Article
Gastroenterology & Hepatology
D. J. M. Barnett, M. F. Endika, C. E. Klostermann, F. Gu, C. Thijs, A. Nauta, H. A. Schols, H. Smidt, I. C. W. Arts, J. Penders
Summary: The infant gut microbiota is influenced by antibiotic exposures and prebiotic oligosaccharides found in breast milk. This study analyzed the stool microbiota of 1023 one-month-old infants and found that breastfeeding and antibiotic exposure both decrease gut microbial diversity, but have different effects on microbiota composition. Other factors such as C-section, homebirth, siblings, and exposure to animals also impact microbiota composition. Understanding these factors can help protect and promote a healthy infant gut microbiota.
Review
Allergy
Erin C. Davis, Vanessa P. Castagna, David A. Sela, Margaret A. Hillard, Samantha Lindberg, Nicholas J. Mantis, Antti E. Seppo, Kirsi M. Jarvinen
Summary: Establishing the gut microbiome in early life is important for long-term health, and breast-feeding plays a significant role in shaping the composition and function of the microbiome. This review aims to summarize the evidence on the effects of breast-feeding on the gut microbiome and discuss the mechanisms behind these effects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Bin Liu, Weicang Qiao, Minghui Zhang, Yanpin Liu, Junying Zhao, Lijun Chen
Summary: This study found that consuming A2-type beta-casein milk can improve intestinal morphology, enhance immune response, and have beneficial effects on gut health by modulating the composition and diversity of gut microbiota. These findings also suggest a potential association between gut microbes, immune response, and short-chain fatty acids.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
William D. Miller, Robert Keskey, John C. Alverdy
Summary: Sepsis-induced alterations in the gut microbiome can lead to organ dysfunction, prompting research into microbiota-directed interventions to address this issue.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Food Science & Technology
Juliana A. S. Leite, Randall C. Robinson, Jaime Salcedo, Juliana N. R. Ract, Virginia S. Quintal, Carmen C. Tadini, Daniela Barile
Summary: This study investigated the impact of microwave-assisted heating on the concentration of key biological compounds in donor human milk. Compared to low-temperature long-time pasteurization, microwave-assisted heating better preserved the concentration of immunoglobulins and lactoferrin, making it a promising alternative method for Human Milk Banks.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Rabia Maqsood, Peter T. Skidmore, LaRinda A. Holland, Joshua L. Au, Adam K. Khan, Lily Wu, Ningxin Ma, Emily R. Begnel, Bhavna H. Chohan, Judith Adhiambo, Grace John-Stewart, James Kiarie, John Kinuthia, Michael H. Chung, Barbra A. Richardson, Jennifer Slyker, Dara A. Lehman, Efrem S. Lim
Summary: A study found that combination antiretroviral therapy (cART) had minimal impact on the breast milk microbiota in women living with HIV, while antibiotic use significantly influenced the diversity of the breast milk microbiota. This study fills an important knowledge gap regarding the impact of cART on the microbiome of women living with HIV.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Fernanda Rosa, Ashok K. Sharma, Manoj Gurung, David Casero, Katelin Matazel, Lars Bode, Christy Simecka, Ahmed A. Elolimy, Patricia Tripp, Christopher Randolph, Timothy W. Hand, Keith D. Williams, Tanya LeRoith, Laxmi Yeruva
Summary: HMOs have a direct impact on gastrointestinal function and immunity, even in the absence of host microbiota. HMO treatment leads to changes in gene expression in intestinal tissues and affects the distribution of immune cells and antibody production.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Cristina Sanchez, Luis Franco, Patricia Regal, Alexandre Lamas, Alberto Cepeda, Cristina Fente
Summary: Breast milk is essential for infant growth and development, and has benefits for both maternal and child health. Research on breast milk components is increasing, shedding light on its lifelong effects on infants and the modulation of immunity.
Article
Nutrition & Dietetics
Maciej Chichlowski, Janna A. van Diepen, Andrei Prodan, Laurentya Olga, Ken K. Ong, Guus A. M. Kortman, David B. Dunger, Gabriele Gross
Summary: This study investigates the associations between infant gut microbiome development, infant age, breastfeeding duration, and human milk oligosaccharides composition in breastmilk. The results show that breastfeeding duration affects infant gut microbiota composition and specific oligosaccharides in breastmilk are associated with bacteria in infant stool.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Michael T. Connelly, Grace Snyder, Ana M. Palacio-Castro, Phillip R. Gillette, Andrew C. Baker, Nikki Traylor-Knowles
Summary: This study demonstrated that antibiotics can alter the composition and reduce the diversity of coral-associated bacteria, leading to decreased oxygen consumption and activation of host immunity without directly impairing symbiotic algae photosynthesis. These findings highlight the importance of coral-associated bacteria for holobiont health and provide insights for future experiments.
Article
Microbiology
Ryan M. Pace, Janet E. Williams, Bianca Robertson, Kimberly A. Lackey, Courtney L. Meehan, William J. Price, James A. Foster, Daniel W. Sellen, Elizabeth W. Kamau-Mbuthia, Egidioh W. Kamundia, Samwel Mbugua, Sophie E. Moore, Andrew M. Prentice, Debela G. Kita, Linda J. Kvist, Gloria E. Otoo, Lorena Ruiz, Juan M. Rodriguez, Rossina G. Pareja, Mark A. McGuire, Lars Bode, Michelle K. McGuire
Summary: Previous studies have shown that human milk composition, including HMOs, lactose, and protein, varies by geography, and these factors are associated with differences in milk and infant fecal microbial community structures. Geographic location strongly influences the microbial composition of milk and infant feces, but samples can be categorized into a smaller number of community state types based on shared microbial profiles.
Article
Nutrition & Dietetics
Rui Li, Yalin Zhou, Yajun Xu
Summary: Currently, there is limited knowledge about the amount and composition of oligosaccharides (OS) in breast-fed babies' feces and their metabolic fate. This study successfully utilized UPLC-QE-HF-MS to identify the profiles of human milk oligosaccharides (HMOs) in breast milk and fecal OS in infants' feces. Significant variations and differences were observed in both the number and composition of HMOs and fecal OS. The metabolism of early-life gut microbiota may play a role in the breakdown, synthesis, bioconversion, or redesign of HMOs. Comparing the OS profiles between breast milk and feces can provide valuable insights into the fate of HMOs in the gastrointestinal tract.
Review
Immunology
Laure Campillo-Gimenez, David Rios-Covian, Jesus Rivera-Nieves, Hiroshi Kiyono, Hiutung Chu, Peter B. Ernst
Summary: Advances in understanding the role of bacteria in gastrointestinal cancers have led to recognizing Helicobacter pylori as a carcinogen and examining the role of enteric microbes in colorectal cancer. Modifying the microbiome may decrease the risk of colorectal cancers, but immune memory responses could potentially complicate attempts to change microbial components.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Mario Daniel Caba-Flores, Angel Ramos-Ligonio, Alberto Camacho-Morales, Carmen Martinez-Valenzuela, Rubi Viveros-Contreras, Mario Caba
Summary: During pregnancy, the human fetus receives timed cues from the mother's circadian rhythms. After birth, breastfeeding allows the newborn to continue receiving these cues, which are important for their health and development. Human milk contains a variety of nutrients and non-nutritive components that follow daily rhythms, and their proper intake is crucial for the infant's well-being.
FRONTIERS IN NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
K. S. Singh, B. P. Singh, N. Rokana, N. Singh, J. Kaur, A. Singh, H. Panwar
Summary: Human milk is a vital source of nutrients and beneficial microbiota for neonates, prompting research into its components as potential therapeutic agents. Current studies focus on understanding the bio-therapeutic components of milk and their efficient usage, highlighting the importance of human milk in infant health.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Letter
Allergy
Natalia Pereverzina, Anastasiia Allenova, Elizaveta Gribaleva, Daniel Munblit, Dayana Skander, Pavel Kolkhir
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
McKenzie A. Dirr, Murad Alam, Christian Apfelbacher, Karl-Philipp Drewitz, Bianca Y. Kang, Daniel Munblit, Nikita Nekliudov, Nina Seylanova
Summary: The virtual meeting brought together developers of core outcome sets (COS) in the fields of dermatology and food allergy, assessing the current state of COS methodology and laying the groundwork for future projects. The conference emphasized the importance of ongoing COS work to improve patient outcomes and reduce research waste.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Allergy
Giulia C. Spolidoro, Yohannes Tesfaye Amera, Mohamed Mustafa Ali, Sungkutu Nyassi, Daniil Lisik, Athina Ioannidou, Graciela Rovner, Ekaterina Khaleva, Carina Venter, Ronald van Ree, Margitta Worm, Berber Vlieg-Boerstra, Aziz Sheikh, Antonella Muraro, Graham Roberts, Bright Nwaru
Summary: The latest estimates of food allergy prevalence and trends in Europe show an increase in self-reported food allergy and sensitization rates. This may be due to a real increase in the prevalence, increased awareness, increased evaluation of food types, or increased number of studies. Future studies need to use standardized methods, including double-blinded placebo-controlled food challenge, to minimize potential biases.
Article
Allergy
Marta Vazquez-Ortiz, Claudia Gore, Cherry Alviani, Elizabeth Angier, Katharina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Teresa Garriga-Baraut, M. Hazel Gowland, Britt Egmose, Rebecca Knibb, Ekaterina Khaleva, Charlotte G. Mortz, Oliver Pfaar, Helena Pite, Marcia Podesta, Alexandra F. Santos, Silvia Sanchez-Garcia, Frans Timmermans, Graham Roberts
Summary: This article summarizes practical resources to support the implementation of guidelines for adolescents and young adults with asthma and allergies in clinical practice. The study found that the identified resources cover various topics and target different stakeholders such as healthcare professionals, adolescents and young adults, parents/caregivers, schools, workplaces, and communities. However, most of the resources are web-based and in English, with limited evidence basis.
Article
Biochemistry & Molecular Biology
Serena Manara, Marta Selma-Royo, Kun D. Huang, Francesco Asnicar, Federica Armanini, Aitor Blanco-Miguez, Fabio Cumbo, Davide Golzato, Paolo Manghi, Federica Pinto, Mireia Valles-Colomer, Loredana Amoroso, Maria Valeria Corrias, Mirco Ponzoni, Roberta Raffaeta, Raul Cabrera-Rubio, Mari Olcina, Edoardo Pasolli, Maria Carmen Collado, Nicola Segata
Summary: Findings reveal that modern westernized lifestyles have an impact on mother-infant microbiome sharing, with differences in composition and diversity observed in newborns compared to non-westernized populations.
Article
Neurosciences
Lea M. Brix, Daniel Monleon, Maria Carmen Collado, Thomas H. A. Ederveen, Irmak Toksoez, Joeri Bordes, Lotte van Doeselaar, Clara Engelhardt, Shiladitya Mitra, Sowmya Narayan, Mathias V. Schmidt
Summary: Early life stress (ELS) can lead to various health problems and there is a need to understand the physiological changes and identify biomarkers. ELS affects the hypothalamic-pituitary-adrenal axis and also the gut microbiota and metabolome. Maternal metabolic status and diet, particularly obesity, can also impact the offspring's health. This study investigated the long-term effects of ELS and maternal obesity on the metabolic and stress phenotypes of rodent offspring and found that ELS has long-term effects on male body weight, while females can counteract ELS-induced weight loss through adaptation of their microbiota.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Obstetrics & Gynecology
Hannah G. Davies, Conor Bowman, Gabriella Watson, Caitlin Dodd, Christine E. Jones, Flor M. Munoz, Paul T. Heath, Clare L. Cutland, Kirsty Le Doare
Summary: In 2014, the Global Alignment on Immunization safety Assessment in pregnancy consortium (GAIA) was established to monitor the safety of vaccines in pregnancy. This review identified and described studies evaluating the performance of 26 standardized definitions for adverse events. Four studies evaluating 13 GAIA case definitions were found, with most assessments done in high-income settings. Recommendations were made to improve the definitions' performance, including ensuring consistency and clarity. Future research should focus on evaluating the remaining case definitions in low- and middle-income settings.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Obstetrics & Gynecology
Helen Skirrow, Dan Kajungu, Kirsty Le Doare, Tracey Chantler, Beate Kampmann
Summary: Investment in electronic health records is necessary for post-licensure studies of Group B streptococcal vaccines for pregnant women in low and middle-income countries.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Public, Environmental & Occupational Health
Phiona Nalubega, Ritah Namugumya, Flavia Zalwango, Agnes Ssali, Robert Mboizi, Lauren Hookham, Janet Seeley, Kirsty Le Doare
Summary: This study investigated the knowledge, perceptions, and experiences of pregnant women and community leaders regarding the COVID-19 vaccination program in Uganda, as well as how these changed during the pandemic. The findings revealed that pregnant women had concerns about the safety and quality of the vaccine but recognized its benefits. Targeted and sustained communication and engagement strategies are needed to improve vaccine confidence among pregnant women and their communities during outbreaks.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2023)
Review
Allergy
Elizabeth Huiwen Tham, Agnes Sze Yin Leung, Kiwako Yamamoto-Hanada, Lamia Dahdah, Thulja Trikamjee, Vrushali Vijay Warad, Matthew Norris, Elsy Navarrete, Daria Levina, Miny Samuel, Andre van Niekerk, Santiago Martinez, Anne K. Ellis, Leonard Bielory, Hugo van Bever, Dana Wallace, Derek K. Chu, Daniel Munblit, Mimi L. K. Tang, James Sublett, Gary Wing Kin Wong
Summary: This study conducted a comprehensive assessment of Clinical Practice Guidelines (CPGs) for primary prevention of food allergy and atopic dermatitis. It found that although some guidelines had high quality, they performed poorly in terms of global applicability. The study calls for guideline developers to consider stakeholders' preferences, local applicability, and adapt existing recommendations to different geographical settings.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Oncology
Faiza Gaba, Oleg Blyuss, Alex Tan, Daniel Munblit, Samuel Oxley, Khalid Khan, Rosa Legood, Ranjit Manchanda
Summary: Women with BRCA1 or BRCA2 gene mutations undergo operations to remove their ovaries in order to prevent ovarian cancer. This study found that the operation was not linked with a reduced risk of developing breast cancer when considering both BRCA1 and BRCA2 carriers together. However, it was linked with a reduced risk of breast cancer when considering only BRCA2 carriers. Additionally, the operation was associated with increased survival following breast cancer in BRCA1 and BRCA2 carriers.
Review
Pediatrics
Anna Parra-Llorca, Alejandro Pinilla-Gonzlez, Laura Torrejon-Rodriguez, Inmaculada Lara-Canton, Julia Kuligowski, Maria Carmen Collado, Maria Gormaz, Marta Aguar, Maximo Vento, Eva Serna, Maria Cernada
Summary: This narrative review discusses the mechanisms of bacterial sepsis in preterm infants, a prevalent and serious illness. It examines the role of the innate immune response and oxidative stress in the pathogenesis and their potential as early biomarkers. Furthermore, it addresses the impact of sepsis-induced mechanisms on dysbiosis and changes in neonatal microbiota.
Article
Rheumatology
Samuel Channon-Wells, Ortensia Vito, Andrew J. McArdle, Eleanor G. Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G. Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Oleg Blyuss, Michael Levin
Summary: This study evaluated immunomodulatory treatments for multisystem inflammatory syndrome in children (MIS-C) and found that glucocorticoids or glucocorticoids plus intravenous immunoglobulin were not significantly different from intravenous immunoglobulin alone in terms of clinical efficacy. Initial treatment with glucocorticoids may be a safe alternative to immunoglobulin or combined therapy.
LANCET RHEUMATOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Syaza Y. Binte Abu Y. Bakar, Malinda Salim, Andrew J. Clulow, Susanne Seibt, Cornelia B. Landersdorfer, Donna T. Geddes, Kevin R. Nicholas, Ben J. Boyd
Summary: Colostrum provides essential bioactive components for the infant gut microbiota colonization and preventing infectious diseases. However, substitutes are urgently needed for premature infants when colostrum is unavailable. This study aimed to design an appropriate lipid component for a colostrum substitute and evaluate its ability to reduce inflammation in intestinal cells. Analysis showed that the digestion of colostrum and the substitute mixtures had similar lipid profiles but exhibited subtle differences in self-assembly behavior. Bifidobacteria cultured on the substitute mixtures modulated the biological markers of necrotizing enterocolitis, suggesting the potential of these substitutes in reducing the characteristics associated with this disease.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Allergy
Doreen Wolff, Karl Philipp Drewitz, Angela Ulrich, Doreen Siegels, Stefanie Deckert, Antonia Anabella Sprenger, Paula Ricarda Kuper, Jochen Schmitt, Daniel Munblit, Christian Apfelbacher
Summary: This study aimed to evaluate whether allergic diseases are risk factors for Long-COVID. The findings suggested that pre-existing asthma or rhinitis may increase the risk of Long-COVID, but the certainty of evidence was very low.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)