Review
Oncology
Guangbing Xiong, Shutao Pan, Jikuan Jin, Xiaoxiang Wang, Ruizhi He, Feng Peng, Xu Li, Min Wang, Jianwei Zheng, Feng Zhu, Renyi Qin
Summary: The study provides a comprehensive review of the role of lncRNAs and miRNAs in the initiation and progression of pancreatic cancer, highlighting the crucial function of ceRNA networks in the biological processes of pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Review
Cell Biology
Surendar Aravindhan, Laith A. Younus, Methaq Hadi Lafta, Alexander Markov, Yulianna Ivanovna Enina, Natalya A. Yushchenko, Lakshmi Thangavelu, Seyed Mojtaba Mostafavi, Michail V. Pokrovskii, Majid Ahmadi
Summary: The protein p53 plays a crucial role in tumor suppression and interacts with long noncoding RNAs (lncRNAs) to control cancer progression by regulating cell cycle and apoptosis. Understanding the crosstalk between p53 and lncRNAs is important for elucidating the mechanisms of various cancers.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Gu Xi, Xu Ziyu, Liu Yiting, Liu Zonghang, Zheng Lifeng
Summary: This study identified two novel lncRNAs (LINC00114 and UCA1) in colon cancer through bioinformatics analysis. These lncRNAs may be associated with the occurrence and development of colon cancer, with LINC00114 potentially impacting the overall survival of patients.
Article
Genetics & Heredity
Zifan Yue, Pei Mou, Sainan Chen, Fei Tong, Ruili Wei
Summary: A study investigated the lncRNA/circRNA-miRNA-mRNA network in Graves' ophthalmopathy (GO) patients, revealing significant differences in RNA expression levels compared to control patients. Through high-throughput sequencing and qPCR validation, the study identified key genes and constructed ceRNA networks. This innovative study identified two important ceRNA pathways that may impact autoimmune response and inflammation in GO patients.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Ke-zhi Li, Yi-xin Yin, Yan-ping Tang, Long Long, Ming-zhi Xie, Ji-lin Li, Ke Ding, Bang-li Hu
Summary: Right-sided and left-sided colon cancers have distinct clinical and molecular characteristics. This study identified location-specific lncRNAs as ceRNAs in colon cancer and established a DEL-based prognostic signature. These differences can be used to assess prognosis and determine treatment strategies for patients with colon cancer.
CANCER CELL INTERNATIONAL
(2021)
Review
Engineering, Chemical
Fernanda Costa Brandao Berti, Sara Cristina Lobo-Alves, Camila de Freitas Oliveira-Tore, Amanda Salviano-Silva, Karen Brajao de Oliveira, Patricia Savio de Araujo-Souza, Jong Kook Park, Gabriel Adelman Cipolla, Danielle Malheiros
Summary: MicroRNAs regulate gene expression by binding to target mRNAs, while interacting in competitive ceRNA networks. Long noncoding RNAs play essential roles in cervical cancer, impacting cell processes by modulating miRNA sponging. This dynamic molecular interaction affects cell growth, proliferation, apoptosis, and adhesion in CC.
Review
Oncology
Chengshun Li, Xiaolan Li, Ziping Jiang, Dongxu Wang, Liqun Sun, Jiaqi Li, Yang Han
Summary: This review discusses the mechanism of flavonoids in cancer treatment through modulating the ceRNA network.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Li-Sha Zheng, Wei Dou, Yu Peng, Wen-Jie Bai, Zhen-Yu Li, John Vontas, Jin-Jun Wang
Summary: The insect cuticle contributes over 40.0% to insecticide resistance, and miR-994 and CPCFC play key roles in regulating cuticle thickness and insecticide penetration.
Article
Oncology
Yuanxu Qu, Jiongdi Lu, Wentong Mei, Yuchen Jia, Chunjing Bian, Yixuan Ding, Yulin Guo, Feng Cao, Fei Li
Summary: This study developed a prognostic model for pancreatic cancer based on a ceRNA network. The model consists of eight genes and has shown effectiveness and independence in predicting the prognosis of patients with pancreatic cancer. These findings have potential implications for clinical management and personalized treatment of pancreatic cancer.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Xiaomin Li, Rui Chen, Ci Ren, Anni Huang, Wencheng Ding, Hui Wang
Summary: The study analyzed differential RNA expression in GBM, constructed lncRNA-miRNA-mRNA regulatory network, and proposed effective prediction models with 2 mRNAs and 5 lncRNAs. Key molecules closely associated with GBM prognosis were identified, and C10orf25/miR-218/DCBLD2 was suggested as an important regulatory pathway.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Shuxia Zhang, Ting Zhu, Qiaoyu Li, Guibo Sun, Xiaobo Sun
Summary: The review discusses the molecular mechanisms of LncRNA-mediated ceRNA networks under I/R injury and their effects in the four major cell types of the neurovascular unit (NVU). It also summarizes studies of LncRNAs as biomarkers and therapeutic targets, analyzing the advantages and limitations of using LncRNAs for IS treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Hani Sabaie, Sharareh Khorami Rouz, Ghazal Kouchakali, Samaneh Heydarzadeh, Mohammad Reza Asadi, Mirmohsen Sharifi-Bonab, Bashdar Mahmud Hussen, Mohammad Taheri, Seyed Abdulmajid Ayatollahi, Maryam Rezazadeh
Summary: This study identified the expression profiles and associated ceRNA regulatory axes in the periplaque region of multiple sclerosis (MS) patients using a bioinformatics approach. The results revealed 15 differentially expressed mRNAs and 4 lncRNAs connected to the MS ceRNA network. Pathway enrichment analysis showed enrichment in several pathways, including MAPK signaling pathway and lipid and atherosclerosis.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaohui Wan, Shuhong Hao, Chunmei Hu, Rongfeng Qu
Summary: This study constructed a lncRNA-miRNA-mRNA ceRNA network for breast cancer based on the TCGA database and identified potential prognostic risk factors, providing a new approach for prognosis prediction in breast cancer patients.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell Biology
Tingrui Wu, Bo Wei, Hao Lin, Boan Zhou, Tao Lin, Qianzheng Liu, Hongxun Sang, Huan Liu, Wenhua Huang
Summary: GSEA and functional enrichment analysis revealed important biological processes in cancer. The hsa_circ_0001753/has_miR_760/CD74 network may serve as a target for the early diagnosis and targeted therapy of OS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Environmental
Ling Li, Longcheng Zhang, Lichen Gou, Siqi Wei, Xiandeng Hou, Li Wu
Summary: Cu2O-Cu@Ni2P/NF is an efficient and stable electrocatalyst for MOR, achieving low potential, high stability, and low Tafel slope. In situ Raman spectroscopy reveals the promotion of beta-NiOOH active phase and conversion to Cu(II)O by Cu2O-Cu under electrolysis conditions. This catalyst as both the cathode and anode in a methanol electrolysis cell delivers lower voltage and higher current density compared to water electrolysis, indicating better performance.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Luchao Yue, Wei Song, Zhenguo Wu, Wenxi Zhao, Longcheng Zhang, Yongsong Luo, Dongdong Zheng, Benhe Zhong, Qian Liu, Shengjun Sun, Xiaodong Guo, Xuping Sun
Summary: Iron sulfides (FeS2) has high theoretical capacity and abundant natural resource, making it a promising anode material for advanced sodium-ion batteries (SIBs). However, its poor electronic conductivity, huge volume expansion, and dissolution of sodium polysulfides limit its practical application. In this study, FeS2/TiO2@CNFs heterostructure was constructed by incorporating TiO2, which has strong affinity for sodium polysulfides, as an active component. The resulting anode material exhibits high specific capacity, superior cycling durability, and excellent rate capability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Qin Yang, Yingchun Yang, Yujie Zhang, Longcheng Zhang, Shengjun Sun, Kai Dong, Yongsong Luo, Junyou Wu, Xiaowen Kang, Qian Liu, Mohamed S. Hamdy, Xuping Sun
Summary: The cobalt nanoparticles decorated biomass Juncus derived carbon (Co@JDC) was used to activate peroxymonosulfate (PMS) for efficient removal of ofloxacin (OFX) in water. The Co@JDC/PMS system showed excellent performance with 97% OFX degradation efficiency and 70.4% chemical oxygen demand removal rate achieved within 24 minutes. The system exhibited broad pH tolerance and was unaffected by Cl-, NO3-, and SO(4)2-. SO4-, ·OH, O2-, and O1(2-) were identified as the main active species in the PMS activation process.
Article
Chemistry, Multidisciplinary
Xiaoya Fan, Donglin Zhao, Zhiqin Deng, Longcheng Zhang, Jun Li, Zerong Li, Shengjun Sun, Yongsong Luo, Dongdong Zheng, Yan Wang, Binwu Ying, Jing Zhang, Abdulmohsen Ali Alshehri, Yuxiao Lin, Chengwu Tang, Xuping Sun, Yinyuan Zheng
Summary: A highly efficient electrocatalyst for electrochemical nitrate reduction reaction (NO3-RR) is presented in this study, which is constructed by anchoring Co nanoparticles on TiO2 nanobelt array on titanium plate (Co@TiO2/TP). The constructed Schottky heterostructures accelerate the rate determining step and facilitate NO3- adsorption, ensuring the selective conversion to NH3. The Co@TiO2/TP electrocatalyst achieves excellent Faradaic efficiency (96.7%) and high NH3 yield (800.0 mu mol h(-1) cm(-2)) under neutral solution. Moreover, the Co@TiO2/TP heterostructure catalyst exhibits remarkable stability in a 50-h electrolysis test.
Article
Chemistry, Physical
Jie Chen, Longcheng Zhang, Jun Li, Xun He, Yinyuan Zheng, Shengjun Sun, Xiaodong Fang, Dongdong Zheng, Yongsong Luo, Yan Wang, Jing Zhang, Lisi Xie, Zhengwei Cai, Yuntong Sun, Abdulmohsen Ali Alshehri, Qingquan Kong, Chengwu Tang, Xuping Sun
Summary: The use of nickel-iron sulfide nanosheet array on nickel foam as a bifunctional electrocatalyst demonstrates high-performance and cost-effective electrolysis of seawater for hydrogen production. It delivers a current density of 500 mA cm(-2) at overpotentials of 300 and 347 mV for the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER) in alkaline seawater respectively. Moreover, it only requires a cell voltage of 1.85 V to drive 500 mA cm(-2) in a two-electrode electrolyzer, and shows strong stability for at least 50 hours of electrolysis in alkaline seawater, outperforming recently reported catalyst electrodes for seawater splitting.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Physical
Jie Liang, Longcheng Zhang, Xun He, Yan Wang, Yongsong Luo, Dongdong Zheng, Shengjun Sun, Zhengwei Cai, Jing Zhang, Ke Ma, Yinyuan Zheng, Xuping Sun, Chengwu Tang
Summary: By introducing chlorine-cycle as a redox mediator, this study developed a simple approach to expand conversion sites from a limited electrode surface to the entire electrolyte, achieving efficient, economical, and environmentally friendly nitrate synthesis. The nitrate formation rates reach 115.45 mg cm(-2) h(-1) in a three-electrode system and 790.1 mg cm(-2) h(-1) in a two-electrode system, both significantly higher than the rates of state-of-the-art nitrogen electrooxidation, confirming the remarkable effectiveness of this strategy in producing nitrate homogeneously and electrochemically. Importantly, almost no side product nitrite is generated in this work. In addition, the structure changes of electrodes are investigated using (quasi)-in situ techniques.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiaoya Fan, Xun He, Xianchang Ji, Longcheng Zhang, Jun Li, Long Hu, Xiuhong Li, Shengjun Sun, Dongdong Zheng, Yongsong Luo, Yan Wang, Lisi Xie, Qian Liu, Binwu Ying, Xuping Sun
Summary: In this study, high-efficiency electrosynthesis of ammonia via nitrite reduction is achieved using an Ag nanoparticle-decorated TiO2 nanoribbon array on a titanium plate. The system demonstrates a large NH3 yield of 514.3 mu mol h(-1) cm(-2) and a high faradaic efficiency of 96.4% at -0.5 V vs. a reversible hydrogen electrode in 0.1 M NaOH containing 0.1 M NO2-. It also exhibits excellent durability for 12 hours of electrolysis.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Physical
Zhengwei Cai, Chaoqun Ma, Donglin Zhao, Xiaoya Fan, Ruizhi Li, Longcheng Zhang, Jun Li, Xun He, Yongsong Luo, Dongdong Zheng, Yan Wang, Binwu Ying, Shengjun Sun, Jia Xu, Qipeng Lu, Xuping Sun
Summary: In this study, Ni-doped TiO2 nanoribbon array on titanium plate (Ni-TiO2/TP) is reported as a highly active NO2RR electrocatalyst, which can simultaneously produce valuable ammonia (NH3) and eliminate NO-2 pollutants in water bodies. The catalyst exhibits a large NH3 yield of 380.27 mmol/h/cm2 and a high Faradaic efficiency of 94.89%, surpassing TiO2/TP. Density functional theory calculations reveal that Ni doping enhances intrinsic electrical conductivity and optimizes the adsorptive free energy of intermediates, leading to high selectivity of NO2--to-NH3 conversion.
MATERIALS TODAY ENERGY
(2023)
Article
Chemistry, Multidisciplinary
Xiuhong Li, Xun He, Jie Yao, Kai Dong, Long Hu, Jie Chen, Longcheng Zhang, Xiaoya Fan, Zhengwei Cai, Shengjun Sun, Dongdong Zheng, Mohamed S. Hamdy, Qian Liu, Yonglan Luo, Yunwen Liao, Xuping Sun
Summary: In this study, Ni nanoparticles strutted 3D honeycomb-like porous carbon framework (Ni@HPCF) was fabricated and used as a high-efficiency electrocatalyst for the selective reduction of nitrite to ammonia. The Ni@HPCF electrode achieved a significant ammonia yield of 12.04 mg h(-1) mg(cat.)(-1) and a Faradaic efficiency of 95.1% in 0.1 M NaOH with nitrite, demonstrating good long-term electrolysis stability.
Article
Chemistry, Inorganic & Nuclear
Chaoxin Yang, Kai Dong, Longcheng Zhang, Xun He, Jie Chen, Shengjun Sun, Meng Yue, Hui Zhang, Min Zhang, Dongdong Zheng, Yongsong Luo, Binwu Ying, Qian Liu, Abdullah M. Asiri, Mohamed S. Hamdy, Xuping Sun
Summary: We report a high-performance and stable seawater splitting electrocatalyst, Fe-NiS/NF, which consists of iron-doped NiS nanosheet array on Ni foam. This catalyst exhibits low overpotentials of 420 and 270 mV for oxygen evolution and hydrogen evolution reactions, respectively, in alkaline seawater. The two-electrode electrolyzer using this catalyst requires a cell voltage of 1.88 V for 1000 mA cm-2 and demonstrates excellent long-term electrochemical durability for 50 hours in alkaline seawater. In situ electrochemical Raman and infrared spectroscopy were employed to study the reconstitution process of NiOOH and the generation of oxygen intermediates under reaction conditions.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Xun He, Long Hu, Lisi Xie, Zerong Li, Jie Chen, Xiuhong Li, Jun Li, Longcheng Zhang, Xiaodong Fang, Dongdong Zheng, Shengjun Sun, Jing Zhang, Abdulmohsen Ali Alshehri, Yongsong Luo, Qian Liu, Yan Wang, Xuping Sun
Summary: Nitrite (NO2-), a nitrogen-containing pollutant, is widely present in aqueous solution and causes environmental and health problems. Electro-catalytic reduction of NO2- is a promising and sustainable method to remove NO2- and produce valuable ammonia (NH3). In this study, NiS2 nanoparticles decorated TiO2 nanoribbon array on titanium mesh (NiS2@TiO2/TM) is reported as an excellent electrocatalyst for ambient NH3 synthesis through NO2- reduction reaction (NO2-RR). NiS2@TiO2/TM demonstrates a satisfactory NH3 yield of 591.9 lmol h-1 cm-2 and a high Faradaic efficiency of 92.1% when tested in NO2--containing solution. Additionally, it exhibits remarkable stability during a 12-hour electrolysis test.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Analytical
Xuwei Liu, Ting Xie, Zhengwei Cai, Zixiao Li, Longcheng Zhang, Xiaoya Fan, Donglin Zhao, Shengjun Sun, Yongsong Luo, Qian Liu, Xuping Sun
Summary: In this study, Fe3C nanoparticles decorated 3D nitrogen-doped carbon foam (Fe3C NPs@NCF) were developed as an efficient electrocatalyst for the reduction of NO3- to NH3. The catalyst exhibited high Faradaic efficiency (96.9%) and a large NH3 yield (8391.8 mu g h-1 cm-2), along with excellent stability.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xianchang Ji, Chaoqun Ma, Fei Zhang, Xun He, Xiaoya Fan, Jun Li, Zixiao Li, Ling Ouyang, Longcheng Zhang, Tengyue Li, Donglin Zhao, Yan Wang, Jing Zhang, Zhengwei Cai, Shengjun Sun, Abdulmohsen Ali Alshehri, Qipeng Lu, Xuping Sun
Summary: The construction of Ni nanoparticles on TiO2 nanoribbon array with the Schottky junction resulted in highly selective reduction of NO2- to NH3. Density functional theory revealed that the Ni@TiO2 Schottky junction caused charge rearrangement and optimized adsorptive energy of intermediates, ensuring the selective conversion from NO2- to NH3. The catalyst achieved an impressive NH3 yield of 568.7 μmol h-1 cm-2 and an ultrahigh Faradaic efficiency of 98.5% under ambient conditions with good stability.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Analytical
Ling Li, Longcheng Zhang, Lichen Gou, Siqi Wei, Xiandeng Hou, Li Wu
Summary: Metal-semiconductor composites are widely used as SERS substrates, but their limited stability and poor active sites hinder their commercial application. In this study, a novel self-supporting flexible SERS substrate, Au@CoP/CC, was developed. The substrate exhibited excellent corrosion resistance and a low limit of detection using rhodamine 6G as a model dye. Finite-difference time-domain simulation results showed that the substrate can provide regions with intense local electric field enhancement. Moreover, the Au@CoP/CC substrate can degrade target organic dyes under visible light irradiation, enabling self-cleaning and reproduction of SERS-active substrates.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Shaorui Shi, Shengjun Sun, Xun He, Longcheng Zhang, Hui Zhang, Kai Dong, Zhengwei Cai, Dongdong Zheng, Yuntong Sun, Yongsong Luo, Qian Liu, Binwu Ying, Bo Tang, Xuping Sun, Wenchuang Hu
Summary: In this study, an iron doped cobalt carbonate hydroxide nanowire array on nickel foam (Fe-CoCH/NF) was reported as a high-efficiency oxygen evolution reaction (OER) electrocatalyst in seawater. It exhibited a lower overpotential and better stability compared to CoCH/NF in alkaline seawater. When paired with Pt/C/NF, it achieved a large current density with a low cell voltage in alkaline seawater, surpassing RuO2/NF & PAR;Pt/C/NF.
INORGANIC CHEMISTRY
(2023)