Article
Cell Biology
Chen Yang, Yiwen Zang, Siqi Wu, Quan Zhou, Yuxi Ou, Qiang Ding, Hao Wang, Zuquan Xiong
Summary: This study demonstrates that the circFTO/miR-514b-3p/DUSP4 axis plays an important role in the development of ccRCC and may serve as a potential biomarker and therapeutic target.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
HengQi Chen, Fang Li, Qi Xue
Summary: Elevated evidences have shown that circular RNAs (circRNAs) play a vital role in the development of human tumors and chemotherapy resistance. This study aimed to investigate the function of Circ-CUL2 in non-small cell lung cancer (NSCLC). The results showed that Circ-CUL2 suppressed the progression of A549/DDP cells and increased their sensitivity to cisplatin (DDP) by inhibiting miR-888-5p and targeting RB1CC1. Therefore, Circ-CUL2 could serve as a potential biomarker and a new therapeutic strategy for NSCLC.
Article
Oncology
Shengyu Zhou, Fayan Zhang, Mengxiang Xu, Lei Zhang, Zhengchuang Liu, Qiong Yang, Chunyang Wang, Baoming Wang, Tonghui Ma, Jiao Feng
Summary: This study analyzed 135 ROS1 fusions from 134 Chinese NSCLC patients using NGS, revealing the distribution preferences of breakpoints within ROS1 and identifying previously unknown breakpoints within intron 28 of ROS1. The study also demonstrated a close association between fusion partners and breakpoints on ROS1, highlighting the importance of understanding the molecular landscape of ROS1 fusions for panel design and treatment decisions.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Brian T. Abe, R. Alexander Wesselhoeft, Robert Chen, Daniel G. Anderson, Howard Y. Chang
Summary: Circular RNAs (circRNAs) are potential regulatory RNAs and a form of gene expression. This study investigates the migration patterns of circRNAs under different conditions using gel electrophoresis and high-performance liquid chromatography (HPLC). Various parameters affecting circRNA migration, such as gel type, electrophoresis time, sample buffer composition, and voltage, are characterized. Additionally, a novel orthogonal analytical test is demonstrated to distinguish circRNA from linear RNA based on their covalently closed structure.
Article
Multidisciplinary Sciences
Ming Wang, Ming Li, Zehan Liu, Cuinan Jiang, Hailong Lv, Qin Yang
Summary: The study aimed to investigate the role of circ_0128846 in pancreatic cancer (PC) and its interaction with miR-1270 and NR3C1. The results showed that circ_0128846 was highly expressed in PC and its deficiency inhibited cancer cell proliferation, colony formation, migration, and tumor growth. Circ_0128846 directly targeted miR-1270, which was downregulated in PC. Inhibition of miR-1270 partially reversed the suppressive effects of circ_0128846 silencing on PC progression. Furthermore, miR-1270 targeted NR3C1, and its knockdown partially abolished the repressive effects on PC cell malignant phenotypes. Our findings suggest that circ_0128846 functions as a potential biomarker and mediator in PC through the miR-1270/NR3C1 pathway.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yonglei Liu, Li Ma, Fanli Hua, Zhihui Min, Yanxia Zhan, Wei Zhang, Junxia Yao
Summary: This study investigates the role of circular RNA (circRNAs) from breast cancer stem cell (BCSC) exosomes in breast cancer cell metabolism reprogramming. The results show that circCARM1 in BCSC exosomes plays an important role in breast cancer cell glycolysis through miR-1252-5p/PFKFB2 regulation.
Article
Medicine, Research & Experimental
Guodong Liu, Xiwu Ouyang, Liansheng Gong, Lei Yao, Shiqing Liu, Jiarong Li, Qi Zhang, Yao Xiao
Summary: The study reveals the crucial role of circ-PRKAR1B in liver cancer progression, promoting cancer advancement through the miR-432-5p/E2F3 pathway. Clinical data and animal experiments further confirm the significance of this newly identified signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Pharmacology & Pharmacy
Zhi-Qiong Yu, Meng Wang, Wen Zhou, Meng-Xia Mao, Yuan-Yuan Chen, Na Li, Xiao-Chun Peng, Jun Cai, Zhi-Qiang Cai
Summary: This article reviews the role of ROS1 fusion kinase in tumor development and discusses the treatment methods for ROS1-positive non-small cell lung cancer patients and the mechanisms of resistance to inhibitors.
JOURNAL OF DRUG TARGETING
(2022)
Article
Multidisciplinary Sciences
Laura Amaya, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A. Wender, Bali Pulendran, Howard Y. Chang
Summary: Circular RNAs (circRNAs) are highly stable RNAs that can be engineered to provide durable protein expression. This study shows that circRNA encoding antigenic protein sequences delivered by a charge-altering releasable transporter can serve as both an adjuvant and an immunogen, inducing potent cellular immunity and leading to tumor clearance as a therapeutic vaccine. These results suggest the potential utility of engineered circRNAs for the development of vaccines and therapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: Studies have shown that circZNF609, a circular RNA, is significantly upregulated in bladder cancer and is associated with poor patient survival. Overexpression of circZNF609 promotes bladder cancer cell proliferation, migration, and resistance to cisplatin chemotherapy. Mechanistically, circZNF609 acts as a sponge for miR-1200, alleviating its inhibitory effect on the target gene CDC25B. These findings suggest that circZNF609 has significant potential as a new diagnostic biomarker and therapeutic target in bladder cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiang Luo, Feng Guo, Qingfeng Fu, Guoqing Sui
Summary: The study identified a novel interactome circ_0001018/miR-338-3p/SOX4 in papillary thyroid cancer (PTC) and demonstrated that circ_0001018 acts as a tumor promoter by sponging miR-338-3p to elevate SOX4 expression level in PTC, promoting cell proliferation, migration, and invasion. These findings suggest that this interaction axis may be a potential therapeutic target for PTC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Jin Xu, Nan Sang, Junning Zhao, Wei He, Nannan Zhang, Xueliang Li
Summary: This study found that circ_0067934 regulates the proliferation, invasion, and migration of gastric cancer cells through the miR-1301-3p/KIF23 signaling axis.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Pharmacology & Pharmacy
James E. Frampton
Summary: Entrectinib is an orally active small-molecule inhibitor targeting TRK and ROS1 genes, showing significant efficacy in treating NTRK+ solid tumors and ROS1+ NSCLC, including patients with CNS metastases. Its efficacy in pediatric patients is based on extrapolation from adult clinical trial data, with generally good tolerability and safety profile.
Article
Oncology
Moritz Glaser, Anna Rasokat, Darinka Prang, Lucia Nogova, Claudia Woempner, Jaqueline Schmitz, Elisabeth Bitter, Inken Terjung, Anna Eisert, Rieke Fischer, Felix John, Cornelia von Levetzow, Sebastian Michels, Richard Riedel, Lea Ruge, Heather Scharpenseel, Udo Siebolts, Sabine Merkelbach-Bruse, Reinhard Buettner, Johannes Braegelmann, Juergen Wolf, Matthias Scheffler
Summary: In this study, we explored the clinical and molecular characteristics of small-scale ROS1 mutations in NSCLC patients without ROS1 fusions or SFMs. We found that approximately 1.0% of patients harbored small-scale ROS1 mutations. Compared to ROS1-fused patients, co-occurrence of KRAS mutations led to shorter survival and immune-checkpoint blockade therapy was beneficial for patients.
Article
Chemistry, Multidisciplinary
Yuanyuan Zheng, Wenchen Pu, Jiao Li, Xianyan Shen, Qiang Zhou, Xin Fan, Sheng-Yong Yang, Yamei Yu, Qiang Chen, Chun Wang, Xin Wu, Yong Peng
CHEMISTRY-AN ASIAN JOURNAL
(2019)
Article
Oncology
Xuesha Liu, Wenchen Pu, Huaiyu He, Xin Fan, Yuanyuan Zheng, Jian-Kang Zhou, Rui Ma, Juan He, Yuzhu Zheng, Ke Wu, Yun Zhao, Sheng-Yong Yang, Chun Wang, Yu-Quan Wei, Xia-Wei Wei, Yong Peng
Article
Chemistry, Multidisciplinary
Xianyan Shen, Xuesha Liu, Shunli Wan, Xin Fan, Huaiyu He, Rong Wei, Wenchen Pu, Yong Peng, Chun Wang
FRONTIERS IN CHEMISTRY
(2019)
Article
Gastroenterology & Hepatology
Zhao Huang, Jian-Kang Zhou, Kui Wang, Haining Chen, Siyuan Qin, Jiayang Liu, Maochao Luo, Yan Chen, Jingwen Jiang, Li Zhou, Lei Zhu, Juan He, Jiao Li, Wenchen Pu, Yanqiu Gong, Jianbo Li, Qin Ye, Dandan Dong, Hongbo Hu, Zongguang Zhou, Lunzhi Dai, Canhua Huang, Xiawei Wei, Yong Peng
Article
Chemistry, Analytical
Xinyuan Wang, Xiuxuan Wang, Xinghua Pu, Wenchen Pu, Yuqi Wang, Yu Liu, Yanqiu Gong, Xiuxiu Jin, Yong Peng, Lunzhi Dai
ANALYTICAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Zhao Huang, Jian-Kang Zhou, Yong Peng, Weifeng He, Canhua Huang
Review
Cell Biology
Wenchen Pu, Yuanyuan Zheng, Yong Peng
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Chemistry, Applied
Tian-Qiong Lang, Guo-Yong Luo, Wen-Chen Pu, Zhi-Wei Wang, Jian Wang, Xiao-Long Tian, Pan Zhang, Neng-Wu Zhao, Wu-De Yang, Hui-Fang Chai
Summary: Five 3-formyl-2-arylbenzofuran derivatives were identified from the extract of Itea yunnanensis, showing significant growth inhibition effect on SK-Hep-1 cells. Mechanism study revealed that one of the compounds could block RAS/RAF/MEK/ERK signaling pathway to inhibit cell growth and induce apoptosis.
NATURAL PRODUCT RESEARCH
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Xinyi Li, Wenchen Pu, Song Chen, Yong Peng
Article
Microbiology
Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li
Summary: This study found that MARK4 promotes the activation of NLRP3 inflammasome and pyroptosis in P. gingivalis-infected macrophages by affecting microtubule dynamics. Inhibition of MARK4 may be a potential therapeutic target for regulating NLRP3 inflammasome during the progress of periodontitis.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Maochao Luo, Zhao Huang, Xingyue Yang, Yan Chen, Jingwen Jiang, Lu Zhang, Li Zhou, Siyuan Qin, Ping Jin, Shuyue Fu, Liyuan Peng, Bowen Li, Yongting Fang, Wenchen Pu, Yanqiu Gong, Yu Liu, Zhixiang Ren, Qiu-Luo Liu, Cun Wang, Fangqiong Xiao, Du He, Hongying Zhang, Changlong Li, Heng Xu, Lunzhi Dai, Yong Peng, Zong-Gung Zhou, Canhua Huang, Hai-Ning Chen
Summary: This study identifies PHLDB2 as a key player in latent liver metastasis of colorectal cancer (CRC). Chemotherapeutic-induced oxidative stress promotes N6-methyladenosine modification of PHLDB2 messenger RNA, leading to increased protein expression of PHLDB2. Upregulated PHLDB2 stabilizes EGFR and promotes its nuclear translocation, resulting in activation of EGFR signaling and resistance to cetuximab. The study proposes PHLDB2 as a potential target for CRC treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xinyi Li, Wenchen Pu, Qingquan Zheng, Min Ai, Song Chen, Yong Peng
Summary: PROTAC is an engineered technique for targeted protein degradation, which recruits target protein and E3 ubiquitin ligase to trigger the degradation of target protein. It has great potential in cancer therapy and offers advantages over traditional anti-cancer therapies.
Review
Dentistry, Oral Surgery & Medicine
Yuangang Wu, Jiao Li, Yi Zeng, Wenchen Pu, Xiaoyu Mu, Kaibo Sun, Yong Peng, Bin Shen
Summary: Osteoarthritis is a prevalent joint disease with no effective treatment currently available. Recent studies have discovered that exosomes, a type of cell-to-cell communication, can regulate cartilage behavior by delivering bioactive molecules, making them promising candidates for monitoring and treating osteoarthritis.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
