Unprecedented tunability of riboswitch structure and regulatory function by sub-millimolar variations in physiological Mg2+

Single-Molecule FRET Kinetics of the Mn2+ Riboswitch: Evidence for Allosteric Mg2+ Control of “Induced-Fit” vs “Conformational Selection” Folding Pathways

(2019) Hsuan-Lei Sung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

(2018) Ryota Yamagami et al.   Nature Communications

Amino Acid Stabilization of Nucleic Acid Secondary Structure: Kinetic Insights from Single-Molecule Studies

(2018) David A. Nicholson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Magnesium controls aptamer-expression platform switching in the SAM-I riboswitch

(2018) Susmita Roy et al.   NUCLEIC ACIDS RESEARCH

Kinetics coming into focus: single-molecule microscopy of riboswitch dynamics

(2018) Sujay Ray et al.   RNA Biology

Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy

(2017) Sven Warhaut et al.   NUCLEIC ACIDS RESEARCH

An integrated perspective on RNA aptamer ligand-recognition models: clearing muddy waters

(2017) K. McCluskey et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation

(2017) Jan Gundlach et al.   mBio

Comparative genomics and phylogenomic analyses of lysine riboswitch distributions in bacteria

(2017) Sumit Mukherjee et al.   PLoS One

Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses

(2016) Anna V. Sherwood et al.   Annual Review of Microbiology

Metal ion induced heterogeneity in RNA folding studied by smFRET

(2016) Richard Börner et al.   COORDINATION CHEMISTRY REVIEWS

Bridging the gap between in vitro and in vivo RNA folding

(2016) Kathleen A. Leamy et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Fluorescence-Based Strategies to Investigate the Structure and Dynamics of Aptamer-Ligand Complexes

(2016) Cibran Perez-Gonzalez et al.   Frontiers in Chemistry

Multiple conformational states of riboswitches fine-tune gene regulation

(2015) Boris Fürtig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mg2+ Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection

(2015) Krishna C. Suddala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding dynamics of a monomeric SSB protein to DNA: a single-molecule multi-process approach

(2015) Michael J. Morten et al.   NUCLEIC ACIDS RESEARCH

Role of lysine binding residues in the global folding of thelysCriboswitch

(2015) Erich Smith-Peter et al.   RNA Biology

Unexpected versatility in bacterial riboswitches

(2015) J.R. Mellin et al.   TRENDS IN GENETICS

Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch

(2015) Aiming Ren et al.   Cell Reports

Fluorescence tools to investigate riboswitch structural dynamics

(2014) Patrick St-Pierre et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Single-molecule studies of riboswitch folding

(2014) Andrew Savinov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Single-Molecule Conformational Dynamics of a Biologically Functional Hydroxocobalamin Riboswitch

(2014) Erik D. Holmstrom et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Is vanadium a biometal for boreal cyanolichens?

(2014) Romain Darnajoux et al.   NEW PHYTOLOGIST

Three-state mechanism couples ligand and temperature sensing in riboswitches

(2013) Anke Reining et al.   NATURE

Single-molecule chemical denaturation of riboswitches

(2013) Paul A. Dalgarno et al.   NUCLEIC ACIDS RESEARCH

Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution

(2013) Andrea Haller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Tertiary Interactions Preorganize the c-di-GMP Riboswitch and Accelerate Ligand Binding

(2012) Sharla Wood et al.   ACS Chemical Biology

Single-Molecule Studies of the Lysine Riboswitch Reveal Effector-Dependent Conformational Dynamics of the Aptamer Domain

(2012) Larry R. Fiegland et al.   BIOCHEMISTRY

Insights into the Regulatory Landscape of the Lysine Riboswitch

(2012) Andrew D. Garst et al.   JOURNAL OF MOLECULAR BIOLOGY

A toolkit and benchmark study for FRET-restrained high-precision structural modeling

(2012) Stanislav Kalinin et al.   NATURE METHODS

Analysis of lysine recognition and specificity of the Bacillus subtilis L box riboswitch

(2012) S. N. Wilson-Mitchell et al.   NUCLEIC ACIDS RESEARCH

Dual-acting riboswitch control of translation initiation and mRNA decay

(2012) M.-P. Caron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folding of the SAM-I riboswitch

(2012) Sébastien H Eschbach et al.   RNA Biology

Molecular insights into the ligand-controlled organization of the SAM-I riboswitch

(2011) Benoit Heppell et al.   Nature Chemical Biology

Conformational capture of the SAM-II riboswitch

(2011) Andrea Haller et al.   Nature Chemical Biology

Multivector Fluorescence Analysis of thexptGuanine Riboswitch Aptamer Domain and the Conformational Role of Guanine

(2010) Michael D. Brenner et al.   BIOCHEMISTRY

Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation

(2010) Simon Blouin et al.   NUCLEIC ACIDS RESEARCH

Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysis

(2010) N. J. Baird et al.   RNA

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Riboswitches: Emerging Themes in RNA Structure and Function

(2008) Rebecca K. Montange et al.   Annual Review of Biophysics

Crystal Structure of the Lysine Riboswitch Regulatory mRNA Element

(2008) Andrew D. Garst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into amino acid binding and gene control by a lysine riboswitch

(2008) Alexander Serganov et al.   NATURE

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

An Oxygen Scavenging System for Improvement of Dye Stability in Single-Molecule Fluorescence Experiments

(2007) Colin Echeverría Aitken et al.   BIOPHYSICAL JOURNAL