期刊
NEUROPHARMACOLOGY
卷 150, 期 -, 页码 59-69出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2019.03.012
关键词
Norepinephrine; Monkey; LATER; Visuo-spatial attention; Reaction time
资金
- French National Research Agency (ANR) grant [ANR-14-CE13-0005-1]
- NEURODIS Foundation
- James S. McDonnell Scholar award
- ANR [ANR-11-LABX-0042, ANR-11-IDEX-0007]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE13-0005] Funding Source: Agence Nationale de la Recherche (ANR)
The role of norepinephrine (NE) in visuo-spatial attention remains poorly understood. Our goal was to identify the attentional processes influenced by atomoxetine (ATX) injections, a NE-reuptake inhibitor that boosts the level of NE in the brain, and to characterize these influences. We tested the effects of ATX injections, on seven monkeys performing a saccadic cued task in which cues and distractors were used to manipulate spatial attention. We found that when the cue accurately predicted the location of the upcoming cue in 80% of the trials, ATX consistently improved attentional orienting, as measured from reaction times (RTs). These effects were best accounted for by a faster accumulation rate in the valid trials, rather than by a change in the decision threshold. By contrast, the effect of ATX on alerting and distractor interference was more inconsistent. Finally, we also found that, under ATX, RTs to non-cued targets were longer when these were presented separately from cued targets. This suggests that the impact of NE on visuo-spatial attention depends on the context, such that the adaptive changes elicited by the highly informative value of the cues in the most frequent trials were accompanied by a cost in the less frequent trials.
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