期刊
NEUROCHEMISTRY INTERNATIONAL
卷 125, 期 -, 页码 57-66出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2019.02.008
关键词
Forsythiaside; 2-Arachidonoylglycerol; beta-Amyloid; Cyclooxygenase-2; Neuroinflammation; Long term potentiation
资金
- National Natural Science Foundation of China [81403130]
- Shanxi Scholarship Council of China [2017-021]
- Natural Science Foundation of Shanxi Province [201801D121290]
In the study, the neuroprotectivities of forsythiaside, a main constituent of Forsythia suspensa (Thunb.) Vahl (F. suspensa, Lianqiao in Chinese), were investigated in the hippocampal slices. Forsythiaside suppressed the overexpression of cyclooxygenase-2 (COX-2) and monoacylglycerol lipase (MAGL) proteins induced by beta-amyloid (A beta(25-35)) to upregulate the levels of 2-arachidonoylglycerol (2-AG), an endogenous endocannabinoids. Then the inhibition of forsythiaside on COX-2 was deeply studied by the molecular docking. Forsythiaside prevented neuroinflammation and apoptosis from A beta(25-35) insults, and this action appeared to be mediated via cannabinoid receptor 1 (CB1R)-dependent nuclear factor-kappa B (NF-kappa B) signaling pathways. More importantly, forsythiaside functionally improved A beta(25-35)-induced learning and memory deficits, which was indicated by long term potentiation (LTP). Taken together, forsythiaside may have therapeutic potential for Alzheimer's diseases (AD) by increasing the levels of 2-AG.
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