Article
Endocrinology & Metabolism
Ana Carolina Monteiro, Adriana Bonomo
Summary: Bone metastases in patients with advanced breast cancer are common, leading to severe morbidity and increased mortality due to osteolytic lesions driven by osteoclasts in the bone marrow microenvironment. The primary tumor can actively modify the bone marrow microenvironment before metastatic spread, with specific T cells playing a crucial role in this process.
Review
Immunology
Marialuisa Bocchino, Serena Zanotta, Ludovica Capitelli, Domenico Galati
Summary: DCs play a crucial role in the pathogenesis of IPF, bridging innate and adaptive immunity and contributing to immune surveillance and fibrotic processes. Peripheral blood DC sub-types are severely depleted in therapy naive IPF patients, and the low frequency of conventional CD1c(+) DCs predicts a worse prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Smeda, Agnieszka Jasztal, Ebrahim H. Maleki, Anna Bar, Magdalena Sternak, Grzegorz Kwiatkowski, Joanna Suraj-Prazmowska, Bartosz Proniewski, Anna Kieronska-Rudek, Kamila Wojnar-Lason, Klaudia Skrzypek, Marcin Majka, Karolina Chrabaszcz, Kamilla Malek, Stefan Chlopicki
Summary: Ageing is a major risk factor for cancer metastasis, but the mechanisms behind it are unclear. This study investigated the effects of ageing on cancer-induced endothelial-mesenchymal transition (EndMT) in a breast cancer model in mice. The results showed that older mice had pre-existing endothelial dysfunction and rapid EndMT progression, leading to a more severe metastatic breast cancer phenotype compared to younger mice.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Zining Wang, Feifei Xu, Jie Hu, Hongxia Zhang, Lei Cui, Wenhua Lu, Wenzhuo He, Xiaojuan Wang, Mengyun Li, Huanling Zhang, Wenjing Xiong, Chunyuan Xie, Yongxiang Liu, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaofeng Frank Qin, Xiaojun Xia
Summary: Clotrimazole was identified as a drug that could enhance DC-mediated antigen presentation and T cell response, by acting on hexokinase 2 to regulate metabolic production and enhancing the lysosome pathway and Chop expression in DCs. In vivo administration of clotrimazole induced immune infiltration and inhibited tumor growth, synergizing with anti-PD1 antibody therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng
Summary: YTHDF1 is overexpressed in gastric cancer and promotes cancer growth by inducing cell proliferation and suppressing dendritic cell-mediated anti-tumor immune response. YTHDF1 is a promising therapeutic target for gastric cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Sara Nava, Daniela Lisini, Simona Frigerio, Anna Bersano
Summary: DCs vaccines have established safety and the ability to induce anti-tumor responses, and combining with other treatments may improve efficacy. Combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy could be the key to cancer treatment paradigms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Katerina Kalkusova, Sindija Smite, Elea Darras, Pavla Taborska, Dmitry Stakheev, Luca Vannucci, Jirina Bartunkova, Daniel Smrz
Summary: The immune checkpoint inhibitors are crucial in cancer immunotherapy, but their efficacy is limited in solid tumors. Mast cells and dendritic cells play important roles in the tumor immune microenvironment and controlling these cells may help overcome the resistance of solid tumors to immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Nesrine Mabrouk, Thi Tran, Ikuan Sam, Ivan Pourmir, Nadege Gruel, Clemence Granier, Josephine Pineau, Alain Gey, Sebastian Kobold, Elizabeth Fabre, Eric Tartour
Summary: CXCR6 is a receptor that interacts with the chemokine CXCL16 and serves as a marker for immunosurveillance and immunotherapy response. It plays a role in controlling tumor proliferation by CD8(+) T cells and NKT cells. Additionally, it is associated with the efficacy of anti-tumor vaccination and intratumoral accumulation of CAR-T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tomohiro Takiguchi, Fumi Takahashi-Yanaga, Shin Ishikane, Fumi Tetsuo, Hiroshi Hosoda, Masaki Arioka, Takanari Kitazono, Toshiyuki Sasaguri
Summary: The study demonstrated that Angiotensin II accelerated primary tumor growth and lung metastasis formation, but had no significant effects on 4T1-Luc cells themselves. Co-culturing with dermal fibroblasts, Ang II accelerated cell migration and promoted the expression of proteins related to epithelial-to-mesenchymal transition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Shuai Zhang, Liwei Zhao, Mengfei Guo, Peng Liu, Sijing Li, Wei Xie, Ai-Ling Tian, Jonathan G. Pol, Hui Chen, Hui Pan, Misha Mao, Yumei Li, Laurence Zitvogel, Yang Jin, Oliver Kepp, Guido Kroemer
Summary: This study identified two small molecule drugs, ikarugamycin and astemizole, with immunotherapeutic potential. Ikarugamycin acts on DCs to enhance their antigen presenting ability, while astemizole activates T cells to strengthen immune response. Both drugs improved the anticancer activity of oxaliplatin.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Javad Masoumi, Nahid Zainodini, Pedram Basirjafar, Tayyebeh Tavakoli, Raziyeh Zandvakili, Maryam Nemati, Mahnaz Ramezani, Mohammad-Taghi Rezayati, Fatemeh Ayoobi, Morteza Khademalhosseini, Hossein Khorramdelazad, Rostamlou Arman, Abdollah Jafarzadeh
Summary: This study aimed to investigate the effects of APJ antagonist ML221 in combination with a DC vaccine on angiogenic, metastatic and apoptotic-related factors in a breast cancer model. The results showed that combination therapy significantly reduced the expression of multiple proteins in tumor tissues, decreased the serum levels of IL-9 and IL-35, and reduced vascular density and vessel diameter. These findings suggest that combination therapy using a blocker of the apelin/APJ axis and DC vaccine is a promising therapeutic program for cancers.
Article
Engineering, Biomedical
Ying-Hua Guan, Na Wang, Zhen-Wei Deng, Xi-Guang Chen, Ya Liu
Summary: Dendritic cells (DCs) play a critical role in regulating immune response and anti-tumor process. However, immunosuppressive cells and factors in the tumor microenvironment pose challenges to DC function. Therefore, designing nanomaterials to regulate DC autophagy is important for enhancing immune function.
Review
Biochemistry & Molecular Biology
Yuqiu Xu, Yihao Mao, Yang Lv, Wentao Tang, Jianmin Xu
Summary: Metastasis is a major cause of cancer-related death, and immunotherapy holds promise for preventing and treating tumor metastasis. While T cells have been extensively studied, less attention has been given to B cells and their subsets, despite their important role in tumor metastasis. B cells secrete antibodies, cytokines, and participate in tumor immunity through antigen presentation. They can either inhibit or promote tumor metastasis, highlighting the complexity of B cells in tumor immunity. Moreover, distinct B cell subgroups have different functions, influenced by the tumor microenvironment and metabolic homeostasis. This review summarizes the role, mechanisms, and prospects of B cells in tumor metastasis and immunotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Giovanni Fuca, Margherita Ambrosini, Luca Agnelli, Silvia Brich, Francesco Sgambelluri, Roberta Mortarini, Serenella M. Pupa, Michele Magni, Liliana Devizzi, Paola Matteucci, Antonello Cabras, Roberta Zappasodi, Francesca De Santis, Andrea Anichini, Filippo De Braud, Alessandro M. Gianni, Massimo Di Nicola
Summary: This study provides a 15-year follow-up of vaccination with tumor-loaded DCs in relapsed iNHL patients, showing long-term benefit without significant toxicity, improved survival rates, and potential for long-lasting complete responses. Biomarker analysis revealed different gene expressions in responder versus non-responder tumors, indicating a potential for personalized treatment approaches. The study suggests that active immunization with DCs may be a promising strategy in relapsed iNHL treatment, warranting further investigation in combination with other novel immunotherapy agents.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Christopher Groth, Rebekka Weber, Samantha Lasser, Feyza Gul Ozbay, Annina Kurzay, Vera Petrova, Peter Altevogt, Jochen Utikal, Viktor Umansky
Summary: This review summarizes the origin of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and their relation to classical neutrophils, outlining their metastasis promoting features and promising strategies for targeting them to enhance the efficacy of cancer immunotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2021)
