Review
Medicine, General & Internal
Miriam Ortiz, Anna Katharina Koch, Holger Cramer, Klaus Linde, Gabriele Rotter, Michael Teut, Benno Brinkhaus, Heidemarie Haller
Summary: This study aimed to systematically review the clinical effects of hydrotherapy according to Kneipp. The results suggested that hydrotherapy showed positive effects in some conditions and outcomes, but the high risk of bias and heterogeneity of the included studies made it difficult to ascertain the treatment effects. Higher-quality studies on Kneipp hydrotherapy are urgently needed.
Review
Clinical Neurology
Florian Holtbernd, N. Jon Shah
Summary: Functional imaging studies consistently show altered functional connectivity in the cerebellum and cerebello-thalamico-cortical circuitry. Structural imaging studies are less consistent, with no clear evidence for cerebellar neurodegeneration, but diffusion tensor imaging robustly points toward microstructural cerebellar changes.
FRONTIERS IN NEUROLOGY
(2021)
Review
Chemistry, Medicinal
Alireza Heiran, Kamran Bagheri Lankarani, Ryan Bradley, Alireza Simab, Mehdi Pasalar
Summary: Herbal remedies showed better improvement in symptoms and quality of life for patients with functional dyspepsia (FD) compared to placebo, with no significant differences in adverse events. Further high-quality studies are needed to firmly establish the clinical efficacy of herbal remedies.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Nobuhiro Asai, Daisuke Sakanashi, Hiroyuki Suematsu, Hideo Kato, Mao Hagihara, Arufumi Shiota, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
Summary: This study reviewed all candidemia patients in the institute from 2014 to 2018 and found that only 24% of the patients were eligible for clinical trials. Compared to those who were not eligible, the eligible patients had better performance status, fewer comorbidities and longer overall survival times. This suggests that clinical trials may not accurately reflect the real world among candidemia patients.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Plant Sciences
Tiantian Meng, Peng Wang, Xiaolong Xie, Tingting Li, Lingbo Kong, Yingzhi Xu, Kegang Cao, Ying Gao, Qingyong He, Xinxing Lai
Summary: SXC is effective and safe for treating essential hypertension, as it can lower blood pressure and improve hypertensive symptoms.
Review
Pharmacology & Pharmacy
Purumea Jun, HuiYan Zhao, In Chul Jung, Ojin Kwon, Chang-Hyun Han, Jiyoon Won, Jung-Hee Jang
Summary: This study aimed to evaluate the efficacy of herbal medicine prescribed according to the syndrome differentiation (SD) approach in Parkinson's disease (PD) treatment. The findings suggest that combined treatment of herbal medicine and western medicine significantly improves the overall assessment of PD symptoms and is more beneficial for non-motor symptoms. However, the methodological quality of the included studies needs improvement.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yamamh Al-Jubori, Nazik Tayfour Babiker Ahmed, Rawan Albusaidi, James Madden, Srijit Das, Srinivasa Rao Sirasanagandla
Summary: This systematic review focuses on the effectiveness of gum arabic (GA) in the treatment of various diseases. The results show that GA has significant effects on lipid profiles, renal function, plaque, gingival scores, biochemical parameters, blood pressure, inflammatory markers, and adiposity. GA has been successfully used in the treatment of sickle cell anemia, rheumatoid arthritis, metabolic disorders, periodontitis, gastrointestinal conditions, and kidney diseases. The findings of this research are important for understanding the potential therapeutic applications of GA in clinical practice.
Review
Chemistry, Medicinal
Mojgan Shavakhi, Amirhossein Sahebkar, Farinaz Shirban, Mohammad Bagherniya
Summary: This review indicates that herbal medicines have significant effects in reducing pain, ulcer size, and healing time in the treatment of recurrent aphthous stomatitis. Few adverse events were reported in the herbal treatment group, suggesting that medicinal plants and phytochemicals are effective and safe agents for RAS treatment.
PHYTOTHERAPY RESEARCH
(2022)
Review
Public, Environmental & Occupational Health
Yuanming Yang, Kehan Rao, Kai Zhan, Min Shen, Huan Zheng, Shumin Qin, Haomeng Wu, Zhaoxiang Bian, Shaogang Huang
Summary: Acupuncture and moxibustion have shown benefits for symptom severity, abdominal pain, and quality of life in patients with IBS, but more rigorous sham control trials are needed to confirm the efficacy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Cardiac & Cardiovascular Systems
Bo Liang, Ning Gu
Summary: Traditional Chinese medicine has a long history and is widely used in clinical practice, but its role in the prevention and treatment of coronary artery disease remains unclear due to lack of scientific evidence. Randomized controlled trials have shown that traditional Chinese medicine can be used as a complementary method in managing coronary artery disease, with similar safety profile to conventional medications. Further research with long-term endpoints is needed to fully assess its safety and efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Anna-Maria Wiesinger, Brian Bigger, Roberto Giugliani, Christina Lampe, Maurizio Scarpa, Tobias Moser, Christoph Kampmann, Georg Zimmermann, Florian B. Lagler
Summary: Mucopolysaccharidosis (MPS) is a rare group of metabolic diseases with limited treatment options. This study proposes the use of immunomodulatory drugs in innovative individual treatment trials (ITTs) for MPS patients and develops a risk-benefit model for drug evaluation. The decision analysis framework (DAF) includes literature analysis, quantitative risk-benefit assessment, and phenotypic profiling. Four immunomodulatory drugs, adalimumab, abatacept, anakinra, and cladribine, show promise for MPS treatment. This evidence-based model provides a step towards precision medicine in MPS using immunomodulators.
Review
Clinical Neurology
Sravani Kondapavulur, Alexander B. Silva, Annette M. Molinaro, Doris D. Wang
Summary: FUS-T and SRS-T have similar efficacy for medically refractory ET, but FUS-T has a higher incidence of adverse events. Smaller lesion volumes could improve the safety of FUS-T.
Article
Clinical Neurology
Luca Angelini, Giulia Paparella, Alessandro De Biase, Annalisa Maraone, Matteo Panfili, Isabella Berardelli, Antonio Cannavacciuolo, Antonella Di Vita, Roberta Margiotta, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
Summary: This study investigated the progression of Essential Tremor (ET) manifestations through clinical and neurophysiological evaluation. The results showed that ET progression is characterized by the spread of tremor in multiple body segments and the emergence of soft signs. Female sex, absence of family history, and rest tremor at baseline were identified as predictive factors of worse disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Virology
Ying Jie Chee, Bingwen Eugene Fan, Barnaby Edward Young, Rinkoo Dalan, David C. C. Lye
Summary: Post-acute sequelae of SARS-CoV-2 infection, also known as long COVID, is an emerging public health concern. This review summarizes published trials and ongoing research on managing long COVID, highlighting the need for standardized diagnostic criteria and outcome measures. Current trials focus on individual symptoms and organ dysfunction, and more research is needed to address the unmet needs of patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Plant Sciences
Le Shao, Yan She, Bowei Chen, Jian Yi, Ya Li, Zhihua Guo, Qibiao Wu
Summary: This study is the first meta-analysis of randomized clinical trials evaluating the effects of Buyang Huanwu decoction (BYHWD) on sequelae of stroke. Adding BYHWD to conventional treatment significantly improved the clinical effective rate and promoted neurological rehabilitation in patients, with no reported adverse events associated with this combination therapy.
Article
Clinical Neurology
Christopher G. G. Goetz, Dongrak Choi, Yuanyuan Guo, Glenn T. T. Stebbins, Tiago A. A. Mestre, Sheng Luo
Summary: The study aimed to reassess the validity of summing scores of MDS-UPDRS parts. The results indicated that summing the scores of Part III with other parts is not reliable. Therefore, it is necessary to adhere to the original limitations when using MDS-UPDRS.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Yuanyuan Guo, Christopher G. Goetz, Glenn T. Stebbins, Tiago A. Mestre, Sheng Luo
Summary: The study developed valid constructs for combining patient-reported and investigator-rated scores in Parkinson's disease, confirming a two-domain construct as a valid summary of PD motor severity.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Steve Vucic, Kai-Hsiang Stanley Chen, Matthew C. Kiernan, Mark Hallett, David. H. Benninger, Vincenzo Di Lazzaro, Paolo M. Rossini, Alberto Benussi, Alfredo Berardelli, Antonio Curra, Sandro M. Krieg, Jean-Pascal Lefaucheur, Yew Long Lo, Richard A. Macdonell, Marcello Massimini, Mario Rosanova, Thomas Picht, Cathy M. Stinear, Walter Paulus, Yoshikazu Ugawa, Ulf Ziemann, Robert Chen
Summary: This review provides a comprehensive update on the clinical diagnostic utility of transcranial magnetic stimulation (TMS) in neurological diseases. TMS techniques have demonstrated clinical utility in various neurodegenerative, movement, episodic, chronic pain, and functional diseases. TMS measures can aid in the diagnosis of amyotrophic lateral sclerosis, stroke, myelopathy, and Alzheimer's disease, among others. Combining TMS with electroencephalography allows for the measurement of parameters altered in neurological disorders.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Johannes Meyne, Mirjam Domschikowski, Johannes Hensler, Ann-Kristin Helmers, Daniela Berg, Guenther Deuschl, Steffen Paschen
Summary: The study found that patients with previous deep brain stimulation (DBS) surgery can undergo intravenous thrombolysis (IVT) and endovascular mechanical thrombectomy therapy (MT) for acute ischemic stroke, without bleeding complications, at least 6 months after the surgery.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Alberto Albanese, Kailash P. Bhatia, Francisco Cardoso, Cynthia Comella, Giovanni Defazio, Victor S. C. Fung, Mark Hallett, Joseph Jankovic, Hyder A. Jinnah, Ryuji Kaji, Joachim K. Krauss, Anthony Lang, Eng King Tan, Marina A. J. Tijssen, Marie Vidailhet
Summary: This document provides a consensus on the diagnosis and classification of isolated cervical dystonia (iCD) and proposes diagnostic criteria and classification. It aims to systematize terminology and the diagnostic process for reproducibility and applicability. The criteria include motor abnormalities and nonmotor manifestations, and three iCD presentations are described. The relationship between iCD and isolated head tremor is also discussed. Continuous revision of the criteria is necessary as knowledge of iCD expands.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Tiago A. Mestre, Michael P. McDermott, Raquel Lobo, Joaquim J. Ferreira, Anthony E. E. Lang
Summary: This study evaluated the "lessebo effect" in disease modification trials in Parkinson's disease and found that it did not exist in these trials. However, the use of placebo instead of an active comparator was a limitation. Prospective measurement of expectation of benefit could help assess the various impacts of placebo use.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Matteo Bologna, Alberto J. Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Haotian Zou, Christopher G. Goetz, Glenn T. Stebbins, Anette Schrag, Tiago A. Mestre, Sheng Luo
MOVEMENT DISORDERS
(2023)
Editorial Material
Clinical Neurology
Guenther Deuschl
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Masahiro Ohara, Kosei Hirata, Mark Hallett, Taiki Matsubayashi, Qingmeng Chen, Satoko Kina, Kaoru Shimano, Akihiro Hirakawa, Takanori Yokota, Takaaki Hattori
Summary: This study aimed to investigate the effect of long-term levodopa treatment on the sequence effect (SE) in gait conditions among Parkinson's disease (PD) patients. The study found that long-term levodopa treatment only improved the SE in single-task straight walking, but had no effect on the SE in circular walking. Additionally, for patients with right-side dominance, long-term levodopa treatment exacerbated the SE in circular walking.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Neurosciences
Mark Hallett
Summary: Pandya made important contributions to the understanding of cortical auditory pathways in 1969, particularly in regards to the observations on transcallosal connections of the primary auditory cortex. His speculation on the role of spatial localization of sound was later found to be incorrect, although the original observation remains valid based on subsequent literature review.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Clinical Neurology
Dana Brinker, Oliver Granert, Felix Goevert, Inken Toedt, Alexander Baumann, Kirsten E. Zeuner, Robin Wolke, Guenther Deuschl, Jos S. Becktepe
Summary: This study aims to explore alterations of brain grey matter in patients with essential tremor (ET) combined with dystonic soft signs (ET + ds). The results showed a significant increase of grey matter in the right lentiform nucleus in ET + ds and tremor associated with manifest dystonia (TAWD) compared to healthy controls and ET patients without dystonic soft signs (ET-ds). Additionally, an increase of cortical grey matter in the middle frontal gyrus was observed in ET + ds. The hypertrophy of the lentiform nucleus in ET + ds was correlated with disease severity and duration.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Steffen Paschen, Jos S. Becktepe, Markus A. Hobert, Kirsten E. Zeuner, Ann-Kristin Helmers, Daniela Berg, Gunther Deuschl
Summary: The current analysis of clinical symptomatology is not sufficient to predict surgical success for patients with combined tremor and dystonia syndromes. Other criteria are needed to determine the best target for deep brain stimulation, and rescue surgery may be considered for severely disabled patients if the initial target fails.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Erin Furr Stimming, Daniel Claassen, Elise Kayson, Jody Goldstein, Raja Mehanna, Hui Zhang, Grace S. Liang, Dietrich Haubenberger
Summary: Valbenazine was evaluated as a treatment for chorea associated with Huntington's disease, and it was found to be more effective than placebo in improving chorea symptoms and well tolerated.