Article
Neurosciences
Kosma Sakrajda, Karolina Bilska, Piotr M. Czerski, Beata Narozna, Monika Dmitrzak-Weglarz, Stefanie Heilmann-Heimbach, Felix F. Brockschmidt, Stefan Herms, Markus M. Noethen, Sven Cichon, Barbara Wieckowska, Janusz K. Rybakowski, Joanna Pawlak, Aleksandra Szczepankiewicz
Summary: This study suggests the involvement of AHI1 in the mode of action of lithium, as well as the association between mood-stabilizing treatment and innate immunity-related gene expression in BD patients.
PSYCHOPHARMACOLOGY
(2023)
Review
Oncology
X. Zhao, A. Chen, Z. Wang, Xiao-Han Xu, Y. Tao
Summary: Huntington disease is a genetic neurodegenerative disease caused by polyglutamine expansion, with HAP1 being a protein directly associated with the disease. HAP1 is expressed in the nervous system, endocrine system, and digestive system, and understanding its function can provide new insights into disease mechanisms.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hong Zhang, Si Wu, Laura S. Itzhaki, Sarah Perrett
Summary: Huntington disease is associated with aggregation of huntingtin protein, and the study explores the interaction between the N-terminal huntingtin exon 1 region and the HEAT repeat structure. The results suggest that the exon 1 region slightly destabilizes the downstream HEAT repeat structure and provides more flexibility. The interaction between exon 1 and HEAT repeats is compatible with the normal function of huntingtin protein and the pathogenesis of Huntington disease.
Article
Cell Biology
M. Reichenstein, N. Borovok, A. Sheinin, T. Brider, I Michaelevski
Summary: Amyloid beta (Aβ) peptides are a key focus in Alzheimer's disease research, with varying effects depending on different molecular forms and experimental conditions. Recent studies suggest that the neurotoxic effects of Aβ peptides may be mediated through the activation of Abl kinases, potentially contributing to synaptic weakening.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yinna Wang, Guoning Liao, Ruping Wang, Dale D. Tang
Summary: Actin cytoskeletal reorganization is crucial for regulating smooth muscle contraction, with Abi1 playing a key role in this process through acetylation at K416. The interaction between Abi1 and N-WASP enhances actin polymerization, ultimately promoting smooth muscle contraction. Additionally, the localization of p300 in the cytoplasm of smooth muscle cells suggests a novel mechanism for the acetylation-dependent regulation of the actin cytoskeleton.
Article
Biochemistry & Molecular Biology
Edward Chau, Jin Ryoun Kim
Summary: This study investigated the interactions between Aβ42 and αS in different conformations. It was found that αS monomers and oligomers promoted the oligomerization and stabilization of soluble Aβ42, while αS fibrils hindered the aggregation of Aβ42. These interactions may be achieved through direct binding or co-assembly, and different parts of Aβ42 mediated the interactions with αS.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Geriatrics & Gerontology
Jinsu Park, Meenu Madan, Srinivasulu Chigurupati, Seung Hyun Baek, Yoonsuk Cho, Mohamed R. Mughal, Amin Yu, Sic L. Chan, Jogi Pattisapu, Mark P. Mattson, Dong-Gyu Jo
Summary: AQP1 levels are elevated in the cerebral cortex during the early stages of AD, particularly in vulnerable neurons, and increase as aging progresses in AD mouse models. AQP1 appears to reduce A beta production by inhibiting the binding between BACE1 and APP.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kevin A. Murray, Carolyn J. Hu, Sarah L. Griner, Hope Pan, Jeannette T. Bowler, Romany Abskharon, Gregory M. Rosenberg, Xinyi Cheng, Paul M. Seidler, David S. Eisenberg
Summary: Neurodegenerative diseases are characterized by the accumulation of aggregated proteins, and inhibiting the formation of these aggregates is a potential therapeutic strategy. Using de novo protein design, researchers have developed a library of mini-protein inhibitors that specifically target the amyloid structures of tau, Aβ, and α Syn. These inhibitors show promising results in preventing aggregation and rescuing motor deficits in animal models of PD and AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P. Reddy, Gurjit Kaur Bhatti, P. Hemachandra Reddy
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that involves synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal imbalance, increased astrocytes & microglia, and accumulation of amyloid & beta; and phosphorylated Tau. Targeting mitochondrial proteins, including dynamin-related protein 1 (Drp1), may be a potential therapeutic approach for preventing AD pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Clinical Neurology
Lei Liu, Hyunchang Kwak, Trebor L. Lawton, Shan-Xue Jin, Angela L. Meunier, Yifan Dang, Beth Ostaszewski, Alison C. Pietras, Andrew M. Stern, Dennis J. Selkoe
Summary: The study developed a new method for detecting and quantifying soluble oligomers of amyloid beta protein in human plasma. The method is highly sensitive, cost-effective, and suitable for high throughput analysis.
ALZHEIMERS & DEMENTIA
(2022)
Review
Endocrinology & Metabolism
Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu
Summary: This article summarizes the regulatory effects of APP and its cleavage peptides on metabolism in the central nervous system and peripheral tissues, indicating that peptides generated by non-amyloidogenic processing can have positive effects on metabolism, while those produced by amyloidogenic processing may have negative impacts. Abnormal expression of APP is associated with metabolic diseases (such as diabetes, obesity, etc.) and cancer.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Physiology
Jerome Garcia, Rudy Chang, Ross A. Steinberg, Aldo Arce, Joshua Yang, Peter van der Eb, Tamara Abdullah, Devaraj V. Chandrashekar, Sydney M. Eck, Pablo Meza, Zhang-Xu Liu, Enrique Cadenas, David H. Cribbs, Neil Kaplowitz, Rachita K. Sumbria, Derick Han
Summary: Heavy alcohol consumption is a known risk factor for dementia and Alzheimer's disease. However, intragastric alcohol feeding-induced liver steatosis, rather than alcohol-induced liver injury, may be more responsible for disrupting A beta processing by the liver and promoting AD.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vladimir Rudajev, Jiri Novotny
Summary: This article discusses the relationship between cholesterol and the development of Alzheimer's disease, as well as the influence of cholesterol on the production of amyloid beta (Aβ).
CELL AND BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero, Clelia Dispenza, Daniela Giacomazza
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, characterized by senile plaques and neurofibrillary tangles. There is currently a lack of treatment options aside from symptomatic medications. This review presents research results on the use of peptides of different sizes for the treatment of Alzheimer's disease.
Article
Chemistry, Multidisciplinary
Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyeon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han, Mu-Hyun Baik, Young-Ho Lee, Mi Hee Lim
Summary: This study reveals that the interaction between APP-C31 and Aβ40 peptides promotes the aggregation and toxicity of Aβ40, leading to nuclear damage, neurite degeneration, and inflammation. This finding may offer a novel target for developing treatments for AD.
Article
Psychology, Biological
Chia-Liang Tsai, Kirk Erickson, H-Sunny Sun, Yu-Min Kuo, Ming-Chyi Pai
Summary: Individuals with a family history of AD who were carriers of the ApoE-4 variant performed worse in the task-switching paradigm, potentially due to compromised task-set and memory updating processes. Physical exercise interventions aimed at enhancing cardiorespiratory fitness levels could be a potential strategy for AD prevention, improving cognitive function, and reducing the accumulation of A beta peptides in high-risk groups.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Neurosciences
Te-Han Kung, Tzu-Cheng Chao, Yi-Ru Xie, Ming-Chyi Pai, Yu-Min Kuo, Gwo Giun Chris Lee
Summary: An algorithm based on three features in hippocampal subfields was established using MRI to model variations in AD progression, proposing a new biomarker RPC to characterize folding patterns. Morphological features associated with hippocampal subfields were assessed for sensitivity to cognitive capacity changes, with a classification accuracy of 79.95% in distinguishing MCI patients progressing to AD using a logical feature selection method.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Ying-Yiu Lam, Sheng-Feng Tsai, Pei-Chun Chen, Yu-Min Kuo, Yun-Wen Chen
Summary: Pioglitazone may be a potential therapeutic agent for metabolic disorders and associated depression, as it alleviated glucose metabolic dysfunctions and depressive phenotypes in mice.
The treatment of pioglitazone reduced depression-like behaviors and astrocytic activation induced by a high-fat diet.
Pioglitazone treatment had no effect on anxiety-like behaviors or hippocampus-related learning and memory in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Tien-Fen Kuo, Shuo-Wen Hsu, Shou-Hsien Huang, Cicero Lee-Tian Chang, Ching-Shan Feng, Ming-Guang Huang, Tzung-Yan Chen, Meng-Ting Yang, Si-Tse Jiang, Tuan-Nan Wen, Chun-Yen Yang, Chung-Yu Huang, Shu-Huei Kao, Keng-Chang Tsai, Greta Yang, Wen-Chin Yang
Summary: The study identified Pdia4 as a crucial regulator in beta-cells, affecting diabetes development by modulating ROS production and other pathways. Elimination of Pdia4 can fully reverse diabetes, while overexpression of Pdia4 leads to opposite outcomes.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Hwang I. S. Thomas, Ying-Shiuan Chen, Ching-Han Hung, Dilip Bhargava Sreerangaraja Urs, Tien-Ling Liao, Yen-Chun Lai, Katerina Komrskova, Pavla Postlerova, Yung-Feng Lin, Shu-Huei Kao
Summary: The study shows that the mitochondrial redox microenvironment and genome integrity play crucial roles in sperm motility and fertility. Mutations and polymorphisms in genes can affect sperm motility and the antioxidative system, ultimately impacting male fertility.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Anatomy & Morphology
Battuvshin Lkhagvasuren, Onanong Mee-inta, Zi-Wei Zhao, Tetsuya Hiramoto, Damdindorj Boldbaatar, Yu-Min Kuo
Summary: The neural regulation of glucose homeostasis is crucial for both type 1 and type 2 diabetes. Despite the abundant innervation of the pancreas, the exact nature of islet innervation remains unclear. Understanding the neurocircuitry and neurochemistry of the neuro-insular network could offer insights for new neuromodulation-based approaches to prevent and treat diabetes.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Biochemistry & Molecular Biology
Binxing Li, Preejith Vachali, Fu-Yen Chang, Aruna Gorusupudi, Ranganathan Arunkumar, Linjia Shi, Gregory T. Rognon, Jeanne M. Frederick, Paul S. Bernstein
Summary: This study found that HDL serves as the primary transporter for macular carotenoids, and ApoA-I may be involved in the selective delivery of these carotenoids to the retinal pigment epithelium.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Feng Tsai, Hao-Chang Hung, Monica Meng-Chun Shih, Fu-Chuan Chang, Bon-chu Chung, Chia-Yih Wang, Yu-Ling Lin, Yu-Min Kuo
Summary: This study aimed to investigate the causal relationship between chronic ingestion of a high-fat diet (HFD)-induced secretion of glucocorticoids (GCs) and the development of non-alcoholic fatty liver disease (NAFLD). The study found that the release of glucocorticoids induced by high-fat diet contributes to the development of NAFLD, and this process involves the upregulation of CD36 in the liver.
Article
Cell Biology
Tzu-Feng Wang, Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yu-Min Kuo
Summary: This study aimed to investigate the role of microglial activation in Parkinson's disease. The results showed that microglial activation was associated with age-related loss of dopaminergic neurons in the substantia nigra and motor deficits. Inhibiting microglial activation reduced dopaminergic neuron death. Exercise upregulated neurotrophic factor signaling and inhibited microglial activation.
Article
Medical Laboratory Technology
Monika Renuka Sanotra, Wen-Chung Huang, Simon Silver, Ching-Yu Lin, Tsuei-Chuan Chang, Doan Phuong Quy Nguyen, Ching-Kuo Lee, Shu-Huei Kao, Jonathan Chang-Cheng Shieh, Yung-Feng Lin
Summary: This study investigates the interactions of A beta, HNE adducts, and responding autoantibodies during the pathogenesis from hyperglycemia to AD. The results suggest that HNE adducts have better diagnostic performances than A beta for both hyperglycemia and AD, and depletion of autoantibodies may promote AD-like pathogenesis.
CLINICAL BIOCHEMISTRY
(2022)
Article
Immunology
Hao-Chang Hung, Sheng-Feng Tsai, Shih-Ren Sie, Yu-Min Kuo
Summary: High glucose exacerbates LPS-induced inflammatory responses of microglia by enhancing the TLR4/p38 pathway and prolonging the activation of NF-kappa B/iNOS signaling. Controlling blood glucose levels is advised to manage neuroinflammation and related neurodegenerative diseases.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Feng Tsai, Pei-Ling Hsu, Yun-Wen Chen, Mohammad Shahadat Hossain, Pei-Chun Chen, Shun-Fen Tzeng, Po-See Chen, Yu-Min Kuo
Summary: This study reveals the comorbidity between metabolic disorders and depressive syndrome and identifies the dysregulated glutamatergic transmission mediated by astrocytes as a therapeutic target for this subtype of depressive mood disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Hao Lin, Yao-Hsiang Shih, Ye Vone Yap, Yen-Wei Chen, Hsiang-Lin Kuo, Tsung-Yun Liu, Li-Jin Hsu, Yu-Min Kuo, Nan-Shan Chang
Summary: When WWOX is downregulated in middle age, protein aggregation occurs and lasts for more than 30 years, leading to the development of Alzheimer's disease. Treatment with neurotoxin MPP+ results in the upregulation and aggregation of TPC6A Delta, which is a common initiator for both Alzheimer's disease and Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nguyen-Tuong Ho, Shu-Wei Lin, Yi-Rong Lee, Chii-Ruey Tzeng, Shu-Huei Kao
Summary: OPNb and OPNc are overexpressed in endometriosis and adenomyosis, and CD44v and the epithelial-mesenchymal transition (EMT) process are also upregulated. Overexpression of OPNb and OPNc splice variants leads to morphological changes, actin remodeling, cell proliferation, cell migration, and EMT through binding with CD44 and alpha v beta 3, subsequently activating the PI3K and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Po-Sheng Hu, Hsiu-Jen Chou, Chi-An Chen, Po-Yi Wu, Kai-Hsien Hsiao, Yu-Min Kuo
Summary: This research investigates the photothermal effects of Cs0.33WO3 nanoparticles on HepG2 liver cancer cells, formulating a thermal dose for near-infrared irradiation and exploring the dependence of cellular survival rate on variable parameters of photothermal dose.
NANOSCALE RESEARCH LETTERS
(2021)
