Article
Psychology, Clinical
Mark A. Straccia, Adam R. Teed, Perri L. Katzman, Kevin M. Tan, Michael H. Parrish, Michael R. Irwin, Naomi Eisenberger, Matthew D. Lieberman, Benjamin A. Tabak
Summary: Although there are theoretical grounds, this study fails to demonstrate the effects of oxytocin (OT) and vasopressin (AVP) on social cognition in healthy individuals, suggesting that the impact of these neuropeptides may be more limited than initially assumed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Kah Kheng Goh, Mong-Liang Lu
Summary: The study suggests that oxytocin levels are associated with social cognition and social dysfunction in patients with schizophrenia. Patients with schizophrenia have more deficits in social cognition and social dysfunction, along with lower plasma oxytocin levels. Plasma oxytocin levels are positively correlated with affective Theory of Mind (ToM) in patients with schizophrenia, and the effects of oxytocin on social functioning are partially mediated by affective ToM.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Obstetrics & Gynecology
Mrinalini Balki, Kristi Downey, Andrew Walker, Gareth Seaward, Jose C. A. Carvalho
Summary: The study compared the prophylactic use of a combination of uterotonic drugs with oxytocin alone in reducing the need for additional uterotonics during cesarean delivery for labor arrest. The results showed no significant difference in the requirement for additional intraoperative uterotonics between the groups, but the combination drug groups had a higher incidence of nausea or vomiting.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Psychiatry
Emilio Lopez-Navarro, Eduardo Fonseca-Pedrero, Jose Errasti, Susana Al-Halabi
Summary: This study found through a randomized clinical trial that a Mindfulness-Based Intervention (MBI) has a positive effect on improving Theory of Mind (ToM) ability in individuals with psychotic disorders.
PSYCHIATRY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Katherine R. Thorson, Scott M. McKernan, Tessa West, Joshua D. Woolley, Wendy Berry Mendes, Christopher S. Stauffer
Summary: The study found that oxytocin may enhance physiological linkage between participants and facilitators in group therapy, improving their connection, especially in the early stages of sessions. This suggests that oxytocin might help improve group cohesion in group therapy.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Christopher S. Stauffer, Tyler E. Morrison, Nathan K. Meinzer, David Leung, Jessica Buffington, Evan G. Sheh, Thomas C. Neylan, Aoife O'Donovan, Joshua D. Woolley
Summary: Co-occurring PTSD and AUD is common and treatment options are limited. Intranasal oxytocin administration may be effective in reducing symptoms, but dosage is important. This study found that oxytocin 20 IU had no effect on startle reactivity in co-occurring patients, while oxytocin 40 IU increased startle reactivity.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Damla Sayar-Akaslan, Bora Baskak, Yagmur Kir, Adnan Kusman, Busra Yalcinkaya, Isik Batuhan Cakmak, Kerim Munir
Summary: This study compared subjects with schizophrenia, bipolar disorder, and healthy controls in Theory of Mind assessment and cortical activity, finding that schizophrenia group performed the worst in meta-representation and empathy, and their ToM scores were negatively correlated with negative symptom severity. Activity in cortical regions during ToM task was higher in healthy controls compared to schizophrenia and bipolar disorder groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Obstetrics & Gynecology
Eran Ashwal, Uri Amikam, Avital Wertheimer, Eran Hadar, Emmanuel Attali, Dikla B. A. Dayan, Amir Aviram, Yariv Yogev, Liran Hiersch
Summary: Different regimens of postpartum oxytocin administration did not show significant differences in hematological measurements, and the postpartum Hb and Hct decline after vaginal deliveries was minor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Clinical Neurology
Jie Zhong, Hong Zhu, Dongqing Yin, Yanzhe Ning, Sisi Zheng, Yanbo Zhang, Hongxiao Jia
Summary: This study compared the efficacy of paliperidone and haloperidol in improving Theory of Mind (ToM) task performance in schizophrenia patients. The results suggested that paliperidone may be more effective than haloperidol in enhancing ToM task performance. Changes in ToM performance scores were observed over 16 weeks of treatment, with notable improvements in tasks such as first-order belief, higher-order belief, faux-pas, and Reading the Mind in the Eyes. Safety was also found to be manageable in both treatment groups.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Psychiatry
Judit Fekete, Zsuzsanna Poto, Eszter Varga, Dora Hebling, Marton Herold, Noemi Albert, Borbala Petho, Tamas Tenyi, Robert Herold
Summary: Recent research suggests that reading literary fiction may improve theory of mind (ToM) skills. This study aimed to assess the effect of prior reading experiences on ToM performance in schizophrenia patients and healthy controls. The results showed that previous reading experience was associated with better ToM performance and comprehension in both groups.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Genetics & Heredity
Nicky Daniels, Matthijs Moerkerke, Jean Steyaert, Annelies Bamps, Edward Debbaut, Jellina Prinsen, Tiffany Tang, Stephanie Van der Donck, Bart Boets, Kaat Alaerts
Summary: This study examined the efficacy of multiple-dose oxytocin administration in children with autism spectrum disorder (ASD). The results showed that both the oxytocin and placebo groups experienced improvements in social responsiveness, but these improvements were not specifically related to oxytocin administration. Interestingly, participants who initially received placebo and later switched to oxytocin showed significant improvement in social responsiveness. Furthermore, children who received psychosocial trainings along with oxytocin administration demonstrated a more pronounced improvement.
Article
Psychology, Developmental
Matthijs Moerkerke, Nicky Daniels, Stephanie Van Der Donck, Laura Tibermont, Tiffany Tang, Edward Debbaut, Annelies Bamps, Jellina Prinsen, Jean Steyaert, Kaat Alaerts, Bart Boets
Summary: This study used frequency-tagging electroencephalography to investigate the impact of repeated oxytocin administration on neural sensitivity towards facial expressions in children with autism spectrum disorder (ASD). The results showed that children with ASD had reduced neural sensitivity towards expressions, and while the placebo group showed increased sensitivity after nasal spray administration, the oxytocin group did not. These findings suggest that repeated oxytocin administration may dampen the learning effects of neural sensitivity.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
Jennifer A. McCoy, Lauren Walheim, Meaghan G. McCabe, Lisa D. Levine
Summary: This study aimed to evaluate the rates of cesarean delivery in patients with prolonged labor who received intravenous propranolol compared with placebo. The results showed no significant difference in cesarean delivery rate between the propranolol group and the placebo group.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Layla Thurston, Tia Hunjan, Natalie Ertl, Matthew B. Wall, Edouard G. Mills, Sofiya Suladze, Bjial Patel, Emma C. Alexander, Beatrice Muzi, Paul A. Bassett, Eugenii A. Rabiner, Paul Bech, David Goldmeier, Ali Abbara, Alexander N. Comninos, Waljit S. Dhillo
Summary: Despite being a common sexual health complaint in women worldwide, hypoactive sexual desire disorder (HSDD) lacks effective treatment options. This study investigates the effects of kisspeptin hormone on brain processing related to sexual and attraction stimuli in women with HSDD.
Article
Psychology, Clinical
Juan Kou, Yingying Zhang, Feng Zhou, Cornelia Sindermann, Christian Montag, Benjamin Becker, Keith M. Kendrick
Summary: Acute and chronic intranasal oxytocin administration have different effects on the amygdala, with infrequent chronic use showing the most therapeutic efficacy and genotype-dependent anxiety attenuation.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neuroimaging
Tobin J. Ehrlich, Jyoti Bhat, Andrea M. Horwege, Daniel H. Mathalon, Gary H. Glover, Brian J. Roach, Bashar W. Badran, Steven D. Forman, Mark S. George, J. Cobb Scott, Michael E. Thase, Jerome A. Yesavage, Deborah A. Yurgelun-Todd, Allyson C. Rosen
Summary: Patients with depression may engage in rumination, which can be divided into reflection and brooding. Reflection is associated with positive outcomes, while brooding is linked to negative outcomes. Repetitive pulse transcranial magnetic stimulation may alter abnormal connectivity associated with rumination, providing a potential mechanistic model for symptom-based neuromodulation of rumination.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
V. A. Cardenas, J. Bhat, A. M. Horwege, T. J. Ehrlich, J. Lavacot, D. H. Mathalon, G. H. Glover, B. J. Roach, B. W. Badran, S. D. Forman, M. S. George, M. E. Thase, J. A. Yesavage, D. Yurgelun-Todd, A. C. Rosen
Summary: This study investigated the effects of various DLPFC stimulation rules on brain systems using structural and functional MRI, finding that scalp-targeting rules were precise in directly targeting DLPFC and frontal networks, while rules involving fixed distances led to variability in regions and networks targeted.
Article
Psychiatry
Megan S. Farris, Amy Braun, Lu Liu, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon, Jean Addington
Summary: Trauma is prevalent among individuals at clinical high risk for psychosis, but it does not significantly increase the risk of transition to psychosis or affect long-term clinical and functional outcomes.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Neurosciences
A. Iraji, A. Faghiri, Z. Fu, P. Kochunov, B. M. Adhikari, A. Belger, J. M. Ford, S. McEwen, D. H. Mathalon, G. D. Pearlson, S. G. Potkin, A. Preda, J. A. Turner, T. G. M. Van Erp, C. Chang, V. D. Calhoun
Summary: Resting-state functional magnetic resonance imaging is the standard method for functional neuroimaging, allowing researchers to identify intrinsic connectivity networks. Little is known about the temporal profiles of these networks, but this study argues for leveraging the full temporal data rather than focusing on isolated neural events. The findings provide evidence for the continuous presence of the default mode in the BOLD signal, including during minimum activity time points. Additionally, different connectivity patterns were observed in different sets of time points, and these patterns were related to schizophrenia symptoms.
Article
Computer Science, Interdisciplinary Applications
Jessica A. Turner, Vince D. Calhoun, Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Sophia Thomopoulos, Eric Verner, Gregory P. Strauss, Anthony O. Ahmed, Matthew D. Turner, Sunitha Basodi, Judith M. Ford, Daniel H. Mathalon, Adrian Preda, Aysenil Belger, Bryon A. Mueller, Kelvin O. Lim, Theo G. M. van Erp
Summary: The application of the FAIR principles to clinical and neuroimaging data aims to make research products findable, accessible, interoperable, and reusable. ENIGMA and COINSTAC platforms combine technological approaches with sociological approaches to facilitate the use of machine-actionable data objects. Current efforts focus on improving access, interoperability, and reusability, with future plans to enhance findability and further connections to other resources.
Article
Psychiatry
Christopher S. Stauffer, Tyler E. Morrison, Nathan K. Meinzer, David Leung, Jessica Buffington, Evan G. Sheh, Thomas C. Neylan, Aoife O'Donovan, Joshua D. Woolley
Summary: Co-occurring PTSD and AUD is common and treatment options are limited. Intranasal oxytocin administration may be effective in reducing symptoms, but dosage is important. This study found that oxytocin 20 IU had no effect on startle reactivity in co-occurring patients, while oxytocin 40 IU increased startle reactivity.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Wisteria Deng, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker, Tyrone D. Cannon
Summary: This study found that there are different covariant trajectories of social anxiety and positive symptoms over time in individuals at clinical high-risk for psychosis. One subgroup showed sustained social anxiety despite moderate recovery in positive symptoms, while the other two subgroups showed recovery in both social anxiety and positive symptoms. The subgroup with sustained social anxiety had poorer long-term functional outcomes and higher levels of genetic and environmental risk factors for psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Michelle A. Worthington, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon
Summary: The study focuses on individuals in the clinical high-risk period before first episode of psychosis (CHR-P) who do not transition to psychosis, and aims to develop a predictive model for remission outcomes. Using a data-driven machine-learning approach, the researchers identified clinical and demographic predictors of symptomatic remission in CHR-P individuals. The study found that individuals who eventually experienced remission had lower baseline prodromal symptoms. This study highlights the importance of understanding factors contributing to resilience and recovery in CHR-P individuals.
SCHIZOPHRENIA BULLETIN
(2022)
Editorial Material
Neurosciences
Holly K. Hamilton, Daniel H. Mathalon
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S. Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A. Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F. Bartholomeusz, Michael W. L. Chee, Tiziano Colibazzi, Rebecca E. Cooper, Cheryl M. Corcoran, Vanessa L. Cropley, Bjorn H. Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj, Holly K. Hamilton, Kristen M. Haut, Rebecca A. Hayes, Ying He, Karsten Heekeren, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Mallory J. Klaunig, Shinsuke Koike, Alex Koppel, Tina D. Kristensen, Yoo Bin Kwak, Jun Soo Kwon, Stephen M. Lawrie, Irina Lebedeva, Jimmy Lee, Ashleigh Lin, Rachel L. Loewy, Daniel H. Mathalon, Chantal Michel, Romina Mizrahi, Paul Moller, Barnaby Nelson, Takahiro Nemoto, Dorte Nordholm, Maria A. Omelchenko, Christos Pantelis, Jayachandra M. Raghava, Jan Rossberg, Wulf Roessler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K. Tamnes, Jinsong Tang, Anastasia Theodoridou, Sophia Thomopoulos, Alexander S. Tomyshev, Peter J. Uhlhaas, Tor G. Vaernes, Therese A. M. J. van Amelsvoort, Theo G. M. Van Erp, James A. Waltz, Lars T. Westlye, Stephen J. Wood, Juan H. Zhou, Philip McGuire, Paul M. Thompson, Maria Jalbrzikowski, Dennis Hernaus, Paolo Fusar-Poli
Summary: Individuals at Clinical High Risk for Psychosis (CHR-P) show heterogeneity in neuroanatomical profiles, with significant differences in cortical surface area, cortical thickness, and subcortical volume compared to healthy controls. However, these profiles are not associated with the subsequent transition to psychosis.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Brian J. Roach, Yoji Hirano, Judith M. Ford, Kevin M. Spencer, Daniel H. Mathalon
Summary: This study reanalyzed EEG data and found that patients with schizophrenia showed phase delay in the left hemisphere in the 40-Hz ASSR. This finding supports previous studies showing abnormal auditory cortex function in the left hemisphere in patients with schizophrenia.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Meghan A. Collins, Jie Lisa Ji, Yoonho Chung, Cole A. Lympus, Yvette Afriyie-Agyemang, Jean M. Addington, Bradley G. Goodyear, Carrie E. Bearden, Kristin S. Cadenhead, Heline Mirzakhanian, Ming T. Tsuang, Barbara A. Cornblatt, Ricardo E. Carrion, Matcheri Keshavan, Wiliam S. Stone, Daniel H. Mathalon, Diana O. Perkins, Elaine F. Walker, Scott W. Woods, Albert R. Powers, Alan Anticevic, Tyrone D. Cannon
Summary: Progressive grey matter loss has been observed among individuals who convert to psychosis, and this study found that accelerated cortical thinning precedes psychosis onset and can differentiate converters from non-converters. These findings highlight the importance of identifying neurobiological mechanisms prior to conversion for early intervention.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Esra Sefik, Michelle Boamah, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri S. Keshavan, Daniel H. Mathalon, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Scott W. Woods, Tyrone D. Cannon, Elaine F. Walker
Summary: This study found clinically relevant deviations in cerebellar cortex and white matter structures among CHR individuals, highlighting the importance of considering the complex interplay between sex and age when studying the neuromaturational substrates of psychosis risk.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Marlena Duda, Armin Iraji, Judith M. Ford, Kelvin O. Lim, Daniel H. Mathalon, Bryon A. Mueller, Steven G. Potkin, Adrian Preda, Theo G. M. Van Erp, Vince D. Calhoun
Summary: By using spatially constrained independent component analysis (scICA), this study found that rsfMRI scans of just 2-5 minutes can provide good clinical utility without significant loss of individual functional network connectivity (FNC) information from longer scan lengths.
HUMAN BRAIN MAPPING
(2023)
Meeting Abstract
Neurosciences
Ryan Guest, Jean Addington, Carrie Bearden, Kristin Cadenhead, Barbara Cornblatt, Daniel Mathalon, Diana Perkins, Ming Tsuang, Scott Woods, Tyrone D. Cannon, William Stone, Elaine Walker
BIOLOGICAL PSYCHIATRY
(2022)