopausal hormone therapy (MHT) on lens opacities in postmenopausal women. The results showed that postmenopausal women who underwent MHT had a higher incidence of cataracts. Low socioeconomic status and high parity were identified as risk factors for cataracts, while living in rural areas and alcohol consumption were associated with a reduced risk of cataracts.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Medicine, General & Internal
Ha Eun Sim, Je Hyung Hwang
Summary: This study reports a case of acute neovascularization of the iris after cataract surgery. The patient developed aggravated CRVO and iris neovascularization, which responded well to bevacizumab treatment.
Article
Ophthalmology
Ha Eun Sim, Jeong Hyun Lee, Jae Yong Park, Jin Choi, Min Ji Kang, Je Hyung Hwang, Jae Suk Kim
Summary: The purpose of this study was to investigate the effects of PRP on retinal blood circulation in patients with diabetic retinopathy. The results showed a significant reduction in VFT after PRP in patients with severe NPDR and early PDR, with no significant changes in ACT and APT. The reductions in VFT were similar in both groups.
JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY
(2021)
