Article
Medicine, General & Internal
Abdulhakim Ibrahim, Miroslav Dimitrov Yordanov, Mohammad Hasso, Benjamin Heine, Alexander Oberhuber
Summary: The aim of this study was to analyze the outcomes and complications in patients who underwent open surgical treatment for AAA in the endovascular era. The study found that open aneurysm repair is safe and effective when performed in specialized high-volume centers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Boonying Siribumrungwong, Jiro Kurita, Tatsuo Ueda, Daisuke Yasui, Ken-ichiro Takahashi, Takashi Sasaki, Yasuo Miyagi, Shun-ichiro Sakamoto, Yosuke Ishii, Tetsuro Morota, Takashi Nitta
Summary: Operative mortality rates did not significantly differ between EVAR and OSR, with EVAR showing less blood loss, shorter operative times, and shorter length of hospital stay but with higher re-intervention rates.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Andrew J. Soo Hoo, James J. Fitzgibbon, Mohamad A. Hussain, Rebecca E. Scully, Andrew B. Servais, Louis L. Nguyen, Edwin C. Gravereaux, Marcus E. Semel, Edward J. Marcaccio, Matthew T. Menard, C. Keith Ozaki, Michael Belkin
Summary: This study aims to define the indications for open aneurysm repair (OAR) and its impact on outcomes in the era of endovascular aneurysm repair (EVAR). The results show that no single anatomical contraindication is a predictor of worse outcomes with OAR in patients who do not meet the criteria for EVAR. Patients who choose OAR based on preference have lower rates of perioperative complications, shorter hospital stays, and superior long-term survival rates compared to those who undergo OAR due to anatomical or systemic contraindications to EVAR.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Kirby R. Qin, Marlon Perera, Nathan Papa, David Mitchell, Jason Chuen
Summary: The landscape of AAA repair in the Australian private sector has drastically changed over the past two decades, with a clear preference towards endovascular AAA repair (EVAR). Despite stable rates of AAA surgery, EVAR saw increased use across all genders, age groups, and states.
JOURNAL OF ENDOVASCULAR THERAPY
(2021)
Review
Surgery
Nikolaos Kontopodis, Nikolaos Galanakis, Christos V. Ioannou, Dimitrios Tsetis, Jean-Pierre Becquemin, George A. Antoniou
Summary: The study found that there were significant differences in all-cause mortality during the perioperative and postoperative period between EVAR and open repair. However, no significant difference was observed in aneurysm-related mortality. Recent studies and treated patients showed a more pronounced advantage for EVAR. The certainty for the body of evidence for overall and postdischarge all-cause mortality was judged to be low, while that for aneurysm-related mortality was high.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Nadin Elsayed, Rami Alhakim, Omar Al Nouri, Donald Baril, Fred Weaver, Mahmoud B. Malas
Summary: The results of this study have shown that C-OAR is associated with a significantly higher risk of perioperative morbidity and mortality compared with P-OAR. Follow-up at 5 and 10 years revealed a significant increase in mortality, aneurysmal rupture, and reintervention rates.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Curtis Woodford, Rym El Khoury, Joel L. Ramirez, Iris H. Liu, Elizabeth M. Lancaster, Joyce Nacario, Jade S. Hiramoto, Charles M. Eichler, Linda M. Reilly, James C. Iannuzzi, Michael S. Conte
Summary: This study reviewed open abdominal aortic surgery cases performed at a tertiary care center from 2007 to 2020 and found that complex open aortic aneurysm repair (OAR) comprised the majority, but were not accounted for in the Vascular Quality Initiative (VQI). The study suggests the creation of a VQI module for complex OAR to improve benchmarking for volume and outcomes in aortic surgery.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Livia E. V. M. de Guerre, Kirsten Dansey, Chun Li, Jinny Lu, Priya B. Patel, Joost A. van Herwaarden, Douglas W. Jones, Philip P. Goodney, Marc L. Schermerhorn
Summary: The diameter of aortic abdominal aneurysm (AAA) is associated with late outcomes following repair, with patients with large AAA having higher rates of reintervention, rupture, mortality, and loss to follow-up after EVAR compared to those with smaller AAA or after open repair. Patients with large AAAs who are medically fit should consider undergoing open repair for better long-term outcomes and rigorous follow-up after EVAR is essential.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Safwan Omran, Ben Raude, Matthias Buerger, Sebastian Kapahnke, Jan Christoph Carstens, Haidar Haidar, Frank Konietschke, Jan Paul Frese, Andreas Greiner
Summary: In this study comparing aortoduodenal fistulas (ADFs) after endovascular abdominal aortic aneurysm repair (EVAR) vs after open aortic repair (OAR), it was found that patients in the OAR group had significantly higher postoperative complication rates compared to the EVAR group. The most common bacteria identified in blood cultures were Escherichia coli, with Candida spp. being the predominant pathogen found on intra-abdominal smears.
JOURNAL OF VASCULAR SURGERY
(2021)
Review
Surgery
Nikolaos Kontopodis, Aikaterini Gavalaki, Nikolaos Galanakis, Michalis Kantzas, Christos Ioannou, George Geroulakos, John Kakisis, George A. Antoniou
Summary: The purpose of this study was to compare the outcomes of endovascular repair and open repair for abdominal aortic aneurysm (AAA) in young patients. A systematic review including observational studies and randomized controlled trials was conducted. The results showed that endovascular repair had lower perioperative mortality, shorter hospital stay, and lower complication risks compared to open repair. It can be considered as a treatment option for young patients with suitable anatomy.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Peripheral Vascular Disease
Kritaya Kritayakirana, Natawat Narueponjirakul, Punthita Aimsupanimitr, Chonlathorn Chaichote, Apinan Uthaipaisanwong, Chanapong Kittayarak
Summary: This study compares the outcomes of endovascular versus conventional open repair of infected aortic aneurysms and finds no significant difference in short- or long-term survival.
Article
Surgery
Takuro Shirasu, Toshiki Kuno, Jun Yasuhara, Yujiro Yokoyama, Hisato Takagi, Michael J. Cullen, K. Craig Kent, W. Darrin Clouse
Summary: This study compared the outcomes of endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) for infected abdominal aortic aneurysms (AAAs). The results indicated that EVAR has become more prevalent in treating infected AAAs, but recurrent infection was more frequent after EVAR compared to OAR.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Andrea Vacirca, Joshua Wong, Aidin Baghbani-Oskouei, Emanuel R. Tenorio, Ying Huang, Aleem Mirza, Naveed Saqib, Titia Sulzer, Thomas Mesnard, Bernardo C. Mendes, Gustavo S. Oderich
Summary: This study compares the outcomes of fenestrated-branched endovascular aortic repair (FB-EVAR) in patients with complex abdominal or thoracoabdominal aortic aneurysms, with or without prior history of abdominal open surgical or endovascular aortic repair. The results show that FB-EVAR is effective regardless of prior aortic repair history, with high technical success, low mortality, and similar risk of major adverse events. However, patients with previous abdominal open surgical repair had lower patient survival rates, while those with previous endovascular aortic repair had lower risk of type II endoleak and sac enlargement.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Pablo Marques de Marino, Melad Abu Jiries, Pavel Tesinsky, Anas Ibraheem, Athanasios Katsargyris, Eric L. Verhoeven
Summary: This study aims to evaluate the mid-term outcomes of fenestrated endovascular aneurysm repair (FEVAR) for proximal aortic pathology after previous open surgical repair (OSR). The study found that FEVAR is a safe and effective alternative for the endovascular treatment of para-anastomotic aneurysms/pseudoaneurysms after OSR, with high technical success, low mortality and morbidity, and good mid-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Polymer Science
Gianmarco de Donato, Edoardo Pasqui, Claudia Panzano, Brenda Brancaccio, Gaia Grottola, Giuseppe Galzerano, Domenico Benevento, Giancarlo Palasciano
Summary: Abdominal aortic aneurysm (AAA) is a condition where the abdominal aorta dilates and grows until it ruptures. EVAR is a minimally invasive procedure using stent grafts to treat this condition. Recent advancements have introduced polymer-based technology as a safe and effective alternative to seal AAA.
Editorial Material
Medicine, General & Internal
Joseph Ali, Margaret Antonelli, Lori Bastian, William Becker, Cynthia A. Brandt, Diana J. Burgess, Amy Burns, Steven P. Cohen, Alison F. Davis, Christopher L. Dearth, Jim Dziura, Rob Edwards, Joe Erdos, Shawn Farrokhi, Julie Fritz, Mary Geda, Steven Z. George, Christine Goertz, Jeffrey Goodie, Susan N. Hastings, Alicia Heapy, Brian M. Ilfeld, Lily Katsovich, Robert D. Kerns, Tassos C. Kyriakides, Allison Lee, Cynthia R. Long, Stephen L. Luther, Steve Martino, Michael E. Matheny, Don McGeary, Amanda Midboe, Paul Pasquina, Peter Peduzzi, Michael Raffanello, Daniel Rhon, Marc Rosen, Elizabeth Russell Esposito, Dylan Scarton, Karen Seal, Norman Silliker, Sakasha Taylor, Stephanie L. Taylor, Megan Tsui, Fred S. Wright, Steven Zeliadt
Summary: Pragmatic clinical trials (PCTs) are effective in addressing unmet healthcare needs such as chronic pain and opioid misuse, however, individual studies may be limited in impact due to existing barriers to dissemination and implementation.
Article
Health Policy & Services
Kevin T. Stroupe, Neil Jordan, Joshua Richman, Gary R. Bond, Terri K. Pogoda, Lishan Cao, Stefan G. Kertesz, Tassos C. Kyriakides, Lori L. Davis
Summary: This study compares the cost-effectiveness and return on investment of Individual Placement and Support (IPS) with transitional work (TW) programs in treating military veterans with PTSD. IPS is more costly but more effective, while TW is less expensive but less effective. Overall, IPS improves employment outcomes for PTSD patients, while TW is cheaper but less effective.
ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH
(2022)
Article
Psychiatry
Sidney Zisook, Beata Planeta, Paul B. Hicks, Peijun Chen, Lori L. Davis, Gerardo Villarreal, Mamta Sapra, Gary R. Johnson, Somaia Mohamed
Summary: The study explores the association between specific types of childhood adversity and clinical features and treatment outcomes in adults with Major Depressive Disorder (MDD). It shows that childhood adversities are linked to demographic characteristics, severity of depression and anxiety, treatment response, and long-term outcomes, emphasizing the importance of considering childhood maltreatment histories in treating individuals with MDD.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Andrie Koutsoulidou, Demetris Koutalianos, Kristia Georgiou, Andrea C. Kakouri, Anastasis Oulas, Marios Tomazou, Tassos C. Kyriakides, Andreas Roos, George K. Papadimas, Constantinos Papadopoulos, Evangelia Kararizou, George M. Spyrou, Eleni Zamba Papanicolaou, Hanns Lochmueller, Leonidas A. Phylactou
Summary: In this study, we identified novel serum-based miRNA biomarkers for rare subtypes of muscular dystrophy through high-throughput next-generation RNA sequencing. Our results suggest that these miRNAs may serve as potential biomarkers for rare muscular dystrophies.
NEUROMUSCULAR DISORDERS
(2022)
Article
Health Policy & Services
Neil Jordan, Kevin T. Stroupe, Joshua Richman, Terri K. Pogoda, Lishan Cao, Stefan Kertesz, Tassos C. Kyriakides, Gary R. Bond, Lori L. Davis
Summary: Among veterans with PTSD, supported employment using the IPS model has shown better employment and functional outcomes compared to usual vocational rehabilitation services. This study compared the health services use and associated costs between IPS and usual care (TW program) among unemployed veterans. The findings suggest that IPS participants had higher costs primarily due to increased utilization and costs of vocational services during the intervention period. However, these differences declined in the postintervention period.
PSYCHIATRIC SERVICES
(2022)
Article
Immunology
Min Zhao, Rebecca Slotkin, Amar H. Sheth, Lauren Pischel, Tassos C. Kyriakides, Brinda Emu, Cynthia McNamara, Qiaosu Shi, Jaden Delgobbo, Jin Xu, Elizabeth Marhoffer, Aleagia Mercer-Falkoff, Jurgen Holleck, David Ardito, Richard E. Sutton, Shaili Gupta
Summary: Multiple clinical factors affect the strength and duration of immune responses after COVID-19 vaccination. Malignancy reduces the immune response after the third dose, indicating the need for clinically guided vaccine dosing regimens.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Megan Lee, Danielle Cosentino, Tassos C. Kyriakides, Tricia Cavallaro, Gary Stack, Shaili Gupta
Summary: This study aimed to characterize the clinical and demographic factors affecting clinical outcomes of COVID-19 and describe viral epidemiology among unvaccinated Veterans in New England. The study found that in a largely male and older cohort, poor outcomes were correlated with increasing age. Most Veterans in New England were infected with B.1 sublineages with the D614G mutation in 2020 and early 2021, while the B.1.617.2 lineage predominated after July 2021.
JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Huidong Xie, Zhao Liu, Luyao Shi, Kathleen Greco, Xiongchao Chen, Bo Zhou, Attila Feher, John C. Stendahl, Nabil Boutagy, Tassos C. Kyriakides, Ge Wang, Albert J. Sinusas, Chi Liu
Summary: In nuclear imaging, partial volume effects caused by limited resolution affect image sharpness and quantitative accuracy. Current anatomical-guided methods for partial volume correction require tedious image registration and segmentation steps. In this work, a deep-learning-based method for fast cardiac SPECT PVC without anatomical information and associated organ segmentation is developed. The proposed network with densely-connected dynamic mechanism produces superior results and statistically comparable measurements to anatomical-guided PVC methods, showing potential for clinical translation.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Multidisciplinary Sciences
Tyra M. Pendergrass Boomer, Lily A. Hoerner, Claudia-Santi F. Fernandes, Amber Maslar, Sherry Aiudi, Tassos C. Kyriakides, Lynn E. Fiellin
Summary: This study aims to evaluate the effectiveness of a digital health game, PlaySmart, in preventing adolescent opioid misuse and improving their mental health outcomes. The study recruited 532 adolescents aged 16-19 who are at risk of opioid misuse, and they were randomized to play either PlaySmart or a set of control videogames for six weeks. Multiple assessments were conducted over a 12-month period to measure outcomes related to opioid misuse and mental health.
Article
Multidisciplinary Sciences
Rebecca Slotkin, Tassos C. Kyriakides, Anupam Kundu, Gary Stack, Richard E. Sutton, Shaili Gupta
Summary: This study aims to describe the correlation between commercially available assays for anti-S1/RBD IgG and protective serum neutralizing antibodies (nAb) against SARS-CoV-2 in vaccinated adults, and determine the impact of clinical variables on this correlation. The results show a strong correlation between IgG anti-S1/RBD and nAb IC50 after vaccination, with clinical comorbidities such as prior COVID infection and renal function affecting this correlation.
Article
Medicine, Research & Experimental
Christine P. Kowalski, Linda M. Kawentel, Tassos C. Kyriakides, Lori Davis, Nicholas W. Bowersox, Amy M. Kilbourne, Grant D. Huang, Andrea L. Nevedal
Summary: Implementation assessment plans are crucial for clinical trials to ensure effective interventions are implemented after trial completion. This article introduces an Implementation Planning Assessment (IPA) Tool to guide post-trial implementation and provides a case study demonstrating its use.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jay Parekh, Jane Morrison, Tassos Kyriakides, Laura A. Magee, Jean Tornatore, Tabassum Firoz
Review
Psychiatry
Erika Kuzminskaite, Anouk W. Gathier, Pim Cuijpers, Brenda W. J. H. Penninx, Robert T. Ammerman, Eva-Lotta Brakemeier, Sanne Bruijniks, Sara Carletto, Trisha Chakrabarty, Katie Douglas, Boadie W. Dunlop, Moritz Elsaesser, Frank Euteneuer, Anne Guhn, Elizabeth D. Handley, Erkki Heinonen, Marcus J. H. Huibers, Andrea Jobst, Gary R. Johnson, Daniel N. Klein, Johannes Kopf-Beck, Lotte Lemmens, Xiao-Wen Lu, Somaia Mohamed, Atsuo Nakagawa, Satoshi Okada, Winfried Rief, Leonardo Tozzi, Madhukar H. Trivedi, Suzanne van Bronswijk, Patricia van Oppen, Sidney Zisook, Ingo Zobel, Christiaan H. Vinkers
Summary: This comprehensive meta-analysis found that patients with major depressive disorder, even with a history of childhood trauma, can significantly improve symptoms after pharmacological and psychotherapeutic treatments. Evidence-based psychotherapy and pharmacotherapy should be offered to these patients regardless of childhood trauma status.
Meeting Abstract
Surgery
Kyla Megan Bennett, Landon Hurley, Jon S. Matsumura, Tassos C. Kyriakides, Julie A. Freischlag
JOURNAL OF VASCULAR SURGERY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Jason A. Dominitz, Douglas J. Robertson, Alexander Beed, Kathy D. Boardman, Barbara Del Curto, Samir Gupta, Thomas F. Imperiale, Andrew J. Lacasse, Meaghan F. Larson, David A. Lieberman, Aasma Shaukat, Shahnaz Sultan, Beata M. Planeta, Alicia M. Williams, Tassos Kyriakides