Chemogenetics defines receptor-mediated functions of short chain free fatty acids

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

(2018) Charlotte Bayer Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing

(2018) Zhiwei Ang et al.   FASEB JOURNAL

The use of chemogenetic approaches to study the physiological roles of muscarinic acetylcholine receptors in the central nervous system

(2018) Sophie J. Bradley et al.   NEUROPHARMACOLOGY

Signaling of free fatty acid receptors 2 and 3 differs in colonic mucosa following selective agonism or coagonism by luminal propionate

(2018) Iain R. Tough et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

(2018) Angeliki Karamitri et al.   Science Signaling

The nutrition-gut microbiome-physiology axis and allergic diseases

(2017) Craig McKenzie et al.   IMMUNOLOGICAL REVIEWS

Discovery of new GPCR ligands to illuminate new biology

(2017) Bryan L Roth et al.   Nature Chemical Biology

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States

(2017) Paulius Viskaitis et al.   Cell Reports

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

(2017) Eugenia Sergeev et al.   Scientific Reports

DREADDS: Use and application in behavioral neuroscience.

(2016) Kyle S. Smith et al.   BEHAVIORAL NEUROSCIENCE

Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

(2016) Florence Namour et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Complex Pharmacology of Free Fatty Acid Receptors

(2016) Graeme Milligan et al.   CHEMICAL REVIEWS

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias

(2016) Daniele Bolognini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of AgonistVersusAntagonist Ligands

(2015) Eugenia Sergeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells

(2015) Maja S. Engelstoft et al.   MOLECULAR ENDOCRINOLOGY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

(2014) Mathieu Pizzonero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gustducin couples fatty acid receptors to GLP-1 release in colon

(2013) Yan Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB

(2013) Su Ui Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

G-protein-coupled designer receptors – new chemical-genetic tools for signal transduction research

(2013) Gerald Thiel et al.   BIOLOGICAL CHEMISTRY

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

(2013) Brian D. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

GPR43/FFA2: physiopathological relevance and therapeutic prospects

(2013) Laure B. Bindels et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

(2012) Brian D. Hudson et al.   FASEB JOURNAL

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

(2008) T. Lee et al.   MOLECULAR PHARMACOLOGY

International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions

(2008) L. A. Stoddart et al.   PHARMACOLOGICAL REVIEWS